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Aliases for LRRC75B Gene

Aliases for LRRC75B Gene

  • Leucine Rich Repeat Containing 75B 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211B 3 4
  • Family With Sequence Similarity 211, Member B 2 3
  • C22orf36 3 4
  • FAM211B 3 4
  • Leucine-Rich Repeat-Containing Protein C22orf36 3
  • Leucine-Rich Repeat-Containing Protein 75B 3
  • Chromosome 22 Open Reading Frame 36 2

External Ids for LRRC75B Gene

Previous HGNC Symbols for LRRC75B Gene

  • C22orf36
  • FAM211B

Previous GeneCards Identifiers for LRRC75B Gene

  • GC22M025185

Summaries for LRRC75B Gene

GeneCards Summary for LRRC75B Gene

LRRC75B (Leucine Rich Repeat Containing 75B) is a Protein Coding gene. An important paralog of this gene is LRRC75A.

Additional gene information for LRRC75B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC75B Gene

Genomics for LRRC75B Gene

Regulatory Elements for LRRC75B Gene

Enhancers for LRRC75B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H024600 1.2 Ensembl ENCODE 10.5 -9.7 -9708 4 ELF3 HDGF NFIB ZNF133 ARID4B DMAP1 NFXL1 RAD21 RARA ZNF121 GGT1 LRRC75B CHCHD10 ENSG00000230947 BCRP3
GH22H023766 1.1 ENCODE 9.7 +825.6 825560 2 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 SMARCB1 VPREB3 ENSG00000234353 POM121L9P SNRPD3 CABIN1 MIF-AS1 ZDHHC8P1 ENSG00000272578 ENSG00000272787
GH22H025402 1.3 ENCODE dbSUPER 7 -811.4 -811402 4 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 ZNF121 ZNF143 RUNX3 LRP5L LRRC75B LOC100419673 ENSG00000272977 PIR32639
GH22H024629 0.6 Ensembl 13 -36.2 -36193 0 CTCF ZNF654 ZBTB48 ZNF341 ZNF143 ZNF18 ENSG00000230947 LRRC75B GGT1 BCRP3
GH22H024559 0.4 dbSUPER 12.8 +33.6 33583 0 PRDM10 GGT1 LRRC75B ENSG00000230947 ADORA2A SPECC1L BCRP3 GUCD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC75B on UCSC Golden Path with GeneCards custom track

Promoters for LRRC75B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000144427 208 1200 MLX ARNT ARID4B YY1 GLIS2 SP5 ZHX2 KAT8 NFIL3 SSRP1

Genomic Location for LRRC75B Gene

Chromosome:
22
Start:
24,585,620 bp from pter
End:
24,593,208 bp from pter
Size:
7,589 bases
Orientation:
Minus strand

Genomic View for LRRC75B Gene

Genes around LRRC75B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75B Gene

Proteins for LRRC75B Gene

  • Protein details for LRRC75B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPJ9-LR75B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 75B
    Protein Accession:
    Q2VPJ9
    Secondary Accessions:
    • Q8N0S9
    • Q8N8B1

    Protein attributes for LRRC75B Gene

    Size:
    315 amino acids
    Molecular mass:
    34740 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC75B Gene

Post-translational modifications for LRRC75B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC75B Gene

No data available for DME Specific Peptides for LRRC75B Gene

Domains & Families for LRRC75B Gene

Gene Families for LRRC75B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC75B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC75B Gene

Graphical View of Domain Structure for InterPro Entry

Q2VPJ9

UniProtKB/Swiss-Prot:

LR75B_HUMAN :
  • Belongs to the LRRC75 family.
Family:
  • Belongs to the LRRC75 family.
genes like me logo Genes that share domains with LRRC75B: view

Function for LRRC75B Gene

Phenotypes From GWAS Catalog for LRRC75B Gene

genes like me logo Genes that share phenotypes with LRRC75B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC75B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC75B Gene

Localization for LRRC75B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC75B gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC75B Gene

Pathways & Interactions for LRRC75B Gene

SuperPathways for LRRC75B Gene

No Data Available

Interacting Proteins for LRRC75B Gene

Selected Interacting proteins: Q2VPJ9-LR75B_HUMAN for LRRC75B Gene via IID

Symbol External ID(s) Details
SIX5

Gene Ontology (GO) - Biological Process for LRRC75B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC75B Gene

Drugs & Compounds for LRRC75B Gene

No Compound Related Data Available

Transcripts for LRRC75B Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC75B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75B Gene

No ASD Table

Relevant External Links for LRRC75B Gene

GeneLoc Exon Structure for
LRRC75B
ECgene alternative splicing isoforms for
LRRC75B

Expression for LRRC75B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC75B Gene

Protein differential expression in normal tissues from HIPED for LRRC75B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC75B Gene



Protein tissue co-expression partners for LRRC75B Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC75B Gene:

LRRC75B

Evidence on tissue expression from TISSUES for LRRC75B Gene

  • Kidney(3.2)
genes like me logo Genes that share expression patterns with LRRC75B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC75B Gene

Orthologs for LRRC75B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM211B 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia LOC100682757 33
  • 86.32 (n)
FAM211B 34
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam211b 33 34
  • 83.88 (n)
Lrrc75b 16
rat
(Rattus norvegicus)
Mammalia Fam211b 33
  • 83.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM211B 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C22ORF36 33
  • 69.29 (n)
FAM211B 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam211b 33
  • 62.84 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148888 33
  • 62.12 (n)
fam211ba 34
  • 46 (a)
OneToMany
BX005006.2 34
  • 44 (a)
OneToMany
Species where no ortholog for LRRC75B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC75B Gene

ENSEMBL:
Gene Tree for LRRC75B (if available)
TreeFam:
Gene Tree for LRRC75B (if available)

Paralogs for LRRC75B Gene

Paralogs for LRRC75B Gene

Pseudogenes.org Pseudogenes for LRRC75B Gene

genes like me logo Genes that share paralogs with LRRC75B: view

Variants for LRRC75B Gene

Sequence variations from dbSNP and Humsavar for LRRC75B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000232388 -- 24,588,993(+) GTGAG(C/T)AGCCC intron-variant, nc-transcript-variant
rs1000266797 -- 24,589,237(+) TCTGC(A/G)GGTGC intron-variant, nc-transcript-variant, reference, missense
rs1000616149 -- 24,587,452(+) CCCAC(C/T)AGCCA intron-variant
rs1000643265 -- 24,593,127(+) CTCCA(A/G)TCACC intron-variant, upstream-variant-2KB
rs1001009331 -- 24,585,860(+) GTCAG(C/T)AGCAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRRC75B Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893463 CNV gain 25118596
nsv1055830 CNV gain 25217958
nsv1057819 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv588744 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv9884 CNV gain+loss 18304495

Variation tolerance for LRRC75B Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC75B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC75B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75B Gene

Disorders for LRRC75B Gene

Relevant External Links for LRRC75B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC75B

No disorders were found for LRRC75B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75B Gene

Publications for LRRC75B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim YJ … Cho YS (Nature genetics 2011) 3 60
  4. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PMID: 18940312) Yuan X … Mooser V (American journal of human genetics 2008) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for LRRC75B Gene

Sources for LRRC75B Gene

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