LRRC58 Gene
protein-coding GIFtS: 37
GCID: GC03M120043
|
|
leucine rich repeat containing 58
| |
Aliases
for LRRC58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 581 2 | | Leucine-Rich Repeat-Containing Protein 582 |
Export aliases for LRRC58 gene to outside databasesPrevious GC identifers: GC03M121532 GC03M117419 |
Summaries
for LRRC58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LRRC58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC58 gene promoter:
TBP ER-alpha NF-1/L Pax-5 AML1a Pax-2 Pax-2a Nkx2-5 Zic3 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.33 Ensembl cytogenetic band: 3q13.33 HGNC cytogenetic band: 3q13.33LRRC58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M120043: view genomic region
(about GC identifiers)
Start:
|
120,043,356 bp from pter |
End:
|
120,068,186 bp from pter |
Size:
|
24,831 bases |
Orientation:
|
minus strand |
|
Proteins
for LRRC58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC58_HUMAN, Q96CX6 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 58 Size: 371 amino acids; 40586 Da
Sequence caution: Sequence=AAH13757.1; Type=Erroneous initiation;Explore the universe of human proteins at neXtProt for LRRC58: NX_Q96CX6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96CX6
LRRC58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001093148.1
ENSEMBL proteins: ENSP00000295628
Human Recombinant Protein Products:
LRRC58 Antibody Products:
Assay Products for LRRC58: |
Protein
Domains /
Families
for LRRC58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC58 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96CX6ProtoNet protein and cluster: Q96CX6 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC58_HUMAN, Q96CX6Similarity: Contains 9 LRR (leucine-rich) repeats |
Function
for LRRC58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LRRC58 (NM_001099678) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC58 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRRC58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC58 |
|
Pathways & Interactions
for LRRC58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC58
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for LRRC58 (ENSP000002956284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for LRRC58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC58
Search CenterWatch for drugs/clinical trials and news about LRRC58 / LRC58
|
Transcripts
for LRRC58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC58 gene: NM_001099678.1 Unigene Cluster for LRRC58: Leucine rich repeat containing 58 Hs.518084 [show with all ESTs]Unigene Representative Sequence: NM_0010996781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000295628(uc003edr.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRC58 (NM_001099678) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC58 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRRC58 |
Additional cDNA sequence: AK056809.1 BC013757.1 11 DOTS entries: DT.91984466 DT.438766 DT.120894551 DT.95261304 DT.95371962 DT.100753298 DT.100690159 DT.120894538 DT.120894547 DT.100690163 DT.102821020 24/212 AceView cDNA sequences (see all 212): BM449935 BF969954 CA397506 BM451508 BQ775777 BF447991 BX114423 BX340744 BM718837 AI821196 AI758141 BQ181170 BM834869 BM668524 AI478922 BU509515 CR613042 BM463695 BF725166 CR614969 CN485155 BF968499 AI023108 BQ674842
GeneLoc Exon Structure
|
Expression
for LRRC58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTCAACAAT
About this image
See LRRC58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC58
SOURCE GeneReport for Unigene cluster: Hs.518084
SABiosciences Custom PCR Arrays for LRRC58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC58 |
Orthologs
for LRRC58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRC58 gene from 6/23 species (see all 23) About this table
ENSEMBL Gene Tree for LRRC58 (if available)
TreeFam Gene Tree for LRRC58 (if available) |
Paralogs
for LRRC58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC58 gene
- LRR12
LRRC58 for paralogs About GeneDecksing
|
Genomic Variants
for LRRC58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC58 (120043356 - 120068186 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LRRC58
1 CNV: 6206 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC58 |
|
Disorders
/ Diseases
for LRRC58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LRRC58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC58 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with LRRC58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- The genetic architecture of economic and political pre ferences. (PubMed id 22566634)1 Benjamin D.J....Visscher P.M. (2012)
- Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)1 Lingappa J.R....Goldstein D. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
|
External Searches for LRRC58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC58 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LRRC58 gene:
Search GeneIP for patents involving LRRC58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC58 | | | OriGene Protein Over-expression Lysate for LRRC58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC58 | | OriGene 3'-UTR Clone for LRRC58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC58 | | OriGene Custom Protein Services for LRRC58 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC58 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC58 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LRRC58 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | LRRC58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC58 |
|  |  |  | | | | ThermoFisher Antibodies for LRRC58 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRRC58 |
|
|
|
|
