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Aliases for LRRC32 Gene

Aliases for LRRC32 Gene

  • Leucine Rich Repeat Containing 32 2 3 5
  • Glycoprotein A Repetitions Predominant 2 3 4
  • D11S833E 3 4
  • Garpin 3 4
  • GARP 3 4
  • Leucine-Rich Repeat-Containing Protein 32 3

External Ids for LRRC32 Gene

Previous HGNC Symbols for LRRC32 Gene

  • D11S833E
  • GARP

Previous GeneCards Identifiers for LRRC32 Gene

  • GC11M076047
  • GC11M076368
  • GC11M072666

Summaries for LRRC32 Gene

Entrez Gene Summary for LRRC32 Gene

  • This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRRC32 Gene

LRRC32 (Leucine Rich Repeat Containing 32) is a Protein Coding gene. An important paralog of this gene is NRROS.

Additional gene information for LRRC32 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC32 Gene

Genomics for LRRC32 Gene

GeneHancer (GH) Regulatory Elements for LRRC32 Gene

Promoters and enhancers for LRRC32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I076669 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.4 -384 5.2 HDAC1 PKNOX1 FOXA2 SIN3A NFXL1 GLI4 EGR1 ZNF143 ATF7 ETV6 LRRC32 LOC107984360 ENSG00000254975
GH11I076601 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.7 +67.3 67269 4.5 MAX PYGO2 ZNF366 POLR2A RCOR1 NR2F6 CHD2 MTA2 RXRA NR2F1 LRRC32 ENSG00000254975 LOC107984360 ENSG00000254810 GVQW3 ENSG00000254755 ENSG00000255479
GH11I076626 Enhancer 1 Ensembl ENCODE 13.3 +43.6 43645 1 PKNOX1 BATF ZNF143 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 SMARCA5 CBFB ENSG00000255479 LOC107984360 ENSG00000254810 LRRC32 ENSG00000254975 LOC101928813 ENSG00000255363
GH11I076614 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.8 +54.7 54690 3.7 POLR2A GABPB1 ZSCAN4 ZFP36 ZIC2 CREM GABPA LRRC32 ENSG00000254975 LOC107984360 ENSG00000254810 GVQW3 ENSG00000255363 ENSG00000255479 LOC101928813 ENSG00000254755
GH11I076605 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.7 +64.5 64524 1 MTA2 NR2F1 NR2C1 NR2F6 PYGO2 NR2F2 NR2C2 LRRC32 ENSG00000254975 LOC107984360 ENSG00000254810 ENSG00000254755 ENSG00000255479
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC32 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC32 gene promoter:

Genomic Locations for LRRC32 Gene

Genomic Locations for LRRC32 Gene
chr11:76,657,524-76,670,946
(GRCh38/hg38)
Size:
13,423 bases
Orientation:
Minus strand
chr11:76,368,568-76,381,791
(GRCh37/hg19)

Genomic View for LRRC32 Gene

Genes around LRRC32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC32 Gene

Proteins for LRRC32 Gene

  • Protein details for LRRC32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14392-LRC32_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 32
    Protein Accession:
    Q14392
    Secondary Accessions:
    • Q86V06

    Protein attributes for LRRC32 Gene

    Size:
    662 amino acids
    Molecular mass:
    71979 Da
    Quaternary structure:
    • Interacts with LAPTM4B; decreases TGFB1 production in regulatory T cells.
    SequenceCaution:
    • Sequence=AAH52210.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC32 Gene

Post-translational modifications for LRRC32 Gene

  • Glycosylation at posLast=203203, isoforms=271, posLast=308308, isoforms=345, and posLast=545545

No data available for DME Specific Peptides for LRRC32 Gene

Domains & Families for LRRC32 Gene

Gene Families for LRRC32 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for LRRC32 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC32: view

No data available for UniProtKB/Swiss-Prot for LRRC32 Gene

Function for LRRC32 Gene

Phenotypes From GWAS Catalog for LRRC32 Gene

Gene Ontology (GO) - Molecular Function for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26126825
genes like me logo Genes that share ontologies with LRRC32: view
genes like me logo Genes that share phenotypes with LRRC32: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC32 Gene

Localization for LRRC32 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC32 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC32 gene
Compartment Confidence
plasma membrane 5
extracellular 3
golgi apparatus 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005887 integral component of plasma membrane TAS 8180135
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC32: view

Pathways & Interactions for LRRC32 Gene

SuperPathways for LRRC32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IEA --
GO:0046007 negative regulation of activated T cell proliferation IEA --
GO:0050710 negative regulation of cytokine secretion IEA --
genes like me logo Genes that share ontologies with LRRC32: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC32 Gene

Drugs & Compounds for LRRC32 Gene

No Compound Related Data Available

Transcripts for LRRC32 Gene

Unigene Clusters for LRRC32 Gene

Leucine rich repeat containing 32:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC32 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - -

Relevant External Links for LRRC32 Gene

GeneLoc Exon Structure for
LRRC32
ECgene alternative splicing isoforms for
LRRC32

Expression for LRRC32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC32 Gene

Protein differential expression in normal tissues from HIPED for LRRC32 Gene

This gene is overexpressed in Serum (41.8) and Peripheral blood mononuclear cells (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC32 Gene



Protein tissue co-expression partners for LRRC32 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC32 Gene:

LRRC32

SOURCE GeneReport for Unigene cluster for LRRC32 Gene:

Hs.151641

mRNA Expression by UniProt/SwissProt for LRRC32 Gene:

Q14392-LRC32_HUMAN
Tissue specificity: Preferentially expressed in regulatory T-cells (T(regs)).

Evidence on tissue expression from TISSUES for LRRC32 Gene

  • Liver(4.2)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with LRRC32: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC32 Gene

Orthologs for LRRC32 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC32 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC32 33 34
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia LRRC32 33 34
  • 86.37 (n)
dog
(Canis familiaris)
Mammalia LRRC32 33 34
  • 86 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc32 33
  • 81.57 (n)
mouse
(Mus musculus)
Mammalia Lrrc32 33 16 34
  • 81 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC32 34
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC32 33 34
  • 52.99 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC32 34
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc32 33
  • 50.27 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100148867 33
  • 53.16 (n)
lrrc32 34
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5195 34
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-15 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
ManyToMany
Species where no ortholog for LRRC32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC32 Gene

ENSEMBL:
Gene Tree for LRRC32 (if available)
TreeFam:
Gene Tree for LRRC32 (if available)

Paralogs for LRRC32 Gene

Paralogs for LRRC32 Gene

(3) SIMAP similar genes for LRRC32 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC32: view

Variants for LRRC32 Gene

Sequence variations from dbSNP and Humsavar for LRRC32 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000154886 -- 76,668,106(-) A/G intron_variant
rs1000188933 -- 76,664,615(-) G/A intron_variant
rs1000610097 -- 76,667,848(-) T/C intron_variant
rs1000699215 -- 76,670,354(-) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000751103 -- 76,670,548(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC32 Gene

Variant ID Type Subtype PubMed ID
dgv1228n100 CNV loss 25217958
nsv1047069 CNV gain 25217958
nsv555448 CNV gain 21841781

Variation tolerance for LRRC32 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.88; 59.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC32 Gene

Human Gene Mutation Database (HGMD)
LRRC32
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC32

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC32 Gene

Disorders for LRRC32 Gene

Additional Disease Information for LRRC32

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for LRRC32 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC32 Gene

Publications for LRRC32 Gene

  1. The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. (PMID: 8180135) Ollendorff V … Birnbaum D (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994) 2 3 4 22 58
  2. Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells. (PMID: 26126825) Huygens C … Lucas S (The Journal of biological chemistry 2015) 3 4 58
  3. Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32). (PMID: 21615933) Chan DV … McCormick TS (BMC biochemistry 2011) 3 4 58
  4. GARP (LRRC32) is essential for the surface expression of latent TGF-beta on platelets and activated FOXP3+ regulatory T cells. (PMID: 19651619) Tran DQ … Shevach EM (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 58
  5. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. (PMID: 19666573) Wang R … Unutmaz D (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 58

Products for LRRC32 Gene

Sources for LRRC32 Gene

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