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Aliases for LRRC58 Gene

Aliases for LRRC58 Gene

  • Leucine Rich Repeat Containing 58 2 3

External Ids for LRRC58 Gene

Previous GeneCards Identifiers for LRRC58 Gene

  • GC03M121532
  • GC03M120043
  • GC03M117419

Summaries for LRRC58 Gene

GeneCards Summary for LRRC58 Gene

LRRC58 (Leucine Rich Repeat Containing 58) is a Protein Coding gene. An important paralog of this gene is LRR1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC58 Gene

Genomics for LRRC58 Gene

Regulatory Elements for LRRC58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRC58 Gene

Start:
120,324,509 bp from pter
End:
120,349,339 bp from pter
Size:
24,831 bases
Orientation:
Minus strand

Genomic View for LRRC58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC58 Gene

Proteins for LRRC58 Gene

  • Protein details for LRRC58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CX6-LRC58_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 58
    Protein Accession:
    Q96CX6
    Secondary Accessions:

    Protein attributes for LRRC58 Gene

    Size:
    371 amino acids
    Molecular mass:
    40586 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13757.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC58 Gene

Proteomics data for LRRC58 Gene at MOPED

Post-translational modifications for LRRC58 Gene

  • Ubiquitination at Lys111 and Lys300
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC58 Gene

Domains for LRRC58 Gene

Protein Domains for LRRC58 Gene

Suggested Antigen Peptide Sequences for LRRC58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96CX6

UniProtKB/Swiss-Prot:

LRC58_HUMAN :
  • Q96CX6
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC58: view

No data available for Gene Families for LRRC58 Gene

Function for LRRC58 Gene

Gene Ontology (GO) - Molecular Function for LRRC58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC58: view

Animal Model Products

CRISPR Products

miRNA for LRRC58 Gene

miRTarBase miRNAs that target LRRC58

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC58

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRRC58 Gene

Localization for LRRC58 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC58 Gene COMPARTMENTS Subcellular localization image for LRRC58 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC58 Gene

Pathways for LRRC58 Gene

SuperPathways for LRRC58 Gene

No Data Available

Interacting Proteins for LRRC58 Gene

Gene Ontology (GO) - Biological Process for LRRC58 Gene

None

No data available for Pathways by source for LRRC58 Gene

Transcripts for LRRC58 Gene

mRNA/cDNA for LRRC58 Gene

(212) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC58 Gene

Leucine rich repeat containing 58:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC58

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for LRRC58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC58 Gene

No ASD Table

Relevant External Links for LRRC58 Gene

GeneLoc Exon Structure for
LRRC58
ECgene alternative splicing isoforms for
LRRC58

Expression for LRRC58 Gene

mRNA expression in normal human tissues for LRRC58 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC58 Gene

SOURCE GeneReport for Unigene cluster for LRRC58 Gene Hs.518084

genes like me logo Genes that share expressions with LRRC58: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC58 Gene

Orthologs for LRRC58 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC58 35
  • 99.46 (n)
  • 99.73 (a)
LRRC58 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC58 35
  • 92 (n)
  • 96.5 (a)
LRRC58 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC58 35
  • 92.98 (n)
  • 94.66 (a)
LRRC58 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc58 35
  • 89.07 (n)
  • 94.54 (a)
Lrrc58 16
Lrrc58 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC58 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC58 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc58 35
  • 89.53 (n)
  • 94.81 (a)
chicken
(Gallus gallus)
Aves LRRC58 35
  • 76.84 (n)
  • 82.35 (a)
LRRC58 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC58 36
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398462 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc58 35
  • 66.09 (n)
  • 69.48 (a)
Str.19464 35
zebrafish
(Danio rerio)
Actinopterygii LOC564300 35
  • 60.46 (n)
  • 60.17 (a)
lrrc58a 36
  • 56 (a)
OneToMany
lrrc58b 36
  • 61 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004458 35
  • 55.72 (n)
  • 51.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG32687 35
  • 52.91 (n)
  • 48.57 (a)
CG32687 36
  • 42 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y42G9A.3 35
  • 47.96 (n)
  • 52.04 (a)
Y42G9A.3 36
  • 41 (a)
OneToOne
Species with no ortholog for LRRC58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC58 Gene

ENSEMBL:
Gene Tree for LRRC58 (if available)
TreeFam:
Gene Tree for LRRC58 (if available)

Paralogs for LRRC58 Gene

Paralogs for LRRC58 Gene

genes like me logo Genes that share paralogs with LRRC58: view

Variants for LRRC58 Gene

Sequence variations from dbSNP and Humsavar for LRRC58 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs701988 -- 120,336,422(+) TACCT(G/T)TTAAT intron-variant
rs787205 -- 120,334,198(+) AAAAC(A/G)TCATT intron-variant
rs787206 -- 120,328,533(-) TAAAA(A/G)ACAGA utr-variant-3-prime
rs923729 -- 120,336,444(+) CATCT(A/T)GAGGA intron-variant
rs939499 -- 120,341,555(+) cttaa(C/T)gttag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC58 Gene

Variant ID Type Subtype PubMed ID
nsv877376 CNV Gain 21882294
nsv829698 CNV Gain 17160897
nsv236293 CNV Loss 16902084
nsv3968 CNV Loss 18451855

Relevant External Links for LRRC58 Gene

HapMap Linkage Disequilibrium report
LRRC58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC58 Gene

Disorders for LRRC58 Gene

Relevant External Links for LRRC58

Genetic Association Database (GAD)
LRRC58
genes like me logo Genes that share disorders with LRRC58: view

No data available for UniProtKB/Swiss-Prot for LRRC58 Gene

Publications for LRRC58 Gene

  1. DNA cloning using in vitro site-specific recombination. (PMID: 11076863) Hartley J.L. … Brasch M.A. (Genome Res. 2000) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. From ORFeome to biology: a functional genomics pipeline. (PMID: 15489336) Wiemann S. … Poustka A. (Genome Res. 2004) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for LRRC58 Gene

Sources for LRRC58 Gene

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