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Aliases for LRRC75A Gene

Aliases for LRRC75A Gene

  • Leucine Rich Repeat Containing 75A 2 3 5
  • Leucine-Rich Repeat-Containing Protein FAM211A 3 4
  • Family With Sequence Similarity 211, Member A 2 3
  • C17orf76 3 4
  • FAM211A 3 4
  • Leucine-Rich Repeat-Containing Protein C17orf76 3
  • Leucine-Rich Repeat-Containing Protein 75A 3
  • Chromosome 17 Open Reading Frame 76 2

External Ids for LRRC75A Gene

Previous HGNC Symbols for LRRC75A Gene

  • C17orf76
  • FAM211A

Previous GeneCards Identifiers for LRRC75A Gene

  • GC17M016346

Summaries for LRRC75A Gene

GeneCards Summary for LRRC75A Gene

LRRC75A (Leucine Rich Repeat Containing 75A) is a Protein Coding gene. An important paralog of this gene is LRRC75B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC75A Gene

Genomics for LRRC75A Gene

Regulatory Elements for LRRC75A Gene

Enhancers for LRRC75A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G016462 1.7 FANTOM5 Ensembl ENCODE dbSUPER 23 +24.9 24945 8.9 FOXA2 PKNOX1 SIN3A INSM2 RAD21 RARA ZEB1 GATA4 ZNF366 GATA2 LRRC75A-AS1 LRRC75A PLD6 PIGL GC17M016479 PIR35161
GH17G016516 1.5 FANTOM5 Ensembl ENCODE 21.6 -24.6 -24557 1.3 FOXA2 ARNT SIN3A FEZF1 TCF12 GLIS2 ZNF766 GATA2 ZNF207 FOS LRRC75A LRRC75A-AS1 GC17P016523 GC17M016496
GH17G016406 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +84.5 84481 2.2 HDGF ZFP64 SIN3A FEZF1 YBX1 ZNF207 ZNF548 SP3 JUNB REST ENSG00000266538 LOC649873 MPRIP-AS1 MEIS3P1 ENSG00000265519 UPF3AP1 FLCN LRRC75A-AS1 LRRC75A TRPV2
GH17G016284 2 FANTOM5 Ensembl ENCODE dbSUPER 11 +204.1 204133 6.4 HDGF PKNOX1 FOXA2 MLX CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZSWIM7 PIGL NCOR1 LRRC75A RNU6-314P TTC19 TRPV2 MIR1288 GC17M016316
GH17G016535 1.7 FANTOM5 Ensembl ENCODE 12.1 -44.0 -44011 2.4 CREB3L1 MLX AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC LRRC75A ENSG00000265511 LOC644422 ZNF287 KRT16P6 CCDC144A ZNF624 GC17M016532 LOC105371554
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC75A on UCSC Golden Path with GeneCards custom track

Promoters for LRRC75A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000091781 91 1001 CTCF KLF1 RB1 ZIC2 RAD21 E2F1 HIC1 ZFHX2 GLIS2 EGR1

Genomic Location for LRRC75A Gene

Chromosome:
17
Start:
16,441,577 bp from pter
End:
16,492,191 bp from pter
Size:
50,615 bases
Orientation:
Minus strand

Genomic View for LRRC75A Gene

Genes around LRRC75A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC75A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC75A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC75A Gene

Proteins for LRRC75A Gene

  • Protein details for LRRC75A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NAA5-LR75A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 75A
    Protein Accession:
    Q8NAA5

    Protein attributes for LRRC75A Gene

    Size:
    344 amino acids
    Molecular mass:
    37780 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC75A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC75A Gene

Post-translational modifications for LRRC75A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC75A Gene

No data available for DME Specific Peptides for LRRC75A Gene

Domains & Families for LRRC75A Gene

Protein Domains for LRRC75A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC75A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NAA5

UniProtKB/Swiss-Prot:

LR75A_HUMAN :
  • Belongs to the LRRC75 family.
Family:
  • Belongs to the LRRC75 family.
genes like me logo Genes that share domains with LRRC75A: view

No data available for Gene Families for LRRC75A Gene

Function for LRRC75A Gene

genes like me logo Genes that share phenotypes with LRRC75A: view

Animal Model Products

CRISPR Products

miRNA for LRRC75A Gene

miRTarBase miRNAs that target LRRC75A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC75A Gene

Localization for LRRC75A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC75A gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC75A Gene

Pathways & Interactions for LRRC75A Gene

SuperPathways for LRRC75A Gene

No Data Available

Interacting Proteins for LRRC75A Gene

Gene Ontology (GO) - Biological Process for LRRC75A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC75A Gene

Transcripts for LRRC75A Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC75A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for LRRC75A Gene

GeneLoc Exon Structure for
LRRC75A
ECgene alternative splicing isoforms for
LRRC75A

Expression for LRRC75A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC75A Gene

mRNA differential expression in normal tissues according to GTEx for LRRC75A Gene

This gene is overexpressed in Colon - Transverse (x6.5), Small Intestine - Terminal Ileum (x4.6), and Adrenal Gland (x4.5).

Protein differential expression in normal tissues from HIPED for LRRC75A Gene

This gene is overexpressed in Cerebrospinal fluid (38.1), Heart (12.4), and Frontal cortex (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRRC75A Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC75A Gene:

LRRC75A

Evidence on tissue expression from TISSUES for LRRC75A Gene

  • Lung(4.6)
  • Nervous system(4.6)
  • Liver(4.1)
  • Stomach(4)
  • Intestine(3.9)
  • Eye(3.6)
  • Skin(3.3)
  • Heart(2.5)
  • Bone(2.3)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LRRC75A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC75A Gene

Orthologs for LRRC75A Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC75A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM211A 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia FAM211A 34 35
  • 90.83 (n)
cow
(Bos Taurus)
Mammalia FAM211A 34 35
  • 89.6 (n)
mouse
(Mus musculus)
Mammalia Fam211a 34 35
  • 87.7 (n)
Lrrc75a 16
rat
(Rattus norvegicus)
Mammalia Fam211a 34
  • 85.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 74 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FAM211A 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves C19H17ORF76 34
  • 72.56 (n)
FAM211A 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM211A 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495315 34
  • 66.87 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC562936 34
  • 68.57 (n)
FAM211A 35
  • 48 (a)
OneToOne
Species where no ortholog for LRRC75A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC75A Gene

ENSEMBL:
Gene Tree for LRRC75A (if available)
TreeFam:
Gene Tree for LRRC75A (if available)

Paralogs for LRRC75A Gene

Paralogs for LRRC75A Gene

genes like me logo Genes that share paralogs with LRRC75A: view

Variants for LRRC75A Gene

Sequence variations from dbSNP and Humsavar for LRRC75A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000110017 -- 16,458,946(+) TGGCA(A/G)TGGAT intron-variant
rs1000128171 -- 16,458,670(+) ATGTT(A/G)GTCAG intron-variant
rs1000181144 -- 16,468,459(+) AGACA(C/T)AAAAG intron-variant
rs1000252494 -- 16,491,524(+) TCGGC(G/T)GGCCT intron-variant
rs1000281348 -- 16,471,836(+) CGTGA(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC75A Gene

Variant ID Type Subtype PubMed ID
dgv5475n54 CNV gain 21841781
dgv5476n54 CNV gain+loss 21841781
esv2715702 CNV deletion 23290073
esv28979 CNV loss 19812545
esv3640102 CNV gain 21293372
esv3640103 CNV gain 21293372
nsv1063764 CNV loss 25217958
nsv1063941 CNV gain 25217958
nsv1070815 CNV deletion 25765185
nsv1118746 CNV deletion 24896259
nsv478412 CNV novel sequence insertion 20440878
nsv574487 CNV gain 21841781
nsv574494 CNV gain 21841781
nsv953836 CNV deletion 24416366

Variation tolerance for LRRC75A Gene

Residual Variation Intolerance Score: 83% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC75A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC75A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC75A Gene

Disorders for LRRC75A Gene

Relevant External Links for LRRC75A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC75A

No disorders were found for LRRC75A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC75A Gene

Publications for LRRC75A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 64
  2. Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. (PMID: 21789175) Yan D. … Chen R. (PLoS ONE 2011) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRRC75A Gene

Sources for LRRC75A Gene

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