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Aliases for LRRC25 Gene

Aliases for LRRC25 Gene

  • Leucine Rich Repeat Containing 25 2 3 5
  • Monocyte And Plasmacytoid-Activated Protein 3 4
  • MAPA 3 4
  • Monocyte And Plasmacytoid Activated Molecule 3
  • Leucine-Rich Repeat-Containing Protein 25 3

External Ids for LRRC25 Gene

Previous GeneCards Identifiers for LRRC25 Gene

  • GC19M018363
  • GC19M018501
  • GC19M018065

Summaries for LRRC25 Gene

GeneCards Summary for LRRC25 Gene

LRRC25 (Leucine Rich Repeat Containing 25) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LRRC25 Gene

  • May be involved in the activation of cells of innate and acquired immunity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC25 Gene

Genomics for LRRC25 Gene

Regulatory Elements for LRRC25 Gene

Enhancers for LRRC25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018168 1.2 FANTOM5 ENCODE 15.6 +225.7 225703 7.4 MLX CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000268030 ENSG00000268938 MVB12A UPF1 ENSG00000269191 COLGALT1 MPV17L2 KXD1 LRRC25 IFI30
GH19F018393 1.2 FANTOM5 ENCODE 14 +3.5 3458 0.9 TBP ELF3 SOX13 DRAP1 TFAP4 SAP130 ARID4B YY1 RARA HNF4G IFI30 LRRC25 KIAA1683 LSM4 ELL ARRDC2 IL12RB1 UBA52 UPF1 GC19P019220
GH19F018328 1.7 FANTOM5 Ensembl ENCODE 13.2 +68.7 68720 1.8 HDGF PKNOX1 ARNT ZFP64 FEZF1 ZNF2 YY1 ZNF143 FOS KLF13 ENSG00000268030 PGPEP1 LSM4 UPF1 LRRC25 MVB12A ENSG00000268938 COLGALT1 ELL MPV17L2
GH19F018332 0.5 ENCODE 13.2 +63.8 63761 3.6 ZBTB10 DRAP1 ZNF687 KLF1 SAP130 ZNF740 MIER2 CEBPG REST ZNF121 PGPEP1 LRRC25 MPV17L2 LSM4 RN7SL513P
GH19F018414 1.1 FANTOM5 ENCODE 10.7 -21.1 -21070 9.2 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 SLC30A9 ZNF143 ZNF207 ENSG00000268030 UPF1 COLGALT1 SSBP4 ENSG00000268199 ENSG00000268938 ELL LRRC25 IFI30 IL12RB1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC25 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418315 525 1401 ARNT MLX ARID4B ZNF48 YY1 ZNF121 ZNF766 GATA2 REST TBX21

Genomic Location for LRRC25 Gene

Chromosome:
19
Start:
18,391,137 bp from pter
End:
18,397,625 bp from pter
Size:
6,489 bases
Orientation:
Minus strand

Genomic View for LRRC25 Gene

Genes around LRRC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC25 Gene

Proteins for LRRC25 Gene

  • Protein details for LRRC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N386-LRC25_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 25
    Protein Accession:
    Q8N386
    Secondary Accessions:
    • Q6IQ00
    • Q8N9A5

    Protein attributes for LRRC25 Gene

    Size:
    305 amino acids
    Molecular mass:
    33179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC25 Gene

Post-translational modifications for LRRC25 Gene

  • Glycosylation at Asn 44, Asn 55, Asn 130, and Asn 148
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC25 Gene

Domains & Families for LRRC25 Gene

Protein Domains for LRRC25 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC25 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N386

UniProtKB/Swiss-Prot:

LRC25_HUMAN :
  • Contains 3 LRR (leucine-rich) repeats.
Similarity:
  • Contains 3 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC25: view

No data available for Gene Families for LRRC25 Gene

Function for LRRC25 Gene

Molecular function for LRRC25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the activation of cells of innate and acquired immunity.
UniProtKB/Swiss-Prot Induction:
Down-regulated in CD40-activated monocyte-derived dendritic cells.

Gene Ontology (GO) - Molecular Function for LRRC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with LRRC25: view
genes like me logo Genes that share phenotypes with LRRC25: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC25 Gene

Localization for LRRC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC25 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC25 Gene COMPARTMENTS Subcellular localization image for LRRC25 gene
Compartment Confidence
extracellular 3
plasma membrane 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for LRRC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC25: view

Pathways & Interactions for LRRC25 Gene

SuperPathways for LRRC25 Gene

No Data Available

Interacting Proteins for LRRC25 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000340983%0d%0a9606.ENSP00000377496%0d%0a
Selected Interacting proteins: Q8N386-LRC25_HUMAN ENSP00000340983 for LRRC25 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for LRRC25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC25 Gene

Transcripts for LRRC25 Gene

mRNA/cDNA for LRRC25 Gene

Unigene Clusters for LRRC25 Gene

Leucine rich repeat containing 25:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC25 Gene

No ASD Table

Relevant External Links for LRRC25 Gene

GeneLoc Exon Structure for
LRRC25
ECgene alternative splicing isoforms for
LRRC25

Expression for LRRC25 Gene

mRNA expression in normal human tissues for LRRC25 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC25 Gene

This gene is overexpressed in Whole Blood (x34.2) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for LRRC25 Gene

This gene is overexpressed in Monocytes (44.3) and Spleen (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC25 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC25 Gene:

LRRC25

SOURCE GeneReport for Unigene cluster for LRRC25 Gene:

Hs.332156

mRNA Expression by UniProt/SwissProt for LRRC25 Gene:

Q8N386-LRC25_HUMAN
Tissue specificity: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.
genes like me logo Genes that share expression patterns with LRRC25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for LRRC25 Gene

Orthologs for LRRC25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LRRC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC25 34 35
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia LRRC25 34 35
  • 75.03 (n)
cow
(Bos Taurus)
Mammalia LRRC25 34 35
  • 70.63 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc25 34
  • 62.78 (n)
mouse
(Mus musculus)
Mammalia Lrrc25 34 16 35
  • 62.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC25 35
  • 31 (a)
OneToOne
Species where no ortholog for LRRC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC25 Gene

ENSEMBL:
Gene Tree for LRRC25 (if available)
TreeFam:
Gene Tree for LRRC25 (if available)

Paralogs for LRRC25 Gene

No data available for Paralogs for LRRC25 Gene

Variants for LRRC25 Gene

Sequence variations from dbSNP and Humsavar for LRRC25 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10413264 -- 18,397,673(+) ATGAA(A/G)ACAGA upstream-variant-2KB
rs10423823 -- 18,399,044(+) aaaaa(A/C)aaaaa upstream-variant-2KB
rs10643129 -- 18,399,602(+) ATCTC(-/AAT/AATAATAAT)AATAA upstream-variant-2KB
rs111378247 -- 18,391,019(+) CCTGA(-/C)AAAAA downstream-variant-500B
rs111815083 -- 18,392,609(+) CTGAG(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC25 Gene

Variant ID Type Subtype PubMed ID
nsv2430 CNV deletion 18451855
nsv952420 CNV deletion 24416366

Variation tolerance for LRRC25 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC25 Gene

Disorders for LRRC25 Gene

Relevant External Links for LRRC25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC25

No disorders were found for LRRC25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC25 Gene

Publications for LRRC25 Gene

  1. Subtractive hybridization reveals the expression of immunoglobulin like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. (PMID: 12384430) Rissoan M.-C. … Bates E.E.M. (Blood 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee O.H. … Songyang Z. (Mol. Cell Proteomics 2011) 3 64
  5. Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k. (PMID: 19737606) Iwano S. … Miyamoto Y. (Toxicol In Vitro 2010) 22 64

Products for LRRC25 Gene

Sources for LRRC25 Gene

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