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Aliases for LRRC59 Gene

Aliases for LRRC59 Gene

  • Leucine Rich Repeat Containing 59 2 3 5
  • Ribosome-Binding Protein P34 3 4
  • P34 3 4
  • Leucine-Rich Repeat-Containing Protein 59 3
  • PRO1855 3

External Ids for LRRC59 Gene

Previous GeneCards Identifiers for LRRC59 Gene

  • GC17M045814
  • GC17M048458
  • GC17M043826

Summaries for LRRC59 Gene

GeneCards Summary for LRRC59 Gene

LRRC59 (Leucine Rich Repeat Containing 59) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for LRRC59 Gene

  • Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC59 Gene

Genomics for LRRC59 Gene

Regulatory Elements for LRRC59 Gene

Enhancers for LRRC59 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F050420 1 Ensembl ENCODE 12.5 -23.9 -23948 2.2 INSM2 KLF17 RARA RCOR1 FOS ZNF362 CEBPB JUNB ZEB2 ZNF518A ENSG00000262837 FLJ45513 LRRC59 ENSG00000253102 COL1A1 FAM117A CHAD ACSF2 ANKRD40
GH17F050423 0.9 Ensembl ENCODE 11.3 -29.4 -29440 6.9 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 RSAD1 ENSG00000262837 CHAD ENSG00000253102 LRRC59 UTP18 CACNA1G-AS1 EPN3 MYCBPAP CACNA1G
GH17F050430 0.2 ENCODE 11.3 -33.8 -33798 1.7 ZNF664 SIX4 PKNOX1 PBX2 GFI1B ZBTB33 TEAD3 ACSF2 CHAD RSAD1 ENSG00000253102 LRRC59 CACNA1G-AS1 EPN3 MYCBPAP SPATA20 MRPS21P9
GH17F049401 0.7 ENCODE 4.4 +993.8 993842 3.5 ZNF362 ZNF341 NR3C1 ZIC2 SPI1 LRRC59 ENSG00000250186 RPL21P124
GH17F050171 1.3 FANTOM5 Ensembl ENCODE 3.2 +204.8 204790 42.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ENSG00000262837 SGCA FLJ45513 TMEM92-AS1 COL1A1 TMEM92 XYLT2 PPP1R9B ENSG00000253730 SAMD14
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC59 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001348773 553 2001 CREB3L1 MLX DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610

Genomic Location for LRRC59 Gene

Chromosome:
17
Start:
50,375,059 bp from pter
End:
50,397,553 bp from pter
Size:
22,495 bases
Orientation:
Minus strand

Genomic View for LRRC59 Gene

Genes around LRRC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC59 Gene

Proteins for LRRC59 Gene

  • Protein details for LRRC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AG4-LRC59_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Protein Accession:
    Q96AG4
    Secondary Accessions:
    • B2RE83
    • D3DTX8
    • Q9P189

    Protein attributes for LRRC59 Gene

    Size:
    307 amino acids
    Molecular mass:
    34930 Da
    Quaternary structure:
    • Can form homodimers. Interacts with SGO1. Interacts with FGF1.
    SequenceCaution:
    • Sequence=AAF69611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LRRC59 Gene

Post-translational modifications for LRRC59 Gene

  • Ubiquitination at Lys 40, Lys 66, Lys 73, Lys 111, and Lys 116
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC59 Gene

Domains & Families for LRRC59 Gene

Protein Domains for LRRC59 Gene

Suggested Antigen Peptide Sequences for LRRC59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96AG4

UniProtKB/Swiss-Prot:

LRC59_HUMAN :
  • Contains 5 LRR (leucine-rich) repeats.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC59: view

No data available for Gene Families for LRRC59 Gene

Function for LRRC59 Gene

Molecular function for LRRC59 Gene

UniProtKB/Swiss-Prot Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Gene Ontology (GO) - Molecular Function for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with LRRC59: view
genes like me logo Genes that share phenotypes with LRRC59: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC59

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC59 Gene

Localization for LRRC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC59 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC59 Gene COMPARTMENTS Subcellular localization image for LRRC59 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
cytosol 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005913 cell-cell adherens junction IDA 25468996
GO:0016020 membrane IEA,IDA 19946888
genes like me logo Genes that share ontologies with LRRC59: view

Pathways & Interactions for LRRC59 Gene

SuperPathways for LRRC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098609 cell-cell adhesion IEA --
genes like me logo Genes that share ontologies with LRRC59: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC59 Gene

Transcripts for LRRC59 Gene

mRNA/cDNA for LRRC59 Gene

Unigene Clusters for LRRC59 Gene

Leucine rich repeat containing 59:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC59 Gene

No ASD Table

Relevant External Links for LRRC59 Gene

GeneLoc Exon Structure for
LRRC59
ECgene alternative splicing isoforms for
LRRC59

Expression for LRRC59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC59 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC59 Gene



Protein tissue co-expression partners for LRRC59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC59 Gene:

LRRC59

SOURCE GeneReport for Unigene cluster for LRRC59 Gene:

Hs.370927

mRNA Expression by UniProt/SwissProt for LRRC59 Gene:

Q96AG4-LRC59_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with LRRC59: view

Primer Products

No data available for mRNA differential expression in normal tissues for LRRC59 Gene

Orthologs for LRRC59 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC59 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia LRRC59 34 35
  • 92.81 (n)
dog
(Canis familiaris)
Mammalia LRRC59 34 35
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc59 34
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Lrrc59 34 16 35
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC59 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC59 34 35
  • 70.93 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC59 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc59 34
  • 61.2 (n)
Str.6358 34
zebrafish
(Danio rerio)
Actinopterygii lrrc59 34 35
  • 61.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3408 35
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56A8.3 34 35
  • 48.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToOne
Species where no ortholog for LRRC59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC59 Gene

ENSEMBL:
Gene Tree for LRRC59 (if available)
TreeFam:
Gene Tree for LRRC59 (if available)

Paralogs for LRRC59 Gene

Pseudogenes.org Pseudogenes for LRRC59 Gene

genes like me logo Genes that share paralogs with LRRC59: view

No data available for Paralogs for LRRC59 Gene

Variants for LRRC59 Gene

Sequence variations from dbSNP and Humsavar for LRRC59 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1043277 -- 50,381,415(-) TACAC(A/C)CAATG nc-transcript-variant, utr-variant-3-prime
rs10491145 -- 50,385,595(-) TAATT(C/G)TAGAG intron-variant
rs10678291 -- 50,387,128(+) AAAAA(-/A)CTAGC intron-variant
rs111341006 -- 50,395,327(+) AGGCC(A/G)GCCTG intron-variant
rs111350209 -- 50,383,237(+) GATTC(C/T)GGAGG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC59 Gene

Variant ID Type Subtype PubMed ID
nsv2080 CNV deletion 18451855
nsv833475 CNV loss 17160897
nsv833476 CNV loss 17160897
nsv960122 CNV duplication 23825009

Variation tolerance for LRRC59 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC59 Gene

Disorders for LRRC59 Gene

Relevant External Links for LRRC59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC59

No disorders were found for LRRC59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC59 Gene

Publications for LRRC59 Gene

  1. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnalpha1 and Kpnbeta1. (PMID: 22321063) Zhen Y. … Wiedlocha A. (Traffic 2012) 3 4 64
  2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima T.S. … Watanabe Y. (Nature 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64

Products for LRRC59 Gene

Sources for LRRC59 Gene

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