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Aliases for LRRC32 Gene

Aliases for LRRC32 Gene

  • Leucine Rich Repeat Containing 32 2 3
  • Glycoprotein A Repetitions Predominant 2 3 4
  • D11S833E 3 4 6
  • GARP 3 4 6
  • Garpin 3 4
  • Leucine-Rich Repeat-Containing Protein 32 3

External Ids for LRRC32 Gene

Previous Symbols for LRRC32 Gene

  • D11S833E
  • GARP

Summaries for LRRC32 Gene

Entrez Gene Summary for LRRC32 Gene

  • This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRC32 Gene

LRRC32 (Leucine Rich Repeat Containing 32) is a Protein Coding gene. An important paralog of this gene is NRROS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC32 Gene

Genomics for LRRC32 Gene

Genomic Location for LRRC32 Gene

Start:
76,657,524 bp from pter
End:
76,670,946 bp from pter
Size:
13,423 bases
Orientation:
Minus strand

Genomic View for LRRC32 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC32 Gene

Regulatory Elements for LRRC32 Gene

Proteins for LRRC32 Gene

  • Protein details for LRRC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14392-LRC32_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 32
    Protein Accession:
    Q14392
    Secondary Accessions:
    • Q86V06

    Protein attributes for LRRC32 Gene

    Size:
    662 amino acids
    Molecular mass:
    71979 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52210.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC32 Gene

Proteomics data for LRRC32 Gene at MOPED

Post-translational modifications for LRRC32 Gene

  • Glycosylation at Asn203, Asn271, Asn308, Asn345, and Asn545

Other Protein References for LRRC32 Gene

No data available for DME Specific Peptides for LRRC32 Gene

Domains for LRRC32 Gene

Suggested Antigen Peptide Sequences for LRRC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14392

UniProtKB/Swiss-Prot:

LRC32_HUMAN
Domain:
  • Contains 1 LRRCT domain.:
    • Q14392
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.:
    • Q14392
genes like me logo Genes that share domains with LRRC32: view

No data available for Gene Families for LRRC32 Gene

Function for LRRC32 Gene

Gene Ontology (GO) - Molecular Function for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC32: view

Phenotypes for LRRC32 Gene

MGI mutant phenotypes for LRRC32:
inferred from 1 alleles
GenomeRNAi human phenotypes for LRRC32:
genes like me logo Genes that share phenotypes with LRRC32: view

miRNA for LRRC32 Gene

miRTarBase miRNAs that target LRRC32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRRC32 Gene

Localization for LRRC32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC32 Gene COMPARTMENTS Subcellular localization image for LRRC32 gene
Compartment Confidence
plasma membrane 4
extracellular 2
golgi apparatus 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8180135
genes like me logo Genes that share ontologies with LRRC32: view

Pathways for LRRC32 Gene

SuperPathways for LRRC32 Gene

No Data Available

Interacting Proteins for LRRC32 Gene

Gene Ontology (GO) - Biological Process for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IEA --
GO:0046007 negative regulation of activated T cell proliferation IEA --
GO:0050710 negative regulation of cytokine secretion IEA --
genes like me logo Genes that share ontologies with LRRC32: view

No data available for Pathways by source for LRRC32 Gene

Transcripts for LRRC32 Gene

Unigene Clusters for LRRC32 Gene

Leucine rich repeat containing 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for LRRC32 Gene

GeneLoc Exon Structure for
LRRC32
ECgene alternative splicing isoforms for
LRRC32

Expression for LRRC32 Gene

mRNA expression in normal human tissues for LRRC32 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRC32 Gene

SOURCE GeneReport for Unigene cluster for LRRC32 Gene Hs.151641

mRNA Expression by UniProt/SwissProt for LRRC32 Gene

Q14392-LRC32_HUMAN
Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs)).
genes like me logo Genes that share expressions with LRRC32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LRRC32 Gene

Orthologs for LRRC32 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC32 35
  • 99.14 (n)
  • 98.94 (a)
LRRC32 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRRC32 35
  • 86.37 (n)
  • 85.07 (a)
LRRC32 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC32 35
  • 86 (n)
  • 84.6 (a)
LRRC32 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc32 35
  • 81 (n)
  • 79.66 (a)
Lrrc32 16
Lrrc32 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRRC32 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc32 35
  • 81.57 (n)
  • 80.9 (a)
chicken
(Gallus gallus)
Aves LRRC32 35
  • 52.99 (n)
  • 47.89 (a)
LRRC32 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC32 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc32 35
  • 50.27 (n)
  • 43.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148867 35
  • 53.16 (n)
  • 43.06 (a)
lrrc32 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for LRRC32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC32 Gene

ENSEMBL:
Gene Tree for LRRC32 (if available)
TreeFam:
Gene Tree for LRRC32 (if available)

Paralogs for LRRC32 Gene

Paralogs for LRRC32 Gene

Selected SIMAP similar genes for LRRC32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC32: view

Variants for LRRC32 Gene

Sequence variations from dbSNP and Humsavar for LRRC32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7685 -- 76,657,595(-) AGGCC(G/T)CAGCC utr-variant-3-prime, nc-transcript-variant
rs867566 -- 76,660,633(-) AATCT(A/G)GATTT synonymous-codon, reference, nc-transcript-variant
rs947998 -- 76,672,762(+) CCCCC(G/T)CCCCC upstream-variant-2KB
rs1056564 -- 76,658,483(-) ACATA(G/T)CCCGA utr-variant-3-prime, intron-variant
rs1078575 -- 76,667,664(+) CAGAA(C/T)GCCAC intron-variant, upstream-variant-2KB

Relevant External Links for LRRC32 Gene

HapMap Linkage Disequilibrium report
LRRC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC32 Gene

Disorders for LRRC32 Gene

Relevant External Links for LRRC32

Genetic Association Database (GAD)
LRRC32
Human Genome Epidemiology (HuGE) Navigator
LRRC32
genes like me logo Genes that share disorders with LRRC32: view

No data available for UniProtKB/Swiss-Prot for LRRC32 Gene

Publications for LRRC32 Gene

  1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PMID: 8180135) Ollendorff V. … Birnbaum D. (Cell Growth Differ. 1994) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PMID: 18628982) Wang R. … Unutmaz D. (PLoS ONE 2008) 3 23
  4. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PMID: 19651619) Tran D.Q. … Shevach E.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  5. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. (PMID: 19666573) Wang R. … Unutmaz D. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for LRRC32 Gene

Sources for LRRC32 Gene

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