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Aliases for LRRC66 Gene

Aliases for LRRC66 Gene

  • Leucine Rich Repeat Containing 66 2 3
  • EC 3.1.4.3 64
  • EC 2.4.2.9 64

External Ids for LRRC66 Gene

Summaries for LRRC66 Gene

GeneCards Summary for LRRC66 Gene

LRRC66 (Leucine Rich Repeat Containing 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC66 Gene

Genomics for LRRC66 Gene

Genomic Location for LRRC66 Gene

Start:
51,993,640 bp from pter
End:
52,020,311 bp from pter
Size:
26,672 bases
Orientation:
Minus strand

Genomic View for LRRC66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC66 Gene

Regulatory Elements for LRRC66 Gene

Proteins for LRRC66 Gene

  • Protein details for LRRC66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68CR7-LRC66_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 66
    Protein Accession:
    Q68CR7
    Secondary Accessions:

    Protein attributes for LRRC66 Gene

    Size:
    880 amino acids
    Molecular mass:
    97778 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC66 Gene

Proteomics data for LRRC66 Gene at MOPED

Selected DME Specific Peptides for LRRC66 Gene

Post-translational modifications for LRRC66 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn45, Asn115, Asn746, and Asn756

Other Protein References for LRRC66 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for LRRC66 Gene

Protein Domains for LRRC66 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

LRC66_HUMAN
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.:
    • Q68CR7
genes like me logo Genes that share domains with LRRC66: view

No data available for Gene Families for LRRC66 Gene

Function for LRRC66 Gene

Enzyme Numbers (IUBMB) for LRRC66 Gene

Gene Ontology (GO) - Molecular Function for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC66: view

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LRRC66 Gene

Localization for LRRC66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC66 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC66 Gene COMPARTMENTS Subcellular localization image for LRRC66 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC66: view

Pathways for LRRC66 Gene

SuperPathways for LRRC66 Gene

No Data Available

Interacting Proteins for LRRC66 Gene

Gene Ontology (GO) - Biological Process for LRRC66 Gene

None

No data available for Pathways by source for LRRC66 Gene

Transcripts for LRRC66 Gene

mRNA/cDNA for LRRC66 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC66 Gene

Leucine rich repeat containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC66 Gene

No ASD Table

Relevant External Links for LRRC66 Gene

GeneLoc Exon Structure for
LRRC66
ECgene alternative splicing isoforms for
LRRC66

Expression for LRRC66 Gene

mRNA expression in normal human tissues for LRRC66 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC66 Gene

This gene is overexpressed in Muscle - Skeletal (6.7) and Small Intestine - Terminal Ileum (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRC66 Gene

SOURCE GeneReport for Unigene cluster for LRRC66 Gene Hs.661450

genes like me logo Genes that share expressions with LRRC66: view

Orthologs for LRRC66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC66 36
  • 99.36 (n)
  • 98.86 (a)
LRRC66 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC66 36
  • 73.41 (n)
  • 59.4 (a)
LRRC66 37
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC66 36
  • 65.49 (n)
  • 51.52 (a)
LRRC66 37
  • 50 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc66 36
  • 67.06 (n)
  • 50.06 (a)
Lrrc66 16
Lrrc66 37
  • 47 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC66 37
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc66 36
  • 66.08 (n)
  • 47.75 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc66 37
  • 37 (a)
OneToOne
Species with no ortholog for LRRC66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC66 Gene

ENSEMBL:
Gene Tree for LRRC66 (if available)
TreeFam:
Gene Tree for LRRC66 (if available)

Paralogs for LRRC66 Gene

No data available for Paralogs for LRRC66 Gene

Variants for LRRC66 Gene

Sequence variations from dbSNP and Humsavar for LRRC66 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs225159 -- 52,010,904(+) taagt(C/T)tcaaa intron-variant
rs225160 -- 52,018,073(-) GGTCA(C/T)GGTTT intron-variant, utr-variant-5-prime
rs711348 -- 52,011,936(-) aagtg(C/T)tggga intron-variant
rs939228 -- 52,000,302(-) TATTT(C/T)CTGTG intron-variant
rs950273 -- 51,998,945(+) TAGCA(A/G)GTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC66 Gene

Variant ID Type Subtype PubMed ID
nsv829932 CNV Gain 17160897
nsv879011 CNV Gain 21882294
esv269372 CNV Insertion 20981092

Relevant External Links for LRRC66 Gene

HapMap Linkage Disequilibrium report
LRRC66

Disorders for LRRC66 Gene

No disorders were found for LRRC66 Gene.

No data available for UniProtKB/Swiss-Prot for LRRC66 Gene

Publications for LRRC66 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for LRRC66 Gene

Sources for LRRC66 Gene

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