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Aliases for LRRC58 Gene

Aliases for LRRC58 Gene

  • Leucine Rich Repeat Containing 58 2 3 5

External Ids for LRRC58 Gene

Previous GeneCards Identifiers for LRRC58 Gene

  • GC03M121532
  • GC03M120043
  • GC03M117419

Summaries for LRRC58 Gene

GeneCards Summary for LRRC58 Gene

LRRC58 (Leucine Rich Repeat Containing 58) is a Protein Coding gene. An important paralog of this gene is LRR1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC58 Gene

Genomics for LRRC58 Gene

Regulatory Elements for LRRC58 Gene

Enhancers for LRRC58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F120090 1.1 ENCODE 15.5 +255.4 255424 7.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 GSK3B LRRC58 POGLUT1 MIR198 GC03M119752
GH03F120416 1.3 Ensembl ENCODE 6.3 -70.0 -70015 6.7 PKNOX1 ARID4B ZNF48 GATA2 ZNF143 FOS DEK NFYC MXD4 MIER2 GPR156 FSTL1 MIR198 RPL10P7 LOC100130701 LRRC58 ENSG00000242613
GH03F119715 1.1 FANTOM5 ENCODE 4.5 +632.4 632388 2.5 SOX13 CTCF RAD21 RARA TEAD3 YY1 POLR2A HNF4G NFE2 MAFK MAATS1 ENSG00000239994 RPL10P7 PLA1A LRRC58 NR1I2
GH03F119699 0.9 ENCODE 5.2 +648.6 648602 2.0 HDGF ELF3 HDAC1 PKNOX1 ATF1 CBX3 ARNT BMI1 RAD21 CHAMP1 MAATS1 ENSG00000239994 LRRC58 PLA1A LOC105374064 PIR40954
GH03F120422 0.8 ENCODE 4.7 -76.3 -76295 5.5 CTCF PKNOX1 TAF1 SIN3A CEBPG RAD21 TEAD3 CTBP1 GATA3 FOS MIR198 FSTL1 GPR156 LOC100130701 LRRC58 GSK3B ADPRH ENSG00000242613
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC58 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001371836 61 3001 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for LRRC58 Gene

120,324,509 bp from pter
120,349,361 bp from pter
24,853 bases
Minus strand

Genomic View for LRRC58 Gene

Genes around LRRC58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC58 Gene

Proteins for LRRC58 Gene

  • Protein details for LRRC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 58
    Protein Accession:

    Protein attributes for LRRC58 Gene

    371 amino acids
    Molecular mass:
    40586 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC58 Gene

Post-translational modifications for LRRC58 Gene

  • Ubiquitination at Lys 111 and Lys 300
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC58 Gene

Domains & Families for LRRC58 Gene

Protein Domains for LRRC58 Gene

Suggested Antigen Peptide Sequences for LRRC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 LRR (leucine-rich) repeats.
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC58: view

No data available for Gene Families for LRRC58 Gene

Function for LRRC58 Gene

Phenotypes for LRRC58 Gene

genes like me logo Genes that share phenotypes with LRRC58: view

Animal Model Products

miRNA for LRRC58 Gene

miRTarBase miRNAs that target LRRC58

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC58 Gene

Localization for LRRC58 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC58 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC58 Gene

Pathways & Interactions for LRRC58 Gene

SuperPathways for LRRC58 Gene

No Data Available

Interacting Proteins for LRRC58 Gene

Gene Ontology (GO) - Biological Process for LRRC58 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC58 Gene

Transcripts for LRRC58 Gene

mRNA/cDNA for LRRC58 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(212) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC58 Gene

Leucine rich repeat containing 58:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC58 Gene

No ASD Table

Relevant External Links for LRRC58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC58 Gene

Protein differential expression in normal tissues from HIPED for LRRC58 Gene

This gene is overexpressed in Adrenal (30.4), Gallbladder (10.3), and Pancreas (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC58 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC58 Gene:


SOURCE GeneReport for Unigene cluster for LRRC58 Gene:

genes like me logo Genes that share expression patterns with LRRC58: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for LRRC58 Gene

Orthologs for LRRC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC58 34 35
  • 99.46 (n)
(Canis familiaris)
Mammalia LRRC58 34 35
  • 92.98 (n)
(Bos Taurus)
Mammalia LRRC58 34 35
  • 92 (n)
(Rattus norvegicus)
Mammalia Lrrc58 34
  • 89.53 (n)
(Mus musculus)
Mammalia Lrrc58 34 16 35
  • 89.07 (n)
(Ornithorhynchus anatinus)
Mammalia LRRC58 35
  • 84 (a)
(Monodelphis domestica)
Mammalia LRRC58 35
  • 82 (a)
(Gallus gallus)
Aves LRRC58 34 35
  • 76.84 (n)
(Anolis carolinensis)
Reptilia LRRC58 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc58 34
  • 66.09 (n)
Str.19464 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398462 34
(Danio rerio)
Actinopterygii lrrc58b 35
  • 61 (a)
LOC564300 34
  • 60.46 (n)
lrrc58a 35
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004458 34
  • 55.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32687 34 35
  • 52.91 (n)
(Caenorhabditis elegans)
Secernentea Y42G9A.3 34 35
  • 47.96 (n)
Species where no ortholog for LRRC58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC58 Gene

Gene Tree for LRRC58 (if available)
Gene Tree for LRRC58 (if available)

Paralogs for LRRC58 Gene

Paralogs for LRRC58 Gene

genes like me logo Genes that share paralogs with LRRC58: view

Variants for LRRC58 Gene

Sequence variations from dbSNP and Humsavar for LRRC58 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10048964 -- 120,349,308(+) GCCGG(C/G)AGCTC upstream-variant-2KB, utr-variant-5-prime
rs1009248 -- 120,345,102(-) CTGAA(A/G)CATCA intron-variant
rs10511400 -- 120,324,989(-) TTAAC(A/G)AAGGG utr-variant-3-prime
rs10552475 -- 120,334,345(+) TAAAA(-/AAA)TACAA intron-variant
rs10707185 -- 120,336,852(+) TATAT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC58 Gene

Variant ID Type Subtype PubMed ID
nsv829698 CNV gain 17160897
nsv3968 CNV deletion 18451855
nsv236293 CNV deletion 16902084

Variation tolerance for LRRC58 Gene

Residual Variation Intolerance Score: 56.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC58 Gene

Disorders for LRRC58 Gene

Relevant External Links for LRRC58

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC58 Gene

Publications for LRRC58 Gene

  1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64
  2. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  3. The genetic architecture of economic and political preferences. (PMID: 22566634) Benjamin D.J. … Visscher P.M. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3 64
  4. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PMID: 22174851) Lingappa J.R. … Goldstein D. (PLoS ONE 2011) 3 64
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64

Products for LRRC58 Gene

Sources for LRRC58 Gene

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