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Aliases for LRRC37A3 Gene

Aliases for LRRC37A3 Gene

  • Leucine Rich Repeat Containing 37 Member A3 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37A3 3
  • KIAA0563 4
  • LRRC37A 3
  • LRRC37 3

External Ids for LRRC37A3 Gene

Previous GeneCards Identifiers for LRRC37A3 Gene

  • GC17M060281
  • GC17M062850
  • GC17M058309

Summaries for LRRC37A3 Gene

GeneCards Summary for LRRC37A3 Gene

LRRC37A3 (Leucine Rich Repeat Containing 37 Member A3) is a Protein Coding gene. An important paralog of this gene is LRRC37A.

Additional gene information for LRRC37A3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC37A3 Gene

Genomics for LRRC37A3 Gene

Regulatory Elements for LRRC37A3 Gene

Enhancers for LRRC37A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H063973 1.3 Ensembl ENCODE dbSUPER 12 +944.8 944794 2.2 SUZ12 JUN SIN3A ZMYM3 PAX8 BMI1 FOSL1 HIC1 ZNF23 ZFHX2 LRRC37A3 PIR61137 ENSG00000263489
GH17H064330 1.9 FANTOM5 Ensembl ENCODE dbSUPER 5.4 +586.8 586780 3.8 PKNOX1 ATF1 FOXA2 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 ZNF592 PECAM1 LRRC37A3 ERN1 DDX5 ICAM2 GC17M064322 ENSG00000239823
GH17H064699 1 ENCODE dbSUPER 9.9 +218.7 218682 2 ZSCAN4 ZFP64 ZNF140 ZNF266 POLR3A ZNF366 NFE2 ZNF433 ZC3H11A REST CEP95 SLC16A6P1 POLG2 DDX42 PLEKHM1P1 ENSG00000265912 ENSG00000265982 DDX5 SMARCD2 FTSJ3
GH17H064607 0.9 dbSUPER 9.9 +311.0 310970 1.5 ZFP64 ZNF121 ZNF138 ZNF366 ZNF354C ZNF207 RCOR1 ZNF202 ZNF654 SP3 CEP95 DDX42 SLC16A6P1 FTSJ3 POLG2 ENSG00000265218 DDX5 ENSG00000265912 SMARCD2 ENSG00000265982
GH17H064657 1.6 Ensembl ENCODE dbSUPER 4.4 +259.2 259234 6.5 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 FTSJ3 CEP95 POLG2 DDX42 SLC16A6P1 SMARCD2 DDX5 PLEKHM1P1 ENSG00000281311 ENSG00000265982
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC37A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for LRRC37A3 Gene

Genomic Locations for LRRC37A3 Gene
65,334 bases
Minus strand

Genomic View for LRRC37A3 Gene

Genes around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A3 Gene

Proteins for LRRC37A3 Gene

  • Protein details for LRRC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 37A3
    Protein Accession:
    Secondary Accessions:
    • Q49A01
    • Q49A80
    • Q8NB33

    Protein attributes for LRRC37A3 Gene

    1634 amino acids
    Molecular mass:
    180621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC37A3 Gene

Post-translational modifications for LRRC37A3 Gene

  • Glycosylation at posLast=296296 and Asn1079
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37A3 Gene

Domains & Families for LRRC37A3 Gene

Gene Families for LRRC37A3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC37A family.
  • Belongs to the LRRC37A family.
genes like me logo Genes that share domains with LRRC37A3: view

Function for LRRC37A3 Gene

Phenotypes From GWAS Catalog for LRRC37A3 Gene

genes like me logo Genes that share phenotypes with LRRC37A3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37A3 Gene

Localization for LRRC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC37A3 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A3: view

Pathways & Interactions for LRRC37A3 Gene

SuperPathways for LRRC37A3 Gene

No Data Available

Interacting Proteins for LRRC37A3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000325713 for LRRC37A3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for LRRC37A3 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC37A3 Gene

Drugs & Compounds for LRRC37A3 Gene

No Compound Related Data Available

Transcripts for LRRC37A3 Gene

Unigene Clusters for LRRC37A3 Gene

Leucine rich repeat containing 37, member A3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A3 Gene

No ASD Table

Relevant External Links for LRRC37A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC37A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC37A3 Gene

Protein differential expression in normal tissues from HIPED for LRRC37A3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC37A3 Gene

Protein tissue co-expression partners for LRRC37A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC37A3 Gene:


SOURCE GeneReport for Unigene cluster for LRRC37A3 Gene:


Evidence on tissue expression from TISSUES for LRRC37A3 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with LRRC37A3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC37A3 Gene

Orthologs for LRRC37A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC37A3 33
  • 95.62 (n)
-- 34
  • 93 (a)
(Bos Taurus)
Mammalia -- 34
  • 46 (a)
(Canis familiaris)
Mammalia -- 34
  • 46 (a)
(Mus musculus)
Mammalia Gm884 34
  • 32 (a)
Lrrc37a 34
  • 16 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 19 (a)
(Gallus gallus)
Aves -- 34
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 25 (a)
Species where no ortholog for LRRC37A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37A3 Gene

Gene Tree for LRRC37A3 (if available)
Gene Tree for LRRC37A3 (if available)

Paralogs for LRRC37A3 Gene

Paralogs for LRRC37A3 Gene

genes like me logo Genes that share paralogs with LRRC37A3: view

Variants for LRRC37A3 Gene

Sequence variations from dbSNP and Humsavar for LRRC37A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193920919 Uncertain significance 64,860,287(-) CAAAG(-/G)CTAGA intron-variant, reference, frameshift-variant
rs1000011529 -- 64,870,219(+) CCAAG(G/T)AGCTG intron-variant
rs1000084158 -- 64,940,225(+) GGGCT(G/T)CCTGG intron-variant
rs1000097939 -- 64,856,985(+) AAGGG(A/G)AAAAA intron-variant
rs1000234686 -- 64,876,803(+) TTAAA(A/G)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A3 Gene

Variant ID Type Subtype PubMed ID
nsv978455 CNV duplication 23825009
nsv9585 CNV gain+loss 18304495
nsv952360 CNV duplication 24416366
nsv575861 CNV gain+loss 21841781
nsv575860 CNV gain 21841781
nsv575857 CNV gain 21841781
nsv575856 CNV gain 21841781
nsv471504 CNV gain 19718026
nsv469875 CNV loss 16826518
nsv1120054 OTHER inversion 24896259
nsv1117181 CNV tandem duplication 24896259
nsv1072747 CNV deletion 25765185
nsv1066765 CNV gain 25217958
esv3436611 CNV duplication 20981092
esv3429501 CNV duplication 20981092
esv3413224 CNV duplication 20981092
esv3397467 CNV duplication 20981092
esv3382298 CNV duplication 20981092
esv3365612 CNV duplication 20981092
esv3344942 CNV duplication 20981092
esv24547 CNV gain 19812545
dgv5743n54 CNV loss 21841781
dgv45n68 CNV loss 17160897
dgv44n68 CNV loss 17160897
dgv3274n100 CNV gain 25217958
dgv1794e59 CNV duplication 20981092
dgv1793e59 CNV duplication 20981092
dgv1494n106 CNV deletion 24896259

Variation tolerance for LRRC37A3 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC37A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Disorders for LRRC37A3 Gene

Relevant External Links for LRRC37A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC37A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC37A3 Gene

Publications for LRRC37A3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 60
  4. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G … Eichler EE (Genome research 2013) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for LRRC37A3 Gene

Sources for LRRC37A3 Gene

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