LRRC61 Gene
protein-coding GIFtS: 43
GCID: GC07P150019
|
|
leucine rich repeat containing 61
| |
Aliases
for LRRC61 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 611 2 | | HSPC2951 2 | | FLJ313921 | | MGC30361 | | Leucine-Rich Repeat-Containing Protein 612 |
Export aliases for LRRC61 gene to outside databasesPrevious GC identifers: GC07P149651 GC07P143836 |
Summaries
for LRRC61 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LRRC61 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC61 gene promoter:
Sox5 RFX1 RREB-1 FOXO3 HSF1 (long) FOXO3b Evi-1 HSF1short FOXO3a Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC61
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC61 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31-q35 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q31-q35LRRC61 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P150019: view genomic region
(about GC identifiers)
Start:
|
150,019,728 bp from pter |
End:
|
150,035,245 bp from pter |
Size:
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15,518 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 149,358,146-149,373,096 |
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Proteins
for LRRC61 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC61_HUMAN, Q9BV99 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 61 Size: 259 amino acids; 28014 Da
Secondary accessions: B3KUW0 D3DWY8Explore the universe of human proteins at neXtProt for LRRC61: NX_Q9BV99
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BV99
LRRC61 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001136400.1 NP_076431.1
ENSEMBL proteins: ENSP00000339047 ENSP00000352642 ENSP00000420560
Human Recombinant Protein Products:
LRRC61 Antibody Products:
Assay Products for LRRC61: |
Protein
Domains /
Families
for LRRC61 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC61 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BV99ProtoNet protein and cluster: Q9BV99 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC61_HUMAN, Q9BV99Similarity: Contains 4 LRR (leucine-rich) repeatsSimilarity: Contains 1 LRRCT domain |
Function
for LRRC61 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): LRRC61 (NM_023942) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC61 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC61 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC61 |
4 GenomeRNAi human phenotypes for LRRC61:
|
Pathways & Interactions
for LRRC61 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC61
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for LRRC61 (Q9BV993 ENSP000003390474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for LRRC61 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC61
Search CenterWatch for drugs/clinical trials and news about LRRC61 / LRC61
|
Transcripts
for LRRC61 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC61 gene (2 alternative transcripts): NM_001142928.1 NM_023942.2 Unigene Cluster for LRRC61: Leucine rich repeat containing 61 Hs.647119 [show with all ESTs]Unigene Representative Sequence: AK0939155 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471872 ENST00000463441 ENST00000323078 ENST00000359623(uc003wgv.3 uc003wgx.3 uc003wgw.3)
ENST00000493307
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LRRC61 (NM_023942) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC61 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC61 |
Additional cDNA sequence: AF161413.1 AK025869.1 AK055954.1 AK093915.1 AK098061.1 BC001354.1 18 DOTS entries: DT.100787027 DT.211956 DT.100028584 DT.121069938 DT.100787025 DT.121069858 DT.100787042 DT.95207663 DT.100787032 DT.92461882 DT.92461867 DT.100787030 DT.92053327 DT.95207671 DT.121069929 DT.40246551 DT.86852737 DT.91981693 24/166 AceView cDNA sequences (see all 166): CR608476 CR608616 AA337557 AA582540 AA338692 CR604499 CR625785 CR606039 CR613542 AI821209 CR596920 CD107920 BQ943022 CR624936 AI821213 CR602087 CR622405 BE872386 BG774135 BC001354 AK025869 CR604731 CR619181 AI937338
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC61 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | - | | - | | - | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LRRC61
|
Expression
for LRRC61 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCAAGGAC
About this image
See LRRC61 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC61
SOURCE GeneReport for Unigene cluster: Hs.647119
SABiosciences Custom PCR Arrays for LRRC61
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC61
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat LRRC61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC61 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC61 |
Orthologs
for LRRC61 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LRRC61 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for LRRC61 (if available)
TreeFam Gene Tree for LRRC61 (if available) |
Paralogs
for LRRC61 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LRRC61 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC61 (150019728 - 150035245 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LRRC61
1 CNV: 52151 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for LRRC61 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LRRC61 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC61 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC61) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for LRRC61 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC61 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC61 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC61 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC61 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LRRC61 gene:
Search GeneIP for patents involving LRRC61
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC61 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC61 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC61 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC61 | | | OriGene Protein Over-expression Lysate for LRRC61 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC61 | | OriGene 3'-UTR Clone for LRRC61 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC61 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LRRC61 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC61 | | OriGene Custom Protein Services for LRRC61 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC61 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC61 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC61 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC61 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LRRC61 |
| |  |  |  |  | | | | |
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 | | | LRRC61 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC61 |
|  |  |  | | | | Search ThermoFisher Antibodies for LRRC61 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC61 |
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