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Aliases for LRRC25 Gene

Aliases for LRRC25 Gene

  • Leucine Rich Repeat Containing 25 2 3 5
  • Monocyte And Plasmacytoid-Activated Protein 3 4
  • MAPA 3 4
  • Monocyte And Plasmacytoid Activated Molecule 3
  • Leucine-Rich Repeat-Containing Protein 25 3

External Ids for LRRC25 Gene

Previous GeneCards Identifiers for LRRC25 Gene

  • GC19M018363
  • GC19M018501
  • GC19M018065

Summaries for LRRC25 Gene

GeneCards Summary for LRRC25 Gene

LRRC25 (Leucine Rich Repeat Containing 25) is a Protein Coding gene. Diseases associated with LRRC25 include Transient Global Amnesia.

UniProtKB/Swiss-Prot for LRRC25 Gene

  • May be involved in the activation of cells of innate and acquired immunity.

Additional gene information for LRRC25 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC25 Gene

Genomics for LRRC25 Gene

GeneHancer (GH) Regulatory Elements for LRRC25 Gene

Promoters and enhancers for LRRC25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I018392 Promoter/Enhancer 1.9 EPDnew FANTOM5 Ensembl ENCODE 564 +1.7 1679 7.9 FOXA2 ARNT ARID4B SIN3A ZNF48 YY1 ZNF143 FOS ATF7 RUNX3 LRRC25 IFI30 IQCN LSM4 PGPEP1 GDF15 ELL SSBP4 KCNN1 ARRDC2
GH19I018168 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +225.7 225702 7.4 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZBTB7B IFI30 MPV17L2 LRRC25 ENSG00000268938 MEF2B MVB12A ENSG00000268030 PGLS UPF1 ENSG00000269191
GH19I018414 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.7 -21.1 -21070 9.2 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 MEF2D SSRP1 ZNF610 GLIS1 RCOR2 SSBP4 NR2C2AP ENSG00000268030 UPF1 COLGALT1 MAU2 ENSG00000268938 IQCN ENSG00000269191 TMEM161A
GH19I018086 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.9 +308.3 308310 5.9 HDGF PKNOX1 ZNF493 ZFP64 IRF4 ZNF48 TCF12 ZNF121 ZNF766 ZNF213 IL12RB1 ENSG00000268030 UPF1 IQCN GTPBP3 SUGP2 ENSG00000268938 ENSG00000269191 LOC100507551 ELL
GH19I018328 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.2 +68.8 68755 1.7 HDGF PKNOX1 ATF1 ARNT SIN3A ZBTB7B ZNF48 YY1 NCOA2 ZNF766 PGPEP1 LSM4 LRRC25 MPV17L2 RN7SL513P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around LRRC25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the LRRC25 gene promoter:

Genomic Locations for LRRC25 Gene

Genomic Locations for LRRC25 Gene
chr19:18,391,137-18,397,625
(GRCh38/hg38)
Size:
6,489 bases
Orientation:
Minus strand
chr19:18,501,954-18,508,427
(GRCh37/hg19)

Genomic View for LRRC25 Gene

Genes around LRRC25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC25 Gene

Proteins for LRRC25 Gene

  • Protein details for LRRC25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N386-LRC25_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 25
    Protein Accession:
    Q8N386
    Secondary Accessions:
    • Q6IQ00
    • Q8N9A5

    Protein attributes for LRRC25 Gene

    Size:
    305 amino acids
    Molecular mass:
    33179 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC25 Gene

Post-translational modifications for LRRC25 Gene

  • Glycosylation at isoforms=44, isoforms=55, posLast=130130, and isoforms=148

Other Protein References for LRRC25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC25 Gene

Domains & Families for LRRC25 Gene

Gene Families for LRRC25 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for LRRC25 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC25 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC25: view

No data available for UniProtKB/Swiss-Prot for LRRC25 Gene

Function for LRRC25 Gene

Molecular function for LRRC25 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the activation of cells of innate and acquired immunity.
UniProtKB/Swiss-Prot Induction:
Down-regulated in CD40-activated monocyte-derived dendritic cells.

Phenotypes From GWAS Catalog for LRRC25 Gene

Gene Ontology (GO) - Molecular Function for LRRC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with LRRC25: view
genes like me logo Genes that share phenotypes with LRRC25: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC25 Gene

Localization for LRRC25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC25 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC25 gene
Compartment Confidence
plasma membrane 3
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for LRRC25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC25: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRRC25 Gene

Pathways & Interactions for LRRC25 Gene

SuperPathways for LRRC25 Gene

No Data Available

Interacting Proteins for LRRC25 Gene

Selected Interacting proteins: Q8N386-LRC25_HUMAN for LRRC25 Gene via IID UniProtKB

Symbol External ID(s) Details
ACD

Gene Ontology (GO) - Biological Process for LRRC25 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC25 Gene

Drugs & Compounds for LRRC25 Gene

No Compound Related Data Available

Transcripts for LRRC25 Gene

mRNA/cDNA for LRRC25 Gene

Unigene Clusters for LRRC25 Gene

Leucine rich repeat containing 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC25 Gene

No ASD Table

Relevant External Links for LRRC25 Gene

GeneLoc Exon Structure for
LRRC25
ECgene alternative splicing isoforms for
LRRC25

Expression for LRRC25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC25 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC25 Gene

This gene is overexpressed in Whole Blood (x34.2) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for LRRC25 Gene

This gene is overexpressed in Monocytes (44.3) and Spleen (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC25 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC25 Gene:

LRRC25

SOURCE GeneReport for Unigene cluster for LRRC25 Gene:

Hs.332156

mRNA Expression by UniProt/SwissProt for LRRC25 Gene:

Q8N386-LRC25_HUMAN
Tissue specificity: Expressed in plasmacytoid dendritic cells (PDC), monocyte-derived dendritic cells (MDDC), granulocytes, monocytes, B-lymphocytes, peripheral blood leukocytes, spleen, bone marrow, and, to a lesser extent, lymph nodes, fetal liver, and appendix but not in thymus.

Evidence on tissue expression from TISSUES for LRRC25 Gene

  • Blood(4.3)
  • Spleen(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with LRRC25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC25 Gene

Orthologs for LRRC25 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LRRC25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC25 33 34
  • 98.8 (n)
dog
(Canis familiaris)
Mammalia LRRC25 33 34
  • 75.03 (n)
cow
(Bos Taurus)
Mammalia LRRC25 33 34
  • 70.63 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc25 33
  • 62.78 (n)
mouse
(Mus musculus)
Mammalia Lrrc25 33 16 34
  • 62.22 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC25 34
  • 31 (a)
OneToOne
Species where no ortholog for LRRC25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC25 Gene

ENSEMBL:
Gene Tree for LRRC25 (if available)
TreeFam:
Gene Tree for LRRC25 (if available)

Paralogs for LRRC25 Gene

No data available for Paralogs for LRRC25 Gene

Variants for LRRC25 Gene

Sequence variations from dbSNP and Humsavar for LRRC25 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000349753 -- 18,398,854(-) T/C upstream_transcript_variant
rs1000402802 -- 18,393,410(-) G/C intron_variant
rs1000433995 -- 18,393,158(-) G/A intron_variant
rs1000440330 -- 18,393,944(-) G/A intron_variant
rs1000938683 -- 18,395,251(-) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC25 Gene

Variant ID Type Subtype PubMed ID
nsv2430 CNV deletion 18451855
nsv952420 CNV deletion 24416366

Variation tolerance for LRRC25 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for LRRC25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC25 Gene

Disorders for LRRC25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
transient global amnesia
  • amnesia, transient global
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for LRRC25

genes like me logo Genes that share disorders with LRRC25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC25 Gene

Publications for LRRC25 Gene

  1. Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. (PMID: 12384430) Rissoan MC … Bates EE (Blood 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  4. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee OH … Songyang Z (Molecular & cellular proteomics : MCP 2011) 3 58
  5. Identification of AhR-regulated genes involved in PAH-induced immunotoxicity using a highly-sensitive DNA chip, 3D-Gene Human Immunity and Metabolic Syndrome 9k. (PMID: 19737606) Iwano S … Miyamoto Y (Toxicology in vitro : an international journal published in association with BIBRA 2010) 22 58

Products for LRRC25 Gene

Sources for LRRC25 Gene

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