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Aliases for LRRC59 Gene

Aliases for LRRC59 Gene

  • Leucine Rich Repeat Containing 59 2 3 5
  • Ribosome-Binding Protein P34 3 4
  • P34 3 4
  • Leucine-Rich Repeat-Containing Protein 59 3
  • PRO1855 3

External Ids for LRRC59 Gene

Previous GeneCards Identifiers for LRRC59 Gene

  • GC17M045814
  • GC17M048458
  • GC17M043826

Summaries for LRRC59 Gene

GeneCards Summary for LRRC59 Gene

LRRC59 (Leucine Rich Repeat Containing 59) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for LRRC59 Gene

  • Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Additional gene information for LRRC59 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC59 Gene

Genomics for LRRC59 Gene

Regulatory Elements for LRRC59 Gene

Enhancers for LRRC59 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H050420 1.1 Ensembl ENCODE 12.5 -23.9 -23943 2 BCOR IRF2 BACH1 ZMYM3 CEBPG BATF ZNF644 RARA FOXK2 ATF7 LRRC59 ENSG00000253102 CHAD ACSF2 ANKRD40
GH17H050423 1.1 ENCODE 11.3 -29.4 -29440 6 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 MBTD1 ENSG00000262837 RSAD1 UTP18 XYLT2 CHAD FAM117A ENSG00000253102 LRRC59 LUC7L3
GH17H050430 0.6 ENCODE 11.3 -33.8 -33798 1 SIX4 PKNOX1 GFI1B ELF1 REST TEAD3 ACSF2 CHAD RSAD1 LRRC59 ENSG00000253102 CACNA1G-AS1 EPN3 MYCBPAP SPATA20 MRPS21P9
GH17H050171 2 FANTOM5 Ensembl ENCODE dbSUPER 3.2 +205.0 205032 41 DMAP1 YBX1 YY1 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN SGCA ENSG00000262837 FLJ45513 TMEM92-AS1 COL1A1 TMEM92 XYLT2 ZNF652 PPP1R9B LUC7L3
GH17H050026 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +369.7 369662 3 TBP RB1 SIN3A RAD21 RFX5 ZNF366 ELK1 ZNF143 RCOR1 FOS ITGA3 LRRC59 XYLT2 PICART1 ENSG00000248172
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC59 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095659 553 1601 MLX DMAP1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 RCOR2

Genomic Location for LRRC59 Gene

Chromosome:
17
Start:
50,375,059 bp from pter
End:
50,397,553 bp from pter
Size:
22,495 bases
Orientation:
Minus strand

Genomic View for LRRC59 Gene

Genes around LRRC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC59 Gene

Proteins for LRRC59 Gene

  • Protein details for LRRC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AG4-LRC59_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Protein Accession:
    Q96AG4
    Secondary Accessions:
    • B2RE83
    • D3DTX8
    • Q9P189

    Protein attributes for LRRC59 Gene

    Size:
    307 amino acids
    Molecular mass:
    34930 Da
    Quaternary structure:
    • Can form homodimers. Interacts with SGO1. Interacts with FGF1.
    SequenceCaution:
    • Sequence=AAF69611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LRRC59 Gene

Post-translational modifications for LRRC59 Gene

  • Ubiquitination at Lys40, Lys66, posLast=7373, posLast=111111, and posLast=116116
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC59 Gene

Domains & Families for LRRC59 Gene

Gene Families for LRRC59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC59 Gene

Suggested Antigen Peptide Sequences for LRRC59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC59: view

No data available for UniProtKB/Swiss-Prot for LRRC59 Gene

Function for LRRC59 Gene

Molecular function for LRRC59 Gene

UniProtKB/Swiss-Prot Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Phenotypes From GWAS Catalog for LRRC59 Gene

Gene Ontology (GO) - Molecular Function for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with LRRC59: view
genes like me logo Genes that share phenotypes with LRRC59: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC59

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC59
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC59 Gene

Localization for LRRC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC59 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC59 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IEA,IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with LRRC59: view

Pathways & Interactions for LRRC59 Gene

SuperPathways for LRRC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC59 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC59 Gene

Drugs & Compounds for LRRC59 Gene

No Compound Related Data Available

Transcripts for LRRC59 Gene

mRNA/cDNA for LRRC59 Gene

Unigene Clusters for LRRC59 Gene

Leucine rich repeat containing 59:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC59
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC59 Gene

No ASD Table

Relevant External Links for LRRC59 Gene

GeneLoc Exon Structure for
LRRC59
ECgene alternative splicing isoforms for
LRRC59

Expression for LRRC59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC59 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC59 Gene



Protein tissue co-expression partners for LRRC59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC59 Gene:

LRRC59

SOURCE GeneReport for Unigene cluster for LRRC59 Gene:

Hs.370927

mRNA Expression by UniProt/SwissProt for LRRC59 Gene:

Q96AG4-LRC59_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for LRRC59 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(3.4)
  • Lung(3)
  • Intestine(2.6)
  • Kidney(2.6)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with LRRC59: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC59 Gene

Orthologs for LRRC59 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC59 33 34
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia LRRC59 33 34
  • 92.81 (n)
dog
(Canis familiaris)
Mammalia LRRC59 33 34
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc59 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Lrrc59 33 16 34
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC59 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC59 33 34
  • 70.93 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC59 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc59 33
  • 61.2 (n)
Str.6358 33
zebrafish
(Danio rerio)
Actinopterygii lrrc59 33 34
  • 61.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3408 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56A8.3 33 34
  • 48.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for LRRC59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC59 Gene

ENSEMBL:
Gene Tree for LRRC59 (if available)
TreeFam:
Gene Tree for LRRC59 (if available)

Paralogs for LRRC59 Gene

Pseudogenes.org Pseudogenes for LRRC59 Gene

genes like me logo Genes that share paralogs with LRRC59: view

No data available for Paralogs for LRRC59 Gene

Variants for LRRC59 Gene

Sequence variations from dbSNP and Humsavar for LRRC59 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000052774 -- 50,399,329(+) CAGCA(A/G)CAAAC upstream-variant-2KB
rs1000181009 -- 50,381,075(+) TCTTA(-/T)TATTT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000191765 -- 50,392,318(+) CCAGG(G/T)GCCCT intron-variant
rs1000348358 -- 50,386,512(+) CTGAA(C/T)AGTAC intron-variant
rs1000395419 -- 50,386,105(+) AAAGT(A/G)AACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC59 Gene

Variant ID Type Subtype PubMed ID
nsv2080 CNV deletion 18451855
nsv833475 CNV loss 17160897
nsv833476 CNV loss 17160897
nsv960122 CNV duplication 23825009

Variation tolerance for LRRC59 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC59 Gene

Disorders for LRRC59 Gene

Relevant External Links for LRRC59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC59

No disorders were found for LRRC59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC59 Gene

Publications for LRRC59 Gene

  1. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1. (PMID: 22321063) Zhen Y … Wiedlocha A (Traffic (Copenhagen, Denmark) 2012) 3 4 60
  2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for LRRC59 Gene

Sources for LRRC59 Gene

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