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Aliases for LRRC26 Gene

Aliases for LRRC26 Gene

  • Leucine Rich Repeat Containing 26 2 3 5
  • BK Channel Auxiliary Gamma Subunit LRRC26 3 4
  • Cytokeratin-Associated Protein In Cancer 3 4
  • CAPC 3 4
  • BK Channel Auxilliary Gamma Subunit LRRC26 3
  • Cytokeratin Associated Protein 3
  • BA350O14.10 3

External Ids for LRRC26 Gene

Previous GeneCards Identifiers for LRRC26 Gene

  • GC09U900600
  • GC09M139184
  • GC09M140063
  • GC09M109523

Summaries for LRRC26 Gene

GeneCards Summary for LRRC26 Gene

LRRC26 (Leucine Rich Repeat Containing 26) is a Protein Coding gene. GO annotations related to this gene include potassium channel regulator activity. An important paralog of this gene is LRTM1.

UniProtKB/Swiss-Prot for LRRC26 Gene

  • Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC26 Gene

Genomics for LRRC26 Gene

Regulatory Elements for LRRC26 Gene

Enhancers for LRRC26 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC26 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC26 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LRRC26 gene promoter:

Genomic Location for LRRC26 Gene

Chromosome:
9
Start:
137,168,758 bp from pter
End:
137,170,051 bp from pter
Size:
1,294 bases
Orientation:
Minus strand

Genomic View for LRRC26 Gene

Genes around LRRC26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC26 Gene

Proteins for LRRC26 Gene

  • Protein details for LRRC26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2I0M4-LRC26_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 26
    Protein Accession:
    Q2I0M4
    Secondary Accessions:
    • B9EIR7
    • C3RUL3
    • Q5VSG2

    Protein attributes for LRRC26 Gene

    Size:
    334 amino acids
    Molecular mass:
    34857 Da
    Quaternary structure:
    • Interacts with KCNMA1.

    Alternative splice isoforms for LRRC26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC26 Gene

Proteomics data for LRRC26 Gene at MOPED

Post-translational modifications for LRRC26 Gene

  • Glycosylation at Asn 147
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC26 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LRRC26 Gene

Domains & Families for LRRC26 Gene

Suggested Antigen Peptide Sequences for LRRC26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2I0M4

UniProtKB/Swiss-Prot:

LRC26_HUMAN :
  • The transmembrane domain is necessary for interaction with KCNMA1.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • The transmembrane domain is necessary for interaction with KCNMA1.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC26: view

No data available for Gene Families for LRRC26 Gene

Function for LRRC26 Gene

Molecular function for LRRC26 Gene

UniProtKB/Swiss-Prot Function:
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.

Phenotypes for LRRC26 Gene

genes like me logo Genes that share phenotypes with LRRC26: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC26 Gene

Localization for LRRC26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC26 Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269 PubMed:15164053}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC26 Gene COMPARTMENTS Subcellular localization image for LRRC26 gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRRC26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with LRRC26: view

Pathways & Interactions for LRRC26 Gene

SuperPathways for LRRC26 Gene

No Data Available

Interacting Proteins for LRRC26 Gene

Gene Ontology (GO) - Biological Process for LRRC26 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC26 Gene

Drugs & Compounds for LRRC26 Gene

No Compound Related Data Available

Transcripts for LRRC26 Gene

mRNA/cDNA for LRRC26 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC26 Gene

Leucine rich repeat containing 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC26 Gene

No ASD Table

Relevant External Links for LRRC26 Gene

GeneLoc Exon Structure for
LRRC26
ECgene alternative splicing isoforms for
LRRC26

Expression for LRRC26 Gene

mRNA expression in normal human tissues for LRRC26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC26 Gene

This gene is overexpressed in Minor Salivary Gland (x27.5), Prostate (x10.6), and Colon - Transverse (x5.0).

Protein differential expression in normal tissues from HIPED for LRRC26 Gene

This gene is overexpressed in Milk (44.6) and Heart (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC26 Gene



SOURCE GeneReport for Unigene cluster for LRRC26 Gene Hs.669977

mRNA Expression by UniProt/SwissProt for LRRC26 Gene

Q2I0M4-LRC26_HUMAN
Tissue specificity: Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines.
genes like me logo Genes that share expression patterns with LRRC26: view

Protein tissue co-expression partners for LRRC26 Gene

Primer Products

Orthologs for LRRC26 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC26 35
  • 81.77 (n)
  • 76.4 (a)
LRRC26 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC26 35
  • 81.07 (n)
  • 78.05 (a)
LRRC26 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc26 35
  • 71.46 (n)
  • 70.18 (a)
Lrrc26 16
Lrrc26 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC26 35
  • 97.41 (n)
  • 97.01 (a)
LRRC26 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc26 35
  • 72.14 (n)
  • 69.85 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC26 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC26 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC26 35
  • 53.75 (n)
  • 40.99 (a)
LRRC26 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC26 36
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kek1 36
  • 9 (a)
ManyToMany
kek2 36
  • 9 (a)
ManyToMany
kek3 36
  • 8 (a)
ManyToMany
kek4 36
  • 13 (a)
ManyToMany
kek5 36
  • 9 (a)
ManyToMany
kek6 36
  • 10 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 14 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
CSA.1672 36
  • 17 (a)
ManyToMany
Species with no ortholog for LRRC26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC26 Gene

ENSEMBL:
Gene Tree for LRRC26 (if available)
TreeFam:
Gene Tree for LRRC26 (if available)

Paralogs for LRRC26 Gene

Paralogs for LRRC26 Gene

(1) SIMAP similar genes for LRRC26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC26: view

Variants for LRRC26 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC26 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8439n71 CNV Loss 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294

Variation tolerance for LRRC26 Gene

Gene Damage Index Score: 7.17; 80.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for LRRC26 Gene

Disorders for LRRC26 Gene

Relevant External Links for LRRC26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC26

No disorders were found for LRRC26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC26 Gene

Publications for LRRC26 Gene

  1. BK potassium channel modulation by leucine-rich repeat-containing proteins. (PMID: 22547800) Yan J. … Aldrich R.W. (Proc. Natl. Acad. Sci. U.S.A. 2012) 2 3 4 67
  2. Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. (PMID: 25825171) Tian Y. … Hoshi T. (J. Gen. Physiol. 2015) 3
  3. Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary I^ subunits. (PMID: 26009545) Li Q. … Yan J. (J. Gen. Physiol. 2015) 3
  4. Functional regulation of BK potassium channels by I^1 auxiliary subunits. (PMID: 24639523) Gonzalez-Perez V. … Lingle C.J. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. CAPC negatively regulates NF-I_B activation and suppresses tumor growth and metastasis. (PMID: 21822313) Liu X.F. … Pastan I. (Oncogene 2012) 3

Products for LRRC26 Gene

Sources for LRRC26 Gene

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