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Aliases for LRRC74A Gene

Aliases for LRRC74A Gene

  • Leucine Rich Repeat Containing 74A 2 3
  • LRRC74 2 3 4
  • Leucine-Rich Repeat-Containing Protein 74 3 4
  • Leucine Rich Repeat Containing 74 2 3
  • C14orf166B 3 4
  • Leucine-Rich Repeat-Containing Protein 74A 3
  • Chromosome 14 Open Reading Frame 166B 2

External Ids for LRRC74A Gene

Previous HGNC Symbols for LRRC74A Gene

  • C14orf166B
  • LRRC74

Summaries for LRRC74A Gene

GeneCards Summary for LRRC74A Gene

LRRC74A (Leucine Rich Repeat Containing 74A) is a Protein Coding gene. An important paralog of this gene is LRRC34.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC74A Gene

Genomics for LRRC74A Gene

Genomic Location for LRRC74A Gene

Start:
76,826,372 bp from pter
End:
76,870,302 bp from pter
Size:
43,931 bases
Orientation:
Plus strand

Genomic View for LRRC74A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC74A Gene

No data available for Regulatory Elements for LRRC74A Gene

Proteins for LRRC74A Gene

  • Protein details for LRRC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAA2-LR74A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 74A
    Protein Accession:
    Q0VAA2
    Secondary Accessions:
    • Q6ZUG6
    • Q9Y627

    Protein attributes for LRRC74A Gene

    Size:
    488 amino acids
    Molecular mass:
    54535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAI21160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC74A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC74A Gene

Proteomics data for LRRC74A Gene at MOPED

Post-translational modifications for LRRC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC74A Gene

No data available for DME Specific Peptides for LRRC74A Gene

Domains for LRRC74A Gene

Protein Domains for LRRC74A Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q0VAA2

UniProtKB/Swiss-Prot:

LR74A_HUMAN :
  • Q0VAA2
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC74A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for LRRC74A Gene

Function for LRRC74A Gene

Gene Ontology (GO) - Molecular Function for LRRC74A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC74A: view

Phenotypes for LRRC74A Gene

GenomeRNAi human phenotypes for LRRC74A:
genes like me logo Genes that share phenotypes with LRRC74A: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC74A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LRRC74A Gene

Localization for LRRC74A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LRRC74A Gene

Pathways for LRRC74A Gene

SuperPathways for LRRC74A Gene

No Data Available

Interacting Proteins for LRRC74A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000377369%0d%0a9606.ENSP00000009180%0d%0a9606.ENSP00000367208%0d%0a
Selected Interacting proteins: Q0VAA2-LR74A_HUMAN ENSP00000377369 for LRRC74A Gene via MINT STRING

Gene Ontology (GO) - Biological Process for LRRC74A Gene

None

No data available for Pathways by source for LRRC74A Gene

Transcripts for LRRC74A Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC74A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LRRC74A
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC74A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for LRRC74A Gene

GeneLoc Exon Structure for
LRRC74A
ECgene alternative splicing isoforms for
LRRC74A

Expression for LRRC74A Gene

mRNA expression in normal human tissues for LRRC74A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRC74A Gene

genes like me logo Genes that share expressions with LRRC74A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC74A Gene

Orthologs for LRRC74A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC74A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf166B 36
  • 99 (a)
OneToOne
LRRC74 35
  • 98.77 (n)
  • 98.57 (a)
cow
(Bos Taurus)
Mammalia C14orf166B 36
  • 71 (a)
OneToOne
LRRC74 35
  • 82.17 (n)
  • 74.45 (a)
dog
(Canis familiaris)
Mammalia C14orf166B 36
  • 74 (a)
OneToOne
LRRC74 35
  • 81.56 (n)
  • 74.39 (a)
mouse
(Mus musculus)
Mammalia Gm6772 35
  • 78.41 (n)
  • 73.57 (a)
Gm6772 16
Gm6772 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf166B 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf166B 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC314328 35
  • 78.09 (n)
  • 71.62 (a)
chicken
(Gallus gallus)
Aves C14orf166B 36
  • 45 (a)
OneToOne
C5H14ORF166B 35
  • 62.14 (n)
  • 50 (a)
lizard
(Anolis carolinensis)
Reptilia C14orf166B 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C17H14orf166B 36
  • 49 (a)
OneToOne
LOC101886467 35
  • 59.49 (n)
  • 51.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14325 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4124 36
  • 33 (a)
OneToOne
Species with no ortholog for LRRC74A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC74A Gene

ENSEMBL:
Gene Tree for LRRC74A (if available)
TreeFam:
Gene Tree for LRRC74A (if available)

Paralogs for LRRC74A Gene

Paralogs for LRRC74A Gene

genes like me logo Genes that share paralogs with LRRC74A: view

Variants for LRRC74A Gene

Sequence variations from dbSNP and Humsavar for LRRC74A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs875111 -- 76,854,759(-) TACTA(A/G)TAAAT intron-variant
rs876257 -- 76,869,412(+) TGCAT(G/T)ATCCT intron-variant
rs909231 -- 76,853,676(+) CCTTC(A/G)GGATC intron-variant
rs909232 -- 76,870,181(+) TCGGC(A/G)AGAGG utr-variant-3-prime
rs909233 -- 76,870,193(+) GTCCT(C/T)GCAAG utr-variant-3-prime

Relevant External Links for LRRC74A Gene

HapMap Linkage Disequilibrium report
LRRC74A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC74A Gene

Disorders for LRRC74A Gene

No disorders were found for LRRC74A Gene.

No data available for UniProtKB/Swiss-Prot for LRRC74A Gene

Publications for LRRC74A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for LRRC74A Gene

Sources for LRRC74A Gene

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