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Aliases for LRRC74A Gene

Aliases for LRRC74A Gene

  • Leucine Rich Repeat Containing 74A 2 3 5
  • LRRC74 2 3 4
  • Leucine-Rich Repeat-Containing Protein 74 3 4
  • Leucine Rich Repeat Containing 74 2 3
  • C14orf166B 3 4
  • Chromosome 14 Open Reading Frame 166B 2

External Ids for LRRC74A Gene

Previous HGNC Symbols for LRRC74A Gene

  • C14orf166B
  • LRRC74

Summaries for LRRC74A Gene

GeneCards Summary for LRRC74A Gene

LRRC74A (Leucine Rich Repeat Containing 74A) is a Protein Coding gene. An important paralog of this gene is TCTE1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC74A Gene

Genomics for LRRC74A Gene

Regulatory Elements for LRRC74A Gene

Enhancers for LRRC74A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC74A on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC74A Gene

76,826,372 bp from pter
76,870,302 bp from pter
43,931 bases
Plus strand

Genomic View for LRRC74A Gene

Genes around LRRC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC74A Gene

Proteins for LRRC74A Gene

  • Protein details for LRRC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 74A
    Protein Accession:
    Secondary Accessions:
    • Q6ZUG6
    • Q9Y627

    Protein attributes for LRRC74A Gene

    488 amino acids
    Molecular mass:
    54535 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAI21160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC74A Gene


neXtProt entry for LRRC74A Gene

Proteomics data for LRRC74A Gene at MOPED

Post-translational modifications for LRRC74A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC74A Gene

No data available for DME Specific Peptides for LRRC74A Gene

Domains & Families for LRRC74A Gene

Protein Domains for LRRC74A Gene


Suggested Antigen Peptide Sequences for LRRC74A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 LRR (leucine-rich) repeats.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC74A: view

No data available for Gene Families for LRRC74A Gene

Function for LRRC74A Gene

genes like me logo Genes that share phenotypes with LRRC74A: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC74A Gene

Localization for LRRC74A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for LRRC74A Gene

Pathways & Interactions for LRRC74A Gene

SuperPathways for LRRC74A Gene

No Data Available

Interacting Proteins for LRRC74A Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q0VAA2-LR74A_HUMAN ENSP00000377369 for LRRC74A Gene via MINT STRING

Gene Ontology (GO) - Biological Process for LRRC74A Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC74A Gene

Drugs & Compounds for LRRC74A Gene

No Compound Related Data Available

Transcripts for LRRC74A Gene

mRNA/cDNA for LRRC74A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC74A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: -

Relevant External Links for LRRC74A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC74A Gene

mRNA expression in normal human tissues for LRRC74A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC74A Gene

This gene is overexpressed in Plasma (31.5), Heart (23.2), and Cardia (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC74A Gene

genes like me logo Genes that share expression patterns with LRRC74A: view

Protein tissue co-expression partners for LRRC74A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC74A Gene

Orthologs for LRRC74A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC74A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC74 35
  • 82.17 (n)
  • 74.45 (a)
C14orf166B 36
  • 71 (a)
(Canis familiaris)
Mammalia LRRC74 35
  • 81.56 (n)
  • 74.39 (a)
C14orf166B 36
  • 74 (a)
(Mus musculus)
Mammalia Gm6772 35
  • 78.41 (n)
  • 73.57 (a)
Lrrc74a 16
Gm6772 36
  • 69 (a)
(Pan troglodytes)
Mammalia LRRC74 35
  • 98.77 (n)
  • 98.57 (a)
C14orf166B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC314328 35
  • 78.09 (n)
  • 71.62 (a)
(Monodelphis domestica)
Mammalia C14orf166B 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf166B 36
  • 64 (a)
(Gallus gallus)
Aves C5H14ORF166B 35
  • 62.14 (n)
  • 50 (a)
C14orf166B 36
  • 45 (a)
(Anolis carolinensis)
Reptilia C14orf166B 36
  • 52 (a)
(Danio rerio)
Actinopterygii LOC101886467 35
  • 59.49 (n)
  • 51.65 (a)
C17H14orf166B 36
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14325 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4124 36
  • 33 (a)
Species with no ortholog for LRRC74A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC74A Gene

Gene Tree for LRRC74A (if available)
Gene Tree for LRRC74A (if available)

Paralogs for LRRC74A Gene

Paralogs for LRRC74A Gene

genes like me logo Genes that share paralogs with LRRC74A: view

Variants for LRRC74A Gene

Sequence variations from dbSNP and Humsavar for LRRC74A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1467372 -- 76,863,622(+) AACTC(C/T)TCCAG intron-variant
rs1467373 -- 76,863,624(+) CTCCT(A/C)CAGGG intron-variant
rs1467374 -- 76,863,911(+) CACAG(C/G)CGCTG intron-variant
rs1467375 -- 76,865,062(+) CTCTG(G/T)GTGGT intron-variant
rs7493768 -- 76,834,876(+) TTGCT(C/T)AGCCC intron-variant

Variation tolerance for LRRC74A Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LRRC74A Gene

Disorders for LRRC74A Gene

Relevant External Links for LRRC74A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC74A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC74A Gene

Publications for LRRC74A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRC74A Gene

Sources for LRRC74A Gene