LRRC20 Gene
protein-coding GIFtS: 43
GCID: GC10M072058
|
|
leucine rich repeat containing 20
| |
Aliases
for LRRC20 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 201 2 | | FLJ107511 | | FLJ108441 | | Leucine-Rich Repeat-Containing Protein 202 |
Export aliases for LRRC20 gene to outside databasesPrevious GC identifers: GC10M071404 GC10M071728 GC10M066052 |
Summaries
for LRRC20 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for LRRC20 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC20 gene promoter:
NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC20
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC20 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.1 HGNC cytogenetic band: 10q22.2LRRC20 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M072058: view genomic region
(about GC identifiers)
Start:
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72,058,729 bp from pter |
End:
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72,142,382 bp from pter |
Size:
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83,654 bases |
Orientation:
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minus strand |
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Proteins
for LRRC20 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC20_HUMAN, Q8TCA0 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 20 Size: 184 amino acids; 20509 Da
Sequence caution: Sequence=BAA91849.1; Type=Erroneous termination; Positions=185; Note=Translated as stop;
Secondary accessions: Q5T6D4 Q5T6D6 Q9NVA6 Q9NVG3Alternative splicing: 3 isoforms: Q8TCA0-1 Q8TCA0-2 Q8TCA0-3 Explore the universe of human proteins at neXtProt for LRRC20: NX_Q8TCA0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TCA0
LRRC20 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_060675.1 NP_060709.2 NP_997002.1
ENSEMBL proteins: ENSP00000362321 ENSP00000348043 ENSP00000350860 ENSP00000350255 ENSP00000413745 ENSP00000378458 ENSP00000378457
Human Recombinant Protein Products:
LRRC20 Antibody Products:
Assay Products for LRRC20: |
Protein
Domains /
Families
for LRRC20 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC20 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8TCA0ProtoNet protein and cluster: Q8TCA0 1 Blocks protein family: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC20_HUMAN, Q8TCA0Similarity: Contains 5 LRR (leucine-rich) repeats |
Function
for LRRC20 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): LRRC20 (NM_018205) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC20 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC20 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC20 |
Animal Models:
Mouse knock-out Lrrc20tm1Lex for LRRC20
1 MGI phenotypic allele  for Lrrc20 (no phenotypes)
LRRC20 for phenotypes About GeneDecksing
|
Pathways & Interactions
for LRRC20 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC20
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for LRRC20 (ENSP000003480434) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for LRRC20 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC20
Search CenterWatch for drugs/clinical trials and news about LRRC20 / LRC20
|
Transcripts
for LRRC20 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC20 gene (3 alternative transcripts): NM_018205.2 NM_018239.2 NM_207119.1 Unigene Cluster for LRRC20: Leucine rich repeat containing 20 Hs.7778 [show with all ESTs]Unigene Representative Sequence: AY3583187 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373224 ENST00000355790(uc001jqx.1) ENST00000358141(uc001jqz.1)
ENST00000357631(uc001jqy.1) ENST00000446961 ENST00000395011 ENST00000395010
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): LRRC20 (NM_018205) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC20 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC20 |
Additional cDNA sequence: AK001613.1 AK001706.1 AK094734.1 AL122117.1 AY358318.1 BC024001.2 11 DOTS entries: DT.415030 DT.100754424 DT.100754416 DT.40209045 DT.100754425 DT.100754417 DT.100754420 DT.121271976 DT.121271963 DT.121272072 DT.95091438 24/155 AceView cDNA sequences (see all 155): BQ951870 NM_207119 BM473749 T32055 BU152983 AI638704 BQ084345 CR590887 CR618443 NM_018239 NM_018205 BM664162 AI962119 AI240692 AL521536 BM788766 AA347766 AI185621 AI825911 AA404474 BC024001 Z45245 AW470597 AW572415
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC20 (see all 10) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LRRC20
|
Expression
for LRRC20 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC20 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRC20 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC20
SOURCE GeneReport for Unigene cluster: Hs.7778
SABiosciences Custom PCR Arrays for LRRC20
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC20
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC20 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC20 |
Orthologs
for LRRC20 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRC20 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for LRRC20 (if available)
TreeFam Gene Tree for LRRC20 (if available) |
Paralogs
for LRRC20 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC20 gene
- LRRC572
LRRC20 for paralogs About GeneDecksing
|
Genomic Variants
for LRRC20 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC20 (72058729 - 72142382 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for LRRC20
1 CNV: 6879 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC20 |
|
Disorders
/ Diseases
for LRRC20 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRRC20 for disorders About GeneDecksing
3  diseases for LRRC20: About MalaCardssystemic lupus erythematosus lupus erythematosus alzheimer's disease
Human Genome Epidemiology (HuGE) Navigator: LRRC20 (3 documents)
Export disorders for LRRC20 gene to outside databases
|
Publications
for LRRC20 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC20 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with LRRC20) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Trait-stratified genome-wide association study identi fies novel and diverse genetic associations with serologic and cytokine phenoty pes in systemic lupus erythematosus. (PubMed id 20659327)1 Kariuki S.N....Niewold T.B. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
|
External Searches for LRRC20 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC20 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC20 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC20 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC20 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LRRC20 gene:
Search GeneIP for patents involving LRRC20
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC20 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC20 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC20 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC20 | | | OriGene Protein Over-expression Lysate for LRRC20 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC20 | | OriGene 3'-UTR Clone for LRRC20 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC20 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LRRC20 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC20 | | OriGene Custom Protein Services for LRRC20 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC20 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC20 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC20 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC20 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC20 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC20 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LRRC20 |
| |  |  |  |  | | | | |
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 | | | LRRC20 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC20 |
|  |  |  | | | | ThermoFisher Antibodies for LRRC20 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC20 |
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