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Aliases for LRRC58 Gene

Aliases for LRRC58 Gene

  • Leucine Rich Repeat Containing 58 2 3 5

External Ids for LRRC58 Gene

Previous GeneCards Identifiers for LRRC58 Gene

  • GC03M121532
  • GC03M120043
  • GC03M117419

Summaries for LRRC58 Gene

GeneCards Summary for LRRC58 Gene

LRRC58 (Leucine Rich Repeat Containing 58) is a Protein Coding gene. An important paralog of this gene is LRR1.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC58 Gene

Genomics for LRRC58 Gene

Regulatory Elements for LRRC58 Gene

Enhancers for LRRC58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G120416 1.5 Ensembl ENCODE dbSUPER 6.3 -70.0 -70015 6.7 PKNOX1 ATF1 FOXA2 ARID4B SIN3A ZNF48 GATA2 ZNF143 FOS DEK GPR156 FSTL1 LOC100130701 LRRC58 MIR198
GH03G119699 1.2 Ensembl ENCODE 5.2 +648.6 648602 2.0 ELF3 HDAC1 HDGF PKNOX1 ATF1 CBX3 ARNT BMI1 RAD21 CHAMP1 MAATS1 ENSG00000239994 LRRC58 PLA1A LOC105374064 PIR40954
GH03G120422 1.3 Ensembl ENCODE dbSUPER 4.7 -76.3 -76295 5.5 CTCF PKNOX1 TAF1 SIN3A CEBPG RAD21 TEAD3 GATA3 CTBP1 FOSL2 FSTL1 GPR156 LOC100130701 LRRC58 GSK3B ADPRH MIR198
GH03G119715 1.1 FANTOM5 ENCODE 4.5 +632.4 632388 2.5 FOXA2 RAD21 RARA YY1 MIXL1 THAP11 NR2F2 KLF16 CEBPA ZBTB33 MAATS1 ENSG00000239994 RPL10P7 PLA1A LRRC58 NR1I2
GH03G119702 0.8 ENCODE 4.5 +646.3 646343 1.1 HDGF MXI1 NFIB SIN3A MAX RBBP5 BMI1 RAD21 ZBTB7B YY1 MAATS1 LRRC58 LOC105374064
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC58 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000157186 61 2201 HNRNPUL1 MLX ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for LRRC58 Gene

Chromosome:
3
Start:
120,324,509 bp from pter
End:
120,349,361 bp from pter
Size:
24,853 bases
Orientation:
Minus strand

Genomic View for LRRC58 Gene

Genes around LRRC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC58 Gene

Proteins for LRRC58 Gene

  • Protein details for LRRC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CX6-LRC58_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 58
    Protein Accession:
    Q96CX6

    Protein attributes for LRRC58 Gene

    Size:
    371 amino acids
    Molecular mass:
    40586 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC58 Gene

Post-translational modifications for LRRC58 Gene

  • Ubiquitination at posLast=111111 and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC58 Gene

Domains & Families for LRRC58 Gene

Protein Domains for LRRC58 Gene

Suggested Antigen Peptide Sequences for LRRC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC58: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRC58 Gene

Function for LRRC58 Gene

Phenotypes for LRRC58 Gene

genes like me logo Genes that share phenotypes with LRRC58: view

Animal Model Products

CRISPR Products

miRNA for LRRC58 Gene

miRTarBase miRNAs that target LRRC58

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC58 Gene

Localization for LRRC58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC58 Gene

Pathways & Interactions for LRRC58 Gene

SuperPathways for LRRC58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC58 Gene

Drugs & Compounds for LRRC58 Gene

No Compound Related Data Available

Transcripts for LRRC58 Gene

mRNA/cDNA for LRRC58 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC58 Gene

Leucine rich repeat containing 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC58 Gene

No ASD Table

Relevant External Links for LRRC58 Gene

GeneLoc Exon Structure for
LRRC58
ECgene alternative splicing isoforms for
LRRC58

Expression for LRRC58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC58 Gene

Protein differential expression in normal tissues from HIPED for LRRC58 Gene

This gene is overexpressed in Adrenal (30.4), Gallbladder (10.3), and Pancreas (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC58 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC58 Gene:

LRRC58

SOURCE GeneReport for Unigene cluster for LRRC58 Gene:

Hs.518084
genes like me logo Genes that share expression patterns with LRRC58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC58 Gene

Orthologs for LRRC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC58 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia LRRC58 34 35
  • 92.98 (n)
cow
(Bos Taurus)
Mammalia LRRC58 34 35
  • 92 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc58 34
  • 89.53 (n)
mouse
(Mus musculus)
Mammalia Lrrc58 34 16 35
  • 89.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC58 35
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC58 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC58 34 35
  • 76.84 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC58 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc58 34
  • 66.09 (n)
Str.19464 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398462 34
zebrafish
(Danio rerio)
Actinopterygii lrrc58b 35
  • 61 (a)
OneToMany
LOC564300 34
  • 60.46 (n)
lrrc58a 35
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004458 34
  • 55.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32687 34 35
  • 52.91 (n)
worm
(Caenorhabditis elegans)
Secernentea Y42G9A.3 34 35
  • 47.96 (n)
Species where no ortholog for LRRC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC58 Gene

ENSEMBL:
Gene Tree for LRRC58 (if available)
TreeFam:
Gene Tree for LRRC58 (if available)

Paralogs for LRRC58 Gene

Paralogs for LRRC58 Gene

genes like me logo Genes that share paralogs with LRRC58: view

Variants for LRRC58 Gene

Sequence variations from dbSNP and Humsavar for LRRC58 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000054844 -- 120,345,514(+) TTTAA(C/T)GCATC intron-variant
rs1000068428 -- 120,330,017(+) TTCCA(C/T)AGTTA utr-variant-3-prime
rs1000097103 -- 120,325,642(+) AAAAG(A/T)ATGGG utr-variant-3-prime
rs1000121522 -- 120,345,786(+) CGCAA(A/G)TGAAA intron-variant
rs1000308175 -- 120,332,887(+) TGGGA(C/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC58 Gene

Variant ID Type Subtype PubMed ID
nsv236293 CNV deletion 16902084
nsv3968 CNV deletion 18451855
nsv829698 CNV gain 17160897

Variation tolerance for LRRC58 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC58 Gene

Disorders for LRRC58 Gene

Relevant External Links for LRRC58

Genetic Association Database (GAD)
LRRC58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC58

No disorders were found for LRRC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC58 Gene

Publications for LRRC58 Gene

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  3. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 64
  4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for LRRC58 Gene

Sources for LRRC58 Gene

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