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Aliases for LRRC32 Gene

Aliases for LRRC32 Gene

  • Leucine Rich Repeat Containing 32 2 3 5
  • Glycoprotein A Repetitions Predominant 2 3 4
  • D11S833E 3 4
  • Garpin 3 4
  • GARP 3 4

External Ids for LRRC32 Gene

Previous HGNC Symbols for LRRC32 Gene

  • D11S833E
  • GARP

Previous GeneCards Identifiers for LRRC32 Gene

  • GC11M076047
  • GC11M076368
  • GC11M072666

Summaries for LRRC32 Gene

Entrez Gene Summary for LRRC32 Gene

  • This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRC32 Gene

LRRC32 (Leucine Rich Repeat Containing 32) is a Protein Coding gene. An important paralog of this gene is NRROS.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC32 Gene

Genomics for LRRC32 Gene

Regulatory Elements for LRRC32 Gene

Promoters for LRRC32 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC32 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC32 Gene

Chromosome:
11
Start:
76,657,524 bp from pter
End:
76,670,946 bp from pter
Size:
13,423 bases
Orientation:
Minus strand

Genomic View for LRRC32 Gene

Genes around LRRC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC32 Gene

Proteins for LRRC32 Gene

  • Protein details for LRRC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14392-LRC32_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 32
    Protein Accession:
    Q14392
    Secondary Accessions:
    • Q86V06

    Protein attributes for LRRC32 Gene

    Size:
    662 amino acids
    Molecular mass:
    71979 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52210.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC32 Gene

Proteomics data for LRRC32 Gene at MOPED

Post-translational modifications for LRRC32 Gene

  • Glycosylation at Asn 203, Asn 271, Asn 308, Asn 345, and Asn 545
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC32 Gene

Antibody Products

No data available for DME Specific Peptides for LRRC32 Gene

Domains & Families for LRRC32 Gene

Suggested Antigen Peptide Sequences for LRRC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14392

UniProtKB/Swiss-Prot:

LRC32_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 20 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
Similarity:
  • Contains 20 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC32: view

No data available for Gene Families for LRRC32 Gene

Function for LRRC32 Gene

genes like me logo Genes that share phenotypes with LRRC32: view

Animal Model Products

miRNA for LRRC32 Gene

miRTarBase miRNAs that target LRRC32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC32 Gene

Localization for LRRC32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC32 Gene COMPARTMENTS Subcellular localization image for LRRC32 gene
Compartment Confidence
plasma membrane 5
extracellular 2
golgi apparatus 2
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for LRRC32 Gene

Pathways & Interactions for LRRC32 Gene

SuperPathways for LRRC32 Gene

No Data Available

Interacting Proteins for LRRC32 Gene

Gene Ontology (GO) - Biological Process for LRRC32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC32 Gene

Drugs & Compounds for LRRC32 Gene

No Compound Related Data Available

Transcripts for LRRC32 Gene

Unigene Clusters for LRRC32 Gene

Leucine rich repeat containing 32:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for LRRC32 Gene

GeneLoc Exon Structure for
LRRC32
ECgene alternative splicing isoforms for
LRRC32

Expression for LRRC32 Gene

mRNA expression in normal human tissues for LRRC32 Gene

Protein differential expression in normal tissues from HIPED for LRRC32 Gene

This gene is overexpressed in Serum (41.8) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC32 Gene



SOURCE GeneReport for Unigene cluster for LRRC32 Gene Hs.151641

mRNA Expression by UniProt/SwissProt for LRRC32 Gene

Q14392-LRC32_HUMAN
Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs)).
genes like me logo Genes that share expression patterns with LRRC32: view

Protein tissue co-expression partners for LRRC32 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LRRC32 Gene

Orthologs for LRRC32 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC32 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC32 35
  • 86.37 (n)
  • 85.07 (a)
LRRC32 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC32 35
  • 86 (n)
  • 84.6 (a)
LRRC32 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc32 35
  • 81 (n)
  • 79.66 (a)
Lrrc32 16
Lrrc32 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC32 35
  • 99.14 (n)
  • 98.94 (a)
LRRC32 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc32 35
  • 81.57 (n)
  • 80.9 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC32 36
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC32 35
  • 52.99 (n)
  • 47.89 (a)
LRRC32 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC32 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc32 35
  • 50.27 (n)
  • 43.15 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148867 35
  • 53.16 (n)
  • 43.06 (a)
lrrc32 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 36
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
ManyToMany
Species with no ortholog for LRRC32:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC32 Gene

ENSEMBL:
Gene Tree for LRRC32 (if available)
TreeFam:
Gene Tree for LRRC32 (if available)

Paralogs for LRRC32 Gene

Paralogs for LRRC32 Gene

(3) SIMAP similar genes for LRRC32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC32: view

Variants for LRRC32 Gene

Sequence variations from dbSNP and Humsavar for LRRC32 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35033061 - 76,660,926(+) GTCTA(C/G/T)CACCC reference, missense
rs35130967 - 76,660,661(+) GGCGG(C/G)CGCTG reference, missense
rs7685 -- 76,657,595(-) AGGCC(G/T)CAGCC utr-variant-3-prime
rs867566 -- 76,660,633(-) AATCT(A/G)GATTT reference, synonymous-codon
rs1056564 -- 76,658,483(-) ACATA(G/T)CCCGA intron-variant, utr-variant-3-prime

Variation tolerance for LRRC32 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC32 Gene

HapMap Linkage Disequilibrium report
LRRC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC32 Gene

Disorders for LRRC32 Gene

Relevant External Links for LRRC32

Genetic Association Database (GAD)
LRRC32
Human Genome Epidemiology (HuGE) Navigator
LRRC32
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC32

No disorders were found for LRRC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC32 Gene

Publications for LRRC32 Gene

  1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PMID: 8180135) Ollendorff V. … Birnbaum D. (Cell Growth Differ. 1994) 2 3 4 23 67
  2. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PMID: 19651619) Tran D.Q. … Shevach E.M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. (PMID: 19666573) Wang R. … Unutmaz D. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. (PMID: 18628982) Wang R. … Unutmaz D. (PLoS ONE 2008) 3 23
  5. New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions. (PMID: 1543912) Ollendorff V. … Birnbaum D. (Mamm. Genome 1992) 2 3

Products for LRRC32 Gene

Sources for LRRC32 Gene

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