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Aliases for LRRC37A3 Gene

Aliases for LRRC37A3 Gene

  • Leucine Rich Repeat Containing 37, Member A3 2 3
  • Leucine-Rich Repeat-Containing Protein 37A3 3
  • KIAA0563 4
  • LRRC37A 3
  • LRRC37 3

External Ids for LRRC37A3 Gene

Previous GeneCards Identifiers for LRRC37A3 Gene

  • GC17M060281
  • GC17M062850
  • GC17M058309

Summaries for LRRC37A3 Gene

GeneCards Summary for LRRC37A3 Gene

LRRC37A3 (Leucine Rich Repeat Containing 37, Member A3) is a Protein Coding gene. An important paralog of this gene is LRRC37A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC37A3 Gene

Genomics for LRRC37A3 Gene

Regulatory Elements for LRRC37A3 Gene

Genomic Location for LRRC37A3 Gene

64,854,312 bp from pter
64,919,480 bp from pter
65,169 bases
Minus strand

Genomic View for LRRC37A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A3 Gene

Proteins for LRRC37A3 Gene

  • Protein details for LRRC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 37A3
    Protein Accession:
    Secondary Accessions:
    • Q49A01
    • Q49A80
    • Q8NB33

    Protein attributes for LRRC37A3 Gene

    1634 amino acids
    Molecular mass:
    180621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC37A3 Gene

Proteomics data for LRRC37A3 Gene at MOPED

Post-translational modifications for LRRC37A3 Gene

  • Glycosylation at Asn296 and Asn1079
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37A3 Gene

Domains for LRRC37A3 Gene

Protein Domains for LRRC37A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • O60309
  • Belongs to the LRRC37A family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC37A3: view

No data available for Gene Families for LRRC37A3 Gene

Function for LRRC37A3 Gene

Gene Ontology (GO) - Molecular Function for LRRC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC37A3: view

Phenotypes for LRRC37A3 Gene

GenomeRNAi human phenotypes for LRRC37A3:
genes like me logo Genes that share phenotypes with LRRC37A3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC37A3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LRRC37A3 Gene

Localization for LRRC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRRC37A3 Gene COMPARTMENTS Subcellular localization image for LRRC37A3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A3: view

Pathways for LRRC37A3 Gene

SuperPathways for LRRC37A3 Gene

No Data Available

Interacting Proteins for LRRC37A3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000325713 for LRRC37A3 Gene via STRING

Gene Ontology (GO) - Biological Process for LRRC37A3 Gene


No data available for Pathways by source for LRRC37A3 Gene

Transcripts for LRRC37A3 Gene

Unigene Clusters for LRRC37A3 Gene

Leucine rich repeat containing 37, member A3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC37A3

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A3 Gene

No ASD Table

Relevant External Links for LRRC37A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC37A3 Gene

mRNA expression in normal human tissues for LRRC37A3 Gene

Protein differential expression in normal tissues for LRRC37A3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRC37A3 Gene

SOURCE GeneReport for Unigene cluster for LRRC37A3 Gene Hs.551962

genes like me logo Genes that share expressions with LRRC37A3: view

Expression partners for LRRC37A3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC37A3 Gene

Orthologs for LRRC37A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC37A3 35
  • 95.62 (n)
  • 93.37 (a)
-- 36
  • 93 (a)
(Mus musculus)
Mammalia Lrrc37a 16
Gm884 36
  • 32 (a)
Lrrc37a 36
  • 16 (a)
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 19 (a)
(Gallus gallus)
Aves -- 36
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 25 (a)
Species with no ortholog for LRRC37A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37A3 Gene

Gene Tree for LRRC37A3 (if available)
Gene Tree for LRRC37A3 (if available)

Paralogs for LRRC37A3 Gene

Paralogs for LRRC37A3 Gene

genes like me logo Genes that share paralogs with LRRC37A3: view

Variants for LRRC37A3 Gene

Sequence variations from dbSNP and Humsavar for LRRC37A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2257595 -- 64,893,104(-) AGTGA(A/G)GTGTG intron-variant
rs2665144 -- 64,915,992(-) gcctc(C/T)gaagt intron-variant
rs2667912 -- 64,885,981(+) AGACA(C/T)GCTTT intron-variant
rs2668700 -- 64,920,333(+) TTTCT(A/G)CAATT upstream-variant-2KB
rs2668701 -- 64,920,454(-) AGTGG(C/T)GTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A3 Gene

Variant ID Type Subtype PubMed ID
nsv908686 CNV Gain 21882294
dgv44n68 CNV Loss 17160897
nsv469875 CNV Loss 16826518
nsv471504 CNV Duplication 19718026
dgv45n68 CNV Loss 17160897
esv24547 CNV Gain 19812545
nsv9585 CNV Gain+Loss 18304495
nsv908688 CNV Loss 21882294

Relevant External Links for LRRC37A3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Disorders for LRRC37A3 Gene

No disorders were found for LRRC37A3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LRRC37A3 Gene

Publications for LRRC37A3 Gene

  1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G. … Eichler E.E. (Genome Res. 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRC37A3 Gene

Sources for LRRC37A3 Gene

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