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Aliases for LRRC56 Gene

Aliases for LRRC56 Gene

  • Leucine Rich Repeat Containing 56 2 3 5

External Ids for LRRC56 Gene

Previous GeneCards Identifiers for LRRC56 Gene

  • GC11P000529
  • GC11P000537
  • GC11P000352

Summaries for LRRC56 Gene

GeneCards Summary for LRRC56 Gene

LRRC56 (Leucine Rich Repeat Containing 56) is a Protein Coding gene.

Additional gene information for LRRC56 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC56 Gene

Genomics for LRRC56 Gene

Regulatory Elements for LRRC56 Gene

Enhancers for LRRC56 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000518 1.6 Ensembl ENCODE dbSUPER 22.4 0.0 -13 1 ARNT ARID4B SIN3A FEZF1 DMAP1 SLC30A9 CBX5 ZNF207 ZNF143 FOS LRRC56 RNH1 PIDD1 TMEM80 ENSG00000255158 LOC105376507
GH11H000443 1.7 Ensembl ENCODE dbSUPER 19.2 -71.3 -71255 8 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 RNH1 LRRC56 TSPAN4 SNORA52 PHRF1 PTDSS2 ENSG00000255237 ANO9 HRAS BET1L
GH11H000501 1.3 ENCODE dbSUPER 22 -13.8 -13770 6 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 SP3 LRRC56 RNH1 PTDSS2 MOB2 GATD1 CD151 DRD4 TMEM80 GC11M000506 GC11M000505
GH11H000534 1.3 ENCODE dbSUPER 18.3 +17.3 17290 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A ZBTB7B ZNF143 ZNF207 FOS TMEM80 LRRC56 HRAS RNH1 PIDD1 DRD4 PHRF1 GATD1 ENSG00000255142 ENSG00000255158
GH11H000528 0.8 ENCODE dbSUPER 16 +10.0 9957 1 PKNOX1 MNT ZNF600 ZBTB33 ATF7 ATF2 LRRC56 HRAS LOC101059906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC56 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC56 Gene

Chromosome:
11
Start:
519,000 bp from pter
End:
554,916 bp from pter
Size:
35,917 bases
Orientation:
Plus strand

Genomic View for LRRC56 Gene

Genes around LRRC56 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC56 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC56 Gene

Proteins for LRRC56 Gene

  • Protein details for LRRC56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYG6-LRC56_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 56
    Protein Accession:
    Q8IYG6
    Secondary Accessions:
    • Q8N3Q4

    Protein attributes for LRRC56 Gene

    Size:
    542 amino acids
    Molecular mass:
    58733 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC56 Gene

Post-translational modifications for LRRC56 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC56 Gene

Domains & Families for LRRC56 Gene

Gene Families for LRRC56 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRRC56 Gene

Suggested Antigen Peptide Sequences for LRRC56 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC56: view

No data available for UniProtKB/Swiss-Prot for LRRC56 Gene

Function for LRRC56 Gene

Phenotypes From GWAS Catalog for LRRC56 Gene

Phenotypes for LRRC56 Gene

genes like me logo Genes that share phenotypes with LRRC56: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC56 Gene

Localization for LRRC56 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC56 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for LRRC56 Gene

Pathways & Interactions for LRRC56 Gene

SuperPathways for LRRC56 Gene

No Data Available

Interacting Proteins for LRRC56 Gene

Gene Ontology (GO) - Biological Process for LRRC56 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC56 Gene

Drugs & Compounds for LRRC56 Gene

No Compound Related Data Available

Transcripts for LRRC56 Gene

Unigene Clusters for LRRC56 Gene

Leucine rich repeat containing 56:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC56 Gene

No ASD Table

Relevant External Links for LRRC56 Gene

GeneLoc Exon Structure for
LRRC56
ECgene alternative splicing isoforms for
LRRC56

Expression for LRRC56 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC56 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC56 Gene

This gene is overexpressed in Testis (x8.2) and Pituitary (x5.5).

Protein differential expression in normal tissues from HIPED for LRRC56 Gene

This gene is overexpressed in Tlymphocyte (27.9), Plasma (21.4), Brain (11.4), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC56 Gene



Protein tissue co-expression partners for LRRC56 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC56 Gene:

LRRC56

SOURCE GeneReport for Unigene cluster for LRRC56 Gene:

Hs.567655
genes like me logo Genes that share expression patterns with LRRC56: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC56 Gene

Orthologs for LRRC56 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC56 34 33
  • 98.34 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc56 33 16 34
  • 79.07 (n)
cow
(Bos Taurus)
Mammalia LRRC56 34 33
  • 79.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC56 34 33
  • 78.3 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc56 33
  • 77.89 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC56 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC56 34
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC56 34
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LRRC56 (1 of 2) 34
  • 51 (a)
OneToMany
LRRC56 (2 of 2) 34
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14185 34
  • 24 (a)
OneToOne
Species where no ortholog for LRRC56 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC56 Gene

ENSEMBL:
Gene Tree for LRRC56 (if available)
TreeFam:
Gene Tree for LRRC56 (if available)

Paralogs for LRRC56 Gene

(1) SIMAP similar genes for LRRC56 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC56: view

No data available for Paralogs for LRRC56 Gene

Variants for LRRC56 Gene

Sequence variations from dbSNP and Humsavar for LRRC56 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs104894226 Pathogenic 534,285(-) CGGCG(A/G/T)TGTGG intron-variant, reference, missense, utr-variant-5-prime
rs104894227 Pathogenic 533,553(-) GAACA(A/G)GTGTG intron-variant, reference, missense
rs104894228 Pathogenic 534,286(-) CCGGC(A/C/G/T)GTGTG intron-variant, reference, missense, utr-variant-5-prime
rs104894229 Pathogenic 534,289(-) GCGCC(A/C/G/T)GCGGT intron-variant, reference, missense, utr-variant-5-prime
rs104894230 Pathogenic 534,288(-) CGCCG(A/C/G/T)CGGTG intron-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LRRC56 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV deletion 23128226
dgv564n106 OTHER inversion 24896259
esv2743844 CNV deletion 23290073
esv2759794 CNV loss 17122850
esv3625069 CNV loss 21293372
esv3625070 CNV loss 21293372
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1077764 OTHER inversion 25765185
nsv1159791 CNV deletion 26073780
nsv467634 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv469924 CNV gain 18288195
nsv527327 CNV loss 19592680
nsv552854 CNV loss 21841781
nsv552855 CNV loss 21841781
nsv552856 CNV gain 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for LRRC56 Gene

Residual Variation Intolerance Score: 94.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.19; 75.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC56 Gene

Human Gene Mutation Database (HGMD)
LRRC56
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC56

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC56 Gene

Disorders for LRRC56 Gene

Relevant External Links for LRRC56

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC56

No disorders were found for LRRC56 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC56 Gene

Publications for LRRC56 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for LRRC56 Gene

Sources for LRRC56 Gene

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