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Aliases for LRRC32 Gene

Aliases for LRRC32 Gene

  • Leucine Rich Repeat Containing 32 2 3 5
  • Glycoprotein A Repetitions Predominant 2 3 4
  • D11S833E 3 4
  • Garpin 3 4
  • GARP 3 4
  • Leucine-Rich Repeat-Containing Protein 32 3

External Ids for LRRC32 Gene

Previous HGNC Symbols for LRRC32 Gene

  • D11S833E
  • GARP

Previous GeneCards Identifiers for LRRC32 Gene

  • GC11M076047
  • GC11M076368
  • GC11M072666

Summaries for LRRC32 Gene

Entrez Gene Summary for LRRC32 Gene

  • This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRC32 Gene

LRRC32 (Leucine Rich Repeat Containing 32) is a Protein Coding gene. An important paralog of this gene is NRROS.

Additional gene information for LRRC32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC32 Gene

Genomics for LRRC32 Gene

Regulatory Elements for LRRC32 Gene


Enhancers around LRRC32 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000264948 146 801 BCOR CTCF TBL1XR1 MAX SIN3A EBF1 POLR2A EGR1 EED ZNF143
ENSR00000264949 1346 401 ZNF664 POLR2A EZH2

Genomic Locations for LRRC32 Gene

Genomic Locations for LRRC32 Gene
chr11:76,657,524-76,670,946
(GRCh38/hg38)
Size:
13,423 bases
Orientation:
Minus strand
chr11:76,368,568-76,381,791
(GRCh37/hg19)

Genomic View for LRRC32 Gene

Genes around LRRC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC32 Gene

Proteins for LRRC32 Gene

  • Protein details for LRRC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14392-LRC32_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 32
    Protein Accession:
    Q14392
    Secondary Accessions:
    • Q86V06

    Protein attributes for LRRC32 Gene

    Size:
    662 amino acids
    Molecular mass:
    71979 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52210.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC32 Gene

Post-translational modifications for LRRC32 Gene

  • Glycosylation at Asn203, posLast=271271, posLast=308308, posLast=345345, and posLast=545545
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC32 Gene

Domains & Families for LRRC32 Gene

Gene Families for LRRC32 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LRRC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC32: view

No data available for UniProtKB/Swiss-Prot for LRRC32 Gene

Function for LRRC32 Gene

Phenotypes From GWAS Catalog for LRRC32 Gene

Gene Ontology (GO) - Molecular Function for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26126825
genes like me logo Genes that share ontologies with LRRC32: view
genes like me logo Genes that share phenotypes with LRRC32: view

miRNA for LRRC32 Gene

miRTarBase miRNAs that target LRRC32

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC32 Gene

Localization for LRRC32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC32 gene
Compartment Confidence
plasma membrane 5
extracellular 3
golgi apparatus 2
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8180135
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC32: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC32 Gene

Pathways & Interactions for LRRC32 Gene

SuperPathways for LRRC32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IEA --
GO:0046007 negative regulation of activated T cell proliferation IEA --
GO:0050710 negative regulation of cytokine secretion IEA --
genes like me logo Genes that share ontologies with LRRC32: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC32 Gene

Drugs & Compounds for LRRC32 Gene

No Compound Related Data Available

Transcripts for LRRC32 Gene

Unigene Clusters for LRRC32 Gene

Leucine rich repeat containing 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for LRRC32 Gene

GeneLoc Exon Structure for
LRRC32
ECgene alternative splicing isoforms for
LRRC32

Expression for LRRC32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC32 Gene

Protein differential expression in normal tissues from HIPED for LRRC32 Gene

This gene is overexpressed in Serum (41.8) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC32 Gene



Protein tissue co-expression partners for LRRC32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC32 Gene:

LRRC32

SOURCE GeneReport for Unigene cluster for LRRC32 Gene:

Hs.151641

mRNA Expression by UniProt/SwissProt for LRRC32 Gene:

Q14392-LRC32_HUMAN
Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs)).

Evidence on tissue expression from TISSUES for LRRC32 Gene

  • Liver(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with LRRC32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC32 Gene

Orthologs for LRRC32 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC32 33 34
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia LRRC32 33 34
  • 86.37 (n)
dog
(Canis familiaris)
Mammalia LRRC32 33 34
  • 86 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc32 33
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Lrrc32 33 16 34
  • 81 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC32 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC32 33 34
  • 52.99 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC32 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc32 33
  • 50.27 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148867 33
  • 53.16 (n)
lrrc32 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 34
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
ManyToMany
Species where no ortholog for LRRC32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC32 Gene

ENSEMBL:
Gene Tree for LRRC32 (if available)
TreeFam:
Gene Tree for LRRC32 (if available)

Paralogs for LRRC32 Gene

Paralogs for LRRC32 Gene

(3) SIMAP similar genes for LRRC32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC32: view

Variants for LRRC32 Gene

Sequence variations from dbSNP and Humsavar for LRRC32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000154886 -- 76,668,106(+) ACAGC(A/G)CACAA intron-variant
rs1000188933 -- 76,664,615(+) CTGTA(A/G)GTCCC intron-variant
rs1000610097 -- 76,667,848(+) GCAGA(C/T)TTTCA intron-variant
rs1000699215 -- 76,670,354(+) GTCTT(A/C)AGGCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000751103 -- 76,670,548(+) GCGCT(C/T)GCTAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRC32 Gene

Variant ID Type Subtype PubMed ID
nsv555448 CNV gain 21841781
nsv1047069 CNV gain 25217958
dgv1228n100 CNV loss 25217958

Variation tolerance for LRRC32 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC32 Gene

Human Gene Mutation Database (HGMD)
LRRC32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC32 Gene

Disorders for LRRC32 Gene

Relevant External Links for LRRC32

Genetic Association Database (GAD)
LRRC32
Human Genome Epidemiology (HuGE) Navigator
LRRC32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC32

No disorders were found for LRRC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC32 Gene

Publications for LRRC32 Gene

  1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PMID: 8180135) Ollendorff V … Birnbaum D (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994) 2 3 4 22 60
  2. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32). (PMID: 21615933) Chan DV … McCormick TS (BMC biochemistry 2011) 3 4 60
  3. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PMID: 19651619) Tran DQ … Shevach EM (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 60
  4. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. (PMID: 19666573) Wang R … Unutmaz D (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 60
  5. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PMID: 18628982) Wang R … Unutmaz D (PloS one 2008) 3 22 60

Products for LRRC32 Gene

Sources for LRRC32 Gene

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