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Aliases for LRRC28 Gene

Aliases for LRRC28 Gene

  • Leucine Rich Repeat Containing 28 2 3

External Ids for LRRC28 Gene

Previous GeneCards Identifiers for LRRC28 Gene

  • GC15P097527
  • GC15P097609
  • GC15P099791
  • GC15P075921

Summaries for LRRC28 Gene

GeneCards Summary for LRRC28 Gene

LRRC28 (Leucine Rich Repeat Containing 28) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC28 Gene

Genomics for LRRC28 Gene

Regulatory Elements for LRRC28 Gene

Genomic Location for LRRC28 Gene

99,251,362 bp from pter
99,390,729 bp from pter
139,368 bases
Plus strand

Genomic View for LRRC28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC28 Gene

Proteins for LRRC28 Gene

  • Protein details for LRRC28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 28
    Protein Accession:
    Secondary Accessions:
    • A8KA22
    • Q6UY49
    • Q6ZSS6

    Protein attributes for LRRC28 Gene

    367 amino acids
    Molecular mass:
    41912 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC28 Gene


neXtProt entry for LRRC28 Gene

Proteomics data for LRRC28 Gene at MOPED

Post-translational modifications for LRRC28 Gene

  • Ubiquitination at Lys 134, Lys 217, Lys 226, and Lys 243
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC28 Gene

Domains & Families for LRRC28 Gene

Protein Domains for LRRC28 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 9 LRR (leucine-rich) repeats.
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC28: view

No data available for Gene Families for LRRC28 Gene

Function for LRRC28 Gene

Gene Ontology (GO) - Molecular Function for LRRC28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC28: view

Phenotypes for LRRC28 Gene

GenomeRNAi human phenotypes for LRRC28:
genes like me logo Genes that share phenotypes with LRRC28: view

Animal Model Products

miRNA for LRRC28 Gene

miRTarBase miRNAs that target LRRC28

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC28

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC28 Gene

Localization for LRRC28 Gene

Subcellular locations from

Jensen Localization Image for LRRC28 Gene COMPARTMENTS Subcellular localization image for LRRC28 gene
Compartment Confidence
golgi apparatus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC28 Gene

Pathways & Interactions for LRRC28 Gene

SuperPathways for LRRC28 Gene

No Data Available

Interacting Proteins for LRRC28 Gene

Gene Ontology (GO) - Biological Process for LRRC28 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC28 Gene

Drugs & Compounds for LRRC28 Gene

No Compound Related Data Available

Transcripts for LRRC28 Gene

Unigene Clusters for LRRC28 Gene

Leucine rich repeat containing 28:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC28 Gene

No ASD Table

Relevant External Links for LRRC28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC28 Gene

mRNA expression in normal human tissues for LRRC28 Gene

Protein differential expression in normal tissues from HIPED for LRRC28 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC28 Gene

SOURCE GeneReport for Unigene cluster for LRRC28 Gene Hs.578684

genes like me logo Genes that share expression patterns with LRRC28: view

Protein tissue co-expression partners for LRRC28 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC28 Gene

Orthologs for LRRC28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC28 35
  • 92.64 (n)
  • 95.37 (a)
LRRC28 36
  • 95 (a)
(Canis familiaris)
Mammalia LRRC28 35
  • 93.19 (n)
  • 96.19 (a)
LRRC28 36
  • 96 (a)
(Mus musculus)
Mammalia Lrrc28 35
  • 88.16 (n)
  • 90.16 (a)
Lrrc28 16
Lrrc28 36
  • 90 (a)
(Pan troglodytes)
Mammalia LRRC28 35
  • 99.18 (n)
  • 99.73 (a)
LRRC28 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrrc28 35
  • 88.34 (n)
  • 90.98 (a)
(Monodelphis domestica)
Mammalia LRRC28 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC28 36
  • 91 (a)
(Gallus gallus)
Aves LRRC28 35
  • 76.16 (n)
  • 83.58 (a)
LRRC28 36
  • 93 (a)
(Anolis carolinensis)
Reptilia LRRC28 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc28 35
  • 73.02 (n)
  • 80.93 (a)
Str.4116 35
(Danio rerio)
Actinopterygii lrrc28 35
  • 67.85 (n)
  • 70.14 (a)
lrrc28 36
  • 70 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for LRRC28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC28 Gene

Gene Tree for LRRC28 (if available)
Gene Tree for LRRC28 (if available)

Paralogs for LRRC28 Gene Pseudogenes for LRRC28 Gene

genes like me logo Genes that share paralogs with LRRC28: view

No data available for Paralogs for LRRC28 Gene

Variants for LRRC28 Gene

Sequence variations from dbSNP and Humsavar for LRRC28 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs768159 -- 99,385,850(-) GTACA(C/T)GTGAA intron-variant, downstream-variant-500B
rs906975 -- 99,264,938(-) TTTCT(C/T)TACTT intron-variant
rs906976 -- 99,263,476(-) TACTT(C/T)TAATA intron-variant
rs906977 -- 99,263,382(-) ATTTT(C/T)TAAGG intron-variant
rs906978 -- 99,263,349(-) TGTTT(C/T)TTAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC28 Gene

Variant ID Type Subtype PubMed ID
nsv904543 CNV Gain 21882294
nsv904546 CNV Gain 21882294
nsv516288 CNV Loss 19592680
esv268373 CNV Insertion 20981092

Variation tolerance for LRRC28 Gene

Residual Variation Intolerance Score: 30.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.74; 46.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC28 Gene

Disorders for LRRC28 Gene

Relevant External Links for LRRC28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LRRC28: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC28 Gene

Publications for LRRC28 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 67
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 67
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67

Products for LRRC28 Gene

Sources for LRRC28 Gene

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