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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRRC28 Gene

protein-coding GIFtS: 39
GCID: GC15P099791

leucine rich repeat containing 28

Search for LRRC28
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine Rich Repeat Containing 28¹ ²
FLJ34269¹
FLJ45242¹
MGC24976¹
Leucine-Rich Repeat-Containing Protein 28²

External Ids:	HGNC: 28355¹	Entrez Gene: 123355²	Ensembl: ENSG00000168904⁷	UniProtKB: Q86X40³

Export aliases for LRRC28 gene to outside databases

Previous GC identifers: GC15P097527 GC15P097609 GC15P075921

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRRC28 gene promoter:
ER-alpha SRF STAT1 SRF (504 AA) STAT1beta HSF1 (long) IRF-1 E47 SRY HSF1short
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRRC28 promoter sequence

Search SABiosciences Chromatin IP Primers for LRRC28

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC28

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26.3

LRRC28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC28 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P099791: view genomic region (about GC identifiers)

Start:	99,791,567 bp from pter	End:	99,930,934 bp from pter
Size:	139,368 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LRC28_HUMAN, Q86X40 (See protein sequence)

Recommended Name: Leucine-rich repeat-containing protein 28

Size: 367 amino acids; 41912 Da

Secondary accessions: A8KA22 Q6UY49 Q6ZSS6

Alternative splicing: 3 isoforms: Q86X40-1 Q86X40-2 Q86X40-3 (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for LRRC28: NX_Q86X40

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q86X40

LRRC28 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_653199.2

ENSEMBL proteins:

ENSP00000453313 ENSP00000304923 ENSP00000453469 ENSP00000452927 ENSP00000452709

ENSP00000404520 ENSP00000453504 ENSP00000452863 ENSP00000332035 ENSP00000452785

ENSP00000454182 ENSP00000398606 ENSP00000404206

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRRC28 for domains About GeneDecksing

1 InterPro domain/family:

IPR003591 Leu-rich_rpt_typical-subtyp

Graphical View of Domain Structure for InterPro Entry Q86X40

ProtoNet protein and cluster: Q86X40

UniProtKB/Swiss-Prot: LRC28_HUMAN, Q86X40

Similarity: Contains 9 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LRRC28

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for LRRC28 (ENSP00000304923⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LRRC28
Search CenterWatch for drugs/clinical trials and news about LRRC28 / LRC28

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LRRC28 gene:

NM_144598.2

Unigene Cluster for LRRC28:

Leucine rich repeat containing 28

Hs.578684 [show with all ESTs]

Unigene Representative Sequence: AL833556

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000558879 ENST00000301981(uc010urs.1 uc002bva.1 uc002bvb.1 uc010urt.1 uc002bvc.1 uc010uru.1 uc002bvd.1)

ENST00000559399 ENST00000560213 ENST00000559433 ENST00000558471 ENST00000561253

ENST00000558500 ENST00000447360 ENST00000558172 ENST00000561276 ENST00000331450

ENST00000558861 ENST00000558771 ENST00000558248 ENST00000558890 ENST00000559819

ENST00000559774

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		hsa-miR-3910 hsa-miR-3659 hsa-miR-544
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Additional cDNA sequence:

AK091588.1 AK127177.1 AK292887.1 AK293832.1 AK295161.1 AK296352.1 AL833556.1 AY358082.1

BC019704.1 BC047306.1

12 DOTS entries:

DT.312730 DT.40262514 DT.99944871 DT.99956048 DT.95073158 DT.121068895 DT.121068942 DT.121068899

DT.40125116 DT.100782682 DT.100832558 DT.121068964

24/139 AceView cDNA sequences (see all 139):

BM727187 BC047306 AA580479 AI809237 BM547483 BP371674 AI912966 BM923994

AI217725 CR606315 AA777514 NM_144598 W21176 BQ188174 AI419434 AI142666

BM728736 CD677519 AI217148 BM718038 AA334258 CR593703 BX109249 AY358082

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRRC28 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTGAGCTTC

About this image
See LRRC28 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC28

SOURCE GeneReport for Unigene cluster: Hs.578684
SABiosciences Custom PCR Arrays for LRRC28

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LRRC28 gene from 4/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LRRC28¹	leucine rich repeat containing 28	78.22(n) 85.4(a)		415512 NM_001005822.1 NP_001005822.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	91(a) 84(a)	1 ↔ many 1 ↔ many	GL343383.1(338840-345417) GL343383.1(355620-370548)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.4116²	Transcribed sequence with weak similarity to protein more	74.81(n)		142004289
zebrafish (Danio rerio)	Actinopterygii	lrrc28¹	leucine rich repeat containing 28	67.95(n) 70.33(a)		555592 XM_678142.5 XP_683234.5

ENSEMBL Gene Tree for LRRC28 (if available)
TreeFam Gene Tree for LRRC28 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRRC28 gene

LRRC8E² LRRC8B² LRRC8A² LRRC8C² LRRC8D² LRRC69²

11 SIMAP similar genes for LRRC28 using alignment to 12 protein entries: LRC28_HUMAN (see all proteins):

LRRD1 LRRC57 PHLPP2 RSU1 LRRC1 SCRIB

LRCH1 LRRC8B ERBB2IP FLII LRCH3

LRRC28 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for LRRC28
PGOHUM00000241856

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs182900885^1,2		--	99791940(+)	`CCTGGC/GACCCG`	1	--	int¹		0	--	--	--	--
rs28433855^1,2	F	--	99792044(+)	`GGCGTG/CTGTTT`	1	--	int¹		1		WA	118
rs60424090^1,2	C,F	--	99792049(+)	`GTGTTT/ATGCCT`	1	--	int¹		2		WA	4
rs187198553^1,2		--	99792155(+)	`GAAATG/TGGAAT`	1	--	int¹		0	--	--	--	--
rs28475427^1,2		--	99792173(+)	`CTACTA/GAATTG`	1	--	int¹		0	--	--	--	--
rs56745438^1,2	C	--	99792334(+)	`CAGCTG/CTATAC`	1	--	int¹		2		WA	120
rs191616282^1,2		--	99792348(+)	`TGATAC/TTAAGT`	1	--	int¹		0	--	--	--	--
rs114400841^1,2	C	--	99792375(+)	`ACTACA/GTAAGA`	1	--	int¹		0	--	--	--	--
rs140199169^1,2		--	99792415(+)	`CTTAAC/GTAGGT`	1	--	int¹		0	--	--	--	--
rs62023768^1,2	C,F	--	99792471(+)	`GGCTGT/CGTATG`	1	--	int¹		6		NA CSA WA EA	364

HapMap Linkage Disequilibrium report for LRRC28 (99791567 - 99930934 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LRRC28
1 CNV: 49635

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC28

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRRC28 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC28)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)² Zody M.C....Nusbaum C. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 123355	HGNC: 28355	AceView: LRRC28	Ensembl:ENSG00000168904	euGenes: HUgn123355
ECgene: LRRC28	H-InvDB: LRRC28

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRRC28	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LRRC28 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LRRC28 gene:
Search GeneIP for patents involving LRRC28

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC28
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	GenScript Custom Purified and Recombinant Proteins Services for LRRC28		GenScript cDNA clones with any tag delivered in your preferred vector for LRRC28
	GenScript Custom Assay Services for LRRC28		GenScript Custom Superior Antibodies Services for LRRC28
	GenScript Custom overexpressing Cell Line Services for LRRC28		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search for Antibodies & Assays

	Regulatory tfbs in LRRC28 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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LRRC28 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC28

	SwitchGear 3'UTR luciferase reporter plasmids for LRRC28
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC28

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LRRC28

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LRRC28 gene at Home site.

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LRRC28 Gene

leucine rich repeat containing 28

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for LRRC28 gene

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Export list of displayed genes

LRRC28 Gene

leucine rich repeat containing 28

Aliasesfor LRRC28 gene

Summariesfor LRRC28 gene

Genomic Viewsfor LRRC28 gene

Proteinsfor LRRC28 gene

Protein Domains /Familiesfor LRRC28 gene

Functionfor LRRC28 gene

Pathways & Interactionsfor LRRC28 gene

Drugs & Compoundsfor LRRC28 gene

Transcriptsfor LRRC28 gene

Expression for LRRC28 gene

Orthologsfor LRRC28 gene

Paralogsfor LRRC28 gene

Genomic Variantsfor LRRC28 gene

Disorders / Diseasesfor LRRC28 gene

Publicationsfor LRRC28 gene

External Searches for LRRC28 gene

Genome Databases showing LRRC28 gene

Other Databases showing LRRC28 gene

Specialized Databases showing LRRC28 gene

Intellectual Propertyfor LRRC28 gene

Productsfor LRRC28 gene

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Aliases
for LRRC28 gene

Summaries
for LRRC28 gene

Genomic Views
for LRRC28 gene

Proteins
for LRRC28 gene

Protein Domains /
Families
for LRRC28 gene

Function
for LRRC28 gene

Pathways & Interactions
for LRRC28 gene

Drugs & Compounds
for LRRC28 gene

Transcripts
for LRRC28 gene

Expression
for LRRC28 gene

Orthologs
for LRRC28 gene

Paralogs
for LRRC28 gene

Genomic Variants
for LRRC28 gene

Disorders / Diseases
for LRRC28 gene

Publications
for LRRC28 gene

Intellectual Property
for LRRC28 gene

Products
for LRRC28 gene