Aliases for LRRC8D Gene
External Ids for LRRC8D Gene
Previous Symbols for LRRC8D Gene
GeneCards Summary for LRRC8D Gene
LRRC8D (Leucine Rich Repeat Containing 8 Family, Member D) is a Protein Coding gene. An important paralog of this gene is MFHAS1.
UniProtKB/Swiss-Prot for LRRC8D Gene
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309).