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Aliases for LRRC69 Gene

Aliases for LRRC69 Gene

  • Leucine Rich Repeat Containing 69 2 3 5

External Ids for LRRC69 Gene

Previous GeneCards Identifiers for LRRC69 Gene

  • GC08U901021
  • GC08P092186
  • GC08P092114
  • GC08P087326

Summaries for LRRC69 Gene

GeneCards Summary for LRRC69 Gene

LRRC69 (Leucine Rich Repeat Containing 69) is a Protein Coding gene. An important paralog of this gene is LRCH1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC69 Gene

Genomics for LRRC69 Gene

Regulatory Elements for LRRC69 Gene

Enhancers for LRRC69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F091179 0.5 Ensembl ENCODE 11 +78.6 78623 1.3 JUN CEBPB MAX ZNF175 SIN3A EP300 ZNF316 JUND ZNF589 ATF3 SLC26A7 LRRC69 GC08P091158 MIR4661
GH08F091080 0.6 ENCODE 10.6 -21.2 -21155 0.1 PRDM1 LRRC69 OTUD6B
GH08F090791 0.5 ENCODE 9.7 -309.9 -309859 0.3 ZNF263 MAZ CBX2 SIN3A E2F1 SMARCA4 POLR2A ZBTB48 ZNF341 CTBP2 LRRC69 LOC105375633 TMEM64 LOC105375635
GH08F091038 0.9 ENCODE 7.5 -61.7 -61688 4.3 ARID4B SIN3A ZNF48 ZNF2 ETS1 GLIS2 GATA2 FOS ZNF263 SP3 OTUD6B-AS1 SLC26A7 LRRC69 LOC105375634 TMEM55A GS1-251I9.3
GH08F091031 1.4 FANTOM5 Ensembl ENCODE 5.5 -68.7 -68696 3.5 HLF CEBPB CEBPG TBX21 GATA3 CEBPA IKZF1 MLLT1 SPI1 OTUD6B-AS1 SLC26A7 LRRC69 TMEM55A GS1-251I9.3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC69 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC69 Gene

Chromosome:
8
Start:
91,101,832 bp from pter
End:
91,219,236 bp from pter
Size:
117,405 bases
Orientation:
Plus strand

Genomic View for LRRC69 Gene

Genes around LRRC69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC69 Gene

Proteins for LRRC69 Gene

  • Protein details for LRRC69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNQ3-LRC69_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 69
    Protein Accession:
    Q6ZNQ3

    Protein attributes for LRRC69 Gene

    Size:
    347 amino acids
    Molecular mass:
    39592 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC69 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC69 Gene

Post-translational modifications for LRRC69 Gene

  • Ubiquitination at Lys 24
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC69 Gene

No data available for DME Specific Peptides for LRRC69 Gene

Domains & Families for LRRC69 Gene

Protein Domains for LRRC69 Gene

Suggested Antigen Peptide Sequences for LRRC69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNQ3

UniProtKB/Swiss-Prot:

LRC69_HUMAN :
  • Belongs to the LRRC69 family.
  • Contains 8 LRR (leucine-rich) repeats.
Family:
  • Belongs to the LRRC69 family.
Similarity:
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC69: view

No data available for Gene Families for LRRC69 Gene

Function for LRRC69 Gene

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC69 Gene

Localization for LRRC69 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC69 Gene COMPARTMENTS Subcellular localization image for LRRC69 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC69 Gene

Pathways & Interactions for LRRC69 Gene

SuperPathways for LRRC69 Gene

No Data Available

Interacting Proteins for LRRC69 Gene

Gene Ontology (GO) - Biological Process for LRRC69 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC69 Gene

Transcripts for LRRC69 Gene

mRNA/cDNA for LRRC69 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC69 Gene

Leucine rich repeat containing 69:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC69 Gene

No ASD Table

Relevant External Links for LRRC69 Gene

GeneLoc Exon Structure for
LRRC69
ECgene alternative splicing isoforms for
LRRC69

Expression for LRRC69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC69 Gene

Protein differential expression in normal tissues from HIPED for LRRC69 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC69 Gene



Protein tissue co-expression partners for LRRC69 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC69 Gene:

LRRC69

SOURCE GeneReport for Unigene cluster for LRRC69 Gene:

Hs.733070
genes like me logo Genes that share expression patterns with LRRC69: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC69 Gene

Orthologs for LRRC69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC69 34 35
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia LRRC69 34 35
  • 85.21 (n)
dog
(Canis familiaris)
Mammalia LRRC69 34 35
  • 85.21 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc69 34
  • 76.03 (n)
mouse
(Mus musculus)
Mammalia Lrrc69 34 16 35
  • 75.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC69 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC69 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc69 34
  • 57.05 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-302o18.2 34
  • 50.78 (n)
LRRC69 35
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5771 35
  • 40 (a)
OneToOne
Species where no ortholog for LRRC69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC69 Gene

ENSEMBL:
Gene Tree for LRRC69 (if available)
TreeFam:
Gene Tree for LRRC69 (if available)

Paralogs for LRRC69 Gene

genes like me logo Genes that share paralogs with LRRC69: view

Variants for LRRC69 Gene

Sequence variations from dbSNP and Humsavar for LRRC69 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086348 -- 91,150,511(+) tttgc(A/G)tcaat intron-variant
rs10087552 -- 91,187,664(+) TGTCT(C/T)CATTC intron-variant
rs10087555 -- 91,187,671(+) ATTCA(C/T)ACTGA intron-variant
rs10091041 -- 91,112,535(+) tcagc(A/G)tccat intron-variant
rs10091375 -- 91,166,999(+) GTTAC(A/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC69 Gene

Variant ID Type Subtype PubMed ID
dgv12235n54 CNV loss 21841781
dgv3860n106 CNV deletion 24896259
dgv7268n100 CNV loss 25217958
esv1005988 CNV insertion 20482838
esv2195824 CNV deletion 18987734
esv2523005 CNV deletion 19546169
esv2656822 CNV deletion 23128226
esv2670300 CNV deletion 23128226
esv2737291 CNV deletion 23290073
esv2759629 CNV loss 17122850
esv3325601 CNV insertion 20981092
esv3452204 CNV insertion 20981092
esv35058 CNV loss 17911159
esv3543836 CNV deletion 23714750
esv3572901 CNV loss 25503493
esv3618014 CNV loss 21293372
esv3618015 CNV loss 21293372
esv3618016 CNV loss 21293372
esv3618017 CNV loss 21293372
esv3891440 CNV loss 25118596
esv6601 OTHER inversion 19470904
esv995698 CNV deletion 20482838
nsv1076096 CNV deletion 25765185
nsv1149896 CNV deletion 26484159
nsv398405 CNV insertion 16902084
nsv465736 CNV loss 19166990
nsv524992 CNV loss 19592680
nsv525292 CNV loss 19592680
nsv611721 CNV loss 21841781
nsv6301 CNV insertion 18451855
nsv831390 CNV gain 17160897
nsv957679 CNV deletion 24416366
nsv967617 CNV duplication 23825009

Variation tolerance for LRRC69 Gene

Gene Damage Index Score: 1.78; 33.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC69 Gene

Human Gene Mutation Database (HGMD)
LRRC69
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC69

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC69 Gene

Disorders for LRRC69 Gene

Relevant External Links for LRRC69

Genetic Association Database (GAD)
LRRC69
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC69

No disorders were found for LRRC69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC69 Gene

Publications for LRRC69 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRRC69 Gene

Sources for LRRC69 Gene

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