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LRRC8A Gene

protein-coding   GIFtS: 54
GCID: GC09P131644

Leucine Rich Repeat Containing 8 Family, Member A

(Previous name: leucine rich repeat containing 8)
(Previous symbol: LRRC8)
  See LRRC8A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 8 Family, Member A1 2
LRRC81 2 3
AGM52 5
KIAA14373 5
Leucine Rich Repeat Containing 81
Leucine-Rich Repeat-Containing Protein 8A2

External Ids:    HGNC: 190271   Entrez Gene: 562622   Ensembl: ENSG000001368027   OMIM: 6083605   UniProtKB: Q8IWT63   

Export aliases for LRRC8A gene to outside databases

Previous GC identifers: GC09P128728 GC09P130684 GC09P101252


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRRC8A Gene:
This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse
biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. This
family member is a putative four-pass transmembrane protein that plays a role in B cell development. Defects in
this gene cause autosomal dominant non-Bruton type agammaglobulinemia, an immunodeficiency disease resulting from
defects in B cell maturation. Multiple alternatively spliced transcript variants, which encode the same protein,
have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for LRRC8A Gene:
LRRC8A (leucine rich repeat containing 8 family, member A) is a protein-coding gene. Diseases associated with LRRC8A include agammaglobulinemia 5, and agammaglobulinemia. An important paralog of this gene is LRRC8E.

UniProtKB/Swiss-Prot: LRC8A_HUMAN, Q8IWT6
Function: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity)

Gene Wiki entry for LRRC8A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC8A gene promoter:
         MAZR   COUP   AP-4   Pax-4a   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC8A promoter sequence
   Search Chromatin IP Primers for LRRC8A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC8A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.11   Ensembl cytogenetic band:  9q34.11   HGNC cytogenetic band: 9q34.2

LRRC8A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC8A gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P131644:  view genomic region     (about GC identifiers)

Start:
131,644,391 bp from pter      End:
131,680,318 bp from pter
Size:
35,928 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRC8A_HUMAN, Q8IWT6 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 8A  
Size: 810 amino acids; 94199 Da
Sequence caution: Sequence=AAQ88653.1; Type=Erroneous initiation; Sequence=BAA92675.1; Type=Erroneous initiation;
Sequence=BAC11161.1; Type=Erroneous initiation;
Secondary accessions: Q6UXM2 Q8NCI0 Q9P2B1

Explore the universe of human proteins at neXtProt for LRRC8A: NX_Q8IWT6

Explore proteomics data for LRRC8A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn83, Asn191, Asn526, Asn554, Asn592, Asn660, Asn696, Asn755
  • Modification sites at PhosphoSitePlus

  • See LRRC8A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001120716.1  NP_001120717.1  NP_062540.2  

    ENSEMBL proteins: 
     ENSP00000361682   ENSP00000361680   ENSP00000259324  

    LRRC8A Human Recombinant Protein Products:

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    Novus Biologicals LRRC8A Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LRRC8A

     
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    antibodies-online proteins for LRRC8A (2 products) 

     
    antibodies-online peptides for LRRC8A

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    antibodies-online antibodies for LRRC8A (21 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR021040 LRR_protein-8_N

    Graphical View of Domain Structure for InterPro Entry Q8IWT6

    ProtoNet protein and cluster: Q8IWT6

    UniProtKB/Swiss-Prot: LRC8A_HUMAN, Q8IWT6
    Similarity: Contains 17 LRR (leucine-rich) repeats


    Find genes that share domains with LRRC8A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRC8A_HUMAN, Q8IWT6
    Function: Involved in B-cell development. Required for the pro-B cell to pre-B cell transition (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRRC8A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LRRC8A:
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Lrrc8a (no phenotypes)

    Find genes that share phenotypes with LRRC8A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrrc8atm1Lex for LRRC8A

       genOway: Develop your customized and physiologically relevant rodent model for LRRC8A

    miRNA
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    miRTarBase miRNAs that target LRRC8A:
    hsa-let-7e-5p (MIRT051458), hsa-let-7b-5p (MIRT032470), hsa-mir-33a-5p (MIRT028222), hsa-mir-335-5p (MIRT018758), hsa-mir-149-5p (MIRT045587), hsa-mir-1 (MIRT001358), hsa-mir-193b-3p (MIRT016581)

    Block miRNA regulation of human, mouse, rat LRRC8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC8A (see all 33):
    hsa-miR-3938 hsa-miR-193a-3p hsa-miR-607 hsa-miR-3194-5p hsa-miR-429 hsa-miR-200a hsa-miR-765 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLRRC8A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRRC8A

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC8A
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC8A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRC8A_HUMAN, Q8IWT6: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LRRC8A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC8A
    Interactions:

        Search GeneGlobe Interaction Network for LRRC8A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for LRRC8A (ENSP000002593244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002329pre-B cell differentiation ISS--

    Find genes that share ontologies with LRRC8A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC8A (LRC8A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRRC8A gene (3 alternative transcripts): 
    NM_001127244.1  NM_001127245.1  NM_019594.3  

    Unigene Cluster for LRRC8A:

    Leucine rich repeat containing 8 family, member A
    Hs.643600  [show with all ESTs]
    Unigene Representative Sequence: NM_001127244
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372600(uc004bwl.4 uc010myp.3) ENST00000372599 ENST00000483638
    ENST00000492784 ENST00000259324(uc010myq.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat LRRC8A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC8A (see all 33):
    hsa-miR-3938 hsa-miR-193a-3p hsa-miR-607 hsa-miR-3194-5p hsa-miR-429 hsa-miR-200a hsa-miR-765 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidLRRC8A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LRRC8A
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC8A
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    GenScript: all cDNA clones in your preferred vector (see all 3): LRRC8A (NM_001127245)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC8A
    Primer
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    OriGene qPCR primer pairs and template standards for LRRC8A
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC8A
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC8A
      QuantiFast Probe-based Assays in human, mouse, rat LRRC8A

    Additional mRNA sequence: 

    AB037858.1 AK001199.1 AK024649.1 AK027495.1 AK074723.1 AK123611.1 AK289842.1 AY143166.1 
    AY358286.1 BC000775.2 BC051322.1 

    14 DOTS entries:

    DT.95254460  DT.446625  DT.40268176  DT.102831288  DT.95254467  DT.100037762  DT.95254469  DT.95309620 
    DT.97781672  DT.100832878  DT.121146554  DT.95240118  DT.99945396  DT.100812588 

    Selected AceView cDNA sequences (see all 275):

    AA367255 BG981885 BU735735 BQ887429 BC051322 BG981845 AI376927 AA678831 
    BQ928489 BQ956942 AI439206 AI094530 CR619692 BQ684743 AA904590 AI870013 
    BX376144 BU167871 BI027985 AL708412 AW339965 BC000775 AI686221 CA446308 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRRC8A (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b
    SP1:        -           -     -                                                   
    SP2:                    -     -                                                   
    SP3:                    -     -                                   -               
    SP4:                          -                                                   
    SP5:                                                                              


    ECgene alternative splicing isoforms for LRRC8A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC8A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGTCTGAA
    LRRC8A Expression
    About this image

    LRRC8A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC8A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643600

    UniProtKB/Swiss-Prot: LRC8A_HUMAN, Q8IWT6
    Tissue specificity: Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at
    high levels in bone marrow; lower levels are detected in peripheral blood cells. Expressed on T-cells as well as
    on B-lineage cells

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRRC8A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc8a1 , 5 leucine rich repeat containing 8A1, 5 92.92(n)1
    99.01(a)1
      2 (21.41 cM)5
    2412961  NM_177725.41  NP_808393.11 
     302377155 
    chicken
    (Gallus gallus)
    Aves LOC1008589171 leucine-rich repeat-containing protein 8A-like 81.19(n)
    94.94(a)
      100858917  XM_003642283.2  XP_003642331.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC8A6
    leucine rich repeat containing 8 family, member A
    94(a)
    1 ↔ 1
    AAWZ02037432(5903-11785)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrrc8a1 leucine rich repeat containing 8 family, member A 79.89(n)
    90.48(a)
      100492279  XM_004916690.1  XP_004916747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrc8a1 leucine rich repeat containing 8 family, member A 79.99(n)
    87.52(a)
      327642  NM_001029949.1  NP_001025120.1 


    ENSEMBL Gene Tree for LRRC8A (if available)
    TreeFam Gene Tree for LRRC8A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC8A gene
    LRRC8E2  LRRC72  ERBB2IP2  RSU12  MFHAS12  LRRC12  LRRIQ42  SCRIB2  
    SHOC22  LRRD12  LRRC8D2  LRRC8B2  LRRC8C2  LRRC402  
    6 SIMAP similar genes for LRRC8A using alignment to 1 protein entry:     LRC8A_HUMAN:
    LRRC8C    DKFZp666L2010    LRRC8B    LRRC5    LRRC8D    LRRC8E

    Find genes that share paralogs with LRRC8A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC8A (see all 787)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872816711,2
    --131646366(+) GAAGCC/TGTTTC 3 -- int10--------
    rs109881411,2
    C,F,A,H--131646429(+) CTGCCG/TTGGGT 3 -- int116Minor allele frequency- T:0.05NS EA NA 1896
    rs1917271621,2
    --131646454(+) GTGGCC/TGGACC 3 -- int10--------
    rs1393319671,2
    --131646559(+) TTCCAA/GGTTTT 3 -- int10--------
    rs1474750561,2
    C--131646674(+) TTGAC-/TCAT  
            
    TCATT
    3 -- int10--------
    rs1426144311,2
    --131646687(+) TCATTC/GATTCA 3 -- int10--------
    rs78607091,2
    C,F--131646718(+) AAAGTG/ACCTGT 3 -- int11Minor allele frequency- A:0.03EA 120
    rs1824549341,2
    --131646800(+) AGAAGA/GCACAT 3 -- int10--------
    rs1150505391,2
    C,F--131646885(+) CTGGGT/AGGTTA 3 -- int11Minor allele frequency- A:0.10WA 118
    rs1875881921,2
    --131647086(+) TGCCTA/GTATAG 3 -- int10--------

    HapMap Linkage Disequilibrium report for LRRC8A (131644391 - 131680318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LRRC8A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8297n71CNV Loss21882294
    dgv8296n71CNV Loss21882294
    nsv893902CNV Gain21882294

    Human Gene Mutation Database (HGMD): LRRC8A
    Locus Specific Mutation Databases (LSDB): LRRC8A

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608360   
    OMIM disorders: 613506  
    UniProtKB/Swiss-Prot: LRC8A_HUMAN, Q8IWT6
  • Agammaglobulinemia 5, autosomal dominant (AGM5) [MIM:613506]: A primary immunodeficiency characterized by
    profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell
    development. Affected individuals develop severe infections in the first years of life. Note=The disease is
    caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving LRRC8 has
    been found in a patient with congenital agammaglobulinemia. Translocation t(9;20)(q33.2;q12). The translocation
    truncates the LRRC8 gene, resulting in deletion of the eighth, ninth, and half of the seventh LRR domains

  • 3 diseases for LRRC8A:    
    About MalaCards
    agammaglobulinemia 5    agammaglobulinemia    agammaglobulinemia 3

    1 disease from the University of Copenhagen DISEASES database for LRRC8A:
    Agammaglobulinemia

    Find genes that share disorders with LRRC8A           About GenesLikeMe

    Genetic Association Database (GAD): LRRC8A

    Export disorders for LRRC8A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC8A gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with LRRC8A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans. (PubMed id 14660746)1, 2, 9 Sawada A....Hara J. (J. Clin. Invest. 2003)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    4. LRRC8 extracellular domain is composed of 17 leucine-rich repeats. (PubMed id 15183935)1, 2 Smits G. and Kajava A.V. (Mol. Immunol. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56262 HGNC: 19027 AceView: LRRC8 Ensembl:ENSG00000136802 euGenes: HUgn56262
    ECgene: LRRC8A H-InvDB: LRRC8A

    (According to HUGE)
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    HUGE: KIAA1437

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC8A Pharmacogenomics, SNPs, Pathways
    LRRC8Abasehttp://bioinf.uta.fi/LRRC8Abase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC8A gene:
    Search GeneIP for patents involving LRRC8A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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