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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRRC7 Gene

protein-coding   GIFtS: 54
GCID: GC01P069998

leucine rich repeat containing 7
 Explore 1 disease affiliated with
LRRC7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for LRRC7    

Aliases
for LRRC7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Leucine Rich Repeat Containing 71 2     Densin3
Densin-1803     Densin-1803
KIAA13651 3     LAP13
DENSIN2     Protein LAP13
Leucine-Rich Repeat-Containing Protein 72     

External Ids:    HGNC: 185311   Entrez Gene: 575542   Ensembl: ENSG000000331227   OMIM: 6144535   UniProtKB: Q96NW73   

Export aliases for LRRC7 gene to outside databases

Previous GC identifers: GC01P069857 GC01P068336


Summaries
for LRRC7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to
postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
receptor-dependent long term depression

Gene Wiki entry for LRRC7


Genomic Views
for LRRC7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRRC7 gene promoter:
         STAT5B   C/EBPbeta   Sox5   Pbx1a   HNF-3beta   Evi-1   c-Rel   POU2F1   POU2F1a   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRRC7 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRRC7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LRRC7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P069998:  view genomic region     (about GC identifiers)

Start:
 70,034,081 bp from pter      End:
 70,617,628 bp from pter
Size:
 583,548 bases      Orientation:
 plus strand

Proteins
for LRRC7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 7  
Size: 1537 amino acids; 172581 Da
Subunit: Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex
with N-cadherin through CTNND2
Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
similarity)
Sequence caution: Sequence=AAP06801.1; Type=Erroneous initiation; Sequence=BAA92603.1; Type=Frameshift; Positions=665;
Sequence=CAH70975.1; Type=Erroneous initiation; Sequence=CAH73692.1; Type=Erroneous initiation; Sequence=CAH74019.1;
Type=Erroneous initiation; Sequence=CAI22426.1; Type=Erroneous initiation; Sequence=CAI23423.1; Type=Erroneous
initiation;
Secondary accessions: Q5VXC2 Q5VXC3 Q68D07 Q86VE8 Q8WX20 Q9P2I2
Alternative splicing: 3 isoforms:  Q96NW7-1   Q96NW7-2   Q96NW7-3   

Explore the universe of human proteins at neXtProt for LRRC7: NX_Q96NW7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NW7

    • LRRC7 Protein expression data from MOPED and PaxDb:    About this image 
    LRRC7 Protein Expression
    REFSEQ proteins: NP_065845.1  
    ENSEMBL proteins: 
     ENSP00000309245   ENSP00000359997   ENSP00000035383   ENSP00000466082   ENSP00000394867  

    Human Recombinant Protein Products for LRRC7: 
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    Uscn Proteins for LRRC7

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0045211postsynaptic membrane IEA--

    LRRC7 for ontologies           About GeneDecksing



    LRRC7 Antibody Products: 
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    Uscn ELISAs and CLIAs for LRRC7

    Protein Domains /
    Families
    for LRRC7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    LRRC7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96NW7

    ProtoNet protein and cluster: Q96NW7

    1 Blocks protein family: IPB001478 PDZ/DHR/GLGF domain

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Similarity: Belongs to the LAP (LRR and PDZ) protein family
    Similarity: Contains 17 LRR (leucine-rich) repeats
    Similarity: Contains 1 PDZ (DHR) domain


    Function
    for LRRC7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRRC7_HUMAN, Q96NW7
    Function: Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to
    postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate
    receptor-dependent long term depression

    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC7:

     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lrrc7):
     behavior/neurological  growth/size  mortality/aging  nervous system  no phenotypic analysis 

    LRRC7 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Lrrc7tm1.1Mabk for LRRC7
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LRRC7 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC7
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: LRRC7 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC7 (see all 7)
    OriGene shRNA RFP: LRRC7
    OriGene siRNA: LRRC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC7
    Sirion Biotech Custom design and validation of potent shRNA sequences against LRRC7 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LRRC7
    Sirion Biotech Customized adenovirus for overexpression of LRRC7 
    Sirion Biotech Customized adenovirus for potent knockdown of LRRC7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC7 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for LRRC7
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7


    Pathways & Interactions
    for LRRC7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRRC7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/25 Interacting proteins for LRRC7 (Q96NW72, 3 ENSP000000353834) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CNKSR2Q8WXI22, 3, ENSP000003688244MINT-1784595 I2D: score=4 STRING: ENSP00000368824
    CAMK2AQ9UQM73, ENSP000003814124I2D: score=3 STRING: ENSP00000381412
    ACTN4O437073, ENSP000002526994I2D: score=2 STRING: ENSP00000252699
    CDH2P190223, ENSP000002691414I2D: score=2 STRING: ENSP00000269141
    CTNND2Q9UQB33, ENSP000003071344I2D: score=2 STRING: ENSP00000307134
    About this table

    Drugs & Compounds
    for LRRC7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRRC7 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRRC7
    3 Novoseek chemical compound relationships for LRRC7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    guanylate 42.7 1 12859686 (1)
    nmda 33.2 5 9185308 (1), 12859686 (1), 16172120 (1)
    glutamate 11 2 9185308 (1), 16172120 (1)

    Search CenterWatch for drugs/clinical trials and news about LRRC7 

    Transcripts
    for LRRC7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LRRC7 gene: 
    NM_020794.2  

    Unigene Cluster for LRRC7:

    Leucine rich repeat containing 7
    Hs.479658  [show with all ESTs]
    Unigene Representative Sequence: BX648943
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310961(uc001dep.3 uc009wbg.3 uc001deq.3) ENST00000370958(uc001deo.1)
    ENST00000035383 ENST00000588515 ENST00000565615 ENST00000441830 ENST00000415775


    miRNA
    Products:             		 OriGene 3'-UTR Clone: LRRC7
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC7
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC7 (see all 44):
    hsa-miR-300 hsa-let-7a-2* hsa-miR-449a hsa-miR-218 hsa-miR-1304 hsa-miR-124 hsa-miR-1276 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: LRRC7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC7 (see all 7)
    OriGene shRNA RFP: LRRC7
    OriGene siRNA: LRRC7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC7
    Sirion Biotech Custom design and validation of potent shRNA sequences against LRRC7 
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: LRRC7 (NM_020794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC7 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC7
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC7

    Additional cDNA sequence: 

    AB037786.1 AF434715.1 AF498274.1 AK294206.1 BC128989.1 BX648943.1 CR749629.1 

    6 DOTS entries:

    DT.100742704  DT.92017744  DT.75112084  DT.304686  DT.121396930  DT.75141837 

    24/28 AceView cDNA sequences (see all 28):

    AI366175 AB037786 AX786956 CR749629 AW204480 BP349281 AI079830 NM_020794 
    BX477690 AF498274 BX105883 AF434715 BI553842 BU527328 BQ948144 BX648943 
    AW895490 BC080568 BG185672 AI080648 BG220442 AW895410 AW895329 AW895578 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC7    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^
    SP1:                                            -                                                                                                               
    SP2:        -                                                                                                                                                   
    SP3:                                                                                                                                      -                     

    ExUns: 26 ^ 27
    SP1:            
    SP2:            
    SP3:            


    ECgene alternative splicing isoforms for LRRC7

    Expression
    for LRRC7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRRC7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTACTTATG
    LRRC7 Expression
    About this image

    LRRC7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Definitive endoderm-like cells (Generation and expan...)
    Endoderm progenitor-like cells (Generation and expan...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See LRRC7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRRC7

    SOURCE GeneReport for Unigene cluster: Hs.479658

    UniProtKB/Swiss-Prot: LRRC7_HUMAN, Q96NW7
    Tissue specificity: Brain-specific. Isoform 3 is ubiquitously expressed

        SABiosciences Custom PCR Arrays for LRRC7
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC7

    Orthologs
    for LRRC7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LRRC7 gene from 4/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LRRC71 leucine rich repeat containing 7 68.77(n)
    68.82(a)    		   424711  XM_003641695.1  XP_003641743.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LRRC76
    		 --
    		 83(a)
    		 1 ↔ 1
    		 GL343328.1(958658-1120404)
    zebrafish
    (Danio rerio)    		 Actinopterygii lrrc71 leucine rich repeat containing 7 68.26(n)
    71.18(a)    		   566023  XM_001920777.3  XP_001920812.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Lap16
    		 Lap1
    		 31(a)
    		 1 → many
    		 2R(10823182-10827807)


    ENSEMBL Gene Tree for LRRC7 (if available)
    TreeFam Gene Tree for LRRC7 (if available) 

    Paralogs
    for LRRC7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRRC7 gene
    LRRC22  ERBB2IP2  MFHAS12  LRRC182  LRRC302  LRRC12  PIDD2  LRRIQ42  
    SCRIB2  SHOC22  LRRD12  LRRC10B2  LRRC392  LRRC402  LRRC102  
    7 SIMAP similar genes for LRRC7 using alignment to 5 protein entries:     LRRC7_HUMAN (see all proteins):
    SCRIB    ERBB2IP    LRRC1    TAX1BP3    TJP2    LRIG3
    DLG4

    LRRC7 for paralogs           About GeneDecksing



    Genomic Variants
    for LRRC7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5456 NCBI SNPs in LRRC7 are shown (see all 5456)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120788961,2
    		F,H--70223895(+) GGTTAT/CGTAAA 1 -- us2k15Minor allele frequency- C:0.02NS EA WA 508
    rs64245931,2
    		C,F,A,H--70223922(+) CTTGCA/GATTCT 1 -- us2k122Minor allele frequency- G:0.48NS EA NA WA CSA 2184
    rs1411586241,2
    		--70223941(+) GAAATG/TAAAAG 1 -- us2k10--------
    rs171310251,2
    		C--70224033(+) CATGTG/TCAAAC 1 -- us2k13Minor allele frequency- T:0.01NA 142
    rs1928515021,2
    		--70224042(+) ACAATC/TGTCTA 1 -- us2k10--------
    rs1845361521,2
    		--70224043(+) CAATCA/GTCTAT 1 -- us2k10--------
    rs664835671,2
    		C,F--70224239(+) TACACG/AGGTAA 1 -- us2k17Minor allele frequency- A:0.18WA NA CSA EA 366
    rs1892414511,2
    		--70224300(+) TGAACA/GTAATA 1 -- us2k10--------
    rs1507276911,2
    		--70224364(+) TAGGCC/TCCAGT 1 -- us2k10--------
    rs1390135331,2
    		--70224402(+) GTTTGC/TGCAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRRC7 (70034081 - 70284081 bp, first 250kb of LRRC7)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for LRRC7
         2 CNVs: 53127 97387

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    Disorders / Diseases
    for LRRC7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    LRRC7 for disorders           About GeneDecksing

    OMIM gene information: 614453    OMIM disorders: --

    1 disease for LRRC7:    About MalaCards
    nephropathy

    Human Genome Epidemiology (HuGE) Navigator: LRRC7 (2 documents)

    Export disorders for LRRC7 gene to outside databases

    Publications
    for LRRC7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRRC7 gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with LRRC7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel splice variant of the brain- specific protein densin-180. (PubMed id 12525888)1, 2, 3, 9 Wang L.... Mao Y. (2003)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. (PubMed id 11729199)1, 2 Izawa I.... Inagaki M. (2002)
    4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    5. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. (PubMed id 17968527)1, 9 Ihalmo P....Groop P.H. (2008)
    6. Genetic association of short sleep duration with hyper tension incidence--a 6-year follow-up in the Korean genome and epidemiology stud y. (PubMed id 22322875)1 Kim S.J....Shin C. (2012)
    7. Genome wide study of maternal and parent-of-origin eff ects on the etiology of orofacial clefts. (PubMed id 22419666)1 Shi M....Beaty T.H. (2012)
    8. Deletion of densin-180 results in abnormal behaviors associated with mental illness and reduces mGluR5 and DISC1 in the postsynaptic density fraction. (PubMed id 22072671)1 Carlisle H.J....Kennedy M.B. (2011)
    9. Genome-wide association study of the child behavior c hecklist dysregulation profile. (PubMed id 21784300)1 Mick E....Faraone S.V. (2011)
    10. Characterization of a central Ca2+/calmodulin-depende nt protein kinase IIalpha/beta binding domain in densin that selectively modula tes glutamate receptor subunit phosphorylation. (PubMed id 21610080)1 Jiao Y....Colbran R.J. (2011)

    External Searches for LRRC7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LRRC7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57554 HGNC: 18531 AceView: KIAA1365 Ensembl:ENSG00000033122 euGenes: HUgn57554
    ECgene: LRRC7 H-InvDB: LRRC7

    Other Databases showing LRRC7 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1365

    Specialized Databases showing LRRC7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRRC7 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LRRC7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LRRC7 gene:
    Search GeneIP for patents involving LRRC7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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