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Aliases for LRRC7 Gene

Aliases for LRRC7 Gene

  • Leucine Rich Repeat Containing 7 2 3 5
  • Densin-180 3 4
  • DENSIN 3 4
  • Protein LAP1 4
  • KIAA1365 4
  • LAP1 4

External Ids for LRRC7 Gene

Previous GeneCards Identifiers for LRRC7 Gene

  • GC01P069857
  • GC01P069998
  • GC01P068336

Summaries for LRRC7 Gene

GeneCards Summary for LRRC7 Gene

LRRC7 (Leucine Rich Repeat Containing 7) is a Protein Coding gene. Diseases associated with LRRC7 include herpes simplex encephalitis 3 and dental pulp necrosis. An important paralog of this gene is LRRC30.

UniProtKB/Swiss-Prot for LRRC7 Gene

  • Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Wiki entry for LRRC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC7 Gene

Genomics for LRRC7 Gene

Regulatory Elements for LRRC7 Gene

Genomic Location for LRRC7 Gene

Chromosome:
1
Start:
69,568,398 bp from pter
End:
70,151,945 bp from pter
Size:
583,548 bases
Orientation:
Plus strand

Genomic View for LRRC7 Gene

Genes around LRRC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC7 Gene

Proteins for LRRC7 Gene

  • Protein details for LRRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NW7-LRRC7_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 7
    Protein Accession:
    Q96NW7
    Secondary Accessions:
    • Q5VXC2
    • Q5VXC3
    • Q68D07
    • Q86VE8
    • Q8WX20
    • Q9P2I2

    Protein attributes for LRRC7 Gene

    Size:
    1537 amino acids
    Molecular mass:
    172581 Da
    Quaternary structure:
    • Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.
    SequenceCaution:
    • Sequence=AAP06801.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92603.1; Type=Frameshift; Positions=665; Evidence={ECO:0000305}; Sequence=CAH70975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH74019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22426.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23423.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC7 Gene

Proteomics data for LRRC7 Gene at MOPED

Post-translational modifications for LRRC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC7 Gene

Domains & Families for LRRC7 Gene

Gene Families for LRRC7 Gene

Protein Domains for LRRC7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NW7

UniProtKB/Swiss-Prot:

LRRC7_HUMAN :
  • Contains 1 PDZ (DHR) domain.
  • Belongs to the LAP (LRR and PDZ) protein family.
  • Contains 17 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 PDZ (DHR) domain.
Family:
  • Belongs to the LAP (LRR and PDZ) protein family.
Similarity:
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC7: view

Function for LRRC7 Gene

Molecular function for LRRC7 Gene

UniProtKB/Swiss-Prot Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Ontology (GO) - Molecular Function for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12390249
genes like me logo Genes that share ontologies with LRRC7: view
genes like me logo Genes that share phenotypes with LRRC7: view

Animal Models for LRRC7 Gene

MGI Knock Outs for LRRC7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC7 Gene

Localization for LRRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC7 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC7 Gene COMPARTMENTS Subcellular localization image for LRRC7 gene
Compartment Confidence
cytosol 4
plasma membrane 4
cytoskeleton 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
GO:0014069 postsynaptic density IEA --
GO:0015629 actin cytoskeleton IEA --
GO:0043005 neuron projection IEA --
genes like me logo Genes that share ontologies with LRRC7: view

Pathways & Interactions for LRRC7 Gene

SuperPathways for LRRC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC7 Gene

Drugs & Compounds for LRRC7 Gene

(1) Drugs for LRRC7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LRRC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LRRC7: view

Transcripts for LRRC7 Gene

Unigene Clusters for LRRC7 Gene

Leucine rich repeat containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2: -
SP3: -

ExUns: 26 ^ 27
SP1:
SP2:
SP3:

Relevant External Links for LRRC7 Gene

GeneLoc Exon Structure for
LRRC7
ECgene alternative splicing isoforms for
LRRC7

Expression for LRRC7 Gene

mRNA expression in normal human tissues for LRRC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.1), Brain - Putamen (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x6.1), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Hippocampus (x4.5), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for LRRC7 Gene

This gene is overexpressed in Brain (17.2), Synovial fluid (13.2), and Breast (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC7 Gene



SOURCE GeneReport for Unigene cluster for LRRC7 Gene Hs.479658

mRNA Expression by UniProt/SwissProt for LRRC7 Gene

Q96NW7-LRRC7_HUMAN
Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed.
genes like me logo Genes that share expression patterns with LRRC7: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for LRRC7 Gene

Orthologs for LRRC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LRRC7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC7 35
  • 95.1 (n)
  • 97.85 (a)
LRRC7 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC7 35
  • 94.12 (n)
  • 97.59 (a)
LRRC7 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc7 35
  • 90.33 (n)
  • 95.58 (a)
Lrrc7 16
Lrrc7 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC7 35
  • 99.89 (n)
  • 100 (a)
LRRC7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc7 35
  • 90.02 (n)
  • 95.44 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC7 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC7 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC7 35
  • 81.44 (n)
  • 87.82 (a)
LRRC7 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC7 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc7 35
  • 74.37 (n)
  • 78.29 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc7 35
  • 66.15 (n)
  • 67.91 (a)
lrrc7 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Lap1 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOG2 38
Species with no ortholog for LRRC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC7 Gene

ENSEMBL:
Gene Tree for LRRC7 (if available)
TreeFam:
Gene Tree for LRRC7 (if available)

Paralogs for LRRC7 Gene

genes like me logo Genes that share paralogs with LRRC7: view

Variants for LRRC7 Gene

Sequence variations from dbSNP and Humsavar for LRRC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035715 A breast cancer sample
VAR_049727 -
rs2846 -- 69,691,403(-) GGATG(C/T)GTCTG intron-variant
rs21507 -- 69,669,478(+) tttgc(A/T)cttga intron-variant
rs227096 -- 69,668,466(+) caaag(A/G)acatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC7 Gene

Variant ID Type Subtype PubMed ID
nsv461784 CNV Loss 19166990
esv269382 CNV Insertion 20981092
esv2749586 CNV Deletion 23290073
nsv521307 CNV Loss 19592680
esv2617051 CNV Deletion 19546169
nsv525370 CNV Loss 19592680
esv1094257 CNV Insertion 17803354
esv1056018 CNV Insertion 17803354
nsv512742 CNV Insertion 21212237
esv269688 CNV Insertion 20981092
nsv871018 CNV Loss 21882294
nsv526839 CNV Gain 19592680
dgv18n27 CNV Loss 19166990

Variation tolerance for LRRC7 Gene

Residual Variation Intolerance Score: 1.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC7 Gene

HapMap Linkage Disequilibrium report
LRRC7
Human Gene Mutation Database (HGMD)
LRRC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC7 Gene

Disorders for LRRC7 Gene

MalaCards: The human disease database

(3) MalaCards diseases for LRRC7 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
herpes simplex encephalitis 3
  • herpes simplex encephalitis, susceptibility to, 3
dental pulp necrosis
  • necrosis of the pulp
dental pulp disease
  • dental pulp disorder
- elite association - COSMIC cancer census association via MalaCards
Search LRRC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LRRC7

Genetic Association Database (GAD)
LRRC7
Human Genome Epidemiology (HuGE) Navigator
LRRC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC7
genes like me logo Genes that share disorders with LRRC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC7 Gene

Publications for LRRC7 Gene

  1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PMID: 12525888) Wang L. … Mao Y. (Int. J. Mol. Med. 2003) 2 3 4 23 67
  2. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PMID: 17968527) Ihalmo P. … Groop P.H. (Diabetologia 2008) 3 23
  3. Novel Cul3 binding proteins function to remodel E3 ligase complexes. (PMID: 25011449) Wimuttisuk W. … Singer J.D. (BMC Cell Biol. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. (PMID: 23782696) Stephenson J.R. … Hall R.A. (J. Biol. Chem. 2013) 3

Products for LRRC7 Gene

Sources for LRRC7 Gene

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