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Aliases for LRRC40 Gene

Aliases for LRRC40 Gene

  • Leucine Rich Repeat Containing 40 2 3
  • Leucine-Rich Repeat-Containing Protein 40 3
  • DJ677H15.1 3

External Ids for LRRC40 Gene

Previous GeneCards Identifiers for LRRC40 Gene

  • GC01M070323
  • GC01M070610
  • GC01M068721

Summaries for LRRC40 Gene

GeneCards Summary for LRRC40 Gene

LRRC40 (Leucine Rich Repeat Containing 40) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

Gene Wiki entry for LRRC40 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC40 Gene

Genomics for LRRC40 Gene

Regulatory Elements for LRRC40 Gene

Genomic Location for LRRC40 Gene

70,144,802 bp from pter
70,205,678 bp from pter
60,877 bases
Minus strand

Genomic View for LRRC40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC40 Gene

Proteins for LRRC40 Gene

  • Protein details for LRRC40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 40
    Protein Accession:
    Secondary Accessions:
    • Q9BTR7
    • Q9NSK1
    • Q9NXC1

    Protein attributes for LRRC40 Gene

    602 amino acids
    Molecular mass:
    68250 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91094.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC40 Gene

Proteomics data for LRRC40 Gene at MOPED

Post-translational modifications for LRRC40 Gene

  • Ubiquitination at Lys86 and Lys93
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC40 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LRRC40 Gene

Domains for LRRC40 Gene

Protein Domains for LRRC40 Gene

Suggested Antigen Peptide Sequences for LRRC40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 20 LRR (leucine-rich) repeats.
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC40: view

No data available for Gene Families for LRRC40 Gene

Function for LRRC40 Gene

Gene Ontology (GO) - Molecular Function for LRRC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC40: view

Phenotypes for LRRC40 Gene

GenomeRNAi human phenotypes for LRRC40:
genes like me logo Genes that share phenotypes with LRRC40: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC40 Gene

Localization for LRRC40 Gene

Subcellular locations from

Jensen Localization Image for LRRC40 Gene COMPARTMENTS Subcellular localization image for LRRC40 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for LRRC40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LRRC40: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRRC40 Gene

Pathways for LRRC40 Gene

SuperPathways for LRRC40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC40 Gene


No data available for Pathways by source for LRRC40 Gene

Transcripts for LRRC40 Gene

mRNA/cDNA for LRRC40 Gene

Unigene Clusters for LRRC40 Gene

Leucine rich repeat containing 40:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC40 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2: - -
SP3: - - -
SP4: - -

Relevant External Links for LRRC40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC40 Gene

mRNA expression in normal human tissues for LRRC40 Gene

Protein differential expression in normal tissues for LRRC40 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.8), Fetal Brain (8.7), and Brain (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC40 Gene

SOURCE GeneReport for Unigene cluster for LRRC40 Gene Hs.147836

genes like me logo Genes that share expressions with LRRC40: view

Expression partners for LRRC40 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC40 Gene

Orthologs for LRRC40 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRRC40 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC40 35
  • 89.37 (n)
  • 91.69 (a)
LRRC40 36
  • 91 (a)
(Canis familiaris)
Mammalia LRRC40 35
  • 89.23 (n)
  • 89.8 (a)
LRRC40 36
  • 89 (a)
(Mus musculus)
Mammalia Lrrc40 35
  • 82.34 (n)
  • 83.06 (a)
Lrrc40 16
Lrrc40 36
  • 83 (a)
(Pan troglodytes)
Mammalia LRRC40 35
  • 99.61 (n)
  • 99.5 (a)
LRRC40 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrrc40 35
  • 81.44 (n)
  • 83.38 (a)
(Monodelphis domestica)
Mammalia LRRC40 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC40 36
  • 79 (a)
(Gallus gallus)
Aves LRRC40 35
  • 69.71 (n)
  • 70.27 (a)
LRRC40 36
  • 70 (a)
(Anolis carolinensis)
Reptilia LRRC40 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc40 35
  • 63.95 (n)
  • 63.06 (a)
(Danio rerio)
Actinopterygii -- 35
lrrc40 35
  • 61.17 (n)
  • 62.83 (a)
lrrc40 36
  • 63 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006993 35
  • 45.4 (n)
  • 40.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta f-cup 35
  • 45.77 (n)
  • 39.23 (a)
f-cup 36
  • 32 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G15410 35
  • 44.18 (n)
  • 38.6 (a)
(Oryza sativa)
Liliopsida Os02g0826600 35
  • 44.97 (n)
  • 37.82 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05545 35
  • 41.42 (n)
  • 34.89 (a)
Species with no ortholog for LRRC40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC40 Gene

Gene Tree for LRRC40 (if available)
Gene Tree for LRRC40 (if available)

Paralogs for LRRC40 Gene

(2) SIMAP similar genes for LRRC40 Gene using alignment to 1 proteins: Pseudogenes for LRRC40 Gene

genes like me logo Genes that share paralogs with LRRC40: view

Variants for LRRC40 Gene

Sequence variations from dbSNP and Humsavar for LRRC40 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs156108 -- 70,195,969(+) ttcca(C/T)tgtca intron-variant
rs269278 -- 70,189,491(-) GCTAA(C/T)GTGTA intron-variant
rs270495 - 70,189,267(-) GCCGC(A/C)GTGTG reference, missense, utr-variant-5-prime, intron-variant
rs482094 -- 70,151,733(+) TGACT(A/T)TTTTT intron-variant
rs487613 -- 70,152,306(+) AACTA(C/T)TGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC40 Gene

Variant ID Type Subtype PubMed ID
nsv871339 CNV Loss 21882294
nsv870841 CNV Loss 21882294
nsv823143 CNV Loss 20364138
esv2665402 CNV Deletion 23128226
nsv1343 CNV Insertion 18451855

Relevant External Links for LRRC40 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC40 Gene

Disorders for LRRC40 Gene

No disorders were found for LRRC40 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LRRC40 Gene

Publications for LRRC40 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for LRRC40 Gene

Sources for LRRC40 Gene

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