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Aliases for LRRC3 Gene

Aliases for LRRC3 Gene

  • Leucine Rich Repeat Containing 3 2 3 5
  • C21orf102 3 4
  • LRRC3 Downstream Neighbor (Non-Protein Coding) 3
  • Leucine-Rich Repeat-Containing Protein 3 3
  • Chromosome 21 Open Reading Frame 102 2
  • Intronless Long ORF, AL117578 3
  • C21orf30 3
  • LRRC3DN 3
  • LRRC3A 4

External Ids for LRRC3 Gene

Previous HGNC Symbols for LRRC3 Gene

  • C21orf102

Previous GeneCards Identifiers for LRRC3 Gene

  • GC21P042386
  • GC21P044732
  • GC21P044699
  • GC21P045875
  • GC21P031231

Summaries for LRRC3 Gene

GeneCards Summary for LRRC3 Gene

LRRC3 (Leucine Rich Repeat Containing 3) is a Protein Coding gene. An important paralog of this gene is LRRC3B.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC3 Gene

Genomics for LRRC3 Gene

Regulatory Elements for LRRC3 Gene

Enhancers for LRRC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G044455 0.8 ENCODE 7.6 -0.2 -174 0.3 KLF1 TFAP4 SAP130 KLF17 FOSL1 ZFHX2 GLIS2 PATZ1 PRDM10 FOS LRRC3 C21orf2 LRRC3-AS1
GH21G044456 0.9 ENCODE 0.7 +0.3 345 0.6 FUS SIN3A ZNF48 RAD21 FOS MXD4 ZBTB26 MYC RBFOX2 CTCF LRRC3 GC21P044459
GH21G044457 0.9 ENCODE 0.7 +2.7 2710 2.2 FOXA2 MLX ARID4B DMAP1 YY1 ZNF263 PPARG KAT8 SREBF1 SSRP1 C21orf2 GC21P044459 LRRC3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC3 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143068 114 1201 FUS KLF17 SIN3A ZNF48 RAD21 GLIS2 FOS EGR2 SP3 SP5

Genomic Location for LRRC3 Gene

Chromosome:
21
Start:
44,455,486 bp from pter
End:
44,462,196 bp from pter
Size:
6,711 bases
Orientation:
Plus strand

Genomic View for LRRC3 Gene

Genes around LRRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC3 Gene

Proteins for LRRC3 Gene

  • Protein details for LRRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY71-LRRC3_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 3
    Protein Accession:
    Q9BY71
    Secondary Accessions:
    • Q0VDJ2

    Protein attributes for LRRC3 Gene

    Size:
    257 amino acids
    Molecular mass:
    28108 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC3 Gene

Post-translational modifications for LRRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC3 Gene

Domains & Families for LRRC3 Gene

Suggested Antigen Peptide Sequences for LRRC3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BY71

UniProtKB/Swiss-Prot:

LRRC3_HUMAN :
  • Belongs to the LRRC3 family.
Family:
  • Belongs to the LRRC3 family.
genes like me logo Genes that share domains with LRRC3: view

No data available for Gene Families for LRRC3 Gene

Function for LRRC3 Gene

Gene Ontology (GO) - Molecular Function for LRRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 17474147
genes like me logo Genes that share ontologies with LRRC3: view

Phenotypes for LRRC3 Gene

genes like me logo Genes that share phenotypes with LRRC3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC3 Gene

Localization for LRRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC3 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC3 gene
Compartment Confidence
plasma membrane 2
extracellular 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC3: view

Pathways & Interactions for LRRC3 Gene

SuperPathways for LRRC3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with LRRC3: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC3 Gene

Drugs & Compounds for LRRC3 Gene

No Compound Related Data Available

Transcripts for LRRC3 Gene

mRNA/cDNA for LRRC3 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC3 Gene

Leucine rich repeat containing 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC3 Gene

No ASD Table

Relevant External Links for LRRC3 Gene

GeneLoc Exon Structure for
LRRC3
ECgene alternative splicing isoforms for
LRRC3

Expression for LRRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC3 Gene

This gene is overexpressed in Liver (x6.8).

Protein differential expression in normal tissues from HIPED for LRRC3 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC3 Gene



Protein tissue co-expression partners for LRRC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC3 Gene:

LRRC3

SOURCE GeneReport for Unigene cluster for LRRC3 Gene:

Hs.326579

mRNA Expression by UniProt/SwissProt for LRRC3 Gene:

Q9BY71-LRRC3_HUMAN
Tissue specificity: Widely expressed; detected in testis, lung, small intestine, breast, brain, heart, bone marrow, placenta, colon, fetal brain, liver, fetal liver, thymus, salivary gland, spinal cord, spleen, trachea and adrenal gland.
genes like me logo Genes that share expression patterns with LRRC3: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC3 Gene

Orthologs for LRRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC3 34 35
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia LRRC3 34 35
  • 86.84 (n)
dog
(Canis familiaris)
Mammalia LRRC3 34 35
  • 85.47 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc3 34
  • 81.73 (n)
mouse
(Mus musculus)
Mammalia Lrrc3 34 16 35
  • 79.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC3 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC3 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492333 34
  • 65.46 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc3 34 35
  • 61.97 (n)
Species where no ortholog for LRRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC3 Gene

ENSEMBL:
Gene Tree for LRRC3 (if available)
TreeFam:
Gene Tree for LRRC3 (if available)

Paralogs for LRRC3 Gene

Paralogs for LRRC3 Gene

(2) SIMAP similar genes for LRRC3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC3: view

Variants for LRRC3 Gene

Sequence variations from dbSNP and Humsavar for LRRC3 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000374229 -- 44,457,738(+) GGGCC(C/G)TGCAG utr-variant-3-prime
rs1001258395 -- 44,456,733(+) CCTGG(A/G)CGCCG upstream-variant-2KB, reference, missense
rs1001419279 -- 44,458,354(+) AGACC(A/G)GGTTT utr-variant-3-prime
rs1002287224 -- 44,458,621(+) CTCAG(A/G)GATAA utr-variant-3-prime
rs1002828057 -- 44,457,312(+) CGTCG(C/T)GTACT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LRRC3 Gene

Variant ID Type Subtype PubMed ID
dgv722n67 CNV gain 20364138
esv2723638 CNV deletion 23290073
esv33817 CNV loss 17666407
nsv1058359 CNV gain 25217958
nsv1122046 CNV deletion 24896259
nsv509800 CNV insertion 20534489
nsv587801 CNV loss 21841781
nsv834109 CNV loss 17160897
nsv953646 CNV deletion 24416366

Variation tolerance for LRRC3 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC3 Gene

Disorders for LRRC3 Gene

Relevant External Links for LRRC3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC3

No disorders were found for LRRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC3 Gene

Publications for LRRC3 Gene

  1. Nineteen additional unpredicted transcripts from human chromosome 21. (PMID: 12036297) Reymond A. … Antonarakis S.E. (Genomics 2002) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters. (PMID: 20494980) Warnatz H.J. … Yaspo M.L. (Nucleic Acids Res. 2010) 3 64
  5. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. (PMID: 19710015) Crawford N.P. … Hunter K.W. (J. Biol. Chem. 2009) 3 64

Products for LRRC3 Gene

Sources for LRRC3 Gene

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