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Aliases for LRRC19 Gene

Aliases for LRRC19 Gene

  • Leucine Rich Repeat Containing 19 2 3 5

External Ids for LRRC19 Gene

Previous GeneCards Identifiers for LRRC19 Gene

  • GC09M026984
  • GC09M026985
  • GC09M026986
  • GC09M026946

Summaries for LRRC19 Gene

GeneCards Summary for LRRC19 Gene

LRRC19 (Leucine Rich Repeat Containing 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC19 Gene

Genomics for LRRC19 Gene

Regulatory Elements for LRRC19 Gene

Enhancers for LRRC19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around LRRC19 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC19 Gene

26,993,136 bp from pter
27,005,693 bp from pter
12,558 bases
Minus strand

Genomic View for LRRC19 Gene

Genes around LRRC19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC19 Gene

Proteins for LRRC19 Gene

  • Protein details for LRRC19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 19
    Protein Accession:
    Secondary Accessions:
    • A0AV00
    • B9EG91

    Protein attributes for LRRC19 Gene

    370 amino acids
    Molecular mass:
    42334 Da
    Quaternary structure:
    No Data Available

neXtProt entry for LRRC19 Gene

Post-translational modifications for LRRC19 Gene

  • Glycosylation at Asn 32, Asn 37, Asn 62, Asn 95, Asn 179, Asn 192, Asn 195, Asn 202, Asn 251, and Asn 256
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC19 Gene

Domains & Families for LRRC19 Gene

Suggested Antigen Peptide Sequences for LRRC19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LRRCT domain.
  • Contains 5 LRR (leucine-rich) repeats.
  • Contains 1 LRRCT domain.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC19: view

No data available for Gene Families for LRRC19 Gene

Function for LRRC19 Gene

Gene Ontology (GO) - Molecular Function for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with LRRC19: view
genes like me logo Genes that share phenotypes with LRRC19: view

Animal Model Products

CRISPR Products

miRNA for LRRC19 Gene

miRTarBase miRNAs that target LRRC19

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC19 Gene

Localization for LRRC19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRRC19 Gene COMPARTMENTS Subcellular localization image for LRRC19 gene
Compartment Confidence
plasma membrane 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRRC19: view

Pathways & Interactions for LRRC19 Gene

SuperPathways for LRRC19 Gene

No Data Available

Interacting Proteins for LRRC19 Gene

Gene Ontology (GO) - Biological Process for LRRC19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
genes like me logo Genes that share ontologies with LRRC19: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC19 Gene

Drugs & Compounds for LRRC19 Gene

No Compound Related Data Available

Transcripts for LRRC19 Gene

mRNA/cDNA for LRRC19 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC19 Gene

Leucine rich repeat containing 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC19 Gene

No ASD Table

Relevant External Links for LRRC19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC19 Gene

mRNA expression in normal human tissues for LRRC19 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC19 Gene

This gene is overexpressed in Colon - Transverse (x27.1), Small Intestine - Terminal Ileum (x10.7), and Kidney - Cortex (x10.4).

Protein differential expression in normal tissues from HIPED for LRRC19 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC19 Gene

Protein tissue co-expression partners for LRRC19 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC19 Gene:


SOURCE GeneReport for Unigene cluster for LRRC19 Gene:

genes like me logo Genes that share expression patterns with LRRC19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRC19 Gene

Orthologs for LRRC19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC19 34
  • 87.12 (n)
  • 80.27 (a)
LRRC19 35
  • 80 (a)
(Canis familiaris)
Mammalia LRRC19 34
  • 86.99 (n)
  • 79.4 (a)
LRRC19 35
  • 79 (a)
(Mus musculus)
Mammalia Lrrc19 34
  • 79.52 (n)
  • 71.9 (a)
Lrrc19 16
Lrrc19 35
  • 68 (a)
(Pan troglodytes)
Mammalia LRRC19 34
  • 99.46 (n)
  • 99.19 (a)
LRRC19 35
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrrc19 34
  • 78.58 (n)
  • 72.91 (a)
(Monodelphis domestica)
Mammalia LRRC19 35
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC19 35
  • 41 (a)
(Gallus gallus)
Aves LOC101752041 34
  • 59.39 (n)
  • 46.9 (a)
LRRC19 35
  • 39 (a)
(Anolis carolinensis)
Reptilia LRRC19 35
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491155 34
  • 53.83 (n)
  • 40.54 (a)
Species where no ortholog for LRRC19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LRRC19 Gene

Gene Tree for LRRC19 (if available)
Gene Tree for LRRC19 (if available)

Paralogs for LRRC19 Gene

No data available for Paralogs for LRRC19 Gene

Variants for LRRC19 Gene

Structural Variations from Database of Genomic Variants (DGV) for LRRC19 Gene

Variant ID Type Subtype PubMed ID
esv3891647 CNV gain 25118596
nsv1015259 CNV gain 25217958
nsv517269 CNV gain 19592680
nsv528614 CNV gain 19592680

Variation tolerance for LRRC19 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for LRRC19 Gene

Disorders for LRRC19 Gene

Relevant External Links for LRRC19

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC19 Gene

Publications for LRRC19 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappaB and induces expression of proinflammatory cytokines. (PMID: 19679103) Chai L. … Yang R. (Biochem. Biophys. Res. Commun. 2009) 3 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PMID: 8125298) Maruyama K. … Sugano S. (Gene 1994) 3 65

Products for LRRC19 Gene

Sources for LRRC19 Gene

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