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Aliases for LRRC7 Gene

Aliases for LRRC7 Gene

  • Leucine Rich Repeat Containing 7 2 3 5
  • Densin-180 3 4
  • DENSIN 3 4
  • Leucine-Rich Repeat-Containing Protein 7 3
  • Protein LAP1 4
  • KIAA1365 4
  • LAP1 4

External Ids for LRRC7 Gene

Previous GeneCards Identifiers for LRRC7 Gene

  • GC01P069857
  • GC01P069998
  • GC01P068336

Summaries for LRRC7 Gene

GeneCards Summary for LRRC7 Gene

LRRC7 (Leucine Rich Repeat Containing 7) is a Protein Coding gene. Diseases associated with LRRC7 include Dental Pulp Necrosis and Dental Pulp Disease. Among its related pathways are Innate Immune System. An important paralog of this gene is ERBIN.

UniProtKB/Swiss-Prot for LRRC7 Gene

  • Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Wiki entry for LRRC7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC7 Gene

Genomics for LRRC7 Gene

Regulatory Elements for LRRC7 Gene

Enhancers for LRRC7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G069566 0.8 ENCODE 25.3 -0.8 -771 2.1 ATF1 ZSCAN4 KLF17 ZNF766 SP3 ELF1 MAFF SMARCA4 IKZF1 KDM1A LRRC7 LOC105378790
GH01G069539 0.9 ENCODE 22 -28.2 -28189 0.4 PKNOX1 ATF1 ARNT TCF12 ZNF766 GATA2 NCOA1 ZNF592 MBD2 SMARCA4 LRRC7 LOC105378790 LOC105378789
GH01G069569 0.6 ENCODE 18.2 +1.4 1360 1.0 ZNF263 RNF2 SUZ12 TEAD4 USF2 ZBTB48 ADNP PRDM1 EZH2 LRRC7 SGO1P1
GH01G070042 0.9 FANTOM5 8 +474.2 474165 0.7 ATF1 NFRKB ZNF766 CREM CEBPB USF2 ZNF426 ZNF781 ZNF518A POLR2H LRRC7 LOC105378792 GC01P070141
GH01G069522 0.5 ENCODE 13.7 -45.0 -44951 1.2 IKZF1 BHLHE40 CEBPB MAFK LRRC7 LOC105378790 LOC105378789
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC7 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC7 Gene

Chromosome:
1
Start:
69,568,398 bp from pter
End:
70,151,945 bp from pter
Size:
583,548 bases
Orientation:
Plus strand

Genomic View for LRRC7 Gene

Genes around LRRC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC7 Gene

Proteins for LRRC7 Gene

  • Protein details for LRRC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NW7-LRRC7_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 7
    Protein Accession:
    Q96NW7
    Secondary Accessions:
    • Q5VXC2
    • Q5VXC3
    • Q68D07
    • Q86VE8
    • Q8WX20
    • Q9P2I2

    Protein attributes for LRRC7 Gene

    Size:
    1537 amino acids
    Molecular mass:
    172581 Da
    Quaternary structure:
    • Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.
    SequenceCaution:
    • Sequence=AAP06801.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA92603.1; Type=Frameshift; Positions=665; Evidence={ECO:0000305}; Sequence=CAH70975.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH73692.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAH74019.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI22426.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI23423.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC7 Gene

Post-translational modifications for LRRC7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC7 Gene

Domains & Families for LRRC7 Gene

Gene Families for LRRC7 Gene

Protein Domains for LRRC7 Gene

Suggested Antigen Peptide Sequences for LRRC7 Gene

Graphical View of Domain Structure for InterPro Entry

Q96NW7

UniProtKB/Swiss-Prot:

LRRC7_HUMAN :
  • Belongs to the LAP (LRR and PDZ) protein family.
Family:
  • Belongs to the LAP (LRR and PDZ) protein family.
genes like me logo Genes that share domains with LRRC7: view

Function for LRRC7 Gene

Molecular function for LRRC7 Gene

UniProtKB/Swiss-Prot Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Gene Ontology (GO) - Molecular Function for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12390249
genes like me logo Genes that share ontologies with LRRC7: view
genes like me logo Genes that share phenotypes with LRRC7: view

Animal Models for LRRC7 Gene

MGI Knock Outs for LRRC7:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC7 Gene

Localization for LRRC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC7 Gene

Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC7 gene
Compartment Confidence
plasma membrane 4
extracellular 4
cytosol 4
mitochondrion 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IBA,IEA --
GO:0005886 plasma membrane IBA,IEA --
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LRRC7: view

Pathways & Interactions for LRRC7 Gene

genes like me logo Genes that share pathways with LRRC7: view

Pathways by source for LRRC7 Gene

3 Reactome pathways for LRRC7 Gene

Gene Ontology (GO) - Biological Process for LRRC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IBA --
GO:0010976 positive regulation of neuron projection development IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with LRRC7: view

No data available for SIGNOR curated interactions for LRRC7 Gene

Drugs & Compounds for LRRC7 Gene

(1) Drugs for LRRC7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for LRRC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with LRRC7: view

Transcripts for LRRC7 Gene

Unigene Clusters for LRRC7 Gene

Leucine rich repeat containing 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
SP1: -
SP2: -
SP3: -

ExUns: 26 ^ 27
SP1:
SP2:
SP3:

Relevant External Links for LRRC7 Gene

GeneLoc Exon Structure for
LRRC7
ECgene alternative splicing isoforms for
LRRC7

Expression for LRRC7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC7 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.1), Brain - Putamen (basal ganglia) (x6.2), Brain - Caudate (basal ganglia) (x6.1), Brain - Frontal Cortex (BA9) (x5.0), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Hippocampus (x4.5), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for LRRC7 Gene

This gene is overexpressed in Brain (17.2), Synovial fluid (13.2), and Breast (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC7 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC7 Gene:

LRRC7

SOURCE GeneReport for Unigene cluster for LRRC7 Gene:

Hs.479658

mRNA Expression by UniProt/SwissProt for LRRC7 Gene:

Q96NW7-LRRC7_HUMAN
Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed.

Evidence on tissue expression from TISSUES for LRRC7 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with LRRC7: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC7 Gene

Orthologs for LRRC7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for LRRC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC7 34 35
  • 99.89 (n)
cow
(Bos Taurus)
Mammalia LRRC7 34 35
  • 95.1 (n)
dog
(Canis familiaris)
Mammalia LRRC7 34 35
  • 94.12 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC7 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc7 34 16 35
  • 90.33 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc7 34
  • 90.02 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC7 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC7 34 35
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC7 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc7 34
  • 74.37 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc7 34 35
  • 66.15 (n)
fruit fly
(Drosophila melanogaster)
Insecta Lap1 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOG2 37
Species where no ortholog for LRRC7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC7 Gene

ENSEMBL:
Gene Tree for LRRC7 (if available)
TreeFam:
Gene Tree for LRRC7 (if available)

Paralogs for LRRC7 Gene

genes like me logo Genes that share paralogs with LRRC7: view

Variants for LRRC7 Gene

Sequence variations from dbSNP and Humsavar for LRRC7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_035715 A breast cancer sample
rs1000003409 -- 70,054,135(+) AAAAA(G/T)TATCA intron-variant
rs1000008454 -- 69,819,576(+) CTCTC(-/TCTGTGTGTGTG)TGTGT intron-variant
rs1000008735 -- 70,076,053(+) CTTTG(A/C)CTGAC intron-variant
rs1000011216 -- 69,629,169(+) AGAGA(A/G)TTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC7 Gene

Variant ID Type Subtype PubMed ID
dgv18n27 CNV loss 19166990
dgv305n54 CNV loss 21841781
dgv6e215 CNV deletion 23714750
esv1056018 CNV insertion 17803354
esv1094257 CNV insertion 17803354
esv2617051 CNV deletion 19546169
esv2749586 CNV deletion 23290073
esv3305104 CNV mobile element insertion 20981092
esv3382626 CNV duplication 20981092
esv3383107 CNV insertion 20981092
esv3448225 CNV insertion 20981092
esv3452085 CNV duplication 20981092
esv3586344 CNV loss 21293372
esv3586345 CNV loss 21293372
esv3586346 CNV gain 21293372
esv3586348 CNV gain 21293372
nsv1110662 CNV insertion 24896259
nsv1133864 CNV deletion 24896259
nsv1142060 CNV tandem duplication 24896259
nsv1151258 CNV duplication 26484159
nsv461784 CNV loss 19166990
nsv512742 CNV insertion 21212237
nsv521307 CNV loss 19592680
nsv525370 CNV loss 19592680
nsv526839 CNV gain 19592680
nsv546452 CNV loss 21841781
nsv954734 CNV insertion 24416366

Variation tolerance for LRRC7 Gene

Residual Variation Intolerance Score: 1.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC7 Gene

Human Gene Mutation Database (HGMD)
LRRC7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC7 Gene

Disorders for LRRC7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dental pulp necrosis
  • necrosis of the pulp
dental pulp disease
  • dental pulp disorder
- elite association - COSMIC cancer census association via MalaCards
Search LRRC7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for LRRC7

Genetic Association Database (GAD)
LRRC7
Human Genome Epidemiology (HuGE) Navigator
LRRC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC7
genes like me logo Genes that share disorders with LRRC7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC7 Gene

Publications for LRRC7 Gene

  1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PMID: 12525888) Wang L. … Mao Y. (Int. J. Mol. Med. 2003) 2 3 4 22 64
  2. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PMID: 17968527) Ihalmo P. … Groop P.H. (Diabetologia 2008) 3 22 46 64
  3. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. (PMID: 22322875) Kim S.J. … Shin C. (Circ. J. 2012) 3 46 64
  4. Genome-wide association study of the child behavior checklist dysregulation profile. (PMID: 21784300) Mick E. … Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for LRRC7 Gene

Sources for LRRC7 Gene

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