Free for academic non-profit institutions. Other users need a Commercial license

Aliases for LRRC20 Gene

Aliases for LRRC20 Gene

  • Leucine Rich Repeat Containing 20 2 3 5

External Ids for LRRC20 Gene

Previous GeneCards Identifiers for LRRC20 Gene

  • GC10M071404
  • GC10M071728
  • GC10M072058
  • GC10M066052

Summaries for LRRC20 Gene

GeneCards Summary for LRRC20 Gene

LRRC20 (Leucine Rich Repeat Containing 20) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC20 Gene

Genomics for LRRC20 Gene

Regulatory Elements for LRRC20 Gene

Promoters for LRRC20 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC20 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC20 Gene

Chromosome:
10
Start:
70,298,970 bp from pter
End:
70,382,650 bp from pter
Size:
83,681 bases
Orientation:
Minus strand

Genomic View for LRRC20 Gene

Genes around LRRC20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC20 Gene

Proteins for LRRC20 Gene

  • Protein details for LRRC20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TCA0-LRC20_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 20
    Protein Accession:
    Q8TCA0
    Secondary Accessions:
    • Q5T6D4
    • Q5T6D6
    • Q9NVA6
    • Q9NVG3

    Protein attributes for LRRC20 Gene

    Size:
    184 amino acids
    Molecular mass:
    20509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91849.1; Type=Erroneous termination; Positions=185; Note=Translated as stop.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC20 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC20 Gene

Proteomics data for LRRC20 Gene at MOPED

Post-translational modifications for LRRC20 Gene

  • Ubiquitination at Lys 43
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for LRRC20 Gene

Domains & Families for LRRC20 Gene

Protein Domains for LRRC20 Gene

Suggested Antigen Peptide Sequences for LRRC20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TCA0

UniProtKB/Swiss-Prot:

LRC20_HUMAN :
  • Contains 5 LRR (leucine-rich) repeats.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC20: view

No data available for Gene Families for LRRC20 Gene

Function for LRRC20 Gene

Phenotypes for LRRC20 Gene

GenomeRNAi human phenotypes for LRRC20:
genes like me logo Genes that share phenotypes with LRRC20: view

Animal Model Products

miRNA for LRRC20 Gene

miRTarBase miRNAs that target LRRC20

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC20 Gene

Localization for LRRC20 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC20 Gene COMPARTMENTS Subcellular localization image for LRRC20 gene
Compartment Confidence
cytosol 4
nucleus 3
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC20 Gene

Pathways & Interactions for LRRC20 Gene

SuperPathways for LRRC20 Gene

No Data Available

Interacting Proteins for LRRC20 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348043%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000370616%0d%0a
Selected Interacting proteins: Q8TCA0-LRC20_HUMAN ENSP00000348043 for LRRC20 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for LRRC20 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC20 Gene

Drugs & Compounds for LRRC20 Gene

No Compound Related Data Available

Transcripts for LRRC20 Gene

Unigene Clusters for LRRC20 Gene

Leucine rich repeat containing 20:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC20 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f
SP1: - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - -
SP9:
SP10: -

Relevant External Links for LRRC20 Gene

GeneLoc Exon Structure for
LRRC20
ECgene alternative splicing isoforms for
LRRC20

Expression for LRRC20 Gene

mRNA expression in normal human tissues for LRRC20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC20 Gene

This gene is overexpressed in Muscle - Skeletal (x11.6).

Protein differential expression in normal tissues from HIPED for LRRC20 Gene

This gene is overexpressed in Tonsil (27.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for LRRC20 Gene



SOURCE GeneReport for Unigene cluster for LRRC20 Gene Hs.7778

genes like me logo Genes that share expression patterns with LRRC20: view

Protein tissue co-expression partners for LRRC20 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LRRC20 Gene

Orthologs for LRRC20 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC20 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC20 35
  • 88.95 (n)
  • 91.3 (a)
LRRC20 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC20 35
  • 90.58 (n)
  • 93.48 (a)
LRRC20 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc20 35
  • 84.6 (n)
  • 89.67 (a)
Lrrc20 16
Lrrc20 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC20 35
  • 99.82 (n)
  • 100 (a)
LRRC20 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc20 35
  • 86.41 (n)
  • 90.22 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC20 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC20 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC20 35
  • 70.97 (n)
  • 64.61 (a)
lizard
(Anolis carolinensis)
Reptilia LRRC20 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc20 35
  • 58.33 (n)
  • 55.95 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc20 35
  • 61.29 (n)
  • 49.68 (a)
lrrc20 36
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Sclp 36
  • 15 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K08E7.8 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for LRRC20:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC20 Gene

ENSEMBL:
Gene Tree for LRRC20 (if available)
TreeFam:
Gene Tree for LRRC20 (if available)

Paralogs for LRRC20 Gene

No data available for Paralogs for LRRC20 Gene

Variants for LRRC20 Gene

Sequence variations from dbSNP and Humsavar for LRRC20 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1626 -- 70,378,283(-) CAGAG(A/G)AAGGA intron-variant, upstream-variant-2KB
rs1043867 -- 70,299,335(-) CTGTG(A/C/G/T)TCAGC nc-transcript-variant, utr-variant-3-prime
rs1043875 -- 70,299,326(-) GCCTC(C/T)TCCCT nc-transcript-variant, utr-variant-3-prime
rs1043884 -- 70,299,248(-) GAGTG(G/T)GACCT nc-transcript-variant, utr-variant-3-prime
rs1075388 -- 70,327,142(-) ACATT(A/G)GCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC20 Gene

Variant ID Type Subtype PubMed ID
esv32737 CNV Gain+Loss 17666407
nsv831908 CNV Gain 17160897
nsv507560 CNV Insertion 20534489
esv1276689 CNV Insertion 17803354
esv1000318 CNV Deletion 20482838

Variation tolerance for LRRC20 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC20 Gene

HapMap Linkage Disequilibrium report
LRRC20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC20 Gene

Disorders for LRRC20 Gene

Relevant External Links for LRRC20

Genetic Association Database (GAD)
LRRC20
Human Genome Epidemiology (HuGE) Navigator
LRRC20
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC20

No disorders were found for LRRC20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC20 Gene

Publications for LRRC20 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. (PMID: 23471985) Jahanshad N. … Thompson P.M. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3
  4. Trait-stratified genome-wide association study identifies novel and diverse genetic associations with serologic and cytokine phenotypes in systemic lupus erythematosus. (PMID: 20659327) Kariuki S.N. … Niewold T.B. (Arthritis Res. Ther. 2010) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for LRRC20 Gene

Sources for LRRC20 Gene

Back to Top

Content