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LRRC32 Gene

protein-coding   GIFtS: 53
GCID: GC11M076368

Leucine Rich Repeat Containing 32

(Previous name: glycoprotein A repetitions predominant)
(Previous symbols: D11S833E, GARP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 321 2     garpin2
D11S833E1 2 3 5     Leucine-Rich Repeat-Containing Protein 322
GARP1 2 3 5     Garpin3
Glycoprotein A Repetitions Predominant1 2 3     

External Ids:    HGNC: 41611   Entrez Gene: 26152   Ensembl: ENSG000001375077   OMIM: 1372075   UniProtKB: Q143923   

Export aliases for LRRC32 gene to outside databases

Previous GC identifers: GC11M076047 GC11M072666


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRRC32 Gene:
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal
region 11q13-11q14 are involved in several pathologies. (provided by RefSeq, Jul 2008)

GeneCards Summary for LRRC32 Gene:
LRRC32 (leucine rich repeat containing 32) is a protein-coding gene. Diseases associated with LRRC32 include allergic rhinitis, and rhinitis. An important paralog of this gene is NRROS.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC32 gene promoter:
         NF-kappaB2   c-Myb   NF-kappaB1   NF-kappaB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRRC32 promoter sequence
   Search Chromatin IP Primers for LRRC32

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5-q14   Ensembl cytogenetic band:  11q13.5   HGNC cytogenetic band: 11q13.5-q14

LRRC32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC32 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M076368:  view genomic region     (about GC identifiers)

Start:
76,368,568 bp from pter      End:
76,381,791 bp from pter
Size:
13,224 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 32 precursor  
Size: 662 amino acids; 71979 Da
Sequence caution: Sequence=AAH52210.2; Type=Erroneous initiation;
Secondary accessions: Q86V06

Explore the universe of human proteins at neXtProt for LRRC32: NX_Q14392

Explore proteomics data for LRRC32 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn203, Asn271, Asn308, Asn345, Asn545

  • See LRRC32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001122394.1  NP_005503.1  

    ENSEMBL proteins: 
     ENSP00000260061   ENSP00000385766   ENSP00000413331   ENSP00000384126  

    LRRC32 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for LRRC32
    OriGene Purified Protein for LRRC32
    OriGene Protein Over-expression Lysate for LRRC32
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRRC32
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    Novus Biologicals LRRC32 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRRC32

    LRRC32 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LRRC32
    R&D Systems Antibodies for LRRC32 (LRRC32/GARP)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for LRRC32
    Novus Biologicals LRRC32 Antibodies
    Search for Antibodies for LRRC32 at Abcam
    Cloud-Clone Corp. Antibodies for LRRC32
    ThermoFisher Antibodies for LRRC32
    LSBio Antibodies in human, mouse, rat for LRRC32

    LRRC32 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRRC32
    R&D Systems Flow Cytometry Kits for LRRC32 (LRRC32/GARP)         (see all)
    GenScript Custom Assay Services for LRRC32
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRRC32
    Cloud-Clone Corp. CLIAs for LRRC32


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000372 LRR-contain_N
     IPR027194 TLR11
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q14392

    ProtoNet protein and cluster: Q14392

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392
    Similarity: Contains 20 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    LRRC32 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0005515protein binding ----
         
    LRRC32 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for LRRC32:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Lrrc32):
     hematopoietic system  immune system 

    LRRC32 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC32
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRRC32

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC32
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC32

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRRC32:
    hsa-mir-335-5p (MIRT017818)

    Block miRNA regulation of human, mouse, rat LRRC32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC32 (see all 21):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-185* hsa-miR-181c hsa-miR-520d-5p hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidLRRC32 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRC32
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC32

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for LRRC32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC32 (NM_005512)
    Sino Biological Human cDNA Clone for LRRC32
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC32

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for LRRC32 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC32


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRC32_HUMAN, Q14392: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    golgi apparatus1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane TAS8180135
    GO:0016021integral component of membrane ----

    LRRC32 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including LRRC32: 
              T Helper Cell Differentiation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LRRC32

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRRC32 (ENSP000002600614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGFB1ENSP000002219304STRING: ENSP00000221930
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002755MyD88-dependent toll-like receptor signaling pathway ----
    GO:0009617response to bacterium ----
    GO:0010628positive regulation of gene expression IEA--
    GO:0034170toll-like receptor 11 signaling pathway ----
    GO:0045087innate immune response ----

    LRRC32 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC32 (LRC32)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRRC32 gene (2 alternative transcripts): 
    NM_001128922.1  NM_005512.2  

    Unigene Cluster for LRRC32:

    Leucine rich repeat containing 32
    Hs.151641  [show with all ESTs]
    Unigene Representative Sequence: NM_005512
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260061(uc001oxr.4) ENST00000404995 ENST00000464145 ENST00000421973
    ENST00000407242(uc001oxq.4 uc010rsf.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRC32 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRRC32 (see all 21):
    hsa-miR-142-3p hsa-miR-3607-3p hsa-miR-185* hsa-miR-181c hsa-miR-520d-5p hsa-miR-3150a-3p hsa-miR-515-5p hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidLRRC32 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRRC32
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC32
    Clone
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    OriGene clones in human, mouse for LRRC32 (see all 12)
    OriGene ORF clones in mouse, rat for LRRC32
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LRRC32 (NM_005512)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC32
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC32
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRRC32
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC32
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC32
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC32
      QuantiFast Probe-based Assays in human, mouse, rat LRRC32

    Additional mRNA sequence: 

    AK314971.1 BC052210.1 BC070079.1 Z24680.1 

    5 DOTS entries:

    DT.415518  DT.100786497  DT.415519  DT.92429412  DT.95267453 

    Selected AceView cDNA sequences (see all 157):

    CA398157 AI831859 BM704943 AI584033 BM716482 BM857468 AW137875 AW025243 
    BU738541 BM721075 CF455348 BM679501 AW003074 BQ723284 CR618700 AI433330 
    AI695331 BM676046 BU074224 AI093446 AI000963 AW951439 BI489753 Z24680 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:        -                           
    SP2:                                    
    SP3:                    -     -         


    ECgene alternative splicing isoforms for LRRC32

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC32 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGTGGGCTC
    LRRC32 Expression
    About this image

    LRRC32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC32 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.151641

    UniProtKB/Swiss-Prot: LRC32_HUMAN, Q14392
    Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs))

        Pathway & Disease-focused RT2 Profiler PCR Array including LRRC32: 
              T Helper Cell Differentiation in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for LRRC32
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    QuantiFast Probe-based Assays in human, mouse, rat LRRC32
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC32

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRRC32 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc321 , 5 leucine rich repeat containing 321, 5 81(n)1
    79.66(a)1
      7 (53.86 cM)5
    4342151  NM_001113379.11  NP_001106850.11 
     984942225 
    chicken
    (Gallus gallus)
    Aves LRRC321 leucine rich repeat containing 32 52.99(n)
    47.89(a)
      428121  XM_004938944.1  XP_004939001.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC326
    leucine rich repeat containing 32
    41(a)
    1 ↔ 1
    GL343493.1(435110-457153)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrrc321 leucine rich repeat containing 32 50.27(n)
    43.15(a)
      100489763  XM_004912216.1  XP_004912273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001488671 leucine-rich repeat-containing protein 32-like 53.16(n)
    43.06(a)
      100148867  XM_001920541.3  XP_001920576.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG51956
    --
    11(a)
    1 → many
    3L(20447790-20457962)
    worm
    (Caenorhabditis elegans)
    Secernentea lron-156
    Protein LRON-15 (lron-15) mRNA, complete cds
    13(a)
    1 → many
    II(6540217-6544892) WBGene00016974


    ENSEMBL Gene Tree for LRRC32 (if available)
    TreeFam Gene Tree for LRRC32 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC32 gene
    NRROS2  
    3 SIMAP similar genes for LRRC32 using alignment to 2 protein entries:     LRC32_HUMAN (see all proteins):
    LINGO1    NRROS    SLIT2

    LRRC32 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC32 (see all 364)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs745507291,2
    C,F--76368110(+) TCACTG/ATTTTT 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs734996111,2
    C--76368198(+) ATGACG/AGGGTA 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs774643121,2
    C,F--76368258(+) CTCTGC/AGATAG 2 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1447339461,2
    --76368324(+) GAAACA/CAACGG 2 -- ds50010--------
    rs49450961,2
    C,F,A,H--76368327(+) ACAAAC/TGGAAG 2 -- ds500127Minor allele frequency- T:0.33NA NS EA WA CSA 2670
    rs1885678871,2
    --76368474(+) GGATTC/TGCCAT 2 -- ds50010--------
    rs1479219511,2
    --76368494(+) ACGACC/TGTAAT 2 -- ds50010--------
    rs1417521101,2
    --76368495(+) CGACCA/GTAATG 2 -- ds50010--------
    rs1500506461,2
    --76368516(+) GCAGGA/GTTCTA 2 -- ds50010--------
    rs1931590371,2
    --76368517(+) CAGGGA/TTCTAG 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRRC32 (76368568 - 76381791 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LRRC32: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC32
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC32

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137207    OMIM disorders: --

    7 diseases for LRRC32:    
    About MalaCards
    allergic rhinitis    rhinitis    hepatitis b    asthma
    type 1 diabetes    hepatitis    endotheliitis


    LRRC32 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC32
    Human Genome Epidemiology (HuGE) Navigator: LRRC32 (1 document)

    Export disorders for LRRC32 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC32 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with LRRC32)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PubMed id 8180135)1, 2, 3, 9 Ollendorff V.... Birnbaum D. (Cell Growth Differ. 1994)
    2. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32). (PubMed id 21615933)1, 2 Chan D.V.... McCormick T.S. (BMC Biochem. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions. (PubMed id 1543912)1, 3 Ollendorff V....Birnbaum D. (Mamm. Genome 1992)
    5. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. (PubMed id 19666573)1, 9 Wang R....Unutmaz D. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    6. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PubMed id 19651619)1, 9 Tran D.Q....Shevach E.M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    7. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PubMed id 18628982)1, 9 Wang R....Unutmaz D. (PLoS ONE 2008)
    8. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. (PubMed id 23817569)1 Hinds D.A....Tung J.Y. (Nat. Genet. 2013)
    9. A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. (PubMed id 23886662)1 Weidinger S....Moffatt M.F. (Hum. Mol. Genet. 2013)
    10. miR-142-3p is involved in CD25+ CD4 T cell proliferation by targeting the expression of glycoprotein A repetitions predominant. (PubMed id 23650616)1 Zhou Q....Skapenko A. (J. Immunol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2615 HGNC: 4161 AceView: GARP Ensembl:ENSG00000137507 euGenes: HUgn2615
    ECgene: LRRC32 H-InvDB: LRRC32

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC32 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC32 gene:
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    GeneCards and IP:
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