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Aliases for LRRC74A Gene

Aliases for LRRC74A Gene

  • Leucine Rich Repeat Containing 74A 2 3 5
  • LRRC74 2 3 4
  • Leucine-Rich Repeat-Containing Protein 74 3 4
  • Leucine Rich Repeat Containing 74 2 3
  • C14orf166B 3 4
  • Leucine-Rich Repeat-Containing Protein 74A 3
  • Chromosome 14 Open Reading Frame 166B 2

External Ids for LRRC74A Gene

Previous HGNC Symbols for LRRC74A Gene

  • C14orf166B
  • LRRC74

Summaries for LRRC74A Gene

GeneCards Summary for LRRC74A Gene

LRRC74A (Leucine Rich Repeat Containing 74A) is a Protein Coding gene. An important paralog of this gene is LRRC74B.

Additional gene information for LRRC74A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC74A Gene

Genomics for LRRC74A Gene

GeneHancer (GH) Regulatory Elements for LRRC74A Gene

Promoters and enhancers for LRRC74A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I076826 Promoter 0.6 EPDnew 550.8 +0.0 45 0.1 KLF1 LRRC74A ANGEL1
GH14I076715 Enhancer 1.1 FANTOM5 Ensembl ENCODE 11 -110.5 -110468 1.8 NFATC3 TEAD4 TAL1 FOSL1 TCF12 POLR2A NCOR1 EGR1 VEZF1 CBFA2T2 VASH1 LRRC74A ANGEL1 ENSG00000259124 LOC105370577 LOC100130048 ENSG00000258569
GH14I077074 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.5 +250.3 250293 4 CTCF FOXA2 TAF1 MAX RAD21 YY1 POLR2A RCOR1 PRDM10 CHD2 LINC02289 TMEM63C CIPC LRRC74A ANGEL1 LINC02288 ENSG00000258473 GC14P077053
GH14I076719 Enhancer 1 Ensembl ENCODE 11 -106.0 -106049 2 NFIB BATF IRF4 THRB RARA ETV6 IKZF2 RUNX3 RXRA JUNB VASH1 ANGEL1 LRRC74A ENSG00000259124 LOC105370577 LOC100130048 ENSG00000258569
GH14I076949 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 3.9 +130.2 130180 13.9 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LINC01629 IRF2BPL SNW1 ALKBH1 ZMYND19P1 RPL22P2 VIPAS39 VASH1 ENSG00000243225 LINC02288
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC74A on UCSC Golden Path with GeneCards custom track

Genomic Locations for LRRC74A Gene

Genomic Locations for LRRC74A Gene
chr14:76,826,372-76,870,302
(GRCh38/hg38)
Size:
43,931 bases
Orientation:
Plus strand
chr14:77,292,715-77,336,645
(GRCh37/hg19)

Genomic View for LRRC74A Gene

Genes around LRRC74A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC74A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC74A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC74A Gene

Proteins for LRRC74A Gene

  • Protein details for LRRC74A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q0VAA2-LR74A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 74A
    Protein Accession:
    Q0VAA2
    Secondary Accessions:
    • Q6ZUG6
    • Q9Y627

    Protein attributes for LRRC74A Gene

    Size:
    488 amino acids
    Molecular mass:
    54535 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44364.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAI21160.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=EAW81265.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC74A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC74A Gene

Post-translational modifications for LRRC74A Gene

No Post-translational modifications

No data available for DME Specific Peptides for LRRC74A Gene

Domains & Families for LRRC74A Gene

Gene Families for LRRC74A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC74A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC74A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC74A: view

No data available for UniProtKB/Swiss-Prot for LRRC74A Gene

Function for LRRC74A Gene

Phenotypes From GWAS Catalog for LRRC74A Gene

genes like me logo Genes that share phenotypes with LRRC74A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC74A Gene

Localization for LRRC74A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC74A gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC74A Gene

Pathways & Interactions for LRRC74A Gene

SuperPathways for LRRC74A Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC74A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC74A Gene

Drugs & Compounds for LRRC74A Gene

No Compound Related Data Available

Transcripts for LRRC74A Gene

mRNA/cDNA for LRRC74A Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC74A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - -
SP2: - - - - - -
SP3: -
SP4: -
SP5:

Relevant External Links for LRRC74A Gene

GeneLoc Exon Structure for
LRRC74A
ECgene alternative splicing isoforms for
LRRC74A

Expression for LRRC74A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC74A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC74A Gene

This gene is overexpressed in Plasma (31.5), Heart (23.2), and Cardia (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC74A Gene



Protein tissue co-expression partners for LRRC74A Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC74A Gene:

LRRC74A
genes like me logo Genes that share expression patterns with LRRC74A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC74A Gene

Orthologs for LRRC74A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC74A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf166B 34
  • 99 (a)
OneToOne
LRRC74 33
  • 98.77 (n)
cow
(Bos Taurus)
Mammalia LRRC74 33
  • 82.17 (n)
C14orf166B 34
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC74 33
  • 81.56 (n)
C14orf166B 34
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm6772 33 34
  • 78.41 (n)
Lrrc74a 16
rat
(Rattus norvegicus)
Mammalia LOC314328 33
  • 78.09 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf166B 34
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf166B 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF166B 33
  • 62.14 (n)
C14orf166B 34
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf166B 34
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC101886467 33
  • 59.49 (n)
C17H14orf166B 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14325 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4124 34
  • 33 (a)
OneToOne
Species where no ortholog for LRRC74A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC74A Gene

ENSEMBL:
Gene Tree for LRRC74A (if available)
TreeFam:
Gene Tree for LRRC74A (if available)

Paralogs for LRRC74A Gene

Paralogs for LRRC74A Gene

genes like me logo Genes that share paralogs with LRRC74A: view

Variants for LRRC74A Gene

Sequence variations from dbSNP and Humsavar for LRRC74A Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000060080 -- 76,844,035(+) G/A intron_variant
rs1000129031 -- 76,832,303(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000152917 -- 76,827,753(+) G/ 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000212016 -- 76,840,784(+) C/A/T intron_variant
rs1000334490 -- 76,835,498(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC74A Gene

Variant ID Type Subtype PubMed ID
esv2748891 CNV deletion 23290073
esv2748892 CNV deletion 23290073
esv2748893 CNV deletion 23290073
esv3303605 CNV mobile element insertion 20981092
esv3341226 CNV insertion 20981092
esv3378063 CNV duplication 20981092
nsv1070645 CNV deletion 25765185
nsv1126369 CNV deletion 24896259
nsv517919 CNV loss 19592680
nsv522389 CNV gain 19592680

Variation tolerance for LRRC74A Gene

Residual Variation Intolerance Score: 91.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.94; 35.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC74A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC74A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC74A Gene

Disorders for LRRC74A Gene

Additional Disease Information for LRRC74A

No disorders were found for LRRC74A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC74A Gene

Publications for LRRC74A Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58

Products for LRRC74A Gene

Sources for LRRC74A Gene

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