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Aliases for LRRC59 Gene

Aliases for LRRC59 Gene

  • Leucine Rich Repeat Containing 59 2 3 5
  • Ribosome-Binding Protein P34 3 4
  • P34 3 4
  • PRO1855 3

External Ids for LRRC59 Gene

Previous GeneCards Identifiers for LRRC59 Gene

  • GC17M045814
  • GC17M048458
  • GC17M043826

Summaries for LRRC59 Gene

GeneCards Summary for LRRC59 Gene

LRRC59 (Leucine Rich Repeat Containing 59) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for LRRC59 Gene

  • Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC59 Gene

Genomics for LRRC59 Gene

Regulatory Elements for LRRC59 Gene

Promoters for LRRC59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC59 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC59 Gene

Chromosome:
17
Start:
50,375,059 bp from pter
End:
50,397,553 bp from pter
Size:
22,495 bases
Orientation:
Minus strand

Genomic View for LRRC59 Gene

Genes around LRRC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC59 Gene

Proteins for LRRC59 Gene

  • Protein details for LRRC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AG4-LRC59_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Protein Accession:
    Q96AG4
    Secondary Accessions:
    • B2RE83
    • D3DTX8
    • Q9P189

    Protein attributes for LRRC59 Gene

    Size:
    307 amino acids
    Molecular mass:
    34930 Da
    Quaternary structure:
    • Can form homodimers. Interacts with SGOL1. Interacts with FGF1.
    SequenceCaution:
    • Sequence=AAF69611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LRRC59 Gene

Proteomics data for LRRC59 Gene at MOPED

Post-translational modifications for LRRC59 Gene

  • Ubiquitination at Lys 40, Lys 66, Lys 73, Lys 111, and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC59 Gene

Domains & Families for LRRC59 Gene

Protein Domains for LRRC59 Gene

Suggested Antigen Peptide Sequences for LRRC59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AG4

UniProtKB/Swiss-Prot:

LRC59_HUMAN :
  • Contains 5 LRR (leucine-rich) repeats.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC59: view

No data available for Gene Families for LRRC59 Gene

Function for LRRC59 Gene

Molecular function for LRRC59 Gene

UniProtKB/Swiss-Prot Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.
genes like me logo Genes that share phenotypes with LRRC59: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC59 Gene

Localization for LRRC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC59 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC59 Gene COMPARTMENTS Subcellular localization image for LRRC59 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0042645 mitochondrial nucleoid IDA 18063578
genes like me logo Genes that share ontologies with LRRC59: view

Pathways & Interactions for LRRC59 Gene

SuperPathways for LRRC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC59 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC59 Gene

Drugs & Compounds for LRRC59 Gene

No Compound Related Data Available

Transcripts for LRRC59 Gene

mRNA/cDNA for LRRC59 Gene

Unigene Clusters for LRRC59 Gene

Leucine rich repeat containing 59:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC59 Gene

No ASD Table

Relevant External Links for LRRC59 Gene

GeneLoc Exon Structure for
LRRC59
ECgene alternative splicing isoforms for
LRRC59

Expression for LRRC59 Gene

mRNA expression in normal human tissues for LRRC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC59 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC59 Gene



SOURCE GeneReport for Unigene cluster for LRRC59 Gene Hs.370927

mRNA Expression by UniProt/SwissProt for LRRC59 Gene

Q96AG4-LRC59_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LRRC59: view

Protein tissue co-expression partners for LRRC59 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LRRC59 Gene

Orthologs for LRRC59 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC59 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC59 35
  • 92.81 (n)
  • 95.75 (a)
LRRC59 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC59 35
  • 89.87 (n)
  • 94.43 (a)
LRRC59 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc59 35
  • 89.58 (n)
  • 95.44 (a)
Lrrc59 16
Lrrc59 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC59 35
  • 99.78 (n)
  • 100 (a)
LRRC59 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc59 35
  • 89.79 (n)
  • 94.46 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC59 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC59 35
  • 70.93 (n)
  • 71.8 (a)
LRRC59 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC59 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc59 35
  • 61.2 (n)
  • 57.05 (a)
Str.6358 35
zebrafish
(Danio rerio)
Actinopterygii lrrc59 35
  • 61.47 (n)
  • 57.63 (a)
lrrc59 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG3408 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56A8.3 35
  • 48.38 (n)
  • 39.38 (a)
F56A8.3 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToOne
Species with no ortholog for LRRC59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC59 Gene

ENSEMBL:
Gene Tree for LRRC59 (if available)
TreeFam:
Gene Tree for LRRC59 (if available)

Paralogs for LRRC59 Gene

Pseudogenes.org Pseudogenes for LRRC59 Gene

genes like me logo Genes that share paralogs with LRRC59: view

No data available for Paralogs for LRRC59 Gene

Variants for LRRC59 Gene

Sequence variations from dbSNP and Humsavar for LRRC59 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1468316 -- 50,394,481(-) ATTTT(A/T)TGGGC intron-variant
rs1468317 -- 50,384,878(-) GATGT(A/G)TCTTG intron-variant
rs1468318 -- 50,384,872(-) TCTTG(A/G)AGCAT intron-variant
rs917026 -- 50,396,492(-) TGACC(C/T)ACACT intron-variant
rs917027 -- 50,393,101(-) GGAGT(G/T)TCCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC59 Gene

Variant ID Type Subtype PubMed ID
nsv833475 CNV Loss 17160897
nsv833476 CNV Loss 17160897
nsv2080 CNV Loss 18451855

Variation tolerance for LRRC59 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC59 Gene

HapMap Linkage Disequilibrium report
LRRC59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC59 Gene

Disorders for LRRC59 Gene

Relevant External Links for LRRC59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC59

No disorders were found for LRRC59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC59 Gene

Publications for LRRC59 Gene

  1. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. (PMID: 22321063) Zhen Y. … Wiedlocha A. (Traffic 2012) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3
  4. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for LRRC59 Gene

Sources for LRRC59 Gene

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