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Aliases for LRRC37A3 Gene

Aliases for LRRC37A3 Gene

  • Leucine Rich Repeat Containing 37 Member A3 2 3 5
  • Leucine-Rich Repeat-Containing Protein 37A3 3
  • KIAA0563 4
  • LRRC37A 3
  • LRRC37 3

External Ids for LRRC37A3 Gene

Previous GeneCards Identifiers for LRRC37A3 Gene

  • GC17M060281
  • GC17M062850
  • GC17M058309

Summaries for LRRC37A3 Gene

GeneCards Summary for LRRC37A3 Gene

LRRC37A3 (Leucine Rich Repeat Containing 37 Member A3) is a Protein Coding gene. An important paralog of this gene is LRRC37A2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC37A3 Gene

Genomics for LRRC37A3 Gene

Regulatory Elements for LRRC37A3 Gene

Enhancers for LRRC37A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F065026 1.1 Ensembl ENCODE 11.1 -109.6 -109601 4.6 PKNOX1 RAD21 ZNF121 CBX5 FOS RCOR1 CREM EGR2 ZNF362 CBFB AMZ2P1 LRRC37A3 ENSG00000265218 ENSG00000266598 GC17P064985
GH17F064622 1.1 Ensembl ENCODE 11 +295.8 295781 2.7 HDGF ZBTB40 RFX5 SCRT2 FOS PAF1 CEBPB MAFF MTA1 PBX2 AMZ2P1 ENSG00000265982 PLEKHM1P1 LRRC37A3 MILR1 STRADA GC17P064641 ENSG00000271779
GH17F065783 0.8 Ensembl ENCODE 11 -865.2 -865184 2.8 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 ZNF121 ZNF207 FOS AMZ2P1 PLEKHM1P1 LRRC37A3 GC17P065784 LOC100419102
GH17F064330 1.1 FANTOM5 Ensembl ENCODE 5.4 +586.8 586780 3.8 ATF1 PKNOX1 CREB3L1 GATA2 NCOA1 CREB3 MBD2 MEF2D MAFF SMARCA4 ENSG00000265982 PLEKHM1P1 PECAM1 LRRC37A3 ERN1 DDX5 ICAM2 GC17M064322 ENSG00000239823
GH17F064571 0.8 Ensembl ENCODE 5.3 +346.9 346863 2.9 TBP CBX3 ATF1 NFRKB NFXL1 ZNF207 CREM ZNF263 CEBPB JUNB MILR1 LRRC37A3 ENSG00000271779 GC17P064546
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC37A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001351191 280 2001 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207

Genomic Location for LRRC37A3 Gene

64,854,147 bp from pter
64,919,480 bp from pter
65,334 bases
Minus strand

Genomic View for LRRC37A3 Gene

Genes around LRRC37A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC37A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC37A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC37A3 Gene

Proteins for LRRC37A3 Gene

  • Protein details for LRRC37A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 37A3
    Protein Accession:
    Secondary Accessions:
    • Q49A01
    • Q49A80
    • Q8NB33

    Protein attributes for LRRC37A3 Gene

    1634 amino acids
    Molecular mass:
    180621 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA25489.3; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03710.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC37A3 Gene

Post-translational modifications for LRRC37A3 Gene

  • Glycosylation at Asn 296 and Asn 1079
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC37A3 Gene

Domains & Families for LRRC37A3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the LRRC37A family.
  • Contains 12 LRR (leucine-rich) repeats.
  • Belongs to the LRRC37A family.
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC37A3: view

No data available for Gene Families for LRRC37A3 Gene

Function for LRRC37A3 Gene

genes like me logo Genes that share phenotypes with LRRC37A3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC37A3 Gene

Localization for LRRC37A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRRC37A3 Gene COMPARTMENTS Subcellular localization image for LRRC37A3 gene
Compartment Confidence
plasma membrane 3
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC37A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC37A3: view

Pathways & Interactions for LRRC37A3 Gene

SuperPathways for LRRC37A3 Gene

No Data Available

Interacting Proteins for LRRC37A3 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000325713 for LRRC37A3 Gene via STRING

Gene Ontology (GO) - Biological Process for LRRC37A3 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC37A3 Gene

Transcripts for LRRC37A3 Gene

Unigene Clusters for LRRC37A3 Gene

Leucine rich repeat containing 37, member A3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC37A3 Gene

No ASD Table

Relevant External Links for LRRC37A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC37A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC37A3 Gene

Protein differential expression in normal tissues from HIPED for LRRC37A3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC37A3 Gene

Protein tissue co-expression partners for LRRC37A3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC37A3 Gene:


SOURCE GeneReport for Unigene cluster for LRRC37A3 Gene:

genes like me logo Genes that share expression patterns with LRRC37A3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC37A3 Gene

Orthologs for LRRC37A3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC37A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC37A3 34
  • 95.62 (n)
-- 35
  • 93 (a)
(Bos Taurus)
Mammalia -- 35
  • 46 (a)
(Canis familiaris)
Mammalia -- 35
  • 46 (a)
(Mus musculus)
Mammalia Gm884 35
  • 32 (a)
Lrrc37a 35
  • 16 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 21 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 19 (a)
(Gallus gallus)
Aves -- 35
  • 44 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 25 (a)
Species where no ortholog for LRRC37A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC37A3 Gene

Gene Tree for LRRC37A3 (if available)
Gene Tree for LRRC37A3 (if available)

Paralogs for LRRC37A3 Gene

Paralogs for LRRC37A3 Gene

genes like me logo Genes that share paralogs with LRRC37A3: view

Variants for LRRC37A3 Gene

Sequence variations from dbSNP and Humsavar for LRRC37A3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs193920919 Uncertain significance 64,860,287(-) CAAAG(-/G)CTAGA intron-variant, reference, frameshift-variant
rs1022175 -- 64,911,070(+) atata(G/T)ataca intron-variant
rs10401012 -- 64,922,614(+) gagaa(C/G)caggg intron-variant
rs10544013 -- 64,959,720(+) GTTAA(-/AC)ACACA intron-variant, upstream-variant-2KB
rs1054820 -- 64,860,400(+) AGGGT(G/T)TCAGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LRRC37A3 Gene

Variant ID Type Subtype PubMed ID
dgv1494n106 CNV deletion 24896259
dgv1793e59 CNV duplication 20981092
dgv1794e59 CNV duplication 20981092
dgv3274n100 CNV gain 25217958
dgv44n68 CNV loss 17160897
dgv45n68 CNV loss 17160897
dgv5743n54 CNV loss 21841781
esv24547 CNV gain 19812545
esv3344942 CNV duplication 20981092
esv3365612 CNV duplication 20981092
esv3382298 CNV duplication 20981092
esv3397467 CNV duplication 20981092
esv3413224 CNV duplication 20981092
esv3429501 CNV duplication 20981092
esv3436611 CNV duplication 20981092
nsv1066765 CNV gain 25217958
nsv1072747 CNV deletion 25765185
nsv1117181 CNV tandem duplication 24896259
nsv1120054 OTHER inversion 24896259
nsv469875 CNV loss 16826518
nsv471504 CNV gain 19718026
nsv575856 CNV gain 21841781
nsv575857 CNV gain 21841781
nsv575860 CNV gain 21841781
nsv575861 CNV gain+loss 21841781
nsv952360 CNV duplication 24416366
nsv9585 CNV gain+loss 18304495
nsv978455 CNV duplication 23825009

Variation tolerance for LRRC37A3 Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC37A3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC37A3 Gene

Disorders for LRRC37A3 Gene

Relevant External Links for LRRC37A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC37A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC37A3 Gene

Publications for LRRC37A3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. Evolutionary dynamism of the primate LRRC37 gene family. (PMID: 23064749) Giannuzzi G. … Eichler E.E. (Genome Res. 2013) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRRC37A3 Gene

Sources for LRRC37A3 Gene

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