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Aliases for LRRC18 Gene

Aliases for LRRC18 Gene

  • Leucine Rich Repeat Containing 18 2 3
  • Leucine-Rich Repeat-Containing Protein 18 3
  • VKGE9338 3
  • UNQ9338 3
  • UNQ933 3

External Ids for LRRC18 Gene

Previous GeneCards Identifiers for LRRC18 Gene

  • GC10U900454
  • GC10M049788
  • GC10M050117
  • GC10M044382

Summaries for LRRC18 Gene

GeneCards Summary for LRRC18 Gene

LRRC18 (Leucine Rich Repeat Containing 18) is a Protein Coding gene. An important paralog of this gene is LRRC30.

UniProtKB/Swiss-Prot for LRRC18 Gene

  • May be involved in the regulation of spermatogenesis and sperm maturation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC18 Gene

Genomics for LRRC18 Gene

Regulatory Elements for LRRC18 Gene

Genomic Location for LRRC18 Gene

48,909,483 bp from pter
48,939,935 bp from pter
30,453 bases
Minus strand

Genomic View for LRRC18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC18 Gene

Proteins for LRRC18 Gene

  • Protein details for LRRC18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 18
    Protein Accession:
    Secondary Accessions:
    • Q6UY02

    Protein attributes for LRRC18 Gene

    261 amino acids
    Molecular mass:
    29737 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC18 Gene


neXtProt entry for LRRC18 Gene

Proteomics data for LRRC18 Gene at MOPED

Post-translational modifications for LRRC18 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC18 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LRRC18 Gene

Domains for LRRC18 Gene

Protein Domains for LRRC18 Gene


Suggested Antigen Peptide Sequences for LRRC18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 LRR (leucine-rich) repeats.
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC18: view

No data available for Gene Families for LRRC18 Gene

Function for LRRC18 Gene

Molecular function for LRRC18 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of spermatogenesis and sperm maturation.

Gene Ontology (GO) - Molecular Function for LRRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC18: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC18 Gene

Localization for LRRC18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC18 Gene


Subcellular locations from

Jensen Localization Image for LRRC18 Gene COMPARTMENTS Subcellular localization image for LRRC18 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LRRC18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LRRC18: view

Pathways for LRRC18 Gene

SuperPathways for LRRC18 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC18 Gene


No data available for Pathways by source for LRRC18 Gene

Transcripts for LRRC18 Gene

mRNA/cDNA for LRRC18 Gene

(10) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC18 Gene

Leucine rich repeat containing 18:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC18 Gene

No ASD Table

Relevant External Links for LRRC18 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC18 Gene

mRNA expression in normal human tissues for LRRC18 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC18 Gene

This gene is overexpressed in Testis (38.0).

Protein differential expression in normal tissues for LRRC18 Gene

This gene is overexpressed in Platelet (57.8) and Liver, secretome (8.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRRC18 Gene

SOURCE GeneReport for Unigene cluster for LRRC18 Gene Hs.202438

genes like me logo Genes that share expressions with LRRC18: view

Expression partners for LRRC18 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRC18 Gene

Orthologs for LRRC18 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC18 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC18 35
  • 85.73 (n)
  • 85.19 (a)
LRRC18 36
  • 85 (a)
(Canis familiaris)
Mammalia LRRC18 35
  • 85.49 (n)
  • 84.71 (a)
LRRC18 36
  • 84 (a)
(Mus musculus)
Mammalia Lrrc18 35
  • 83.13 (n)
  • 81.93 (a)
Lrrc18 16
Lrrc18 36
  • 82 (a)
(Pan troglodytes)
Mammalia LRRC18 35
  • 98.6 (n)
  • 97.32 (a)
LRRC18 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Lrrc18 35
  • 82.65 (n)
  • 82.79 (a)
(Monodelphis domestica)
Mammalia LRRC18 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC18 36
  • 67 (a)
(Gallus gallus)
Aves LRRC18 35
  • 62.98 (n)
  • 59.84 (a)
LRRC18 36
  • 60 (a)
(Anolis carolinensis)
Reptilia LRRC18 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc18 35
  • 63.79 (n)
  • 64.61 (a)
(Danio rerio)
Actinopterygii lrrc18b 35
  • 59.44 (n)
  • 55 (a)
lrrc18a 36
  • 48 (a)
lrrc18b 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10307 36
  • 20 (a)
CG11099 36
  • 15 (a)
(Caenorhabditis elegans)
Secernentea C14F11.2 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
Species with no ortholog for LRRC18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC18 Gene

Gene Tree for LRRC18 (if available)
Gene Tree for LRRC18 (if available)

Paralogs for LRRC18 Gene

genes like me logo Genes that share paralogs with LRRC18: view

Variants for LRRC18 Gene

Sequence variations from dbSNP and Humsavar for LRRC18 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_028161 -
VAR_028162 -

Structural Variations from Database of Genomic Variants (DGV) for LRRC18 Gene

Variant ID Type Subtype PubMed ID
nsv7203 OTHER Inversion 18451855
nsv895365 CNV Loss 21882294
nsv895369 CNV Gain 21882294
nsv895371 CNV Gain 21882294
nsv831865 CNV Gain 17160897
nsv517287 CNV Loss 19592680

Relevant External Links for LRRC18 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC18 Gene

Disorders for LRRC18 Gene

Relevant External Links for LRRC18

Genetic Association Database (GAD)

No disorders were found for LRRC18 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LRRC18 Gene

Publications for LRRC18 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PMID: 17903303) O'Donnell C.J. … Demissie S. (BMC Med. Genet. 2007) 3 48
  4. Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. (PMID: 19838193) Han J.W. … Zhang X.J. (Nat. Genet. 2009) 3 48
  5. Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis. (PMID: 15707978) Nie D.S. … Lu G.X. (Biochem. Biophys. Res. Commun. 2005) 3

Products for LRRC18 Gene

Sources for LRRC18 Gene

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