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Aliases for LRRC74A Gene

Aliases for LRRC74A Gene

  • Leucine Rich Repeat Containing 74A 2 3 5
  • LRRC74 2 3 4
  • Leucine-Rich Repeat-Containing Protein 74 3 4
  • Leucine Rich Repeat Containing 74 2 3
  • C14orf166B 3 4
  • Leucine-Rich Repeat-Containing Protein 74A 3
  • Chromosome 14 Open Reading Frame 166B 2

External Ids for LRRC74A Gene

Previous HGNC Symbols for LRRC74A Gene

  • C14orf166B
  • LRRC74

Summaries for LRRC74A Gene

GeneCards Summary for LRRC74A Gene

LRRC74A (Leucine Rich Repeat Containing 74A) is a Protein Coding gene. An important paralog of this gene is LRRC74B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC74A Gene

Genomics for LRRC74A Gene

Regulatory Elements for LRRC74A Gene

Enhancers for LRRC74A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G076715 1.5 FANTOM5 Ensembl ENCODE 11 -110.5 -110469 1.8 PKNOX1 ZNF76 SIN3A ZNF48 RAD21 ZNF335 TCF12 EGR1 ZNF143 EGR2 VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC100130048
GH14G077074 1.3 Ensembl ENCODE dbSUPER 10.5 +250.3 250294 4.0 TBP HDGF FOXA2 FEZF1 RAD21 YY1 TCF12 RCOR1 ETV6 FOS TMEM63C CIPC LRRC74A ANGEL1 LINC02288 LINC02289 LOC105370580
GH14G076719 1.1 Ensembl ENCODE 11 -106.0 -106049 2.0 NFIB ZSCAN4 THRB RARA FOS RELB ETV6 IKZF2 ZNF263 CEBPB VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC100130048
GH14G076718 0.8 ENCODE 11 -107.8 -107826 0.8 ELF3 FOXA2 ARID4B DMAP1 SLC30A9 FOS MIXL1 MXD4 TBX21 PPARG VASH1 LRRC74A ANGEL1 ENSG00000259124 LOC100130048
GH14G076717 0.8 ENCODE 11 -108.3 -108300 0.2 ELF3 SOX13 FOXA2 SAP130 ZNF792 ARID4B DMAP1 ZIC2 ZNF644 SLC30A9 VASH1 LRRC74A ANGEL1 ENSG00000259124 LOC100130048
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC74A on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC74A Gene

Chromosome:
14
Start:
76,826,372 bp from pter
End:
76,870,302 bp from pter
Size:
43,931 bases
Orientation:
Plus strand

Genomic View for LRRC74A Gene

Genes around LRRC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC74A Gene

Proteins for LRRC74A Gene

  • Protein details for LRRC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAA2-LR74A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 74A
    Protein Accession:
    Q0VAA2
    Secondary Accessions:
    • Q6ZUG6
    • Q9Y627

    Protein attributes for LRRC74A Gene

    Size:
    488 amino acids
    Molecular mass:
    54535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAI21160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC74A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC74A Gene

Post-translational modifications for LRRC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC74A Gene

Domains & Families for LRRC74A Gene

Protein Domains for LRRC74A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC74A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC74A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRC74A Gene

Function for LRRC74A Gene

genes like me logo Genes that share phenotypes with LRRC74A: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC74A Gene

Localization for LRRC74A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC74A gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC74A Gene

Pathways & Interactions for LRRC74A Gene

SuperPathways for LRRC74A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC74A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC74A Gene

Transcripts for LRRC74A Gene

mRNA/cDNA for LRRC74A Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC74A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for LRRC74A Gene

GeneLoc Exon Structure for
LRRC74A
ECgene alternative splicing isoforms for
LRRC74A

Expression for LRRC74A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC74A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC74A Gene

This gene is overexpressed in Plasma (31.5), Heart (23.2), and Cardia (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC74A Gene



Protein tissue co-expression partners for LRRC74A Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC74A Gene:

LRRC74A
genes like me logo Genes that share expression patterns with LRRC74A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC74A Gene

Orthologs for LRRC74A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC74A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf166B 35
  • 99 (a)
OneToOne
LRRC74 34
  • 98.77 (n)
cow
(Bos Taurus)
Mammalia LRRC74 34
  • 82.17 (n)
C14orf166B 35
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC74 34
  • 81.56 (n)
C14orf166B 35
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6772 34 35
  • 78.41 (n)
Lrrc74a 16
rat
(Rattus norvegicus)
Mammalia LOC314328 34
  • 78.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf166B 35
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf166B 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF166B 34
  • 62.14 (n)
C14orf166B 35
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf166B 35
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886467 34
  • 59.49 (n)
C17H14orf166B 35
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14325 35
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4124 35
  • 33 (a)
OneToOne
Species where no ortholog for LRRC74A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC74A Gene

ENSEMBL:
Gene Tree for LRRC74A (if available)
TreeFam:
Gene Tree for LRRC74A (if available)

Paralogs for LRRC74A Gene

Paralogs for LRRC74A Gene

genes like me logo Genes that share paralogs with LRRC74A: view

Variants for LRRC74A Gene

Sequence variations from dbSNP and Humsavar for LRRC74A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000060080 -- 76,844,035(+) GGTCT(A/G)TCACC intron-variant
rs1000129031 -- 76,832,303(+) TAAGG(A/G)GTTCT intron-variant
rs1000152917 -- 76,827,753(+) AGGAA(-/G)AGAAG intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000212016 -- 76,840,784(+) TTCAC(A/C/T)GTGTT intron-variant
rs1000334490 -- 76,835,498(+) AAAAA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC74A Gene

Variant ID Type Subtype PubMed ID
esv2748891 CNV deletion 23290073
esv2748892 CNV deletion 23290073
esv2748893 CNV deletion 23290073
esv3303605 CNV mobile element insertion 20981092
esv3341226 CNV insertion 20981092
esv3378063 CNV duplication 20981092
nsv1070645 CNV deletion 25765185
nsv1126369 CNV deletion 24896259
nsv517919 CNV loss 19592680
nsv522389 CNV gain 19592680

Variation tolerance for LRRC74A Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC74A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC74A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC74A Gene

Disorders for LRRC74A Gene

Relevant External Links for LRRC74A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC74A

No disorders were found for LRRC74A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC74A Gene

Publications for LRRC74A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for LRRC74A Gene

Sources for LRRC74A Gene

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