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Aliases for LRRC26 Gene

Aliases for LRRC26 Gene

  • Leucine Rich Repeat Containing 26 2 3 5
  • BK Channel Auxiliary Gamma Subunit LRRC26 3 4
  • Cytokeratin-Associated Protein In Cancer 3 4
  • CAPC 3 4
  • BK Channel Auxilliary Gamma Subunit LRRC26 3
  • Leucine-Rich Repeat-Containing Protein 26 3
  • Cytokeratin Associated Protein 3
  • BA350O14.10 3

External Ids for LRRC26 Gene

Previous GeneCards Identifiers for LRRC26 Gene

  • GC09U900600
  • GC09M139184
  • GC09M140063
  • GC09M109523

Summaries for LRRC26 Gene

GeneCards Summary for LRRC26 Gene

LRRC26 (Leucine Rich Repeat Containing 26) is a Protein Coding gene. GO annotations related to this gene include potassium channel regulator activity. An important paralog of this gene is LRRC55.

UniProtKB/Swiss-Prot for LRRC26 Gene

  • Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC26 Gene

Genomics for LRRC26 Gene

Regulatory Elements for LRRC26 Gene

Enhancers for LRRC26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G137166 1.8 FANTOM5 Ensembl ENCODE dbSUPER 0.7 -1.1 -1094 10.1 HDGF AGO1 SIN3A ZNF2 ZBTB7B GLIS2 KLF7 ZNF263 SP3 REST TPRN DPH7 ARRDC1-AS1 TMEM203 NDOR1 GRIN1 DPP7 MAN1B1 SNAPC4 ANAPC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC26 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LRRC26 gene promoter:

Genomic Location for LRRC26 Gene

Chromosome:
9
Start:
137,168,758 bp from pter
End:
137,170,051 bp from pter
Size:
1,294 bases
Orientation:
Minus strand

Genomic View for LRRC26 Gene

Genes around LRRC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC26 Gene

Proteins for LRRC26 Gene

  • Protein details for LRRC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2I0M4-LRC26_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 26
    Protein Accession:
    Q2I0M4
    Secondary Accessions:
    • B9EIR7
    • C3RUL3
    • Q5VSG2

    Protein attributes for LRRC26 Gene

    Size:
    334 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    • Interacts with KCNMA1.

    Alternative splice isoforms for LRRC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC26 Gene

Post-translational modifications for LRRC26 Gene

  • Glycosylation at Asn147
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC26 Gene

Domains & Families for LRRC26 Gene

Suggested Antigen Peptide Sequences for LRRC26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2I0M4

UniProtKB/Swiss-Prot:

LRC26_HUMAN :
  • The transmembrane domain is necessary for interaction with KCNMA1.
Domain:
  • The transmembrane domain is necessary for interaction with KCNMA1.
genes like me logo Genes that share domains with LRRC26: view

No data available for Gene Families for LRRC26 Gene

Function for LRRC26 Gene

Molecular function for LRRC26 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

Gene Ontology (GO) - Molecular Function for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20613726
GO:0015459 potassium channel regulator activity IDA 20613726
genes like me logo Genes that share ontologies with LRRC26: view
genes like me logo Genes that share phenotypes with LRRC26: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC26 Gene

Localization for LRRC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC26 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269 PubMed:15164053}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC26 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with LRRC26: view

Pathways & Interactions for LRRC26 Gene

SuperPathways for LRRC26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with LRRC26: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC26 Gene

Drugs & Compounds for LRRC26 Gene

No Compound Related Data Available

Transcripts for LRRC26 Gene

mRNA/cDNA for LRRC26 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC26 Gene

Leucine rich repeat containing 26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC26 Gene

No ASD Table

Relevant External Links for LRRC26 Gene

GeneLoc Exon Structure for
LRRC26
ECgene alternative splicing isoforms for
LRRC26

Expression for LRRC26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC26 Gene

This gene is overexpressed in Minor Salivary Gland (x27.5), Prostate (x10.6), and Colon - Transverse (x5.0).

Protein differential expression in normal tissues from HIPED for LRRC26 Gene

This gene is overexpressed in Milk (44.6) and Heart (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC26 Gene



Protein tissue co-expression partners for LRRC26 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC26 Gene:

LRRC26

SOURCE GeneReport for Unigene cluster for LRRC26 Gene:

Hs.669977

mRNA Expression by UniProt/SwissProt for LRRC26 Gene:

Q2I0M4-LRC26_HUMAN
Tissue specificity: Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.

Evidence on tissue expression from TISSUES for LRRC26 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with LRRC26: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC26 Gene

Orthologs for LRRC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC26 34 35
  • 97.41 (n)
cow
(Bos Taurus)
Mammalia LRRC26 34 35
  • 81.77 (n)
dog
(Canis familiaris)
Mammalia LRRC26 34 35
  • 81.07 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc26 34
  • 72.14 (n)
mouse
(Mus musculus)
Mammalia Lrrc26 34 16 35
  • 71.46 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC26 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC26 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC26 34 35
  • 53.75 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC26 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kek4 35
  • 13 (a)
ManyToMany
kek6 35
  • 10 (a)
ManyToMany
kek1 35
  • 9 (a)
ManyToMany
kek2 35
  • 9 (a)
ManyToMany
kek5 35
  • 9 (a)
ManyToMany
kek3 35
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
ManyToMany
CSA.1672 35
  • 17 (a)
ManyToMany
-- 35
  • 14 (a)
ManyToMany
Species where no ortholog for LRRC26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC26 Gene

ENSEMBL:
Gene Tree for LRRC26 (if available)
TreeFam:
Gene Tree for LRRC26 (if available)

Paralogs for LRRC26 Gene

Paralogs for LRRC26 Gene

(1) SIMAP similar genes for LRRC26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC26: view

Variants for LRRC26 Gene

Sequence variations from dbSNP and Humsavar for LRRC26 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000093890 -- 137,171,173(+) CATGA(C/T)GGGCC intron-variant, upstream-variant-2KB
rs1000146335 -- 137,170,959(+) CCCCC(A/G)GCTGC upstream-variant-2KB, utr-variant-3-prime
rs1001159501 -- 137,171,962(+) AGAAG(A/G)GACAA upstream-variant-2KB, reference, synonymous-codon
rs1002169460 -- 137,168,707(+) CCCAA(C/G)CCCCA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1002712150 -- 137,171,930(+) GGCAG(A/G)AGGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRRC26 Gene

Variant ID Type Subtype PubMed ID
dgv13007n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
esv2761561 CNV gain 21179565
esv3622023 CNV gain 21293372
nsv1161918 CNV duplication 26073780
nsv469918 CNV loss 18288195
nsv524322 CNV loss 19592680
nsv616005 CNV loss 21841781
nsv616007 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for LRRC26 Gene

Gene Damage Index Score: 7.17; 80.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC26 Gene

Disorders for LRRC26 Gene

Relevant External Links for LRRC26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC26

No disorders were found for LRRC26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC26 Gene

Publications for LRRC26 Gene

  1. BK potassium channel modulation by leucine-rich repeat-containing proteins. (PMID: 22547800) Yan J. … Aldrich R.W. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4 64
  2. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. (PMID: 20613726) Yan J. … Aldrich R.W. (Nature 2010) 3 4 64
  3. Non-AUG translational initiation of a short CAPC transcript generating protein isoform. (PMID: 19250639) Anaganti S. … Bera T.K. (Biochem. Biophys. Res. Commun. 2009) 3 4 64
  4. High expression of a cytokeratin-associated protein in many cancers. (PMID: 16585525) Egland K.A. … Pastan I. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 64
  5. Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. (PMID: 25825171) Tian Y. … Hoshi T. (J. Gen. Physiol. 2015) 3 64

Products for LRRC26 Gene

Sources for LRRC26 Gene

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