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LRRC7 Gene

protein-coding   GIFtS: 55
GCID: GC01P069998

Leucine Rich Repeat Containing 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 71 2     Densin3
DENSIN2 5     Densin-1803
KIAA13653 5     LAP13
densin-1802     Protein LAP13
Leucine-Rich Repeat-Containing Protein 72     

External Ids:    HGNC: 185311   Entrez Gene: 575542   Ensembl: ENSG000000331227   OMIM: 6144535   UniProtKB: Q96NW73   

Export aliases for LRRC7 gene to outside databases

Previous GC identifers: GC01P069857 GC01P068336


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC7 Gene:
LRRC7 (leucine rich repeat containing 7) is a protein-coding gene. Diseases associated with LRRC7 include orofacial cleft, and diabetic nephropathy. An important paralog of this gene is LRRC8E.

UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization
to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
receptor-dependent long term depression

Gene Wiki entry for LRRC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC7 gene promoter:
         STAT5B   C/EBPbeta   Sox5   Pbx1a   HNF-3beta   Evi-1   c-Rel   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC7 promoter sequence
   Search Chromatin IP Primers for LRRC7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LRRC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P069998:  view genomic region     (about GC identifiers)

Start:
70,034,081 bp from pter      End:
70,617,628 bp from pter
Size:
583,548 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 7  
Size: 1537 amino acids; 172581 Da
Subunit: Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a
complex with N-cadherin through CTNND2
Sequence caution: Sequence=AAP06801.1; Type=Erroneous initiation; Sequence=BAA92603.1; Type=Frameshift;
Positions=665; Sequence=CAH70975.1; Type=Erroneous initiation; Sequence=CAH73692.1; Type=Erroneous initiation;
Sequence=CAH74019.1; Type=Erroneous initiation; Sequence=CAI22426.1; Type=Erroneous initiation;
Sequence=CAI23423.1; Type=Erroneous initiation;
Secondary accessions: Q5VXC2 Q5VXC3 Q68D07 Q86VE8 Q8WX20 Q9P2I2
Alternative splicing: 3 isoforms:  Q96NW7-1   Q96NW7-2   Q96NW7-3   

Explore the universe of human proteins at neXtProt for LRRC7: NX_Q96NW7

Explore proteomics data for LRRC7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LRRC7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065845.1  
    ENSEMBL proteins: 
     ENSP00000309245   ENSP00000359997   ENSP00000035383   ENSP00000466082   ENSP00000476660  
     ENSP00000476307   ENSP00000477399   ENSP00000394867  

    LRRC7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LRRC7

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    Abcam antibodies for LRRC7
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    LSBio Antibodies in human, mouse, rat for LRRC7

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    Cloud-Clone Corp. CLIAs for LRRC7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96NW7

    ProtoNet protein and cluster: Q96NW7

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Similarity: Belongs to the LAP (LRR and PDZ) protein family
    Similarity: Contains 17 LRR (leucine-rich) repeats
    Similarity: Contains 1 PDZ (DHR) domain


    LRRC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRRC7_HUMAN, Q96NW7
    Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization
    to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
    receptor-dependent long term depression

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12390249
         
    LRRC7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrrc7):
     behavior/neurological  growth/size/body  mortality/aging  nervous system  no phenotypic analysis 

    LRRC7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lrrc7tm1.1Mabk for LRRC7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRRC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC7

    miRNA
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    Block miRNA regulation of human, mouse, rat LRRC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidLRRC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRC7
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC7

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LRRC7

    Clone
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    OriGene clones in human, mouse for LRRC7 (see all 6)
    OriGene ORF clones in mouse, rat for LRRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC7 (NM_020794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRRC7_HUMAN, Q96NW7: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    mitochondrion3
    plasma membrane3
    cytoskeleton2
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    LRRC7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC7
    Interactions:

        GeneGlobe Interaction Network for LRRC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRRC7 (Q96NW71, 2, 3 ENSP000000353834) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNKSR2Q8WXI22, 3, ENSP000003688244MINT-1784595 I2D: score=4 STRING: ENSP00000368824
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=3 STRING: ENSP00000381412
    ACTN4O437073, ENSP000002526994I2D: score=2 STRING: ENSP00000252699
    CTNND2Q9UQB33, ENSP000003071344I2D: score=2 STRING: ENSP00000307134
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC7

    3 Novoseek inferred chemical compound relationships for LRRC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 42.7 1 12859686 (1)
    nmda 33.2 5 9185308 (1), 12859686 (1), 16172120 (1)
    glutamate 11 2 9185308 (1), 16172120 (1)



    LRRC7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRRC7 gene: 
    NM_020794.2  

    Unigene Cluster for LRRC7:

    Leucine rich repeat containing 7
    Hs.479658  [show with all ESTs]
    Unigene Representative Sequence: BX648943
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310961(uc001dep.3 uc009wbg.3 uc001deq.3) ENST00000370958(uc001deo.1)
    ENST00000035383 ENST00000588515 ENST00000609498 ENST00000608815 ENST00000608744
    ENST00000609072 ENST00000608470 ENST00000607936 ENST00000565615 ENST00000441830
    ENST00000415775
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRC7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidLRRC7 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LRRC7
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC7 (NM_020794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC7
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC7
      QuantiFast Probe-based Assays in human, mouse, rat LRRC7

    Additional mRNA sequence: 

    AB037786.1 AF434715.1 AF498274.1 AK294206.1 BC128989.1 BX648943.1 CR749629.1 

    6 DOTS entries:

    DT.100742704  DT.92017744  DT.75112084  DT.304686  DT.121396930  DT.75141837 

    Selected AceView cDNA sequences (see all 28):

    BX477690 BX105883 AI366175 AX786956 AB037786 AW204480 NM_020794 CR749629 
    BP349281 AI079830 AF434715 AF498274 BQ948144 BU527328 BC080568 AW895490 
    BG185672 AI080648 BX648943 BI553842 BG220442 AW895578 AW895329 AW895410 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                            -                                                                                                               
    SP2:        -                                                                                                                                                   
    SP3:                                                                                                                                      -                     

    ExUns: 26 ^ 27
    SP1:            
    SP2:            
    SP3:            


    ECgene alternative splicing isoforms for LRRC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACTTATG
    LRRC7 Expression
    About this image


    LRRC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Definitive endoderm-like cells
    LRRC7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479658

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRRC7 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc71 , 5 leucine rich repeat containing 71, 5 90.33(n)1
    95.58(a)1
      3 (81.68 cM)5
    2422741  NM_001081358.11  NP_001074827.11 
     1580844395 
    chicken
    (Gallus gallus)
    Aves LRRC71 leucine rich repeat containing 7 81.44(n)
    87.82(a)
      424711  XM_004936887.1  XP_004936944.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC76
    leucine rich repeat containing 7
    83(a)
    1 ↔ 1
    GL343328.1(904714-1120404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrrc71 leucine rich repeat containing 7 74.37(n)
    78.29(a)
      780049  NM_001079126.1  NP_001072594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrc71 leucine rich repeat containing 7 66.15(n)
    67.91(a)
      566023  XM_005165966.1  XP_005166023.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lap16
    Lap1
    33(a)
    1 → many
    2R(10823182-10827807)


    ENSEMBL Gene Tree for LRRC7 (if available)
    TreeFam Gene Tree for LRRC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC7 gene
    LRRC8E2  ERBB2IP2  RSU12  LRRC8A2  MFHAS12  LRRC12  LRRIQ42  SCRIB2  
    SHOC22  LRRD12  LRRC8D2  LRRC8B2  LRRC8C2  LRRC402  
    7 SIMAP similar genes for LRRC7 using alignment to 8 protein entries:     LRRC7_HUMAN (see all proteins):
    SCRIB    LRRC1    ERBB2IP    TAX1BP3    TJP2    LRIG3
    DLG4

    LRRC7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC7 (see all 6452)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357154
    A breast cancer sample4--see VAR_0357152 L M mis40--------
    rs120788961,2
    F,H--70223895(+) GGTTAT/CGTAAA 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 508
    rs64245931,2
    C,F,A,H--70223922(+) CTTGCA/GATTCT 1 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2184
    rs1411586241,2
    C--70223941(+) GAAATG/TAAAAG 1 -- us2k10--------
    rs171310251,2
    C,F--70224033(+) CATGTG/TCAAAC 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1928515021,2
    --70224042(+) ACAATC/TGTCTA 1 -- us2k10--------
    rs1845361521,2
    --70224043(+) CAATCA/GTCTAT 1 -- us2k10--------
    rs664835671,2
    C,F--70224239(+) TACACG/AGGTAA 1 -- us2k17Minor allele frequency- A:0.18WA NA CSA EA 366
    rs1892414511,2
    --70224300(+) TGAACA/GTAATA 1 -- us2k10--------
    rs1507276911,2
    --70224364(+) TAGGCC/TCCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRC7 (70034081 - 70284081 bp, first 250kb of LRRC7)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRRC7 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749586CNV Deletion23290073
    esv2617051CNV Deletion19546169
    esv1056018CNV Insertion17803354
    nsv512742CNV Insertion21212237
    esv269688CNV Insertion20981092
    esv269382CNV Insertion20981092
    esv1094257CNV Insertion17803354
    nsv525370CNV Loss19592680
    nsv871018CNV Loss21882294
    nsv521307CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614453    OMIM disorders: --

    7 diseases for LRRC7:    
    About MalaCards
    orofacial cleft    diabetic nephropathy    type 1 diabetes    breast and colorectal cancer
    hypertension    obesity    colorectal cancer


    LRRC7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC7
    Human Genome Epidemiology (HuGE) Navigator: LRRC7 (2 documents)

    Export disorders for LRRC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC7 gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with LRRC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PubMed id 12525888)1, 2, 3, 9 Wang L.... Mao Y. (Int. J. Mol. Med. 2003)
    2. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PubMed id 17968527)1, 4, 9 Ihalmo P....Groop P.H. (Diabetologia 2008)
    3. Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study. (PubMed id 22322875)1, 4 Kim S.J....Shin C. (Circ. J. 2012)
    4. Genome-wide association study of the child behavior checklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (J Am Acad Child Adolesc Psychiatry 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. (PubMed id 11729199)1, 2 Izawa I.... Inagaki M. (J. Biol. Chem. 2002)
    8. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    9. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. (PubMed id 23782696)1 Stephenson J.R....Hall R.A. (J. Biol. Chem. 2013)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57554 HGNC: 18531 AceView: KIAA1365 Ensembl:ENSG00000033122 euGenes: HUgn57554
    ECgene: LRRC7 H-InvDB: LRRC7

    (According to HUGE)
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    HUGE: KIAA1365

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LRRC7 gene:
    Search GeneIP for patents involving LRRC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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