LRRC59 Gene
protein-coding GIFtS: 44
GCID: GC17M048458
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|
leucine rich repeat containing 59
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Aliases
for LRRC59 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 591 2 | | Ribosome-Binding Protein P342 3 | | P341 | | FLJ216751 | | PRO18551 | | Leucine-Rich Repeat-Containing Protein 592 |
Export aliases for LRRC59 gene to outside databasesPrevious GC identifers: GC17M045814 GC17M043826 |
Summaries
for LRRC59 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LRC59_HUMAN, Q96AG4Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 byfacilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possiblythrough, the nuclear pores
|
Genomic Views
for LRRC59 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC59 gene promoter:
ER-alpha ATF-2 IRF-1 HNF-4alpha2 LCR-F1 Gfi-1 YY1 Evi-1 HNF-4alpha1 CRE-BP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC59
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC59 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.33 Ensembl cytogenetic band: 17q21.33 HGNC cytogenetic band: 17q21.33LRRC59 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M048458: view genomic region
(about GC identifiers)
Start:
|
48,452,420 bp from pter |
End:
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48,474,914 bp from pter |
Size:
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22,495 bases |
Orientation:
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minus strand |
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Proteins
for LRRC59 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC59_HUMAN, Q96AG4 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 59 Size: 307 amino acids; 34930 Da
Subunit: Can form homodimers. Interacts with SGOL1. Interacts with FGF1
Subcellular location: Microsome membrane; Single-pass type II membrane protein (By similarity). Endoplasmic reticulummembrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope dependsupon the nuclear import machinery, including KPNB1
Sequence caution: Sequence=AAF69611.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAG38180.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RE83 D3DTX8 Q9P189Explore the universe of human proteins at neXtProt for LRRC59: NX_Q96AG4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96AG4
LRRC59 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060979.2
ENSEMBL proteins: ENSP00000459616 ENSP00000225972 ENSP00000459305
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
LRRC59 for ontologies About GeneDecksing
LRRC59 Antibody Products:
Assay Products for LRRC59: |
Protein
Domains /
Families
for LRRC59 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC59 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96AG4ProtoNet protein and cluster: Q96AG4 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC59_HUMAN, Q96AG4Similarity: Contains 5 LRR (leucine-rich) repeats |
Function
for LRRC59 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LRC59_HUMAN, Q96AG4Function: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 byfacilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possiblythrough, the nuclear pores
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC59 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for LRRC59 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC59 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC59 |
2 GenomeRNAi human phenotypes for LRRC59:
|
Pathways & Interactions
for LRRC59 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC59
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/112 Interacting proteins for LRRC59 (Q96AG42, 3 ENSP000002259724) via UniProtKB, MINT, STRING, and/or I2D (see all 112)About this table
|
Drugs & Compounds
for LRRC59 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC59
Search CenterWatch for drugs/clinical trials and news about LRRC59 / LRC59
|
Transcripts
for LRRC59 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC59 gene: NM_018509.3 Unigene Cluster for LRRC59: Leucine rich repeat containing 59 Hs.370927 [show with all ESTs]Unigene Representative Sequence: NM_0185093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000503118 ENST00000225972(uc002iqt.3) ENST00000576448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC59 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC59 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRC59 (NM_018509) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC59 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC59 |
Additional cDNA sequence: AF119857.1 AK025328.1 AK130572.1 AK316593.1 BC017168.1 BC052279.1 21 DOTS entries: DT.452042 DT.86837118 DT.97857340 DT.99943210 DT.95217223 DT.100824073 DT.120945873 DT.91777536 DT.100824063 DT.95171848 DT.97862540 DT.100768842 DT.100824069 DT.102831855 DT.120945779 DT.95152965 DT.95171852 DT.95171860 DT.95328650 DT.97862543 DT.120945879 24/661 AceView cDNA sequences (see all 661): BI916153 BU686531 BX108233 BQ056852 BQ689649 AA344380 BM747829 BQ059697 BQ064226 BQ056955 CB117344 CR614409 BM791811 BM558590 BE396356 AI697165 BE251453 BI088431 CA421683 BE295456 BQ059965 BU146051 BU507399 BU730735
GeneLoc Exon Structure
|
Expression
for LRRC59 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC59 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRC59 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC59
SOURCE GeneReport for Unigene cluster: Hs.370927
UniProtKB/Swiss-Prot: LRC59_HUMAN, Q96AG4Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for LRRC59
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC59
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC59 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC59 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC59 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC59 |
Orthologs
for LRRC59 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRC59 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for LRRC59 (if available)
TreeFam Gene Tree for LRRC59 (if available) |
Paralogs
for LRRC59 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC59 gene
LRRC59 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for LRRC59
PGOHUM00000248942 PGOHUM00000235756 PGOHUM00000243655
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Genomic Variants
for LRRC59 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC59 (48452420 - 48474914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LRRC59: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC59 |
|
Disorders
/ Diseases
for LRRC59 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRRC59 for disorders About GeneDecksing
OMIM gene information: 614854
OMIM disorders: --
1  disease for LRRC59: About MalaCardsmetastasis efficiency
Export disorders for LRRC59 gene to outside databases
|
Publications
for LRRC59 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC59 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with LRRC59) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Nuclear import of exogenous FGF1 requires the ER-prote in LRRC59 and the importins Kpna1 and Kpnb1. (PubMed id 22321063)1, 2 Zhen Y....Wiedlocha A. (2012)
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PubMed id 16541025)1, 2 Kitajima T.S.... Watanabe Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for LRRC59 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC59 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC59 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC59 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC59 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LRRC59 gene:
Search GeneIP for patents involving LRRC59
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC59 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC59 | | OriGene Custom Protein Services for LRRC59 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC59 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC59 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC59 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC59 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC59 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC59 |
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| | | | Search Tocris compounds for LRRC59 |
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 | | | LRRC59 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC59 |
|  |  |  | | | | Search ThermoFisher Antibodies for LRRC59 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC59 |
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