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LRRC40 Gene

protein-coding   GIFtS: 50
GCID: GC01M070610

Leucine Rich Repeat Containing 40

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 401 2
dJ677H15.12
Leucine-Rich Repeat-Containing Protein 402

External Ids:    HGNC: 260041   Entrez Gene: 556312   Ensembl: ENSG000000665577   UniProtKB: Q9H9A63   

Export aliases for LRRC40 gene to outside databases

Previous GC identifers: GC01M070323 GC01M068721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC40 Gene:
LRRC40 (leucine rich repeat containing 40) is a protein-coding gene. Diseases associated with LRRC40 include malaria. An important paralog of this gene is LRRC8E.

Gene Wiki entry for LRRC40 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC40 gene promoter:
         E2F-4   E2F-5   GATA-3   POU6F1 (c2)   HNF-3beta   GATA-1   GATA-2   FOXL1   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC40 promoter sequence
   Search Chromatin IP Primers for LRRC40

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

LRRC40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC40 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M070610:  view genomic region     (about GC identifiers)

Start:
70,610,485 bp from pter      End:
70,671,361 bp from pter
Size:
60,877 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRC40_HUMAN, Q9H9A6 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 40  
Size: 602 amino acids; 68250 Da
Sequence caution: Sequence=BAA91094.1; Type=Erroneous initiation;
Secondary accessions: Q9BTR7 Q9NSK1 Q9NXC1

Explore the universe of human proteins at neXtProt for LRRC40: NX_Q9H9A6

Explore proteomics data for LRRC40 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys86, Lys93
  • Modification sites at PhosphoSitePlus

  • See LRRC40 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060238.3  
    ENSEMBL proteins: 
     ENSP00000359990  

    LRRC40 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for LRRC40


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR025875 Leu-rich_rpt_4
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q9H9A6

    ProtoNet protein and cluster: Q9H9A6

    UniProtKB/Swiss-Prot: LRC40_HUMAN, Q9H9A6
    Similarity: Contains 20 LRR (leucine-rich) repeats


    LRRC40 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRRC40 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC40:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC40
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC40

    miRNA
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    miRTarBase miRNAs that target LRRC40:
    hsa-let-7b-5p (MIRT032216), hsa-mir-26b-5p (MIRT028855), hsa-mir-128-3p (MIRT021873), hsa-mir-155-5p (MIRT020510), hsa-mir-425-5p (MIRT016662), hsa-mir-193b-3p (MIRT016325), hsa-mir-34a-5p (MIRT025256)

    Block miRNA regulation of human, mouse, rat LRRC40 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC40 (see all 15):
    hsa-miR-30c hsa-miR-34c-5p hsa-miR-1283 hsa-miR-449b hsa-miR-30d hsa-miR-551b* hsa-miR-449a hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidLRRC40 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRRC40

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC40

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC40


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC40
    Interactions:

        Search GeneGlobe Interaction Network for LRRC40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for LRRC40 (Q9H9A62, 3 ENSP000003599904) via UniProtKB, MINT, STRING, and/or I2D (see all 787)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    CDC73Q6P1J92, ENSP000003564054MINT-7945693 MINT-7947479 STRING: ENSP00000356405
    SF3B1O755332, ENSP000003353214MINT-7945693 MINT-7947479 STRING: ENSP00000335321
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC40 (LRC40)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRRC40 gene: 
    NM_017768.4  

    Unigene Cluster for LRRC40:

    Leucine rich repeat containing 40
    Hs.147836  [show with all ESTs]
    Unigene Representative Sequence: AL390149
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370952(uc001der.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat LRRC40 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC40 (see all 15):
    hsa-miR-30c hsa-miR-34c-5p hsa-miR-1283 hsa-miR-449b hsa-miR-30d hsa-miR-551b* hsa-miR-449a hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidLRRC40 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRRC40
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC40
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    OriGene clones in human, mouse for LRRC40 (see all 7)
    OriGene ORF clones in mouse, rat for LRRC40
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC40 (NM_017768)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC40
    Primer
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    OriGene qPCR primer pairs and template standards for LRRC40
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC40
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC40
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC40
      QuantiFast Probe-based Assays in human, mouse, rat LRRC40

    Additional mRNA sequence: 

    AK000338.1 AK022951.1 AK225337.1 AL162076.1 AL390149.2 BC003407.1 BC008586.1 

    10 DOTS entries:

    DT.95275304  DT.413768  DT.102826567  DT.102826568  DT.121411751  DT.92432898  DT.121411656  DT.434851 
    DT.91826408  DT.97819601 

    Selected AceView cDNA sequences (see all 131):

    AL162076 BU163359 BC008586 AL390149 D61645 AI354270 AW771727 BM722718 
    AU280533 AA564978 BC003407 AI015897 AA232403 BM984696 AA081097 AA310521 
    AA299216 AW673312 BQ277533 AL602762 AI656613 BP429183 CA495358 BG257922 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC40    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                -                                                                                       
    SP2:              -     -                                                                                                   
    SP3:              -     -           -                                                                                       
    SP4:                    -           -                                                                                       


    ECgene alternative splicing isoforms for LRRC40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGAATAA
    LRRC40 Expression
    About this image

    LRRC40 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC40 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.147836
        Custom PCR Arrays for LRRC40
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LRRC40 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc401 , 5 leucine rich repeat containing 401, 5 82.34(n)1
    83.06(a)1
      3 (81.65 cM)5
    671441  NM_024194.51  NP_077156.21 
     1580366625 
    chicken
    (Gallus gallus)
    Aves LRRC401 leucine rich repeat containing 40 69.71(n)
    70.27(a)
      424713  NM_001031295.1  NP_001026466.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC406
    leucine rich repeat containing 40
    60(a)
    1 ↔ 1
    GL343328.1(1131752-1158370)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrrc401 leucine rich repeat containing 40 63.95(n)
    63.06(a)
      496765  NM_001011310.1  NP_001011310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY394934.12   -- 72.79(n)   334130  AY394934.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta f-cup1 flyers-cup 45.77(n)
    39.23(a)
      41677  NM_142049.3  NP_650306.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G154101 AT3G15410 44.18(n)
    38.6(a)
      820780  NM_112409.3  NP_188160.2 
    rice
    (Oryza sativa)
    Liliopsida Os02g08266001 Os02g0826600 44.97(n)
    37.82(a)
      4331218  NM_001055123.1  NP_001048588.1 


    ENSEMBL Gene Tree for LRRC40 (if available)
    TreeFam Gene Tree for LRRC40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC40 gene
    LRRC8E2  LRRC72  ERBB2IP2  RSU12  LRRC8A2  MFHAS12  LRRC12  LRRIQ42  
    SCRIB2  SHOC22  LRRD12  LRRC8D2  LRRC8B2  LRRC8C2  
    2 SIMAP similar genes for LRRC40 using alignment to 1 protein entry:     LRC40_HUMAN:
    LRIG3    RSU1

    LRRC40 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LRRC40
    PGOHUM00000238811


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC40 (see all 969)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1472706181,2
    C--70610147(+) GAGAT-/GGAGGAGT 1 -- int10--------
    rs1919420551,2
    --70610191(+) GGCGCC/GATCTC 1 -- int10--------
    rs6109531,2
    C,F,A,H--70610215(-) GGAGGC/TAGAGG 1 -- int110Minor allele frequency- T:0.12NS EA WA NA CSA 741
    rs1842718811,2
    --70610230(+) TTCAAA/GTGATT 1 -- int10--------
    rs1894239201,2
    --70610234(+) AGTGAG/TTCTCC 1 -- int10--------
    rs1113886531,2
    C--70610404(+) CCTCCT/CGAAGT 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs1165591801,2
    C--70610464(+) TTTTTA/TAAATG 1 -- int10--------
    rs1482366081,2
    C--70610497(+) ATTTG-/AAAAAA 1 -- ut310--------
    rs1123961461,2
    C--70610738(+) TTACCTA/-TATCA 1 -- ut311Minor allele frequency- -:0.00CSA 2
    rs762720361,2
    C--70610842(+) TGAAAC/TGTGTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LRRC40 (70610485 - 70671361 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for LRRC40:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665402CNV Deletion23128226
    nsv1343CNV Insertion18451855
    nsv870841CNV Loss21882294
    nsv871339CNV Loss21882294
    nsv823143CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC40
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC40

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for LRRC40:    
    About MalaCards
    malaria


    LRRC40 for disorders           About GeneDecksing


    Export disorders for LRRC40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC40 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with LRRC40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55631 HGNC: 26004 AceView: FLJ20331 Ensembl:ENSG00000066557 euGenes: HUgn55631
    ECgene: LRRC40 H-InvDB: LRRC40

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC40 gene:
    Search GeneIP for patents involving LRRC40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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