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Aliases for LRRC66 Gene

Aliases for LRRC66 Gene

  • Leucine Rich Repeat Containing 66 2 3 5
  • EC 58
  • EC 58

External Ids for LRRC66 Gene

Previous GeneCards Identifiers for LRRC66 Gene

  • GC04M052555
  • GC04M052859
  • GC04M048801

Summaries for LRRC66 Gene

Entrez Gene Summary for LRRC66 Gene

  • This gene encodes a protein belonging to the leucine-rich repeat family of proteins, which are involved in diverse biological processes, including cell adhesion, cellular trafficking, and hormone-receptor interactions. [provided by RefSeq, Apr 2017]

GeneCards Summary for LRRC66 Gene

LRRC66 (Leucine Rich Repeat Containing 66) is a Protein Coding gene.

Additional gene information for LRRC66 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC66 Gene

Genomics for LRRC66 Gene

Regulatory Elements for LRRC66 Gene

Enhancers for LRRC66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H051895 1.1 Ensembl ENCODE 11.2 +124.4 124427 1.3 CTCF BACH1 RAD21 MTA3 ZNF316 FOXK2 POLR2A SMC3 ZNF143 FOSL2 LRRC66 DCUN1D4 GC04P051914 DUTP7
GH04H051879 0.8 ENCODE 11.5 +139.7 139661 2 TBP FOXA2 SAP130 TAF1 ARID4B MAX ZNF644 RAD21 RARA YY1 DCUN1D4 LRRC66 DUTP7 GC04P051914
GH04H052014 0.6 ENCODE 0.7 +2.6 2563 6.2 CTCF FOXA2 NFIA ZNF644 RAD21 TEAD3 BCL6 MIXL1 RXRB DCUN1D4 LRRC66 GC04P051994
GH04H052036 0.7 ENCODE 0.4 -17.5 -17522 2.6 STAT1 MXI1 MAZ L3MBTL2 NRF1 ZBTB8A E2F1 FOXM1 POLR2A PATZ1 SGCB LRRC66
GH04H052010 0.2 ENCODE 0.4 +8.1 8092 3.1 SGCB DCUN1D4 LINC02480 LRRC66 GC04P051994
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC66 on UCSC Golden Path with GeneCards custom track

Genomic Locations for LRRC66 Gene

Genomic Locations for LRRC66 Gene
26,672 bases
Minus strand

Genomic View for LRRC66 Gene

Genes around LRRC66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC66 Gene

Proteins for LRRC66 Gene

  • Protein details for LRRC66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 66
    Protein Accession:

    Protein attributes for LRRC66 Gene

    880 amino acids
    Molecular mass:
    97778 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC66 Gene

Selected DME Specific Peptides for LRRC66 Gene


Post-translational modifications for LRRC66 Gene

  • Glycosylation at posLast=4545, Asn115, posLast=746746, and posLast=756756
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC66 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for LRRC66 Gene

Gene Families for LRRC66 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRC66 Gene

Suggested Antigen Peptide Sequences for LRRC66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC66: view

No data available for UniProtKB/Swiss-Prot for LRRC66 Gene

Function for LRRC66 Gene

Enzyme Numbers (IUBMB) for LRRC66 Gene

Gene Ontology (GO) - Molecular Function for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with LRRC66: view
genes like me logo Genes that share phenotypes with LRRC66: view

Animal Model Products

Clone Products

No data available for Molecular function , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC66 Gene

Localization for LRRC66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC66 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC66 gene
Compartment Confidence
plasma membrane 3
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC66: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC66 Gene

Pathways & Interactions for LRRC66 Gene

SuperPathways for LRRC66 Gene

No Data Available

Interacting Proteins for LRRC66 Gene

Gene Ontology (GO) - Biological Process for LRRC66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with LRRC66: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC66 Gene

Drugs & Compounds for LRRC66 Gene

No Compound Related Data Available

Transcripts for LRRC66 Gene

mRNA/cDNA for LRRC66 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC66 Gene

Leucine rich repeat containing 66:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC66 Gene

No ASD Table

Relevant External Links for LRRC66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC66 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC66 Gene

This gene is overexpressed in Muscle - Skeletal (x6.7) and Small Intestine - Terminal Ileum (x5.9).

Protein differential expression in normal tissues from HIPED for LRRC66 Gene

This gene is overexpressed in Heart (39.8) and Adipocyte (29.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC66 Gene

Protein tissue co-expression partners for LRRC66 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC66 Gene:


SOURCE GeneReport for Unigene cluster for LRRC66 Gene:

genes like me logo Genes that share expression patterns with LRRC66: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC66 Gene

Orthologs for LRRC66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC66 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC66 33 34
  • 99.36 (n)
(Bos Taurus)
Mammalia LRRC66 33 34
  • 73.41 (n)
(Mus musculus)
Mammalia Lrrc66 33 16 34
  • 67.06 (n)
(Rattus norvegicus)
Mammalia Lrrc66 33
  • 66.08 (n)
(Canis familiaris)
Mammalia LRRC66 33 34
  • 65.49 (n)
(Monodelphis domestica)
Mammalia LRRC66 34
  • 50 (a)
(Danio rerio)
Actinopterygii lrrc66 34
  • 37 (a)
Species where no ortholog for LRRC66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC66 Gene

Gene Tree for LRRC66 (if available)
Gene Tree for LRRC66 (if available)

Paralogs for LRRC66 Gene

No data available for Paralogs for LRRC66 Gene

Variants for LRRC66 Gene

Sequence variations from dbSNP and Humsavar for LRRC66 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs147275302 Likely benign 52,021,991(+) TTACT(-/TAAA)TAAAC upstream-variant-2KB, utr-variant-3-prime
rs116538326 Uncertain significance 52,021,671(+) AAAAT(A/G/T)AATTA upstream-variant-2KB, utr-variant-3-prime
rs138349341 Uncertain significance 52,021,050(+) TTAAA(A/G)TATTA upstream-variant-2KB, utr-variant-3-prime
rs182133472 Uncertain significance 52,020,699(+) ATTAA(C/G/T)AGCAA upstream-variant-2KB, utr-variant-3-prime
rs192993435 Uncertain significance 52,021,791(+) AAAGT(A/G)TCATA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRRC66 Gene

Variant ID Type Subtype PubMed ID
nsv829932 CNV gain 17160897
nsv594201 CNV loss 21841781
esv3399485 CNV insertion 20981092

Variation tolerance for LRRC66 Gene

Residual Variation Intolerance Score: 42.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC66 Gene

Disorders for LRRC66 Gene

Relevant External Links for LRRC66

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC66 Gene

Publications for LRRC66 Gene

  1. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for LRRC66 Gene

Sources for LRRC66 Gene

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