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LRRC8C Gene

protein-coding   GIFtS: 48
GCID: GC01P090098

Leucine Rich Repeat Containing 8 Family, Member C

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Leucine Rich Repeat Containing 8 Family, Member C1 2     Factor For Adipocyte Differentiation 1582 3
AD1582 3 5     Leucine Rich Repeat Containing 8C2
FAD1582 3 5     Leucine-Rich Repeat-Containing Protein 8C2
Hypothetical Protein AD1581 2     

External Ids:    HGNC: 250751   Entrez Gene: 842302   Ensembl: ENSG000001714887   OMIM: 6128895   UniProtKB: Q8TDW03   
ORGUL members:         

Export aliases for LRRC8C gene to outside databases

Previous GC identifers: GC01P089811 GC01P089871 GC01P088215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC8C Gene:
LRRC8C (leucine rich repeat containing 8 family, member C) is a protein-coding gene. An important paralog of this gene is LRRC8E.

UniProtKB/Swiss-Prot: LRC8C_HUMAN, Q8TDW0
Function: May play a role in adipogenesis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC8C gene promoter:
         ER-alpha   Max1   Sox5   AML1a   FOXD3   CUTL1   MZF-1   FOXO4   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC8C promoter sequence
   Search Chromatin IP Primers for LRRC8C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC8C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p22.2   Ensembl cytogenetic band:  1p22.2   HGNC cytogenetic band: 1p22.2

LRRC8C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC8C gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P090098:  view genomic region     (about GC identifiers)

Start:
90,098,631 bp from pter      End:
90,235,462 bp from pter
Size:
136,832 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRC8C_HUMAN, Q8TDW0 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 8C  
Size: 803 amino acids; 92450 Da
Secondary accessions: B3KXS9 Q29RV6 Q9H075

Explore the universe of human proteins at neXtProt for LRRC8C: NX_Q8TDW0

Explore proteomics data for LRRC8C at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys219, Lys401, Lys499
  • Glycosylation2 at Asn70, Asn194, Asn305, Asn552, Asn590
  • Modification sites at PhosphoSitePlus

  • See LRRC8C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115646.2  
    ENSEMBL proteins: 
     ENSP00000359483   ENSP00000436638  

    LRRC8C Human Recombinant Protein Products:

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    antibodies-online antibodies for LRRC8C (2 products) 

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    antibodies-online kits for LRRC8C (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR021040 LRR_protein-8_N

    Graphical View of Domain Structure for InterPro Entry Q8TDW0

    ProtoNet protein and cluster: Q8TDW0

    UniProtKB/Swiss-Prot: LRC8C_HUMAN, Q8TDW0
    Similarity: Contains 17 LRR (leucine-rich) repeats


    Find genes that share domains with LRRC8C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRC8C_HUMAN, Q8TDW0
    Function: May play a role in adipogenesis (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRRC8C           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LRRC8C

    miRNA
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    miRTarBase miRNAs that target LRRC8C:
    hsa-mir-1 (MIRT023754), hsa-mir-30a-5p (MIRT005169), hsa-mir-124-3p (MIRT022568), hsa-mir-192-5p (MIRT026398)

    Block miRNA regulation of human, mouse, rat LRRC8C using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC8C (see all 45):
    hsa-miR-21* hsa-miR-4291 hsa-miR-188-5p hsa-miR-30d hsa-miR-570 hsa-miR-10b* hsa-miR-9 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC8C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRC8C_HUMAN, Q8TDW0: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LRRC8C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC8C
    Interactions:

        Search GeneGlobe Interaction Network for LRRC8C

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRRC8C (ENSP000003594834) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC8C (LRC8C)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRRC8C gene: 
    NM_032270.4  

    Unigene Cluster for LRRC8C:

    Leucine rich repeat containing 8 family, member C
    Hs.412836  [show with all ESTs]
    Unigene Representative Sequence: NM_032270
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000370454(uc001dnl.4) ENST00000479252 ENST00000482063 ENST00000416805

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LRRC8C (see all 45):
    hsa-miR-21* hsa-miR-4291 hsa-miR-188-5p hsa-miR-30d hsa-miR-570 hsa-miR-10b* hsa-miR-9 hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC8C
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC8C
      QuantiFast Probe-based Assays in human, mouse, rat LRRC8C

    Additional mRNA sequence: 

    AB081509.1 AK094804.1 AK127881.1 AL136919.1 BC036122.1 BC103929.2 BC113973.1 

    6 DOTS entries:

    DT.97770424  DT.101977605  DT.100021918  DT.121373265  DT.411876  DT.92049196 

    Selected AceView cDNA sequences (see all 43):

    AI701230 BM788356 BU620963 AA478900 AL136919 AW302620 CA419859 AA722683 
    AA479597 AA360898 AA478781 AI475288 BQ228027 NM_032270 AK127881 AI241484 
    AW512498 BX119226 BC036122 AB081509 AW316765 BC043369 AI949072 AA187369 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC8C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTTAATG
    LRRC8C Expression
    About this image


    LRRC8C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
    LRRC8C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC8C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412836

    UniProtKB/Swiss-Prot: LRC8C_HUMAN, Q8TDW0
    Tissue specificity: Expressed at highest levels in skeletal muscle, and at moderate levels in heart, lung and
    peripheral blood leukocytes

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC8C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRRC8C gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc8c1 , 5 leucine rich repeat containing 8 family, member C1, 5 87.13(n)1
    97.51(a)1
      5 (50.68 cM)5
    1006041  NM_133897.21  NP_598658.11 
     1055193885 
    chicken
    (Gallus gallus)
    Aves LRRC8C1 leucine rich repeat containing 8 family, member C 80.01(n)
    90.4(a)
      424515  XM_422353.4  XP_422353.2 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC8C6
    leucine rich repeat containing 8 family, member C
    86(a)
    1 ↔ 1
    4(95733139-95766411)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.114832 Transcribed sequence with weak similarity to protein more 74.91(n)    CF785227.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrc8c1 leucine rich repeat containing 8 family, member C 72.43(n)
    80.03(a)
      571216  XM_001919346.4  XP_001919381.1 


    ENSEMBL Gene Tree for LRRC8C (if available)
    TreeFam Gene Tree for LRRC8C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC8C gene
    LRRC8E2  LRRC72  ERBB2IP2  RSU12  LRRC8A2  MFHAS12  LRRC12  LRRIQ42  
    SCRIB2  SHOC22  LRRD12  LRRC8D2  LRRC8B2  LRRC402  
    9 SIMAP similar genes for LRRC8C using alignment to 3 protein entries:     LRC8C_HUMAN (see all proteins):
    LRRC8E    LRRC8D    LRRC8A    LRRC8B    DKFZp666L2010    LRRC5
    LRRD1    LRRC1    RSU1

    Find genes that share paralogs with LRRC8C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC8C (see all 1639)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860966781,2
    --90118374(+) TCAGTC/GAAGAG 1 -- us2k10--------
    rs1910638261,2
    --90118798(+) TAAGAG/TAATTG 1 -- us2k10--------
    rs1814463241,2
    --90118961(+) GTAAGC/TCCGGA 1 -- us2k10--------
    rs12155001,2
    C,F,O,A,H--90118964(-) AGGTCG/CGGGCT 1 -- us2k120Minor allele frequency- C:0.34MN EA NS NA WA CSA 2273
    rs1409317131,2
    --90118980(+) TTTGTC/TTTGTT 1 -- us2k10--------
    rs1857845481,2
    --90119026(+) TAAGGC/GCTAAG 1 -- us2k10--------
    rs1446948051,2
    --90119032(+) CTAAGA/CGAATT 1 -- us2k10--------
    rs1906902951,2
    --90119075(+) CAGCAC/TTGGAA 1 -- us2k10--------
    rs1386413981,2
    C--90119353(+) TAGCTC/GGCATT 1 -- us2k10--------
    rs1403053831,2
    --90119405(+) TCGGTA/GCATTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRC8C (90098631 - 90235462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LRRC8C:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2430347CNV Deletion19546169
    esv2674468CNV Deletion23128226
    esv2676348CNV Deletion23128226
    nsv521773CNV Loss19592680
    esv25406CNV Loss19812545
    esv21711CNV Loss19812545
    nsv830559CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612889    OMIM disorders: --


    Find genes that share disorders with LRRC8C           About GenesLikeMe

    Genetic Association Database (GAD): LRRC8C
    Human Genome Epidemiology (HuGE) Navigator: LRRC8C (1 document)

    Export disorders for LRRC8C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC8C gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with LRRC8C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation. (PubMed id 15564382)2 Tominaga K.... Imagawa M. (J. Cell Sci. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84230 HGNC: 25075 AceView: FAD158 Ensembl:ENSG00000171488 euGenes: HUgn84230
    ECgene: LRRC8C H-InvDB: LRRC8C

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC8C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC8C gene:
    Search GeneIP for patents involving LRRC8C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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