Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRRC7 Gene

protein-coding   GIFtS: 56
GCID: GC01P069998

Leucine Rich Repeat Containing 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine Rich Repeat Containing 71 2     Densin-1803
DENSIN2     KIAA13653
densin-1802     LAP13
Leucine-Rich Repeat-Containing Protein 72     Protein LAP13
Densin3     

External Ids:    HGNC: 185311   Entrez Gene: 575542   Ensembl: ENSG000000331227   OMIM: 6144535   UniProtKB: Q96NW73   

Export aliases for LRRC7 gene to outside databases

Previous GC identifers: GC01P069857 GC01P068336


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRRC7 Gene: 
LRRC7 (leucine rich repeat containing 7) is a protein-coding gene. Diseases associated with LRRC7 include orofacial cleft, and type 1 diabetes. An important paralog of this gene is LRRC2.

UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization
to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
receptor-dependent long term depression

Gene Wiki entry for LRRC7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRRC7 gene promoter:
         STAT5B   C/EBPbeta   Sox5   Pbx1a   HNF-3beta   Evi-1   c-Rel   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRRC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LRRC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P069998:  view genomic region     (about GC identifiers)

Start:
70,034,081 bp from pter      End:
70,617,628 bp from pter
Size:
583,548 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 7  
Size: 1537 amino acids; 172581 Da
Subunit: Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a
complex with N-cadherin through CTNND2
Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
similarity)
Sequence caution: Sequence=AAP06801.1; Type=Erroneous initiation; Sequence=BAA92603.1; Type=Frameshift;
Positions=665; Sequence=CAH70975.1; Type=Erroneous initiation; Sequence=CAH73692.1; Type=Erroneous initiation;
Sequence=CAH74019.1; Type=Erroneous initiation; Sequence=CAI22426.1; Type=Erroneous initiation;
Sequence=CAI23423.1; Type=Erroneous initiation;
Secondary accessions: Q5VXC2 Q5VXC3 Q68D07 Q86VE8 Q8WX20 Q9P2I2
Alternative splicing: 3 isoforms:  Q96NW7-1   Q96NW7-2   Q96NW7-3   

Explore the universe of human proteins at neXtProt for LRRC7: NX_Q96NW7

Explore proteomics data for LRRC7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96NW7

  • LRRC7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRRC7 Protein Expression
    REFSEQ proteins: NP_065845.1  
    ENSEMBL proteins: 
     ENSP00000309245   ENSP00000359997   ENSP00000035383   ENSP00000466082   ENSP00000394867  

    Human Recombinant Protein Products for LRRC7: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LRRC7
    GenScript Custom Purified and Recombinant Proteins Services for LRRC7
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRC7 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    LRRC7 for ontologies           About GeneDecksing



    LRRC7 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LRRC7
    GenScript Custom Superior Antibodies Services for LRRC7
    Novus Biologicals LRRC7 Antibodies
    Abcam antibodies for LRRC7
    Cloud-Clone Corp. Antibodies for LRRC7 
    Search ThermoFisher Antibodies for LRRC7
    LSBio Antibodies in human, mouse, rat for LRRC7 

    Assay Products for LRRC7: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRRC7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRRC7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRRC7 
    Cloud-Clone Corp. CLIAs for LRRC7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96NW7

    ProtoNet protein and cluster: Q96NW7

    1 Blocks protein domain: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Similarity: Belongs to the LAP (LRR and PDZ) protein family
    Similarity: Contains 17 LRR (leucine-rich) repeats
    Similarity: Contains 1 PDZ (DHR) domain


    LRRC7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRRC7_HUMAN, Q96NW7
    Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization
    to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
    receptor-dependent long term depression

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12390249
         
    LRRC7 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC7:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrrc7):
     behavior/neurological  growth/size  mortality/aging  nervous system  no phenotypic analysis 

    LRRC7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lrrc7tm1.1Mabk for LRRC7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRC7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRC7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC7 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC7
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidLRRC7 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRRC7
    Sirion Biotech Customized adenovirus for overexpression of LRRC7

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LRRC7 (see all 5)
    OriGene ORF clones in mouse, rat for LRRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC7 (NM_020794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRRC7
    Search LifeMap BioReagents cell lines for LRRC7
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRRC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/26 Interacting proteins for LRRC7 (Q96NW72, 3 ENSP000000353834) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNKSR2Q8WXI22, 3, ENSP000003688244MINT-1784595 I2D: score=4 STRING: ENSP00000368824
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=3 STRING: ENSP00000381412
    ACTN4O437073, ENSP000002526994I2D: score=2 STRING: ENSP00000252699
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CTNND2Q9UQB33, ENSP000003071344I2D: score=2 STRING: ENSP00000307134
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRRC7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRRC7

    3 Novoseek inferred chemical compound relationships for LRRC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 42.7 1 12859686 (1)
    nmda 33.2 5 9185308 (1), 12859686 (1), 16172120 (1)
    glutamate 11 2 9185308 (1), 16172120 (1)

    Search CenterWatch for drugs/clinical trials and news about LRRC7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRRC7 gene: 
    NM_020794.2  

    Unigene Cluster for LRRC7:

    Leucine rich repeat containing 7
    Hs.479658  [show with all ESTs]
    Unigene Representative Sequence: BX648943
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310961(uc001dep.3 uc009wbg.3 uc001deq.3) ENST00000370958(uc001deo.1)
    ENST00000035383 ENST00000588515 ENST00000565615 ENST00000441830 ENST00000415775

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC7
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidLRRC7 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC7
    Clone
    Products:
         
    OriGene clones in human, mouse for LRRC7 (see all 5)
    OriGene ORF clones in mouse, rat for LRRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC7 (NM_020794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC7
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC7

    Additional mRNA sequence: 

    AB037786.1 AF434715.1 AF498274.1 AK294206.1 BC128989.1 BX648943.1 CR749629.1 

    6 DOTS entries:

    DT.100742704  DT.92017744  DT.75112084  DT.304686  DT.121396930  DT.75141837 

    24/28 AceView cDNA sequences (see all 28):

    AF498274 BX105883 CR749629 BX477690 AW204480 AI079830 AB037786 AI366175 
    AF434715 NM_020794 AX786956 BP349281 BQ948144 BX648943 BI553842 BC080568 
    BG185672 AI080648 AW895490 BU527328 BG220442 AW895578 AW895410 AW895329 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                            -                                                                                                               
    SP2:        -                                                                                                                                                   
    SP3:                                                                                                                                      -                     

    ExUns: 26 ^ 27
    SP1:            
    SP2:            
    SP3:            


    ECgene alternative splicing isoforms for LRRC7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRRC7 expression in normal human tissues (normalized intensities)      LRRC7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTACTTATG
    LRRC7 Expression
    About this image


    LRRC7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             postcentral gyrus   
     
     Primitive Streak (Early Embryonic Tissues)
             Definitive endoderm-like cells ( Generation and expansion of endodermal progenitor...
     
     Gut Tube (Gastrointestinal Tract)
             Endoderm progenitor-like cells ( Generation and expansion of endodermal progenitor...

    See LRRC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRRC7

    SOURCE GeneReport for Unigene cluster: Hs.479658

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed

        SABiosciences Custom PCR Arrays for LRRC7
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC7
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC7
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC7
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRRC7 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc71 , 5 leucine rich repeat containing 71, 5 90.33(n)1
    95.58(a)1
      3 (81.68 cM)5
    2422741  NM_001081358.11  NP_001074827.11 
     1580844395 
    chicken
    (Gallus gallus)
    Aves LRRC71 leucine rich repeat containing 7 68.77(n)
    68.82(a)
      424711  XM_003641695.1  XP_003641743.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC76
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343328.1(904714-1120404)
    zebrafish
    (Danio rerio)
    Actinopterygii lrrc71 leucine rich repeat containing 7 68.26(n)
    71.18(a)
      566023  XM_001920777.3  XP_001920812.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Lap16
    Lap1
    32(a)
    1 → many
    2R(10823182-10827807)


    ENSEMBL Gene Tree for LRRC7 (if available)
    TreeFam Gene Tree for LRRC7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRRC7 gene
    LRRC22  ERBB2IP2  MFHAS12  LRRC12  LRRC302  LRRIQ42  SCRIB2  SHOC22  
    LRRD12  LRRC10B2  LRRC392  LRRC402  LRRC102  
    7 SIMAP similar genes for LRRC7 using alignment to 5 protein entries:     LRRC7_HUMAN (see all proteins):
    SCRIB    LRRC1    ERBB2IP    TAX1BP3    TJP2    LRIG3
    DLG4

    LRRC7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6452 SNPs in LRRC7 are shown (see all 6452)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357154
    A breast cancer sample4--see VAR_0357152 L M mis40--------
    rs120788961,2
    F,H--70223895(+) GGTTAT/CGTAAA 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 508
    rs64245931,2
    C,F,A,H--70223922(+) CTTGCA/GATTCT 1 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2184
    rs1411586241,2
    C--70223941(+) GAAATG/TAAAAG 1 -- us2k10--------
    rs171310251,2
    C,F--70224033(+) CATGTG/TCAAAC 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1928515021,2
    --70224042(+) ACAATC/TGTCTA 1 -- us2k10--------
    rs1845361521,2
    --70224043(+) CAATCA/GTCTAT 1 -- us2k10--------
    rs664835671,2
    C,F--70224239(+) TACACG/AGGTAA 1 -- us2k17Minor allele frequency- A:0.18WA NA CSA EA 366
    rs1892414511,2
    --70224300(+) TGAACA/GTAATA 1 -- us2k10--------
    rs1507276911,2
    --70224364(+) TAGGCC/TCCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRC7 (70034081 - 70284081 bp, first 250kb of LRRC7)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for LRRC7 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749586CNV Deletion23290073
    esv2617051CNV Deletion19546169
    esv1056018CNV Insertion17803354
    nsv512742CNV Insertion21212237
    esv269688CNV Insertion20981092
    esv269382CNV Insertion20981092
    esv1094257CNV Insertion17803354
    nsv525370CNV Loss19592680
    nsv871018CNV Loss21882294
    nsv521307CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC7
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614453    OMIM disorders: --

    2 diseases for LRRC7:    About MalaCards
    orofacial cleft    type 1 diabetes


    LRRC7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC7
    Human Genome Epidemiology (HuGE) Navigator: LRRC7 (2 documents)

    Export disorders for LRRC7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRRC7 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with LRRC7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PubMed id 12525888)1, 2, 3, 9 Wang L.... Mao Y. (2003)
    2. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PubMed id 17968527)1, 4, 9 Ihalmo P....Groop P.H. (2008)
    3. Genetic association of short sleep duration with hyper tension incidence--a 6-year follow-up in the Korean genome and epidemiology stud y. (PubMed id 22322875)1, 4 Kim S.J....Shin C. (2012)
    4. Genome-wide association study of the child behavior c hecklist dysregulation profile. (PubMed id 21784300)1, 4 Mick E....Faraone S.V. (2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. (PubMed id 11729199)1, 2 Izawa I.... Inagaki M. (2002)
    8. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    9. Brain-specific angiogenesis inhibitor-1 signaling, reg ulation, and enrichment in the postsynaptic density. (PubMed id 23782696)1 Stephenson J.R....Hall R.A. (2013)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57554 HGNC: 18531 AceView: KIAA1365 Ensembl:ENSG00000033122 euGenes: HUgn57554
    ECgene: LRRC7 H-InvDB: LRRC7

    (According to HUGE)
    About This Section
    HUGE: KIAA1365

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRRC7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRRC7 gene:
    Search GeneIP for patents involving LRRC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LRRC7  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LRRC7  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRRC7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LRRC7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRRC7   OriGene Custom Protein Services for LRRC7  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC7
     QIAGEN SeqTarget long-range PCR primers for resequencing LRRC7
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC7
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC7
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC7
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC7
     GenScript Custom Purified and Recombinant Proteins Services for LRRC7 GenScript cDNA clones with any tag delivered in your preferred vector for LRRC7
     GenScript Custom Assay Services for LRRC7 GenScript Custom Superior Antibodies Services for LRRC7
     GenScript Custom overexpressing Cell Line Services for LRRC7 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LRRC7 promoter
     Search Chromatin IP Primers for LRRC7
     RT2 qPCR Primer Assay in human, mouse, rat LRRC7
     GNC Network for LRRC7
     SABiosciences Custom PCR Arrays for LRRC7
     Search Tocris compounds for LRRC7
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LRRC7 antibodies
     Antibodies for LRRC7
     See all of Abcam's Antibodies, Kits and Proteins for LRRC7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LRRC7
     Antibodies for LRRC7
     ELISAs for LRRC7
     CLIAs for LRRC7
     Search LifeMap BioReagents cell lines for LRRC7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7
     SwitchGear 3'UTR luciferase reporter plasmids for LRRC7
     SwitchGear Promoter luciferase reporter plasmids for LRRC7
     Search ThermoFisher Antibodies for LRRC7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRC7
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRC7
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of LRRC7
     LSBio Antibodies in human, mouse, rat for LRRC7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LRRC7 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4