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LRRC19 Gene

protein-coding   GIFtS: 42
GCID: GC09M026993

Leucine Rich Repeat Containing 19

  Search for LRRC19
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine Rich Repeat Containing 191 2
Leucine-Rich Repeat-Containing Protein 192

External Ids:    HGNC: 233791   Entrez Gene: 649222   Ensembl: ENSG000001844347   UniProtKB: Q9H7563   

Export aliases for LRRC19 gene to outside databases

Previous GC identifers: GC09M026984 GC09M026985 GC09M026986 GC09M026946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRRC19 Gene:
LRRC19 (leucine rich repeat containing 19) is a protein-coding gene. An important paralog of this gene is ELFN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NC_018920.2  NT_008413.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRRC19 gene promoter:
         STAT5B   STAT1   ATF-2   STAT4   STAT1beta   STAT6   STAT5A   STAT1alpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRRC19 promoter sequence
   Search Chromatin IP Primers for LRRC19

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.2   Ensembl cytogenetic band:  9p21.2   HGNC cytogenetic band: 9p21.1

LRRC19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC19 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M026993:  view genomic region     (about GC identifiers)

Start:
26,993,134 bp from pter      End:
27,005,691 bp from pter
Size:
12,558 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LRC19_HUMAN, Q9H756 (See protein sequence)
Recommended Name: Leucine-rich repeat-containing protein 19 precursor  
Size: 370 amino acids; 42334 Da
Secondary accessions: A0AV00 B9EG91

Explore the universe of human proteins at neXtProt for LRRC19: NX_Q9H756

Explore proteomics data for LRRC19 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn32, Asn37, Asn62, Asn95, Asn179, Asn192, Asn195, Asn202, Asn251, Asn256

  • See LRRC19 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075052.1  
    ENSEMBL proteins: 
     ENSP00000369395  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000483 Cys-rich_flank_reg_C

    Graphical View of Domain Structure for InterPro Entry Q9H756

    ProtoNet protein and cluster: Q9H756

    1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

    UniProtKB/Swiss-Prot: LRC19_HUMAN, Q9H756
    Similarity: Contains 5 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain


    LRRC19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC19
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    SwitchGear 3'UTR luciferase reporter plasmidLRRC19 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRC19_HUMAN, Q9H756: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    extracellular1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    LRRC19 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRRC19
    Interactions:

        Search GeneGlobe Interaction Network for LRRC19

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LRRC19 (ENSP000003693954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRRC19 (LRC19)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRRC19 gene: 
    NM_022901.2  

    Unigene Cluster for LRRC19:

    Leucine rich repeat containing 19
    Hs.128071  [show with all ESTs]
    Unigene Representative Sequence: NM_022901
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380055(uc003zqh.3) ENST00000482770
    miRNA
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    hsa-miR-875-3p hsa-miR-570 hsa-miR-223 hsa-miR-374c hsa-miR-889 hsa-miR-4326 hsa-miR-3153 hsa-miR-3671
    SwitchGear 3'UTR luciferase reporter plasmidLRRC19 3' UTR sequence
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    Additional mRNA sequence: 

    AK024955.1 AK025070.1 AK222987.1 BC056252.1 BC126156.1 BC136298.1 

    1 DOTS entry:

    DT.95262027 

    21 AceView cDNA sequences:

    BF593214 AW006844 BC056252 AW243469 AA970851 NM_022901 BX102611 AW614627 
    AI860122 AK024955 AI793331 BX482229 AK025070 BF431646 BI764790 BG399137 
    AI521730 AW236768 AW780015 AW388092 BI764801 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRRC19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LRRC19 Expression
    About this image

    LRRC19 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRRC19 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128071
        Custom PCR Arrays for LRRC19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRRC19 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrrc191 , 5 leucine rich repeat containing 191, 5 79.52(n)1
    71.9(a)1
      4 (43.34 cM)5
    1000611  NM_175305.41  NP_780514.11 
     946366535 
    chicken
    (Gallus gallus)
    Aves LOC1017520411 leucine-rich repeat-containing protein 19-like 59.39(n)
    46.9(a)
      101752041  XM_004949578.1  XP_004949635.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRRC196
    leucine rich repeat containing 19
    40(a)
    1 ↔ 1
    2(58955367-58966483)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004911551 leucine-rich repeat-containing protein 19-like 53.83(n)
    40.54(a)
      100491155  XM_002933977.2  XP_002934023.1 


    ENSEMBL Gene Tree for LRRC19 (if available)
    TreeFam Gene Tree for LRRC19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRRC19 gene
    ELFN12  ELFN22  

    LRRC19 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for LRRC19:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528614CNV Gain19592680
    nsv517269CNV Gain19592680
    nsv892862CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRRC19
    DNA2.0 Custom Variant and Variant Library Synthesis for LRRC19

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    LRRC19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): LRRC19

    Export disorders for LRRC19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRRC19 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LRRC19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. (PubMed id 19679103)1 Chai L....Yang R. (Biochem. Biophys. Res. Commun. 2009)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64922 HGNC: 23379 AceView: LRRC19 Ensembl:ENSG00000184434 euGenes: HUgn64922
    ECgene: LRRC19 H-InvDB: LRRC19

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRRC19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRRC19 gene:
    Search GeneIP for patents involving LRRC19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC19
     SwitchGear 3'UTR luciferase reporter plasmids for LRRC19
     SwitchGear Promoter luciferase reporter plasmids for LRRC19
     ThermoFisher Antibodies for LRRC19
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC19
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRRC19
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRRC19
     LSBio Antibodies in human, mouse, rat for LRRC19
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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