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Aliases for LRRC75B Gene

Aliases for LRRC75B Gene

  • Leucine Rich Repeat Containing 75B 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211B 3 4
  • Family With Sequence Similarity 211, Member B 2 3
  • C22orf36 3 4
  • FAM211B 3 4
  • Leucine-Rich Repeat-Containing Protein C22orf36 3
  • Leucine-Rich Repeat-Containing Protein 75B 3
  • Chromosome 22 Open Reading Frame 36 2

External Ids for LRRC75B Gene

Previous HGNC Symbols for LRRC75B Gene

  • C22orf36
  • FAM211B

Previous GeneCards Identifiers for LRRC75B Gene

  • GC22M025185

Summaries for LRRC75B Gene

GeneCards Summary for LRRC75B Gene

LRRC75B (Leucine Rich Repeat Containing 75B) is a Protein Coding gene. An important paralog of this gene is LRRC75A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC75B Gene

Genomics for LRRC75B Gene

Regulatory Elements for LRRC75B Gene

Enhancers for LRRC75B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F024622 0.2 Ensembl 13.1 -29.6 -29593 0.4 SMARCE1 HDAC1 SAP130 ETV1 MAFG ARID4B DPF2 PPARG GATA3 SMARCA4 ENSG00000230947 LRRC75B GGT1 BCRP3
GH22F024629 0.6 Ensembl 13 -36.3 -36293 0.6 SOX13 CTCF ZNF654 ZNF623 RAD21 ZNF644 NR2F2 ZNF664 OSR2 ZBTB48 ENSG00000230947 LRRC75B GGT1 BCRP3
GH22F024600 0.2 ENCODE 10.5 -9.7 -9708 4.1 HDGF ZNF133 ARID4B FEZF1 DMAP1 ZNF48 ZNF121 GLIS2 ZNF263 SP3 GGT1 LRRC75B CHCHD10 ENSG00000230947 BCRP3
GH22F023766 0.2 ENCODE 9.7 +825.6 825560 2.8 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A ZNF2 YY1 ZNF143 KLF13 SMARCB1 VPREB3 ENSG00000234353 SNRPD3 MIF-AS1 ENSG00000272578 GGTLC4P ENSG00000272787 LRRC75B CHCHD10
GH22F025402 0.2 ENCODE 7 -811.4 -811402 5.0 MLX WRNIP1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ELK1 LRP5L LRRC75B LOC100419673 LOC105372966 PIR32639
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC75B on UCSC Golden Path with GeneCards custom track

Promoters for LRRC75B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000673075 308 1401 MLX SIN3A ARID4B ZNF48 GLIS2 SP5 REST KAT8 SSRP1 ATF4

Genomic Location for LRRC75B Gene

Chromosome:
22
Start:
24,585,620 bp from pter
End:
24,593,208 bp from pter
Size:
7,589 bases
Orientation:
Minus strand

Genomic View for LRRC75B Gene

Genes around LRRC75B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75B Gene

Proteins for LRRC75B Gene

  • Protein details for LRRC75B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2VPJ9-LR75B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 75B
    Protein Accession:
    Q2VPJ9
    Secondary Accessions:
    • Q8N0S9
    • Q8N8B1

    Protein attributes for LRRC75B Gene

    Size:
    315 amino acids
    Molecular mass:
    34740 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC75B Gene

Post-translational modifications for LRRC75B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC75B Gene

No data available for DME Specific Peptides for LRRC75B Gene

Domains & Families for LRRC75B Gene

Protein Domains for LRRC75B Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC75B Gene

Graphical View of Domain Structure for InterPro Entry

Q2VPJ9

UniProtKB/Swiss-Prot:

LR75B_HUMAN :
  • Belongs to the LRRC75 family.
  • Contains 2 LRR (leucine-rich) repeats.
Family:
  • Belongs to the LRRC75 family.
Similarity:
  • Contains 2 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC75B: view

No data available for Gene Families for LRRC75B Gene

Function for LRRC75B Gene

genes like me logo Genes that share phenotypes with LRRC75B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC75B Gene

Localization for LRRC75B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LRRC75B Gene

Pathways & Interactions for LRRC75B Gene

SuperPathways for LRRC75B Gene

No Data Available

Interacting Proteins for LRRC75B Gene

Selected Interacting proteins: Q2VPJ9-LR75B_HUMAN for LRRC75B Gene via IID

Symbol External ID(s) Details
SIX5

Gene Ontology (GO) - Biological Process for LRRC75B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC75B Gene

Transcripts for LRRC75B Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75B Gene

No ASD Table

Relevant External Links for LRRC75B Gene

GeneLoc Exon Structure for
LRRC75B
ECgene alternative splicing isoforms for
LRRC75B

Expression for LRRC75B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC75B Gene

Protein differential expression in normal tissues from HIPED for LRRC75B Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC75B Gene



Protein tissue co-expression partners for LRRC75B Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC75B Gene:

LRRC75B
genes like me logo Genes that share expression patterns with LRRC75B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC75B Gene

Orthologs for LRRC75B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM211B 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia LOC100682757 34
  • 86.32 (n)
FAM211B 35
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam211b 34 35
  • 83.88 (n)
Lrrc75b 16
rat
(Rattus norvegicus)
Mammalia Fam211b 34
  • 83.44 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FAM211B 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves C22ORF36 34
  • 69.29 (n)
FAM211B 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam211b 34
  • 62.84 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148888 34
  • 62.12 (n)
fam211ba 35
  • 46 (a)
OneToMany
BX005006.2 35
  • 44 (a)
OneToMany
Species where no ortholog for LRRC75B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC75B Gene

ENSEMBL:
Gene Tree for LRRC75B (if available)
TreeFam:
Gene Tree for LRRC75B (if available)

Paralogs for LRRC75B Gene

Paralogs for LRRC75B Gene

Pseudogenes.org Pseudogenes for LRRC75B Gene

genes like me logo Genes that share paralogs with LRRC75B: view

Variants for LRRC75B Gene

Sequence variations from dbSNP and Humsavar for LRRC75B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs111248278 -- 24,586,213(+) CGGGG(C/T)AGCGC intron-variant, nc-transcript-variant, reference, synonymous-codon
rs111303493 -- 24,588,354(+) CCATG(A/G)TGAAT intron-variant
rs112108503 -- 24,592,838(+) AGCCC(A/C)GGGGC intron-variant
rs112337160 -- 24,587,937(+) AGGCC(A/G)TGTAA intron-variant, downstream-variant-500B
rs112636236 -- 24,587,768(+) ATCAG(A/G)GTAGA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for LRRC75B Gene

Variant ID Type Subtype PubMed ID
dgv4528n100 CNV gain 25217958
dgv8039n54 CNV gain 21841781
esv2724041 CNV deletion 23290073
esv2724068 CNV deletion 23290073
esv3575443 CNV gain 25503493
esv3893463 CNV gain 25118596
nsv1055830 CNV gain 25217958
nsv1057819 CNV gain 25217958
nsv1110863 OTHER inversion 24896259
nsv526567 CNV gain 19592680
nsv588744 CNV gain 21841781
nsv7350 OTHER inversion 18451855
nsv9884 CNV gain+loss 18304495

Variation tolerance for LRRC75B Gene

Residual Variation Intolerance Score: 98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC75B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC75B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75B Gene

Disorders for LRRC75B Gene

Relevant External Links for LRRC75B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC75B

No disorders were found for LRRC75B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75B Gene

Publications for LRRC75B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. (PMID: 21909109) Kim Y.J. … Cho Y.S. (Nat. Genet. 2011) 3 64
  4. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (PMID: 18940312) Yuan X. … Mooser V. (Am. J. Hum. Genet. 2008) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRRC75B Gene

Sources for LRRC75B Gene

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