Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRRC32 Gene

protein-coding   GIFtS: 53
GCID: GC11M076368

Leucine Rich Repeat Containing 32

(Previous name: glycoprotein A repetitions predominant)
(Previous symbols: D11S833E, GARP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leucine Rich Repeat Containing 321 2     garpin2
D11S833E1 2 3 5     Leucine-Rich Repeat-Containing Protein 322
GARP1 2 3 5     Garpin3
Glycoprotein A Repetitions Predominant1 2 3     

External Ids:    HGNC: 41611   Entrez Gene: 26152   Ensembl: ENSG000001375077   OMIM: 1372075   UniProtKB: Q143923   

Export aliases for LRRC32 gene to outside databases

Previous GC identifers: GC11M076047 GC11M072666


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LRRC32 Gene:
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal
region 11q13-11q14 are involved in several pathologies. (provided by RefSeq, Jul 2008)

GeneCards Summary for LRRC32 Gene: 
LRRC32 (leucine rich repeat containing 32) is a protein-coding gene. Diseases associated with LRRC32 include allergic rhinitis, and rhinitis. An important paralog of this gene is NRROS.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRRC32 gene promoter:
         NF-kappaB2   c-Myb   NF-kappaB1   NF-kappaB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRRC32 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRRC32

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5-q14   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5-q14

LRRC32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M076368:  view genomic region     (about GC identifiers)

Start:
76,368,568 bp from pter      End:
76,381,791 bp from pter
Size:
13,224 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 32 precursor  
Size: 662 amino acids; 71979 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=AAH52210.2; Type=Erroneous initiation;
Secondary accessions: Q86V06

Explore the universe of human proteins at neXtProt for LRRC32: NX_Q14392

Explore proteomics data for LRRC32 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14392

  • LRRC32 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRRC32 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001122394.1  NP_005503.1  

    ENSEMBL proteins: 
     ENSP00000260061   ENSP00000385766   ENSP00000413331   ENSP00000384126  

    Human Recombinant Protein Products for LRRC32: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LRRC32 (LRRC32/GARP)
    Enzo Life Sciences proteins for LRRC32
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LRRC32
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for LRRC32
    GenScript Custom Purified and Recombinant Proteins Services for LRRC32
    Novus Biologicals LRRC32 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRC32 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS8180135

    LRRC32 for ontologies           About GeneDecksing



    LRRC32 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of LRRC32
    R&D Systems Antibodies for LRRC32 (LRRC32/GARP)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LRRC32
    GenScript Custom Superior Antibodies Services for LRRC32
    Novus Biologicals LRRC32 Antibody
    Search for Antibodies for LRRC32 at Abcam
    Cloud-Clone Corp. Antibodies for LRRC32 
    ThermoFisher Antibodies for LRRC32
    LSBio Antibodies in human, mouse, rat for LRRC32 

    Assay Products for LRRC32: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRRC32
    R&D Systems Flow Cytometry Kits for LRRC32 (LRRC32/GARP)
    GenScript Custom Assay Services for LRRC32
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRRC32 
    Cloud-Clone Corp. CLIAs for LRRC32


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q14392

    ProtoNet protein and cluster: Q14392

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392
    Similarity: Contains 20 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    LRRC32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    LRRC32 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC32:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRC32 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRC32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC32 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC32 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC32
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC32 (see all 21):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-185* hsa-miR-181c hsa-miR-520d-5p hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidLRRC32 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRC32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC32

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRRC32
    Sirion Biotech Customized adenovirus for overexpression of LRRC32

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LRRC32 (see all 13)
    OriGene ORF clones in mouse, rat for LRRC32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC32 (NM_005512)
    Sino Biological Human cDNA Clone for LRRC32
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC32
    Sirion Biotech Customized lentivirus for stable overexpression of LRRC32 
                         Customized lentivirus expression plasmids for stable overexpression of LRRC32 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRRC32
    Search LifeMap BioReagents cell lines for LRRC32
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC32


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC32

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for LRRC32 (ENSP000002600614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1ENSP000002219304STRING: ENSP00000221930
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010628positive regulation of gene expression IEA--
    GO:0046007negative regulation of activated T cell proliferation IEA--
    GO:0050710negative regulation of cytokine secretion IEA--

    LRRC32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRRC32 (LRC32)

    Search CenterWatch for drugs/clinical trials and news about LRRC32 / LRC32

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRRC32 gene (2 alternative transcripts): 
    NM_001128922.1  NM_005512.2  

    Unigene Cluster for LRRC32:

    Leucine rich repeat containing 32
    Hs.151641  [show with all ESTs]
    Unigene Representative Sequence: NM_005512
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260061(uc001oxr.4) ENST00000404995 ENST00000464145 ENST00000421973
    ENST00000407242(uc001oxq.4 uc010rsf.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRRC32
    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate LRRC32 (see all 21):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-185* hsa-miR-181c hsa-miR-520d-5p hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidLRRC32 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRRC32
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC32
    Clone
    Products:
         
    OriGene clones in human, mouse for LRRC32 (see all 13)
    OriGene ORF clones in mouse, rat for LRRC32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC32 (NM_005512)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC32
    Sirion Biotech Customized lentivirus for stable overexpression of LRRC32 
                         Customized lentivirus expression plasmids for stable overexpression of LRRC32 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRRC32
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC32
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC32
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC32
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC32

    Additional mRNA sequence: 

    AK314971.1 BC052210.1 BC070079.1 Z24680.1 

    5 DOTS entries:

    DT.415518  DT.100786497  DT.415519  DT.92429412  DT.95267453 

    24/157 AceView cDNA sequences (see all 157):

    AI093446 AW951439 BM857468 AI831859 BM716482 CR618700 BM704943 BQ723284 
    AI695331 CF455348 AW137875 AW025243 AI433330 AI584033 AW003074 BU074224 
    CA398157 BU738541 BM721075 BM679501 BM676046 AI000963 BG150541 AW337932 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:        -                           
    SP2:                                    
    SP3:                    -     -         


    ECgene alternative splicing isoforms for LRRC32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRRC32 expression in normal human tissues (normalized intensities)      LRRC32 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGGGCTC
    LRRC32 Expression
    About this image


    LRRC32 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial progenitor 30-MV2-12
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Human Brain Vascular Smooth Muscle Cells (HBVSMC)   
             optic nerve head astrocytes   
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             PureStem endothelial progenitor 30-MV2-12
     
     Eye (Sensory Organs)
             optic nerve head astrocytes   

    See LRRC32 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRRC32

    SOURCE GeneReport for Unigene cluster: Hs.151641

    UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392
    Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs))

        SABiosciences Expression via Pathway-Focused PCR Array including LRRC32: 
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LRRC32
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC32
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC32
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC32
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC32
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRRC32 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc321 , 5 leucine rich repeat containing 321, 5 81.17(n)1
    79.61(a)1
      7 (53.86 cM)5
    4342151  NM_001113379.11  NP_001106850.11 
     984942225 
    chicken
    (Gallus gallus)
    Aves LRRC321 leucine rich repeat containing 32 52.96(n)
    48.48(a)
      428121  XM_425678.2  XP_425678.2 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC326
    leucine rich repeat containing 32
    42(a)
    1 ↔ 1
    GL343493.1(435110-457153)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001488671 leucine-rich repeat-containing protein 32-like 52.87(n)
    42.02(a)
      100148867  XM_001920541.2  XP_001920576.2 
    worm
    (Caenorhabditis elegans)
    Secernentea lron-56
    Protein LRON-5
    21(a)
    1 → many
    III(4623052-4626173)


    ENSEMBL Gene Tree for LRRC32 (if available)
    TreeFam Gene Tree for LRRC32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LRRC32 gene
    NRROS2  
    3 SIMAP similar genes for LRRC32 using alignment to 2 protein entries:     LRC32_HUMAN (see all proteins):
    LINGO1    LRRC33    SLIT2

    LRRC32 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/364 SNPs in LRRC32 are shown (see all 364)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745507291,2
    C,F--76368110(+) TCACTG/ATTTTT 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs734996111,2
    C--76368198(+) ATGACG/AGGGTA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs774643121,2
    C,F--76368258(+) CTCTGC/AGATAG 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1447339461,2
    --76368324(+) GAAACA/CAACGG 2 -- ds50010--------
    rs49450961,2
    C,F,A,H--76368327(+) ACAAAC/TGGAAG 2 -- ds500127Minor allele frequency- T:0.33NA NS EA WA CSA 2670
    rs1885678871,2
    --76368474(+) GGATTC/TGCCAT 2 -- ds50010--------
    rs1479219511,2
    --76368494(+) ACGACC/TGTAAT 2 -- ds50010--------
    rs1417521101,2
    --76368495(+) CGACCA/GTAATG 2 -- ds50010--------
    rs1500506461,2
    --76368516(+) GCAGGA/GTTCTA 2 -- ds50010--------
    rs1931590371,2
    --76368517(+) CAGGGA/TTCTAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRRC32 (76368568 - 76381791 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LRRC32: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC32
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 137207    OMIM disorders: --

    5 diseases for LRRC32:    About MalaCards
    allergic rhinitis    rhinitis    hepatitis b    asthma
    hepatitis


    LRRC32 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC32
    Human Genome Epidemiology (HuGE) Navigator: LRRC32 (1 document)

    Export disorders for LRRC32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRRC32 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with LRRC32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PubMed id 8180135)1, 2, 3, 9 Ollendorff V.... Birnbaum D. (1994)
    2. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 3 2 (LRRC32). (PubMed id 21615933)1, 2 Chan D.V....McCormick T.S. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions. (PubMed id 1543912)1, 3 Ollendorff V....Birnbaum D. (1992)
    5. Expression of GARP selectively identifies activated h uman FOXP3+ regulatory T cells. (PubMed id 19666573)1, 9 Wang R....Unutmaz D. (2009)
    6. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PubMed id 19651619)1, 9 Tran D.Q....Shevach E.M. (2009)
    7. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PubMed id 18628982)1, 9 Wang R....Unutmaz D. (2008)
    8. miR-142-3p is involved in CD25+ CD4 T cell proliferati on by targeting the expression of glycoprotein A repetitions predominant. (PubMed id 23650616)1 Zhou Q....Skapenko A. (2013)
    9. GARP regulates the bioavailability and activation of T GFb. (PubMed id 22278742)1 Wang R....Springer T.A. (2012)
    10. The C11orf30-LRRC32 region is associated with total se rum IgE levels in asthmatic patients. (PubMed id 22070912)1 Li X....Meyers D.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2615 HGNC: 4161 AceView: GARP Ensembl:ENSG00000137507 euGenes: HUgn2615
    ECgene: LRRC32 H-InvDB: LRRC32

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRRC32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRRC32 gene:
    Search GeneIP for patents involving LRRC32

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of LRRC32
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for LRRC32 (LRRC32/GARP)   Browse Cell Culture Products  
     Browse ELISAs   Flow Cytometry Kits for LRRC32 (LRRC32/GARP)  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for LRRC32 (LRRC32/GARP)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LRRC32  
     OriGene qPCR primer pairs and template standards for LRRC32   OriGene Protein Over-expression Lysate for LRRC32  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LRRC32  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRRC32   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LRRC32   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRRC32   OriGene Custom Protein Services for LRRC32  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC32
     QIAGEN SeqTarget long-range PCR primers for resequencing LRRC32
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC32
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC32
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC32
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC32
     GenScript Custom Purified and Recombinant Proteins Services for LRRC32 GenScript cDNA clones with any tag delivered in your preferred vector for LRRC32
     GenScript Custom Assay Services for LRRC32 GenScript Custom Superior Antibodies Services for LRRC32
     GenScript Custom overexpressing Cell Line Services for LRRC32 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LRRC32 promoter
     Search Chromatin IP Primers for LRRC32
     RT2 qPCR Primer Assay in human, mouse, rat LRRC32
     Search GNC Networks for LRRC32
     SABiosciences PCR Arrays including human, mouse, rat LRRC32
     Search Tocris compounds for LRRC32 (LRC32)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for LRRC32
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for LRRC32
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LRRC32 antibodies
     LRRC32 lysates
     Search for Antibodies for LRRC32 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for LRRC32
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for LRRC32
     Antibodies for LRRC32
     ELISAs for LRRC32
     CLIAs for LRRC32
     Search LifeMap BioReagents cell lines for LRRC32
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC32
     SwitchGear 3'UTR luciferase reporter plasmids for LRRC32
     SwitchGear Promoter luciferase reporter plasmids for LRRC32
     ThermoFisher Antibodies for LRRC32
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC32
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LRRC32
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRRC32
    Customized:
     lentivirus for stable overexpression of LRRC32
     lentivirus expression plasmids for stable overexpression of LRRC32
     adenovirus for overexpression of LRRC32
     LSBio Antibodies in human, mouse, rat for LRRC32
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LRRC32 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4