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Aliases for LRRC4B Gene

Aliases for LRRC4B Gene

  • Leucine Rich Repeat Containing 4B 2 3
  • Netrin-G3 Ligand 2 3 4
  • Leucine-Rich Repeats And Immunoglobulin-Like Domains 4 2 3
  • LRIG4 3 4
  • NGL-3 3 4
  • HSM 3

External Ids for LRRC4B Gene

Previous HGNC Symbols for LRRC4B Gene

  • LRIG4

Previous GeneCards Identifiers for LRRC4B Gene

  • GC19M055713
  • GC19M055714
  • GC19M051020
  • GC19M047356

Summaries for LRRC4B Gene

GeneCards Summary for LRRC4B Gene

LRRC4B (Leucine Rich Repeat Containing 4B) is a Protein Coding gene. Among its related pathways are Cell adhesion molecules (CAMs). GO annotations related to this gene include receptor binding. An important paralog of this gene is LINGO1.

UniProtKB/Swiss-Prot for LRRC4B Gene

  • Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC4B Gene

Genomics for LRRC4B Gene

Regulatory Elements for LRRC4B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRC4B Gene

Chromosome:
19
Start:
50,516,892 bp from pter
End:
50,568,219 bp from pter
Size:
51,328 bases
Orientation:
Minus strand

Genomic View for LRRC4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC4B Gene

Proteins for LRRC4B Gene

  • Protein details for LRRC4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NT99-LRC4B_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 4B
    Protein Accession:
    Q9NT99
    Secondary Accessions:
    • Q3ZCQ4
    • Q58F20

    Protein attributes for LRRC4B Gene

    Size:
    713 amino acids
    Molecular mass:
    76434 Da
    Quaternary structure:
    • Interacts with PTPRF. Interacts with DLG4.
    SequenceCaution:
    • Sequence=AAH19687.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC4B Gene

Proteomics data for LRRC4B Gene at MOPED

Post-translational modifications for LRRC4B Gene

  • N-glycosylated. O-glycosylated; contains sialic acid.
  • Glycosylation at Asn 224, Asn 283, Asn 333, Asn 374, Asn 400, Asn 422, Asn 425, Asn 444, and Asn 452
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC4B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for LRRC4B (NGL-3/LRRC4B)
  • Santa Cruz Biotechnology (SCBT) Antibodies for LRRC4B

No data available for DME Specific Peptides for LRRC4B Gene

Domains & Families for LRRC4B Gene

Gene Families for LRRC4B Gene

Suggested Antigen Peptide Sequences for LRRC4B Gene

Graphical View of Domain Structure for InterPro Entry

Q9NT99

UniProtKB/Swiss-Prot:

LRC4B_HUMAN :
  • The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.
  • Contains 9 LRR (leucine-rich) repeats.
Domain:
  • The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC4B: view

Function for LRRC4B Gene

Molecular function for LRRC4B Gene

UniProtKB/Swiss-Prot Function:
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

Gene Ontology (GO) - Molecular Function for LRRC4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC4B: view

Phenotypes for LRRC4B Gene

genes like me logo Genes that share phenotypes with LRRC4B: view

Animal Model Products

miRNA for LRRC4B Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC4B Gene

Localization for LRRC4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC4B Gene

Membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC4B Gene COMPARTMENTS Subcellular localization image for LRRC4B gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LRRC4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0042734 presynaptic membrane IEA --
GO:0044300 cerebellar mossy fiber IEA --
genes like me logo Genes that share ontologies with LRRC4B: view

Pathways & Interactions for LRRC4B Gene

SuperPathways for LRRC4B Gene

genes like me logo Genes that share pathways with LRRC4B: view

Pathways by source for LRRC4B Gene

1 KEGG pathway for LRRC4B Gene

Interacting Proteins for LRRC4B Gene

Gene Ontology (GO) - Biological Process for LRRC4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051965 positive regulation of synapse assembly ISS --
genes like me logo Genes that share ontologies with LRRC4B: view

No data available for SIGNOR curated interactions for LRRC4B Gene

Drugs & Compounds for LRRC4B Gene

No Compound Related Data Available

Transcripts for LRRC4B Gene

Unigene Clusters for LRRC4B Gene

Leucine rich repeat containing 4B:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC4B Gene

No ASD Table

Relevant External Links for LRRC4B Gene

GeneLoc Exon Structure for
LRRC4B
ECgene alternative splicing isoforms for
LRRC4B

Expression for LRRC4B Gene

mRNA expression in normal human tissues for LRRC4B Gene

mRNA differential expression in normal tissues according to GTEx for LRRC4B Gene

This gene is overexpressed in Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for LRRC4B Gene

This gene is overexpressed in Cerebrospinal fluid (24.4), Fetal Brain (23.1), Frontal cortex (9.8), and Vitreous humor (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC4B Gene



SOURCE GeneReport for Unigene cluster for LRRC4B Gene Hs.120873

genes like me logo Genes that share expression patterns with LRRC4B: view

Protein tissue co-expression partners for LRRC4B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRC4B Gene

Orthologs for LRRC4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC4B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC4B 35
  • 93.25 (n)
  • 97.75 (a)
LRRC4B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC4B 35
  • 92.33 (n)
  • 97.19 (a)
LRRC4B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc4b 35
  • 88.15 (n)
  • 95.75 (a)
Lrrc4b 16
Lrrc4b 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC4B 35
  • 99.86 (n)
  • 100 (a)
LRRC4B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc4b 35
  • 87.58 (n)
  • 95.47 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC4B 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC4B 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc4b 35
  • 73.4 (n)
  • 85.58 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc4ba 36
  • 66 (a)
OneToMany
lrrc4bb 36
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for LRRC4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC4B Gene

ENSEMBL:
Gene Tree for LRRC4B (if available)
TreeFam:
Gene Tree for LRRC4B (if available)

Paralogs for LRRC4B Gene

(8) SIMAP similar genes for LRRC4B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with LRRC4B: view

Variants for LRRC4B Gene

Sequence variations from dbSNP and Humsavar for LRRC4B Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs748917 -- 50,566,775(+) TGAGA(C/T)TGGGG intron-variant
rs1379283 -- 50,553,347(+) cagag(A/G)tgagg intron-variant, upstream-variant-2KB
rs1544764 -- 50,547,717(+) TGCCC(A/G)CCAAA intron-variant
rs1544765 -- 50,549,300(+) GGGAA(A/G)AGCAA intron-variant
rs1862476 -- 50,554,069(+) GCTCA(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC4B Gene

Variant ID Type Subtype PubMed ID
nsv912282 CNV Loss 21882294
nsv509750 CNV Insertion 20534489
nsv912284 CNV Loss 21882294
esv994565 CNV Deletion 20482838
nsv2530 CNV Loss 18451855

Variation tolerance for LRRC4B Gene

Residual Variation Intolerance Score: 6.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.46; 71.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC4B Gene

HapMap Linkage Disequilibrium report
LRRC4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC4B Gene

Disorders for LRRC4B Gene

Relevant External Links for LRRC4B

Genetic Association Database (GAD)
LRRC4B
Human Genome Epidemiology (HuGE) Navigator
LRRC4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC4B
genes like me logo Genes that share disorders with LRRC4B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC4B Gene

Publications for LRRC4B Gene

  1. Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution. (PMID: 11441184) Dehal P. … Stubbs L. (Science 2001) 2 67
  2. MxA interacts with and is modified by the SUMOylation machinery. (PMID: 25447205) Brantis-de-Carvalho C.E. … Valentini S.R. (Exp. Cell Res. 2015) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for LRRC4B Gene

Sources for LRRC4B Gene

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