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Aliases for LRRC57 Gene

Aliases for LRRC57 Gene

  • Leucine Rich Repeat Containing 57 2 3

External Ids for LRRC57 Gene

Previous GeneCards Identifiers for LRRC57 Gene

  • GC15M040623
  • GC15M042836
  • GC15M019682

Summaries for LRRC57 Gene

GeneCards Summary for LRRC57 Gene

LRRC57 (Leucine Rich Repeat Containing 57) is a Protein Coding gene. An important paralog of this gene is LRRC30.

Gene Wiki entry for LRRC57 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC57 Gene

Genomics for LRRC57 Gene

Regulatory Elements for LRRC57 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRC57 Gene

42,537,820 bp from pter
42,548,804 bp from pter
10,985 bases
Minus strand

Genomic View for LRRC57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC57 Gene

Proteins for LRRC57 Gene

  • Protein details for LRRC57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 57
    Protein Accession:
    Secondary Accessions:
    • Q7Z2Z6
    • Q8N1T6

    Protein attributes for LRRC57 Gene

    239 amino acids
    Molecular mass:
    26754 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC57 Gene

Proteomics data for LRRC57 Gene at MOPED

Post-translational modifications for LRRC57 Gene

  • Ubiquitination at Lys35 and Lys140
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC57 Gene

Antibody Products

No data available for DME Specific Peptides for LRRC57 Gene

Domains for LRRC57 Gene

Protein Domains for LRRC57 Gene

Suggested Antigen Peptide Sequences for LRRC57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 8 LRR (leucine-rich) repeats.
  • Contains 8 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC57: view

No data available for Gene Families for LRRC57 Gene

Function for LRRC57 Gene

Gene Ontology (GO) - Molecular Function for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC57: view

Animal Model Products

miRNA for LRRC57 Gene

miRTarBase miRNAs that target LRRC57

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC57

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC57 Gene

Localization for LRRC57 Gene

Subcellular locations from

Jensen Localization Image for LRRC57 Gene COMPARTMENTS Subcellular localization image for LRRC57 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LRRC57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LRRC57: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC57 Gene

Pathways for LRRC57 Gene

SuperPathways for LRRC57 Gene

No Data Available

Interacting Proteins for LRRC57 Gene

Gene Ontology (GO) - Biological Process for LRRC57 Gene


No data available for Pathways by source for LRRC57 Gene

Transcripts for LRRC57 Gene

Unigene Clusters for LRRC57 Gene

Leucine rich repeat containing 57:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC57

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC57 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7
SP1: - - -
SP2: -
SP3: -
SP4: - -

Relevant External Links for LRRC57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC57 Gene

mRNA expression in normal human tissues for LRRC57 Gene

Protein differential expression in normal tissues for LRRC57 Gene

This gene is overexpressed in Brain (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC57 Gene

SOURCE GeneReport for Unigene cluster for LRRC57 Gene Hs.234681

genes like me logo Genes that share expressions with LRRC57: view

Expression partners for LRRC57 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC57 Gene

Orthologs for LRRC57 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRC57 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC57 35
  • 89.96 (n)
  • 94.14 (a)
LRRC57 36
  • 93 (a)
(Canis familiaris)
Mammalia LRRC57 35
  • 91.77 (n)
  • 94.98 (a)
LRRC57 36
  • 95 (a)
(Mus musculus)
Mammalia Lrrc57 35
  • 88.98 (n)
  • 95.4 (a)
Lrrc57 16
Lrrc57 36
  • 95 (a)
(Pan troglodytes)
Mammalia LRRC57 35
  • 99.72 (n)
  • 100 (a)
LRRC57 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrrc57 35
  • 89.26 (n)
  • 95.4 (a)
(Monodelphis domestica)
Mammalia LRRC57 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC57 36
  • 82 (a)
(Gallus gallus)
Aves LRRC57 35
  • 74.93 (n)
  • 85.71 (a)
LRRC57 36
  • 86 (a)
(Anolis carolinensis)
Reptilia LRRC57 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc57 35
  • 69.47 (n)
  • 76.47 (a)
(Danio rerio)
Actinopterygii lrrc57 35
  • 67.23 (n)
  • 70.17 (a)
lrrc57 36
  • 70 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001491 35
  • 51.4 (n)
  • 46.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3040 35
  • 55.27 (n)
  • 50.21 (a)
CG3040 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea ZK546.2 35
  • 48.01 (n)
  • 43.59 (a)
ZK546.2 36
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G30105 35
  • 42.2 (n)
  • 33.03 (a)
(Oryza sativa)
Liliopsida Os10g0456200 35
  • 41.32 (n)
  • 29.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
Species with no ortholog for LRRC57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC57 Gene

Gene Tree for LRRC57 (if available)
Gene Tree for LRRC57 (if available)

Paralogs for LRRC57 Gene

(11) SIMAP similar genes for LRRC57 Gene using alignment to 2 proteins: Pseudogenes for LRRC57 Gene

genes like me logo Genes that share paralogs with LRRC57: view

Variants for LRRC57 Gene

Sequence variations from dbSNP and Humsavar for LRRC57 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs115365491 -- 42,543,195(+) AAAAA(A/T)TTATT utr-variant-3-prime
rs113689799 -- 42,545,449(+) ACTAC(A/G)CCCCC intron-variant
rs113416544 -- 42,543,183(+) TACTT(A/T)AAAAA utr-variant-3-prime
rs113153798 -- 42,543,827(+) ATGGT(C/T)TTGAA utr-variant-3-prime
rs113081875 -- 42,545,233(+) GGACA(A/G)CAAGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LRRC57 Gene

Variant ID Type Subtype PubMed ID
nsv528725 CNV Gain 19592680

Relevant External Links for LRRC57 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC57 Gene

Disorders for LRRC57 Gene

No disorders were found for LRRC57 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LRRC57 Gene

Publications for LRRC57 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LRRC57 Gene

Sources for LRRC57 Gene

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