Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRRC69 Gene

Aliases for LRRC69 Gene

  • Leucine Rich Repeat Containing 69 2 3 5

External Ids for LRRC69 Gene

Previous GeneCards Identifiers for LRRC69 Gene

  • GC08U901021
  • GC08P092186
  • GC08P092114
  • GC08P087326

Summaries for LRRC69 Gene

GeneCards Summary for LRRC69 Gene

LRRC69 (Leucine Rich Repeat Containing 69) is a Protein Coding gene. An important paralog of this gene is LRRC8D.

Additional gene information for LRRC69 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC69 Gene

Genomics for LRRC69 Gene

Regulatory Elements for LRRC69 Gene

Enhancers for LRRC69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H091179 0.9 Ensembl ENCODE 11.1 +78.6 78623 1 ZNF639 JUN MAX ZNF175 CEBPB CEBPG EP300 FOSL1 ZNF589 JUND SLC26A7 LRRC69 GC08P091158 MIR4661
GH08H091039 1.1 ENCODE 7.5 -61.7 -61688 4 ARID4B SIN3A ZNF2 ETS1 GLIS2 GATA2 SP3 SP5 NCOA1 SMARCB1 OTUD6B-AS1 SLC26A7 LRRC69 LOC105375634 PIP4P2 ENSG00000253358
GH08H090675 1.1 Ensembl ENCODE dbSUPER 4.5 -425.5 -425522 1 ZNF217 CTCF CTBP1 NFIB POLR2A RCOR1 FOXA1 OTUD6B-AS1 OTUD6B TMEM64 LRRC69 ENSG00000254182 LOC102724670
GH08H091068 1.1 ENCODE 4.4 -31.8 -31794 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF207 OTUD6B-AS1 SLC26A7 LOC102724670 LRRC69 ENSG00000254219
GH08H091034 0.6 Ensembl ENCODE 5.5 -67.5 -67496 1 GATA3 OTUD6B-AS1 LRRC69 PIP4P2 ENSG00000253358
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC69 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC69 Gene

91,101,832 bp from pter
91,219,236 bp from pter
117,405 bases
Plus strand

Genomic View for LRRC69 Gene

Genes around LRRC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC69 Gene

Proteins for LRRC69 Gene

  • Protein details for LRRC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 69
    Protein Accession:

    Protein attributes for LRRC69 Gene

    347 amino acids
    Molecular mass:
    39592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC69 Gene


neXtProt entry for LRRC69 Gene

Post-translational modifications for LRRC69 Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC69 Gene

No data available for DME Specific Peptides for LRRC69 Gene

Domains & Families for LRRC69 Gene

Gene Families for LRRC69 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC69 Gene

Suggested Antigen Peptide Sequences for LRRC69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC69 family.
  • Belongs to the LRRC69 family.
genes like me logo Genes that share domains with LRRC69: view

Function for LRRC69 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC69
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC69 Gene

Localization for LRRC69 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC69 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC69 Gene

Pathways & Interactions for LRRC69 Gene

SuperPathways for LRRC69 Gene

No Data Available

Interacting Proteins for LRRC69 Gene

Gene Ontology (GO) - Biological Process for LRRC69 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC69 Gene

Drugs & Compounds for LRRC69 Gene

No Compound Related Data Available

Transcripts for LRRC69 Gene

mRNA/cDNA for LRRC69 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC69 Gene

Leucine rich repeat containing 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC69
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC69 Gene

No ASD Table

Relevant External Links for LRRC69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC69 Gene

Protein differential expression in normal tissues from HIPED for LRRC69 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC69 Gene

Protein tissue co-expression partners for LRRC69 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC69 Gene:


SOURCE GeneReport for Unigene cluster for LRRC69 Gene:

genes like me logo Genes that share expression patterns with LRRC69: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC69 Gene

Orthologs for LRRC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC69 34 33
  • 99.81 (n)
(Bos Taurus)
Mammalia LRRC69 33 34
  • 85.21 (n)
(Canis familiaris)
Mammalia LRRC69 33 34
  • 85.21 (n)
(Rattus norvegicus)
Mammalia Lrrc69 33
  • 76.03 (n)
(Mus musculus)
Mammalia Lrrc69 33 16 34
  • 75.72 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC69 34
  • 55 (a)
(Monodelphis domestica)
Mammalia LRRC69 34
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc69 33
  • 57.05 (n)
(Danio rerio)
Actinopterygii si:ch73-302o18.2 33
  • 50.78 (n)
LRRC69 34
  • 37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5771 34
  • 40 (a)
Species where no ortholog for LRRC69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC69 Gene

Gene Tree for LRRC69 (if available)
Gene Tree for LRRC69 (if available)

Paralogs for LRRC69 Gene

Paralogs for LRRC69 Gene

genes like me logo Genes that share paralogs with LRRC69: view

Variants for LRRC69 Gene

Sequence variations from dbSNP and Humsavar for LRRC69 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000020769 -- 91,191,097(+) GTGAC(C/G)ATTCT intron-variant
rs1000074558 -- 91,191,346(+) CTCCT(C/T)TCATC intron-variant
rs1000096778 -- 91,214,661(+) TCTTC(C/T)AGCAT intron-variant
rs1000131594 -- 91,134,079(+) TGGGA(G/T)ACTGA intron-variant
rs1000132376 -- 91,140,029(+) GTTGC(A/G)GTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC69 Gene

Variant ID Type Subtype PubMed ID
dgv12235n54 CNV loss 21841781
dgv3860n106 CNV deletion 24896259
dgv7268n100 CNV loss 25217958
esv1005988 CNV insertion 20482838
esv2195824 CNV deletion 18987734
esv2523005 CNV deletion 19546169
esv2656822 CNV deletion 23128226
esv2670300 CNV deletion 23128226
esv2737291 CNV deletion 23290073
esv2759629 CNV loss 17122850
esv3325601 CNV insertion 20981092
esv3452204 CNV insertion 20981092
esv35058 CNV loss 17911159
esv3543836 CNV deletion 23714750
esv3572901 CNV loss 25503493
esv3618014 CNV loss 21293372
esv3618015 CNV loss 21293372
esv3618016 CNV loss 21293372
esv3618017 CNV loss 21293372
esv3891440 CNV loss 25118596
esv6601 OTHER inversion 19470904
esv995698 CNV deletion 20482838
nsv1076096 CNV deletion 25765185
nsv1149896 CNV deletion 26484159
nsv398405 CNV insertion 16902084
nsv465736 CNV loss 19166990
nsv524992 CNV loss 19592680
nsv525292 CNV loss 19592680
nsv611721 CNV loss 21841781
nsv6301 CNV insertion 18451855
nsv831390 CNV gain 17160897
nsv957679 CNV deletion 24416366
nsv967617 CNV duplication 23825009

Variation tolerance for LRRC69 Gene

Gene Damage Index Score: 1.78; 33.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC69 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC69 Gene

Disorders for LRRC69 Gene

Relevant External Links for LRRC69

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC69 Gene

Publications for LRRC69 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for LRRC69 Gene

Sources for LRRC69 Gene

Loading form....