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Aliases for LRRC19 Gene

Aliases for LRRC19 Gene

  • Leucine Rich Repeat Containing 19 2 3 5

External Ids for LRRC19 Gene

Previous GeneCards Identifiers for LRRC19 Gene

  • GC09M026984
  • GC09M026985
  • GC09M026986
  • GC09M026946

Summaries for LRRC19 Gene

GeneCards Summary for LRRC19 Gene

LRRC19 (Leucine Rich Repeat Containing 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC19 Gene

Genomics for LRRC19 Gene

Regulatory Elements for LRRC19 Gene

Enhancers for LRRC19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G026953 1.4 FANTOM5 ENCODE 18.8 +49.9 49924 3.9 FOXA2 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF207 ZNF263 SP3 IFT74 CAAP1 LRRC19 IFT74-AS1 PLAA
GH09G026889 1.1 ENCODE 19.3 +113.8 113775 3.8 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 IFT74 LRRC19 PLAA CAAP1 ENSG00000232466
GH09G026974 0.9 Ensembl ENCODE 20.6 +29.5 29516 3.0 CTCF ZNF654 PHF8 MXI1 TEAD4 CHD1 RBBP5 KDM5A RAD21 HDAC2 IFT74 LRRC19 CAAP1 PLAA IFT74-AS1
GH09G027019 0.6 ENCODE 17.2 -14.1 -14080 1.4 CTCF MAFG ZNF316 MAFF NFE2 FOS MAFK EMSY NFE2L2 IFT74 LRRC19 ENSG00000254396
GH09G027053 0.8 ENCODE 12.9 -48.4 -48354 1.9 SOX13 FOXA2 JUN GATA3 GATA2 FOS HOMEZ ZNF652 TCF7L2 MIXL1 IFT74 LRRC19 TEK EQTN ENSG00000254396
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC19 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC19 Gene

Chromosome:
9
Start:
26,993,136 bp from pter
End:
27,005,693 bp from pter
Size:
12,558 bases
Orientation:
Minus strand

Genomic View for LRRC19 Gene

Genes around LRRC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC19 Gene

Proteins for LRRC19 Gene

  • Protein details for LRRC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H756-LRC19_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 19
    Protein Accession:
    Q9H756
    Secondary Accessions:
    • A0AV00
    • B9EG91

    Protein attributes for LRRC19 Gene

    Size:
    370 amino acids
    Molecular mass:
    42334 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC19 Gene

Post-translational modifications for LRRC19 Gene

  • Glycosylation at posLast=3232, posLast=3737, posLast=6262, Asn95, Asn179, posLast=192192, posLast=195195, Asn202, Asn251, and Asn256
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC19 Gene

Domains & Families for LRRC19 Gene

Suggested Antigen Peptide Sequences for LRRC19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC19: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRC19 Gene

Function for LRRC19 Gene

Gene Ontology (GO) - Molecular Function for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with LRRC19: view
genes like me logo Genes that share phenotypes with LRRC19: view

Animal Model Products

CRISPR Products

miRNA for LRRC19 Gene

miRTarBase miRNAs that target LRRC19

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC19 Gene

Localization for LRRC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC19 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC19: view

Pathways & Interactions for LRRC19 Gene

SuperPathways for LRRC19 Gene

No Data Available

Interacting Proteins for LRRC19 Gene

Gene Ontology (GO) - Biological Process for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with LRRC19: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC19 Gene

Drugs & Compounds for LRRC19 Gene

No Compound Related Data Available

Transcripts for LRRC19 Gene

mRNA/cDNA for LRRC19 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC19 Gene

Leucine rich repeat containing 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC19 Gene

No ASD Table

Relevant External Links for LRRC19 Gene

GeneLoc Exon Structure for
LRRC19
ECgene alternative splicing isoforms for
LRRC19

Expression for LRRC19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC19 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC19 Gene

This gene is overexpressed in Colon - Transverse (x27.1), Small Intestine - Terminal Ileum (x10.7), and Kidney - Cortex (x10.4).

Protein differential expression in normal tissues from HIPED for LRRC19 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC19 Gene



Protein tissue co-expression partners for LRRC19 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC19 Gene:

LRRC19

SOURCE GeneReport for Unigene cluster for LRRC19 Gene:

Hs.128071

Evidence on tissue expression from TISSUES for LRRC19 Gene

  • Intestine(4.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with LRRC19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC19 Gene

Orthologs for LRRC19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC19 34 35
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia LRRC19 34 35
  • 87.12 (n)
dog
(Canis familiaris)
Mammalia LRRC19 34 35
  • 86.99 (n)
mouse
(Mus musculus)
Mammalia Lrrc19 34 16 35
  • 79.52 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc19 34
  • 78.58 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC19 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC19 35
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101752041 34
  • 59.39 (n)
LRRC19 35
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC19 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491155 34
  • 53.83 (n)
Species where no ortholog for LRRC19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC19 Gene

ENSEMBL:
Gene Tree for LRRC19 (if available)
TreeFam:
Gene Tree for LRRC19 (if available)

Paralogs for LRRC19 Gene

No data available for Paralogs for LRRC19 Gene

Variants for LRRC19 Gene

Sequence variations from dbSNP and Humsavar for LRRC19 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000189768 -- 26,999,172(+) GATAT(A/G)GATGG intron-variant
rs1000472215 -- 26,992,804(+) ACAAA(A/G)ATCTA intron-variant
rs1000483613 -- 27,000,412(+) TTATC(C/T)ATTGG intron-variant
rs1000532138 -- 27,000,518(+) GGCGT(G/T)GTAGA intron-variant
rs1000552661 -- 27,004,415(+) ATTGA(A/T)CCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC19 Gene

Variant ID Type Subtype PubMed ID
esv3891647 CNV gain 25118596
nsv1015259 CNV gain 25217958
nsv517269 CNV gain 19592680
nsv528614 CNV gain 19592680

Variation tolerance for LRRC19 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC19 Gene

Disorders for LRRC19 Gene

Relevant External Links for LRRC19

Genetic Association Database (GAD)
LRRC19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC19

No disorders were found for LRRC19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC19 Gene

Publications for LRRC19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. (PMID: 19679103) Chai L. … Yang R. (Biochem. Biophys. Res. Commun. 2009) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3 64

Products for LRRC19 Gene

Sources for LRRC19 Gene

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