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Aliases for LRRC59 Gene

Aliases for LRRC59 Gene

  • Leucine Rich Repeat Containing 59 2 3 5
  • Ribosome-Binding Protein P34 3 4
  • P34 3 4
  • Leucine-Rich Repeat-Containing Protein 59 3
  • PRO1855 3

External Ids for LRRC59 Gene

Previous GeneCards Identifiers for LRRC59 Gene

  • GC17M045814
  • GC17M048458
  • GC17M043826

Summaries for LRRC59 Gene

GeneCards Summary for LRRC59 Gene

LRRC59 (Leucine Rich Repeat Containing 59) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LRRC59 Gene

  • Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Additional gene information for LRRC59 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC59 Gene

Genomics for LRRC59 Gene

GeneHancer (GH) Regulatory Elements for LRRC59 Gene

Promoters and enhancers for LRRC59 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I050395 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.7 743 2.7 CLOCK MLX DMAP1 IRF4 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ENSG00000253102 LRRC59 ENSG00000262837 MBTD1 LOC105371824 LUC7L3 CACNA1G-AS1 UTP18 FLJ45513 FAM117A
GH17I050423 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.3 -29.4 -29440 6.9 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ACSF2 MBTD1 ENSG00000262837 RSAD1 UTP18 XYLT2 CHAD ENSG00000253102 FAM117A LRRC59
GH17I050420 Enhancer 0.9 Ensembl ENCODE 12.5 -23.9 -23942 2.1 BCOR IRF2 BACH1 ZMYM3 PAX8 CEBPG BATF ZNF644 RARA FOXK2 LRRC59 ENSG00000253102 CHAD ACSF2 ANKRD40
GH17I050171 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.2 +205.0 205031 42 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D COL1A1 SGCA ENSG00000262837 LUC7L3 TMEM92-AS1 TMEM92 XYLT2 ZNF652 PPP1R9B FLJ45513
GH17I050430 Enhancer 0.5 ENCODE 11.3 -33.8 -33797 1.7 SIX4 MEIS2 PKNOX1 GFI1B REST ELF1 TEAD3 ACSF2 CHAD RSAD1 ENSG00000253102 LRRC59 CACNA1G-AS1 EPN3 MYCBPAP SPATA20 MRPS21P9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC59 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC59 gene promoter:

Genomic Locations for LRRC59 Gene

Genomic Locations for LRRC59 Gene
chr17:50,375,059-50,397,553
(GRCh38/hg38)
Size:
22,495 bases
Orientation:
Minus strand
chr17:48,452,420-48,474,914
(GRCh37/hg19)

Genomic View for LRRC59 Gene

Genes around LRRC59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC59 Gene

Proteins for LRRC59 Gene

  • Protein details for LRRC59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AG4-LRC59_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 59
    Protein Accession:
    Q96AG4
    Secondary Accessions:
    • B2RE83
    • D3DTX8
    • Q9P189

    Protein attributes for LRRC59 Gene

    Size:
    307 amino acids
    Molecular mass:
    34930 Da
    Quaternary structure:
    • Can form homodimers. Interacts with SGO1. Interacts with FGF1.
    SequenceCaution:
    • Sequence=AAF69611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG38180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for LRRC59 Gene

Post-translational modifications for LRRC59 Gene

  • Ubiquitination at isoforms=40, posLast=6666, isoforms=73, posLast=111111, and posLast=116116

Other Protein References for LRRC59 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC59 Gene

Domains & Families for LRRC59 Gene

Gene Families for LRRC59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for LRRC59 Gene

Suggested Antigen Peptide Sequences for LRRC59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC59: view

No data available for UniProtKB/Swiss-Prot for LRRC59 Gene

Function for LRRC59 Gene

Molecular function for LRRC59 Gene

UniProtKB/Swiss-Prot Function:
Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores.

Phenotypes From GWAS Catalog for LRRC59 Gene

Gene Ontology (GO) - Molecular Function for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with LRRC59: view
genes like me logo Genes that share phenotypes with LRRC59: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC59 Gene

Localization for LRRC59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC59 Gene

Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Note=Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC59 gene
Compartment Confidence
mitochondrion 5
nucleus 5
endoplasmic reticulum 5
peroxisome 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IDA,IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane HDA,IEA 19946888
genes like me logo Genes that share ontologies with LRRC59: view

Pathways & Interactions for LRRC59 Gene

SuperPathways for LRRC59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC59 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC59 Gene

Drugs & Compounds for LRRC59 Gene

No Compound Related Data Available

Transcripts for LRRC59 Gene

mRNA/cDNA for LRRC59 Gene

Unigene Clusters for LRRC59 Gene

Leucine rich repeat containing 59:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC59 Gene

No ASD Table

Relevant External Links for LRRC59 Gene

GeneLoc Exon Structure for
LRRC59
ECgene alternative splicing isoforms for
LRRC59

Expression for LRRC59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC59 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC59 Gene



Protein tissue co-expression partners for LRRC59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC59 Gene:

LRRC59

SOURCE GeneReport for Unigene cluster for LRRC59 Gene:

Hs.370927

mRNA Expression by UniProt/SwissProt for LRRC59 Gene:

Q96AG4-LRC59_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for LRRC59 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Skin(3.4)
  • Lung(3)
  • Intestine(2.6)
  • Kidney(2.6)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with LRRC59: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC59 Gene

Orthologs for LRRC59 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC59 34 33
  • 99.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC59 33 34
  • 92.81 (n)
dog
(Canis familiaris)
Mammalia LRRC59 33 34
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc59 33
  • 89.79 (n)
mouse
(Mus musculus)
Mammalia Lrrc59 33 16 34
  • 89.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC59 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC59 33 34
  • 70.93 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC59 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc59 33
  • 61.2 (n)
Str.6358 33
zebrafish
(Danio rerio)
Actinopterygii lrrc59 33 34
  • 61.47 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3408 34
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F56A8.3 33 34
  • 48.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToOne
Species where no ortholog for LRRC59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC59 Gene

ENSEMBL:
Gene Tree for LRRC59 (if available)
TreeFam:
Gene Tree for LRRC59 (if available)

Paralogs for LRRC59 Gene

Pseudogenes.org Pseudogenes for LRRC59 Gene

genes like me logo Genes that share paralogs with LRRC59: view

No data available for Paralogs for LRRC59 Gene

Variants for LRRC59 Gene

Sequence variations from dbSNP and Humsavar for LRRC59 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000052774 -- 50,399,329(-) G/A upstream_transcript_variant
rs1000181009 -- 50,381,075(-) TT/T downstream_transcript_variant
rs1000191765 -- 50,392,318(-) T/G intron_variant
rs1000348358 -- 50,386,512(-) T/C intron_variant
rs1000395419 -- 50,386,105(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC59 Gene

Variant ID Type Subtype PubMed ID
nsv2080 CNV deletion 18451855
nsv833475 CNV loss 17160897
nsv833476 CNV loss 17160897
nsv960122 CNV duplication 23825009

Variation tolerance for LRRC59 Gene

Residual Variation Intolerance Score: 49.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.11; 22.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC59 Gene

Disorders for LRRC59 Gene

Additional Disease Information for LRRC59

No disorders were found for LRRC59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC59 Gene

Publications for LRRC59 Gene

  1. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpnα1 and Kpnβ1. (PMID: 22321063) Zhen Y … Wiedlocha A (Traffic (Copenhagen, Denmark) 2012) 3 4 58
  2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for LRRC59 Gene

Sources for LRRC59 Gene

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