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Aliases for LRRC39 Gene

Aliases for LRRC39 Gene

  • Leucine Rich Repeat Containing 39 2 3 5
  • Densin Hlg 4

External Ids for LRRC39 Gene

Previous GeneCards Identifiers for LRRC39 Gene

  • GC01M100327
  • GC01M100614
  • GC01M098737

Summaries for LRRC39 Gene

GeneCards Summary for LRRC39 Gene

LRRC39 (Leucine Rich Repeat Containing 39) is a Protein Coding gene. An important paralog of this gene is LRRC30.

Gene Wiki entry for LRRC39 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC39 Gene

Genomics for LRRC39 Gene

Regulatory Elements for LRRC39 Gene

Enhancers for LRRC39 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC39 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC39 Gene

100,148,448 bp from pter
100,178,273 bp from pter
29,826 bases
Minus strand

Genomic View for LRRC39 Gene

Genes around LRRC39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC39 Gene

Proteins for LRRC39 Gene

  • Protein details for LRRC39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 39
    Protein Accession:
    Secondary Accessions:
    • B3KUD2
    • D3DT56
    • Q5VVK7

    Protein attributes for LRRC39 Gene

    335 amino acids
    Molecular mass:
    38793 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC39 Gene


neXtProt entry for LRRC39 Gene

Proteomics data for LRRC39 Gene at MOPED

Post-translational modifications for LRRC39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC39 Gene

No data available for DME Specific Peptides for LRRC39 Gene

Domains & Families for LRRC39 Gene

Protein Domains for LRRC39 Gene

Suggested Antigen Peptide Sequences for LRRC39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 LRR (leucine-rich) repeats.
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC39: view

No data available for Gene Families for LRRC39 Gene

Function for LRRC39 Gene

genes like me logo Genes that share phenotypes with LRRC39: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC39 Gene

Localization for LRRC39 Gene

Subcellular locations from

Jensen Localization Image for LRRC39 Gene COMPARTMENTS Subcellular localization image for LRRC39 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC39 Gene

Pathways & Interactions for LRRC39 Gene

SuperPathways for LRRC39 Gene

No Data Available

Interacting Proteins for LRRC39 Gene

Gene Ontology (GO) - Biological Process for LRRC39 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC39 Gene

Drugs & Compounds for LRRC39 Gene

No Compound Related Data Available

Transcripts for LRRC39 Gene

Unigene Clusters for LRRC39 Gene

Leucine rich repeat containing 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC39 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: - -
SP2: -

Relevant External Links for LRRC39 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC39 Gene

mRNA expression in normal human tissues for LRRC39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC39 Gene

This gene is overexpressed in Muscle - Skeletal (x17.4), Heart - Left Ventricle (x13.4), and Heart - Atrial Appendage (x7.2).

Protein differential expression in normal tissues from HIPED for LRRC39 Gene

This gene is overexpressed in Gallbladder (15.6), Plasma (14.7), Rectum (10.9), and Prostate (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC39 Gene

SOURCE GeneReport for Unigene cluster for LRRC39 Gene Hs.44277

genes like me logo Genes that share expression patterns with LRRC39: view

Protein tissue co-expression partners for LRRC39 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LRRC39 Gene

Orthologs for LRRC39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC39 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC39 35
  • 91.52 (n)
  • 90.42 (a)
LRRC39 36
  • 87 (a)
(Canis familiaris)
Mammalia LRRC39 35
  • 91.94 (n)
  • 93.13 (a)
LRRC39 36
  • 89 (a)
(Mus musculus)
Mammalia Lrrc39 35
  • 86.03 (n)
  • 85.93 (a)
Lrrc39 16
Lrrc39 36
  • 82 (a)
(Pan troglodytes)
Mammalia LRRC39 35
  • 99.6 (n)
  • 99.4 (a)
LRRC39 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrrc39 35
  • 84.93 (n)
  • 85.63 (a)
(Monodelphis domestica)
Mammalia LRRC39 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC39 36
  • 80 (a)
(Gallus gallus)
Aves LRRC39 35
  • 69.85 (n)
  • 65.97 (a)
LRRC39 36
  • 64 (a)
(Anolis carolinensis)
Reptilia LRRC39 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc39 35
  • 61.17 (n)
  • 61.17 (a)
(Danio rerio)
Actinopterygii lrrc39 35
  • 63.43 (n)
  • 62.7 (a)
lrrc39 36
  • 59 (a)
Species with no ortholog for LRRC39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC39 Gene

Gene Tree for LRRC39 (if available)
Gene Tree for LRRC39 (if available)

Paralogs for LRRC39 Gene

Paralogs for LRRC39 Gene

(2) SIMAP similar genes for LRRC39 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC39: view

Variants for LRRC39 Gene

Sequence variations from dbSNP and Humsavar for LRRC39 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs34920283 - 100,159,274(+) CAGAG(A/T)TACCA reference, missense
rs593161 -- 100,158,656(-) AATCG(A/C)GACCA intron-variant
rs571579 -- 100,151,816(-) GCTAT(C/T)AGTGC intron-variant
rs580611 -- 100,157,369(-) aggca(C/T)gtctt intron-variant
rs664319 -- 100,151,967(-) ttgtt(G/T)gtttg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC39 Gene

Variant ID Type Subtype PubMed ID
nsv830804 CNV Gain 17160897
nsv2121 CNV Insertion 18451855

Variation tolerance for LRRC39 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LRRC39 Gene

Disorders for LRRC39 Gene

Relevant External Links for LRRC39

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC39 Gene

Publications for LRRC39 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing. (PMID: 20847312) Will R.D. … Frey N. (Circ. Res. 2010) 3
  5. The LIFEdb database in 2006. (PMID: 16381901) Mehrle A. … Wiemann S. (Nucleic Acids Res. 2006) 3

Products for LRRC39 Gene

Sources for LRRC39 Gene