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Aliases for LRRC66 Gene

Aliases for LRRC66 Gene

  • Leucine Rich Repeat Containing 66 2 3 5
  • EC 63
  • EC 63

External Ids for LRRC66 Gene

Previous GeneCards Identifiers for LRRC66 Gene

  • GC04M052555
  • GC04M052859
  • GC04M048801

Summaries for LRRC66 Gene

GeneCards Summary for LRRC66 Gene

LRRC66 (Leucine Rich Repeat Containing 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC66 Gene

Genomics for LRRC66 Gene

Regulatory Elements for LRRC66 Gene

Genomic Location for LRRC66 Gene

51,993,640 bp from pter
52,020,311 bp from pter
26,672 bases
Minus strand

Genomic View for LRRC66 Gene

Genes around LRRC66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC66 Gene

Proteins for LRRC66 Gene

  • Protein details for LRRC66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 66
    Protein Accession:

    Protein attributes for LRRC66 Gene

    880 amino acids
    Molecular mass:
    97778 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC66 Gene

Proteomics data for LRRC66 Gene at MOPED

Selected DME Specific Peptides for LRRC66 Gene

Post-translational modifications for LRRC66 Gene

  • Glycosylation at Asn 45, Asn 115, Asn 746, and Asn 756
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC66 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LRRC66 Gene

Protein Domains for LRRC66 Gene

Suggested Antigen Peptide Sequences for LRRC66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 LRR (leucine-rich) repeats.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC66: view

No data available for Gene Families for LRRC66 Gene

Function for LRRC66 Gene

Enzyme Numbers (IUBMB) for LRRC66 Gene

Gene Ontology (GO) - Molecular Function for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with LRRC66: view
genes like me logo Genes that share phenotypes with LRRC66: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC66 Gene

Localization for LRRC66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC66 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for LRRC66 Gene COMPARTMENTS Subcellular localization image for LRRC66 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for LRRC66 Gene

Pathways & Interactions for LRRC66 Gene

SuperPathways for LRRC66 Gene

No Data Available

Interacting Proteins for LRRC66 Gene

Gene Ontology (GO) - Biological Process for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with LRRC66: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC66 Gene

Drugs & Compounds for LRRC66 Gene

No Compound Related Data Available

Transcripts for LRRC66 Gene

mRNA/cDNA for LRRC66 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC66 Gene

Leucine rich repeat containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC66 Gene

No ASD Table

Relevant External Links for LRRC66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC66 Gene

mRNA expression in normal human tissues for LRRC66 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC66 Gene

This gene is overexpressed in Muscle - Skeletal (x6.7) and Small Intestine - Terminal Ileum (x5.9).

Protein differential expression in normal tissues from HIPED for LRRC66 Gene

This gene is overexpressed in Heart (39.8) and Adipocyte (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC66 Gene

SOURCE GeneReport for Unigene cluster for LRRC66 Gene Hs.661450

genes like me logo Genes that share expression patterns with LRRC66: view

Protein tissue co-expression partners for LRRC66 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRC66 Gene

Orthologs for LRRC66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC66 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC66 35
  • 73.41 (n)
  • 59.4 (a)
LRRC66 36
  • 58 (a)
(Canis familiaris)
Mammalia LRRC66 35
  • 65.49 (n)
  • 51.52 (a)
LRRC66 36
  • 50 (a)
(Mus musculus)
Mammalia Lrrc66 35
  • 67.06 (n)
  • 50.06 (a)
Lrrc66 16
Lrrc66 36
  • 47 (a)
(Pan troglodytes)
Mammalia LRRC66 35
  • 99.36 (n)
  • 98.86 (a)
LRRC66 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrrc66 35
  • 66.08 (n)
  • 47.75 (a)
(Monodelphis domestica)
Mammalia LRRC66 36
  • 50 (a)
(Danio rerio)
Actinopterygii lrrc66 36
  • 37 (a)
Species with no ortholog for LRRC66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC66 Gene

Gene Tree for LRRC66 (if available)
Gene Tree for LRRC66 (if available)

Paralogs for LRRC66 Gene

No data available for Paralogs for LRRC66 Gene

Variants for LRRC66 Gene

Sequence variations from dbSNP and Humsavar for LRRC66 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs17081784 - 51,995,997(+) CAGAG(C/G/T)CGGCC reference, missense
rs225159 -- 52,010,904(+) taagt(C/T)tcaaa intron-variant
rs225160 -- 52,018,073(-) GGTCA(C/T)GGTTT intron-variant, utr-variant-5-prime
rs225161 -- 52,019,161(-) gtggt(G/T)gctca intron-variant, upstream-variant-2KB
rs225162 -- 52,020,004(+) CCACT(C/G)AGAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRC66 Gene

Variant ID Type Subtype PubMed ID
nsv829932 CNV Gain 17160897
nsv879011 CNV Gain 21882294
esv269372 CNV Insertion 20981092

Variation tolerance for LRRC66 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC66 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC66 Gene

Disorders for LRRC66 Gene

Relevant External Links for LRRC66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC66 Gene

Publications for LRRC66 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRC66 Gene

Sources for LRRC66 Gene

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