LRRC57 Gene
protein-coding GIFtS: 41
GCID: GC15M042836
|
|
leucine rich repeat containing 57
| |
Aliases
for LRRC57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 571 2 | | FLJ368121 | | Leucine-Rich Repeat-Containing Protein 572 |
Export aliases for LRRC57 gene to outside databasesPrevious GC identifers: GC15M040623 GC15M019682 |
Summaries
for LRRC57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for LRRC57
|
Genomic Views
for LRRC57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC57 gene promoter:
c-Fos AP-1 JunB FosB Fra-1 HNF-4alpha1 POU2F1 JunD POU2F1a c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q15.2 Ensembl cytogenetic band: 15q15.2 HGNC cytogenetic band: 15q15.1LRRC57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M042836: view genomic region
(about GC identifiers)
Start:
|
42,834,720 bp from pter |
End:
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42,841,002 bp from pter |
Size:
|
6,283 bases |
Orientation:
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minus strand |
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Proteins
for LRRC57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC57_HUMAN, Q8N9N7 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 57 Size: 239 amino acids; 26754 Da
Secondary accessions: Q7Z2Z6 Q8N1T6Explore the universe of human proteins at neXtProt for LRRC57: NX_Q8N9N7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9N7
LRRC57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694992.2
ENSEMBL proteins: ENSP00000380319 ENSP00000326817 ENSP00000455445 ENSP00000456900
Human Recombinant Protein Products:
LRRC57 Antibody Products:
Assay Products for LRRC57: |
Protein
Domains /
Families
for LRRC57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC57 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N9N7ProtoNet protein and cluster: Q8N9N7 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC57_HUMAN, Q8N9N7Similarity: Contains 8 LRR (leucine-rich) repeats |
Function
for LRRC57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LRRC57 (NM_153260) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC57 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC57 |
|
Pathways & Interactions
for LRRC57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC57
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for LRRC57 (ENSP000003268174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for LRRC57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC57
Search CenterWatch for drugs/clinical trials and news about LRRC57 / LRC57
|
Transcripts
for LRRC57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC57 gene: NM_153260.2 Unigene Cluster for LRRC57: Leucine rich repeat containing 57 Hs.234681 [show with all ESTs]Unigene Representative Sequence: AK0948916 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397130 ENST00000323443(uc001zqd.2 uc001zqc.3) ENST00000563454
ENST00000562868 ENST00000569830 ENST00000570160
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRC57 (NM_153260) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC57 |
Additional cDNA sequence: AF087994.1 AK094131.1 AK094891.1 AK309861.1 BC051262.1 BC058935.1 BX538324.1 CR749223.1 7 DOTS entries: DT.75145820 DT.100022225 DT.121079656 DT.100022226 DT.97837342 DT.92419486 DT.121079629 24/89 AceView cDNA sequences (see all 89): AI768867 AA926997 AW263802 CB216376 BQ683323 BF935877 AW969301 BQ109307 BQ689564 N51106 AW440091 AA788980 BE301068 AW518030 AI284140 BU607483 CA435043 AW467699 BU607463 BF843622 AI660372 BX093236 CK905821 BP340221
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC57 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LRRC57
|
Expression
for LRRC57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRC57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC57
SOURCE GeneReport for Unigene cluster: Hs.234681
SABiosciences Custom PCR Arrays for LRRC57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC57 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC57 |
Orthologs
for LRRC57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for LRRC57 gene from 8/23 species (see all 23) About this table
ENSEMBL Gene Tree for LRRC57 (if available)
TreeFam Gene Tree for LRRC57 (if available) |
Paralogs
for LRRC57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC57 gene
- LRRC202
11 SIMAP similar genes for LRRC57 using alignment to 2 protein entries: LRC57_HUMAN (see all proteins):LRIG3 PHLPP2 LRRC28 LRCH1 LRCH3 MFHAS1
LRRD1 FLII SCRIB LRRC8B LRCH4
LRRC57 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for LRRC57
PGOHUM00000240967
|
Genomic Variants
for LRRC57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC57 (42834720 - 42841002 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LRRC57: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC57 |
|
Disorders
/ Diseases
for LRRC57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for LRRC57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC57 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with LRRC57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
|
External Searches for LRRC57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC57 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LRRC57 gene:
Search GeneIP for patents involving LRRC57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC57 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC57 | | OriGene 3'-UTR Clone for LRRC57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC57 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC57 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC57 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC57 |
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| | | | Search Tocris compounds for LRRC57 |
| |  |  |  |  | | | | |
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 | | | LRRC57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC57 |
|  |  |  | | | | ThermoFisher Antibodies for LRRC57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC57 |
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