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Aliases for LRRC7 Gene

Aliases for LRRC7 Gene

  • Leucine Rich Repeat Containing 7 2 3
  • DENSIN 3 4 6
  • Densin-180 3 4
  • KIAA1365 4 6
  • Leucine-Rich Repeat-Containing Protein 7 3
  • Protein LAP1 4
  • LAP1 4

External Ids for LRRC7 Gene

Summaries for LRRC7 Gene

GeneCards Summary for LRRC7 Gene

LRRC7 (Leucine Rich Repeat Containing 7) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

UniProtKB/Swiss-Prot for LRRC7 Gene

  • Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Wiki entry for LRRC7 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC7 Gene

Genomics for LRRC7 Gene

Genomic Location for LRRC7 Gene

69,567,547 bp from pter
70,151,945 bp from pter
584,399 bases
Plus strand

Genomic View for LRRC7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC7 Gene

Regulatory Elements for LRRC7 Gene

Proteins for LRRC7 Gene

  • Protein details for LRRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • Q5VXC2
    • Q5VXC3
    • Q68D07
    • Q86VE8
    • Q8WX20
    • Q9P2I2

    Protein attributes for LRRC7 Gene

    1537 amino acids
    Molecular mass:
    172581 Da
    Quaternary structure:
    • Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.
    • Sequence=AAP06801.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92603.1; Type=Frameshift; Positions=665; Evidence={ECO:0000305}; Sequence=CAH70975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH74019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22426.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23423.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC7 Gene


neXtProt entry for LRRC7 Gene

Proteomics data for LRRC7 Gene at MOPED

Post-translational modifications for LRRC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC7 Gene

Domains for LRRC7 Gene

Protein Domains for LRRC7 Gene


  • Contains 1 PDZ (DHR) domain.:
    • Q96NW7
  • Belongs to the LAP (LRR and PDZ) protein family.:
    • Q96NW7
  • Contains 17 LRR (leucine-rich) repeats.:
    • Q96NW7
genes like me logo Genes that share domains with LRRC7: view

No data available for Gene Families for LRRC7 Gene

Function for LRRC7 Gene

Molecular function for LRRC7 Gene

UniProtKB/Swiss-Prot Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Ontology (GO) - Molecular Function for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12390249
genes like me logo Genes that share ontologies with LRRC7: view
genes like me logo Genes that share phenotypes with LRRC7: view

Animal Models for LRRC7 Gene

MGI Knock Outs for LRRC7:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for LRRC7 Gene

Localization for LRRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC7 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Jensen Localization Image for LRRC7 Gene COMPARTMENTS Subcellular localization image for LRRC7 gene
Compartment Confidence
cytosol 3
mitochondrion 3
plasma membrane 3
cytoskeleton 2
nucleus 1

Gene Ontology (GO) - Cellular Components for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0045211 postsynaptic membrane IEA --
genes like me logo Genes that share ontologies with LRRC7: view

Pathways for LRRC7 Gene

SuperPathways for LRRC7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC7 Gene


No data available for Pathways by source for LRRC7 Gene

Compounds for LRRC7 Gene

(3) Novoseek inferred chemical compound relationships for LRRC7 Gene

Compound -log(P) Hits PubMed IDs
guanylate 42.7 1
nmda 33.2 3
glutamate 11 2
genes like me logo Genes that share compounds with LRRC7: view

Transcripts for LRRC7 Gene

Unigene Clusters for LRRC7 Gene

Leucine rich repeat containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2: -
SP3: -

ExUns: 26 ^ 27

Relevant External Links for LRRC7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC7 Gene

mRNA expression in normal human tissues for LRRC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (7.1), Brain - Putamen (basal ganglia) (6.2), Brain - Caudate (basal ganglia) (6.1), Brain - Frontal Cortex (BA9) (5.0), Brain - Anterior cingulate cortex (BA24) (5.0), Brain - Hippocampus (4.5), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC7 Gene

SOURCE GeneReport for Unigene cluster for LRRC7 Gene Hs.479658

mRNA Expression by UniProt/SwissProt for LRRC7 Gene

Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed.
genes like me logo Genes that share expressions with LRRC7: view

Orthologs for LRRC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LRRC7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC7 36
  • 99.89 (n)
  • 100 (a)
LRRC7 37
  • 100 (a)
(Bos Taurus)
Mammalia LRRC7 36
  • 95.1 (n)
  • 97.85 (a)
LRRC7 37
  • 94 (a)
(Canis familiaris)
Mammalia LRRC7 36
  • 94.12 (n)
  • 97.59 (a)
LRRC7 37
  • 98 (a)
(Mus musculus)
Mammalia Lrrc7 36
  • 90.33 (n)
  • 95.58 (a)
Lrrc7 16
Lrrc7 37
  • 95 (a)
(Monodelphis domestica)
Mammalia LRRC7 37
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC7 37
  • 88 (a)
(Rattus norvegicus)
Mammalia Lrrc7 36
  • 90.02 (n)
  • 95.44 (a)
(Gallus gallus)
Aves LRRC7 36
  • 81.44 (n)
  • 87.82 (a)
LRRC7 37
  • 88 (a)
(Anolis carolinensis)
Reptilia LRRC7 37
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc7 36
  • 74.37 (n)
  • 78.29 (a)
(Danio rerio)
Actinopterygii lrrc7 36
  • 66.15 (n)
  • 67.91 (a)
lrrc7 37
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lap1 37
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOG2 39
Species with no ortholog for LRRC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC7 Gene

Gene Tree for LRRC7 (if available)
Gene Tree for LRRC7 (if available)

Paralogs for LRRC7 Gene

Selected SIMAP similar genes for LRRC7 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with LRRC7: view

Variants for LRRC7 Gene

Sequence variations from dbSNP and Humsavar for LRRC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2846 -- 69,691,403(-) GGATG(C/T)GTCTG intron-variant
rs21507 -- 69,669,478(+) tttgc(A/T)cttga intron-variant
rs227096 -- 69,668,466(+) caaag(A/G)acatg intron-variant
rs227097 -- 69,668,478(+) actca(A/T)ccctt intron-variant
rs227098 -- 69,668,576(+) gtctt(C/T)gctat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC7 Gene

Variant ID Type Subtype PubMed ID
nsv461784 CNV Loss 19166990
esv269382 CNV Insertion 20981092
esv2749586 CNV Deletion 23290073
nsv521307 CNV Loss 19592680
esv2617051 CNV Deletion 19546169
nsv525370 CNV Loss 19592680
esv1094257 CNV Insertion 17803354
esv1056018 CNV Insertion 17803354
nsv512742 CNV Insertion 21212237
esv269688 CNV Insertion 20981092
nsv871018 CNV Loss 21882294
nsv526839 CNV Gain 19592680
dgv18n27 CNV Loss 19166990

Relevant External Links for LRRC7 Gene

HapMap Linkage Disequilibrium report

Disorders for LRRC7 Gene

Relevant External Links for LRRC7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with LRRC7: view

No data available for UniProtKB/Swiss-Prot for LRRC7 Gene

Publications for LRRC7 Gene

  1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PMID: 12525888) Wang L. … Mao Y. (Int. J. Mol. Med. 2003) 2 3 4 23
  2. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PMID: 17968527) Ihalmo P. … Groop P.H. (Diabetologia 2008) 3 23 49
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. (PMID: 11729199) Izawa I. … Inagaki M. (J. Biol. Chem. 2002) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for LRRC7 Gene

Sources for LRRC7 Gene

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