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LRRC8D Gene

protein-coding   GIFtS: 51
GCID: GC01P090286

Leucine Rich Repeat Containing 8 Family, Member D

(Previous name: leucine rich repeat containing 5)
(Previous symbol: LRRC5)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 8 Family, Member D1 2
LRRC51 2 3 5
Leucine Rich Repeat Containing 51 2
Leucine-Rich Repeat-Containing Protein 52 3
Leucine-Rich Repeat-Containing 52
Leucine-Rich Repeat-Containing Protein 8D2

External Ids:    HGNC: 169921   Entrez Gene: 551442   Ensembl: ENSG000001714927   OMIM: 6128905   UniProtKB: Q7L1W43   

Export aliases for LRRC8D gene to outside databases

Previous GC identifers: GC01P089999 GC01P090060 GC01P088403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC8D Gene:
LRRC8D (leucine rich repeat containing 8 family, member D) is a protein-coding gene. Diseases associated with LRRC8D include hiv-1. An important paralog of this gene is LRRC8E.

Gene Wiki entry for LRRC8D Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC8D gene promoter:
         TBP   NF-1   AML1a   Evi-1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRRC8D promoter sequence
   Search Chromatin IP Primers for LRRC8D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC8D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.2   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22.2

LRRC8D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC8D gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P090286:  view genomic region     (about GC identifiers)

Start:
90,286,573 bp from pter      End:
90,402,170 bp from pter
Size:
115,598 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRC8D_HUMAN, Q7L1W4 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 8D  
Size: 858 amino acids; 98201 Da
Sequence caution: Sequence=AAQ89233.1; Type=Erroneous initiation; Sequence=BAA91631.1; Type=Erroneous initiation;
Secondary accessions: D3DT29 Q6UWB2 Q9NVW3

Explore the universe of human proteins at neXtProt for LRRC8D: NX_Q7L1W4

Explore proteomics data for LRRC8D at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr68, Thr76, Thr77, Thr114, Thr118, Asn255, Asn598, Asn605, Asn740
  • Modification sites at PhosphoSitePlus

  • See LRRC8D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001127951.1  NP_060573.2  

    ENSEMBL proteins: 
     ENSP00000435609   ENSP00000338887   ENSP00000378093   ENSP00000435504   ENSP00000415117  
     ENSP00000433422   ENSP00000405784  

    LRRC8D Human Recombinant Protein Products:

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    Novus Biologicals LRRC8D Protein
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    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for LRRC8D

    LRRC8D Antibody Products:

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    Abcam antibodies for LRRC8D
    Cloud-Clone Corp. Antibodies for LRRC8D
    Search ThermoFisher Antibodies for LRRC8D
    Search LSBio for Antibodies for LRRC8D

    LRRC8D Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LRRC8D
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    Cloud-Clone Corp. ELISAs for LRRC8D
    Cloud-Clone Corp. CLIAs for LRRC8D


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR021040 LRR_protein-8_N

    Graphical View of Domain Structure for InterPro Entry Q7L1W4

    ProtoNet protein and cluster: Q7L1W4

    UniProtKB/Swiss-Prot: LRC8D_HUMAN, Q7L1W4
    Similarity: Contains 13 LRR (leucine-rich) repeats


    LRRC8D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRRC8D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC8D:
     Decreased Tat-dependent transc 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC8D
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC8D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC8D

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRRC8D:
    hsa-mir-26b-5p (MIRT029937), hsa-mir-454-3p (MIRT039220), hsa-mir-615-3p (MIRT040025), hsa-mir-1 (MIRT023944), kshv-mir-k12-3-5p (MIRT005467)

    Block miRNA regulation of human, mouse, rat LRRC8D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC8D (see all 39):
    hsa-miR-548j hsa-miR-199a-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidLRRC8D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRC8D
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC8D

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC8D (NM_018103)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC8D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC8D

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LRRC8D 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC8D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRC8D_HUMAN, Q7L1W4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    nucleus2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    LRRC8D for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC8D
    Interactions:

        Search GeneGlobe Interaction Network for LRRC8D

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRRC8D (Q7L1W43 ENSP000003388874) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXOSC4Q9NPD33, ENSP000003154764I2D: score=3 STRING: ENSP00000315476
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC8D (LRC8D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRRC8D gene (2 alternative transcripts): 
    NM_001134479.1  NM_018103.4  

    Unigene Cluster for LRRC8D:

    Leucine rich repeat containing 8 family, member D
    Hs.482087  [show with all ESTs]
    Unigene Representative Sequence: NM_001134479
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000525774 ENST00000337338(uc001dnm.3 uc001dnn.3) ENST00000394593
    ENST00000532201 ENST00000414841 ENST00000527156 ENST00000441269
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRC8D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC8D (see all 39):
    hsa-miR-548j hsa-miR-199a-3p hsa-miR-1245 hsa-miR-30d hsa-miR-30a hsa-miR-548d-5p hsa-miR-548a-5p hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidLRRC8D 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRRC8D
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC8D
    Clone
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    OriGene clones in human, mouse for LRRC8D (see all 13)
    OriGene ORF clones in mouse, rat for LRRC8D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC8D (NM_018103)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC8D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC8D
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRRC8D
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC8D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC8D
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC8D
      QuantiFast Probe-based Assays in human, mouse, rat LRRC8D

    Additional mRNA sequence: 

    AK001332.1 AK092238.1 AK222787.1 AL831880.1 AL832952.1 AY007147.1 AY358874.1 BC009486.1 
    BC024159.2 

    8 DOTS entries:

    DT.100775244  DT.412880  DT.95099224  DT.100026414  DT.121373251  DT.95257931  DT.95161836  DT.100683653 

    Selected AceView cDNA sequences (see all 126):

    AL831880 BI467059 BC024159 AW024375 CD515492 AX747423 CR624835 AK001332 
    AA151029 CA868250 AK092238 BP345087 N50769 AA316383 BI439844 AW612007 
    BX093623 NM_018103 AL832952 AY358874 BI324880 BG034111 AY007147 BM468225 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRRC8D (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -     -     -     -     -     -           -                                       
    SP2:                                      -           -     -                                 
    SP3:        -     -     -     -     -     -           -     -                                 
    SP4:                                                                                          
    SP5:                    -     -     -     -           -     -                                 


    ECgene alternative splicing isoforms for LRRC8D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC8D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAAACTT
    LRRC8D Expression
    About this image

    LRRC8D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC8D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.482087
        Custom PCR Arrays for LRRC8D
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC8D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRRC8D gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc8d1 , 5 leucine rich repeat containing 8D1, 5 86.36(n)1
    96.04(a)1
      5 (50.68 cM)5
    2315491  NM_178701.31  NP_848816.31 
     1056999695 
    chicken
    (Gallus gallus)
    Aves LRRC8D1 leucine rich repeat containing 8 family, member D 81.4(n)
    89.45(a)
      424513  XM_004936629.1  XP_004936686.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC8D6
    leucine rich repeat containing 8 family, member D
    90(a)
    1 ↔ 1
    4(95565825-95568407)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrrc8d1 leucine rich repeat containing 8 family, member D 75.15(n)
    83.24(a)
      100145421  NM_001126881.1  NP_001120353.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.197202 Transcribed sequence with weak similarity to protein more 77.63(n)    AL922652.1 


    ENSEMBL Gene Tree for LRRC8D (if available)
    TreeFam Gene Tree for LRRC8D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC8D gene
    LRRC8E2  LRRC72  ERBB2IP2  RSU12  LRRC8A2  MFHAS12  LRRC12  LRRIQ42  
    SCRIB2  SHOC22  LRRD12  LRRC8B2  LRRC8C2  LRRC402  
    7 SIMAP similar genes for LRRC8D using alignment to 7 protein entries:     LRC8D_HUMAN (see all proteins):
    DKFZp666L2010    LRRC5    LRRC8C    LRRC8E    LRRC8A    LRRC8B
    LRIG3

    LRRC8D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC8D (see all 2241)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105564721,2
    C--88417991(+) GCCAG-/AC/CA 
            
    CTAGG
    2 -- int11CSA 2
    rs800564311,2
    C--90284630(+) GTGTGT/AGAGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs344680871,2
    C--90284631(+) GTGAG-/AG/GA 
            
    TGTCT
    1 -- us2k11NA 2
    rs765201011,2
    --90284634(+) GTGAGT/AGTCTA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1824809061,2
    --90284686(+) TTTCTC/TGATTT 1 -- us2k10--------
    rs1498506621,2
    --90284752(+) GAAGAA/TCAAAA 1 -- us2k10--------
    rs1868216451,2
    --90284787(+) TTTTGG/TTTTTT 1 -- us2k10--------
    rs1900691921,2
    --90284827(+) CCCAGA/GCTGGA 1 -- us2k10--------
    rs1458800341,2
    --90284868(+) CCTCCA/GCCTCC 1 -- us2k10--------
    rs1490111791,2
    --90284870(+) TCCGCA/CTCCCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRC8D (90286573 - 90402170 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LRRC8D:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv267816CNV Insertion20981092
    esv273544CNV Insertion20981092
    nsv1832CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC8D
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC8D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612890    OMIM disorders: --

    1 disease for LRRC8D:    
    About MalaCards
    hiv-1


    LRRC8D for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC8D
    Human Genome Epidemiology (HuGE) Navigator: LRRC8D (1 document)

    Export disorders for LRRC8D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC8D gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with LRRC8D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)
    6. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    9. Identification of host proteins required for HIV infection through a functional genomic screen. (PubMed id 18187620)1 Brass A.L....Elledge S.J. (Science 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55144 HGNC: 16992 AceView: LRRC5 Ensembl:ENSG00000171492 euGenes: HUgn55144
    ECgene: LRRC8D H-InvDB: LRRC8D

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC8D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LRRC8D Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC8D gene:
    Search GeneIP for patents involving LRRC8D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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