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Aliases for LRRC41 Gene

Aliases for LRRC41 Gene

  • Leucine Rich Repeat Containing 41 2 3 5
  • Protein Muf1 3 4
  • MUF1 3 4
  • Elongin BC-Interacting Leucine-Rich Repeat Protein 3
  • MUF1 Protein (MUF1) 3
  • PP7759 3

External Ids for LRRC41 Gene

Previous GeneCards Identifiers for LRRC41 Gene

  • GC01M046457
  • GC01M046726
  • GC01M044859

Summaries for LRRC41 Gene

GeneCards Summary for LRRC41 Gene

LRRC41 (Leucine Rich Repeat Containing 41) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include protein homodimerization activity.

UniProtKB/Swiss-Prot for LRRC41 Gene

  • Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Wiki entry for LRRC41 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC41 Gene

Genomics for LRRC41 Gene

Regulatory Elements for LRRC41 Gene

Enhancers for LRRC41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC41 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC41 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC41 Gene

Chromosome:
1
Start:
46,261,196 bp from pter
End:
46,303,608 bp from pter
Size:
42,413 bases
Orientation:
Minus strand

Genomic View for LRRC41 Gene

Genes around LRRC41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC41 Gene

Proteins for LRRC41 Gene

  • Protein details for LRRC41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15345-LRC41_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 41
    Protein Accession:
    Q15345
    Secondary Accessions:
    • A8K5G8
    • Q3MJ96
    • Q5TDF5
    • Q71RA8
    • Q9BSM0

    Protein attributes for LRRC41 Gene

    Size:
    812 amino acids
    Molecular mass:
    88650 Da
    Quaternary structure:
    • Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
    SequenceCaution:
    • Sequence=AAQ15266.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAQ15266.1; Type=Frameshift; Positions=56, 132; Evidence={ECO:0000305}; Sequence=CAA60013.1; Type=Frameshift; Positions=799; Evidence={ECO:0000305}; Sequence=CAD97609.1; Type=Frameshift; Positions=132, 186; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC41 Gene

Proteomics data for LRRC41 Gene at MOPED

Post-translational modifications for LRRC41 Gene

  • Ubiquitination at Lys 199 and Lys 375
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC41 Gene

No data available for DME Specific Peptides for LRRC41 Gene

Domains & Families for LRRC41 Gene

Protein Domains for LRRC41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15345

UniProtKB/Swiss-Prot:

LRC41_HUMAN :
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
  • Contains 7 LRR (leucine-rich) repeats.
Domain:
  • The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].
Similarity:
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC41: view

No data available for Gene Families for LRRC41 Gene

Function for LRRC41 Gene

Molecular function for LRRC41 Gene

UniProtKB/Swiss-Prot Function:
Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Phenotypes for LRRC41 Gene

genes like me logo Genes that share phenotypes with LRRC41: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC41 Gene

Localization for LRRC41 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC41 Gene COMPARTMENTS Subcellular localization image for LRRC41 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LRRC41: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC41 Gene

Pathways & Interactions for LRRC41 Gene

genes like me logo Genes that share pathways with LRRC41: view

UniProtKB/Swiss-Prot Q15345-LRC41_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for LRRC41 Gene

None

No data available for SIGNOR curated interactions for LRRC41 Gene

Drugs & Compounds for LRRC41 Gene

No Compound Related Data Available

Transcripts for LRRC41 Gene

Unigene Clusters for LRRC41 Gene

Leucine rich repeat containing 41:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC41 Gene

No ASD Table

Relevant External Links for LRRC41 Gene

GeneLoc Exon Structure for
LRRC41
ECgene alternative splicing isoforms for
LRRC41

Expression for LRRC41 Gene

mRNA expression in normal human tissues for LRRC41 Gene

Protein differential expression in normal tissues from HIPED for LRRC41 Gene

This gene is overexpressed in Breast (27.0), Bone (13.7), and Monocytes (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC41 Gene



SOURCE GeneReport for Unigene cluster for LRRC41 Gene Hs.144941

genes like me logo Genes that share expression patterns with LRRC41: view

Protein tissue co-expression partners for LRRC41 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC41 Gene

Orthologs for LRRC41 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC41 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC41 35
  • 94.82 (n)
  • 99.54 (a)
-- 36
  • 55 (a)
OneToMany
-- 36
  • 96 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LRRC41 35
  • 94.5 (n)
  • 97.66 (a)
LRRC41 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc41 35
  • 90.23 (n)
  • 95.16 (a)
Lrrc41 16
Lrrc41 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC41 35
  • 99.92 (n)
  • 100 (a)
LRRC41 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc41 35
  • 90.26 (n)
  • 95.79 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC41 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC41 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC41 35
  • 59.31 (n)
  • 54.56 (a)
LRRC41 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC41 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc41 35
  • 52.81 (n)
  • 47.66 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch1073-342h5.2 35
  • 42.8 (n)
  • 33.07 (a)
LRRC41 36
  • 28 (a)
OneToOne
Species with no ortholog for LRRC41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC41 Gene

ENSEMBL:
Gene Tree for LRRC41 (if available)
TreeFam:
Gene Tree for LRRC41 (if available)

Paralogs for LRRC41 Gene

No data available for Paralogs for LRRC41 Gene

Variants for LRRC41 Gene

Sequence variations from dbSNP and Humsavar for LRRC41 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs11542623 - 46,280,492(+) CAGAA(C/G/T)GGAGC reference, missense
rs1150065 -- 46,285,027(-) AGTTT(A/G)ACCTC intron-variant
rs1258476 -- 46,283,713(-) aaaaa(A/G)aaaaG intron-variant
rs3753362 -- 46,301,079(-) TTCCC(G/T)TGTGG intron-variant
rs4660919 -- 46,288,814(+) TAAGA(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC41 Gene

Variant ID Type Subtype PubMed ID
nsv470711 CNV Gain 18288195
nsv829748 CNV Loss 17160897

Variation tolerance for LRRC41 Gene

Residual Variation Intolerance Score: 8.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.05; 84.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC41 Gene

Human Gene Mutation Database (HGMD)
LRRC41

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC41 Gene

Disorders for LRRC41 Gene

Relevant External Links for LRRC41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC41

No disorders were found for LRRC41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC41 Gene

Publications for LRRC41 Gene

  1. Muf1, a novel elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. (PMID: 11384984) Kamura T. … Conaway J.W. (J. Biol. Chem. 2001) 2 3 4 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for LRRC41 Gene

Sources for LRRC41 Gene

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