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Aliases for LRRC57 Gene

Aliases for LRRC57 Gene

  • Leucine Rich Repeat Containing 57 2 3 5

External Ids for LRRC57 Gene

Previous GeneCards Identifiers for LRRC57 Gene

  • GC15M040623
  • GC15M042836
  • GC15M019682

Summaries for LRRC57 Gene

GeneCards Summary for LRRC57 Gene

LRRC57 (Leucine Rich Repeat Containing 57) is a Protein Coding gene. An important paralog of this gene is PIDD1.

Gene Wiki entry for LRRC57 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC57 Gene

Genomics for LRRC57 Gene

Regulatory Elements for LRRC57 Gene

Enhancers for LRRC57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G042497 1.5 Ensembl ENCODE dbSUPER 40.6 +49.2 49197 4.3 HDGF PKNOX1 CREB3L1 ARNT FEZF1 TCF12 GTF3C2 FOS MEF2D SMARCA4 LRRC57 GANC HAUS2 TUBGCP4 LOC105370795 RPAP1 CDAN1 LCMT2 RPS3AP47 MAPKBP1
GH15G042490 1.4 ENCODE dbSUPER 31.1 +57.5 57536 2.4 PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 LRRC57 GANC HAUS2 RPS3AP47 TMEM87A SNAP23 ENSG00000261684
GH15G042502 1.3 Ensembl ENCODE dbSUPER 26.4 +44.5 44504 3.7 HDGF CTCF TBP CEBPG RAD21 ZNF121 ZFHX2 EGR1 CBX5 EED LRRC57 HAUS2 TMEM87A GANC RPAP1 ADAL SNAP23 ENSG00000261684
GH15G042493 1.7 FANTOM5 ENCODE dbSUPER 19.5 +53.5 53500 3.7 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YBX1 DMAP1 ZNF2 LRRC57 HAUS2 GANC TMEM87A ZSCAN29 SNAP23 ADAL TTBK2 ENSG00000261684
GH15G042507 1.2 FANTOM5 ENCODE dbSUPER 27.3 +40.4 40369 1.6 CTCF PKNOX1 ESRRA RAD21 ATF2 NR2F2 SMARCA4 MYNN ZSCAN29 ZBTB33 LRRC57 HAUS2 TMEM87A GANC SNAP23 ENSG00000261684
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC57 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075772 -96 2201 HDGF FOXA2 CREB3L1 AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for LRRC57 Gene

Chromosome:
15
Start:
42,528,444 bp from pter
End:
42,548,804 bp from pter
Size:
20,361 bases
Orientation:
Minus strand

Genomic View for LRRC57 Gene

Genes around LRRC57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC57 Gene

Proteins for LRRC57 Gene

  • Protein details for LRRC57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9N7-LRC57_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 57
    Protein Accession:
    Q8N9N7
    Secondary Accessions:
    • Q7Z2Z6
    • Q8N1T6

    Protein attributes for LRRC57 Gene

    Size:
    239 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC57 Gene

Post-translational modifications for LRRC57 Gene

  • Ubiquitination at Lys35 and posLast=140140
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC57 Gene

No data available for DME Specific Peptides for LRRC57 Gene

Domains & Families for LRRC57 Gene

Protein Domains for LRRC57 Gene

Suggested Antigen Peptide Sequences for LRRC57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC57: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRC57 Gene

Function for LRRC57 Gene

genes like me logo Genes that share phenotypes with LRRC57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC57 Gene

Localization for LRRC57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC57 Gene

Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC57 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LRRC57: view

Pathways & Interactions for LRRC57 Gene

SuperPathways for LRRC57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC57 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC57 Gene

Drugs & Compounds for LRRC57 Gene

No Compound Related Data Available

Transcripts for LRRC57 Gene

Unigene Clusters for LRRC57 Gene

Leucine rich repeat containing 57:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5:
SP6:

Relevant External Links for LRRC57 Gene

GeneLoc Exon Structure for
LRRC57
ECgene alternative splicing isoforms for
LRRC57

Expression for LRRC57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC57 Gene

Protein differential expression in normal tissues from HIPED for LRRC57 Gene

This gene is overexpressed in Brain (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC57 Gene



Protein tissue co-expression partners for LRRC57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC57 Gene:

LRRC57

SOURCE GeneReport for Unigene cluster for LRRC57 Gene:

Hs.234681

Evidence on tissue expression from TISSUES for LRRC57 Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LRRC57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC57 Gene

Orthologs for LRRC57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRC57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC57 34 35
  • 99.72 (n)
dog
(Canis familiaris)
Mammalia LRRC57 34 35
  • 91.77 (n)
cow
(Bos Taurus)
Mammalia LRRC57 34 35
  • 89.96 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc57 34
  • 89.26 (n)
mouse
(Mus musculus)
Mammalia Lrrc57 34 16 35
  • 88.98 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC57 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC57 35
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC57 34 35
  • 74.93 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC57 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc57 34
  • 69.47 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc57 34 35
  • 67.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3040 34 35
  • 55.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001491 34
  • 51.4 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK546.2 34 35
  • 48.01 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30105 34
  • 42.2 (n)
rice
(Oryza sativa)
Liliopsida Os10g0456200 34
  • 41.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 10 (a)
ManyToMany
Species where no ortholog for LRRC57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC57 Gene

ENSEMBL:
Gene Tree for LRRC57 (if available)
TreeFam:
Gene Tree for LRRC57 (if available)

Paralogs for LRRC57 Gene

(11) SIMAP similar genes for LRRC57 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LRRC57 Gene

genes like me logo Genes that share paralogs with LRRC57: view

Variants for LRRC57 Gene

Sequence variations from dbSNP and Humsavar for LRRC57 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000026125 -- 42,544,594(+) GCGGC(A/G)GGCAG intron-variant
rs1000033769 -- 42,547,765(+) GGCCC(A/C)AGGCA intron-variant, upstream-variant-2KB
rs1000085531 -- 42,548,183(+) CGATC(-/TTG)TTGTT upstream-variant-2KB, cds-indel
rs1000097704 -- 42,543,062(+) GACAG(A/G)GTTTC intron-variant, utr-variant-3-prime
rs1000221779 -- 42,531,630(+) TTCTT(C/T)TTTGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRRC57 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV gain 19592680

Variation tolerance for LRRC57 Gene

Residual Variation Intolerance Score: 47.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC57 Gene

Disorders for LRRC57 Gene

Relevant External Links for LRRC57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC57

No disorders were found for LRRC57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC57 Gene

Publications for LRRC57 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. (PMID: 25468996) Guo Z. … Zaidel-Bar R. (Sci Signal 2014) 3 64

Products for LRRC57 Gene

Sources for LRRC57 Gene

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