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LRRC28 Gene

protein-coding   GIFtS: 44
GCID: GC15P099791

Leucine Rich Repeat Containing 28

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 281 2
Leucine-Rich Repeat-Containing Protein 282

External Ids:    HGNC: 283551   Entrez Gene: 1233552   Ensembl: ENSG000001689047   UniProtKB: Q86X403   

Export aliases for LRRC28 gene to outside databases

Previous GC identifers: GC15P097527 GC15P097609 GC15P075921


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC28 Gene:
LRRC28 (leucine rich repeat containing 28) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC28 gene promoter:
         ER-alpha   SRF   STAT1   SRF (504 AA)   STAT1beta   HSF1 (long)   IRF-1   E47   SRY   HSF1short   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC28 promoter sequence
   Search Chromatin IP Primers for LRRC28

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3   Ensembl cytogenetic band:  15q26.3   HGNC cytogenetic band: 15q26.3

LRRC28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC28 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P099791:  view genomic region     (about GC identifiers)

Start:
99,791,567 bp from pter      End:
99,930,934 bp from pter
Size:
139,368 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRC28_HUMAN, Q86X40 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 28  
Size: 367 amino acids; 41912 Da
Secondary accessions: A8KA22 Q6UY49 Q6ZSS6
Alternative splicing: 3 isoforms:  Q86X40-1   Q86X40-2   Q86X40-3   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for LRRC28: NX_Q86X40

Explore proteomics data for LRRC28 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys134, Lys217, Lys226, Lys243
  • Modification sites at PhosphoSitePlus

  • See LRRC28 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001271329.1  NP_653199.2  

    ENSEMBL proteins: 
     ENSP00000453313   ENSP00000304923   ENSP00000453469   ENSP00000452927   ENSP00000452709  
     ENSP00000404520   ENSP00000453504   ENSP00000452863   ENSP00000332035   ENSP00000452785  
     ENSP00000454182   ENSP00000398606   ENSP00000404206  

    LRRC28 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for LRRC28

     
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    LSBio Antibodies in human, mouse, rat for LRRC28

    LRRC28 Assay Products:

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    Cloud-Clone Corp. ELISAs for LRRC28
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    Search eBioscience for ELISAs for LRRC28 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR003591 Leu-rich_rpt_typical-subtyp

    Graphical View of Domain Structure for InterPro Entry Q86X40

    ProtoNet protein and cluster: Q86X40

    UniProtKB/Swiss-Prot: LRC28_HUMAN, Q86X40
    Similarity: Contains 9 LRR (leucine-rich) repeats


    Find genes that share domains with LRRC28           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRRC28           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC28
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRRC28
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRRC28

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRRC28:
    hsa-mir-34a-5p (MIRT047396)

    Block miRNA regulation of human, mouse, rat LRRC28 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LRRC28:
    hsa-miR-3910 hsa-miR-3659 hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidLRRC28 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRRC28
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC28

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LRRC28

    Clone
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    GenScript: all cDNA clones in your preferred vector: LRRC28 (NM_144598)
    Sino Biological Human cDNA Clone for LRRC28
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC28

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC28


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    extracellular1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC28
    Interactions:

        Search GeneGlobe Interaction Network for LRRC28

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LRRC28 (ENSP000003049234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC28 (LRC28)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRRC28 gene (2 alternative transcripts): 
    NM_001284400.1  NM_144598.3  

    Unigene Cluster for LRRC28:

    Leucine rich repeat containing 28
    Hs.578684  [show with all ESTs]
    Unigene Representative Sequence: AL833556
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000558879 ENST00000301981(uc010urs.1 uc002bva.1 uc002bvb.1 uc010urt.1 uc002bvc.1 uc010uru.1 uc002bvd.1)
    ENST00000559399 ENST00000560213 ENST00000559433 ENST00000558471 ENST00000561253
    ENST00000558500 ENST00000447360 ENST00000558172 ENST00000561276 ENST00000331450
    ENST00000558861 ENST00000558771 ENST00000558248 ENST00000558890 ENST00000559819
    ENST00000559774
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRRC28 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate LRRC28:
    hsa-miR-3910 hsa-miR-3659 hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidLRRC28 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRRC28
    Predesigned siRNA for gene silencing in human, mouse, rat LRRC28
    Clone
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    OriGene clones in human, mouse for LRRC28 (see all 8)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRRC28 (NM_144598)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRRC28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC28
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRRC28
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRRC28
      QuantiTect SYBR Green Assays in human, mouse, rat LRRC28
      QuantiFast Probe-based Assays in human, mouse, rat LRRC28

    Additional mRNA sequence: 

    AK091588.1 AK127177.1 AK292887.1 AK293832.1 AK295161.1 AK296352.1 AL833556.1 AY358082.1 
    BC019704.1 BC047306.1 

    12 DOTS entries:

    DT.312730  DT.40262514  DT.99944871  DT.99956048  DT.95073158  DT.121068895  DT.121068942  DT.121068899 
    DT.40125116  DT.100782682  DT.100832558  DT.121068964 

    Selected AceView cDNA sequences (see all 139):

    AA580479 BX110980 AW769415 AY358082 AA994195 AI677843 BX109249 CD677519 
    BM718038 AI217148 AA334258 BM728736 CR593703 AI912966 BM547483 AI809237 
    BQ188174 AI419434 NM_144598 W21176 BP371674 AA777514 CR606315 AI217725 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGAGCTTC
    LRRC28 Expression
    About this image

    LRRC28 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC28 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.578684
        Custom PCR Arrays for LRRC28
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRRC28 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc281 , 5 leucine rich repeat containing 281, 5 88.16(n)1
    90.16(a)1
      7 (37.05 cM)5
    678671  NM_175124.51  NP_780333.31 
     675134115 
    chicken
    (Gallus gallus)
    Aves LRRC281 leucine rich repeat containing 28 76.16(n)
    83.58(a)
      415512  NM_001005822.1  NP_001005822.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC286
    leucine rich repeat containing 28
    87(a)
    1 ↔ 1
    GL343383.1(338680-370840)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.41162 Transcribed sequence with weak similarity to protein more 74.81(n)    142004289 
    zebrafish
    (Danio rerio)
    Actinopterygii lrrc281 leucine rich repeat containing 28 67.85(n)
    70.14(a)
      555592  XM_005166377.1  XP_005166434.1 


    ENSEMBL Gene Tree for LRRC28 (if available)
    TreeFam Gene Tree for LRRC28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC28 gene
    10 SIMAP similar genes for LRRC28 using alignment to 12 protein entries:     LRC28_HUMAN (see all proteins):
    LRRD1    LRRC57    PHLPP2    LRRC1    SCRIB    LRCH1
    LRRC8B    ERBB2IP    FLII    LRCH3

    Find genes that share paralogs with LRRC28           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LRRC28
    PGOHUM00000241856


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRRC28 (see all 2544)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829008851,2
    --99791940(+) CCTGGC/GACCCG 1 -- int10--------
    rs284338551,2
    F--99792044(+) GGCGTG/CTGTTT 1 -- int11Minor allele frequency- C:0.07WA 118
    rs604240901,2
    C,F--99792049(+) GTGTTT/ATGCCT 1 -- int12Minor allele frequency- A:0.50WA 4
    rs1871985531,2
    --99792155(+) GAAATG/TGGAAT 1 -- int10--------
    rs284754271,2
    C--99792173(+) CTACTA/GAATTG 1 -- int10--------
    rs567454381,2
    C,F--99792334(+) CAGCTG/CTATAC 1 -- int12Minor allele frequency- C:0.08WA 120
    rs1916162821,2
    --99792348(+) TGATAC/TTAAGT 1 -- int10--------
    rs1144008411,2
    C--99792375(+) ACTACA/GTAAGA 1 -- int10--------
    rs1401991691,2
    --99792415(+) CTTAAC/GTAGGT 1 -- int10--------
    rs620237681,2
    C,F--99792471(+) GGCTGT/CGTATG 1 -- int16Minor allele frequency- C:0.12NA CSA WA EA 364

    HapMap Linkage Disequilibrium report for LRRC28 (99791567 - 99930934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LRRC28:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv268373CNV Insertion20981092
    nsv516288CNV Loss19592680
    nsv904543CNV Gain21882294
    nsv904546CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC28
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC28

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC28 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LRRC28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 123355 HGNC: 28355 AceView: LRRC28 Ensembl:ENSG00000168904 euGenes: HUgn123355
    ECgene: LRRC28 H-InvDB: LRRC28

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC28 gene:
    Search GeneIP for patents involving LRRC28

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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