LRRC18 Gene
protein-coding GIFtS: 40
GCID: GC10M050117
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leucine rich repeat containing 18
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Aliases
for LRRC18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 181 2 | | UNQ9331 2 | | UNQ93381 2 | | VKGE93381 2 | | MGC347731 | | Leucine-Rich Repeat-Containing Protein 182 |
Export aliases for LRRC18 gene to outside databasesPrevious GC identifers: GC10U900454 GC10M049788 GC10M044382 |
Summaries
for LRRC18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: LRC18_HUMAN, Q8N456Function: May be involved in the regulation of spermatogenesis and sperm maturation (By similarity)
|
Genomic Views
for LRRC18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC18 gene promoter:
Pbx1a AML1a p300 E47 MZF-1 Nkx6-1 FOXJ2 (long isoform) Hand1 FOXJ2 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.23 Ensembl cytogenetic band: 10q11.23 HGNC cytogenetic band: 10q11.23LRRC18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M050117: view genomic region
(about GC identifiers)
Start:
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50,117,528 bp from pter |
End:
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50,143,242 bp from pter |
Size:
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25,715 bases |
Orientation:
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minus strand |
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Proteins
for LRRC18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC18_HUMAN, Q8N456 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 18 Size: 261 amino acids; 29737 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q6UY02Alternative splicing: 2 isoforms: Q8N456-1 Q8N456-2 Explore the universe of human proteins at neXtProt for LRRC18: NX_Q8N456
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N456
LRRC18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001006940.3
ENSEMBL proteins: ENSP00000363275 ENSP00000298124
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
LRRC18 for ontologies About GeneDecksing
LRRC18 Antibody Products:
Assay Products for LRRC18: |
Protein
Domains /
Families
for LRRC18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC18 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N456ProtoNet protein and cluster: Q8N456 UniProtKB/Swiss-Prot: LRC18_HUMAN, Q8N456Similarity: Contains 7 LRR (leucine-rich) repeats |
Function
for LRRC18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: LRC18_HUMAN, Q8N456Function: May be involved in the regulation of spermatogenesis and sperm maturation (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC18 |
|
Pathways & Interactions
for LRRC18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for LRRC18 (Q8N4562, 3 ENSP000002981244) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
|
Drugs & Compounds
for LRRC18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC18
Search CenterWatch for drugs/clinical trials and news about LRRC18 / LRC18
|
Transcripts
for LRRC18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC18 gene: NM_001006939.3 Unigene Cluster for LRRC18: Leucine rich repeat containing 18 Hs.202438 [show with all ESTs]Unigene Representative Sequence: BC0367222 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374160(uc001jhd.3) ENST00000298124(uc001jhe.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRC18 (NM_001006939) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LRRC18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC18 |
Additional cDNA sequence: AY358137.1 BC036722.1 2 DOTS entries: DT.75140908 DT.75132912
GeneLoc Exon Structure
|
Expression
for LRRC18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See LRRC18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC18
SOURCE GeneReport for Unigene cluster: Hs.202438
SABiosciences Custom PCR Arrays for LRRC18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC18 |
Orthologs
for LRRC18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for LRRC18 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for LRRC18 (if available)
TreeFam Gene Tree for LRRC18 (if available) |
Paralogs
for LRRC18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC18 gene
- LRRC72 LRRC22 ERBB2IP2 MFHAS12 LRRC302 LRRC12 PIDD2 LRRIQ42
- SCRIB2 SHOC22 LRRD12 LRRC10B2 LRRC392 LRRC402 LRRC102
LRRC18 for paralogs About GeneDecksing
|
Genomic Variants
for LRRC18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LRRC18
2 CNVs: 48562 48561 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC18 |
|
Disorders
/ Diseases
for LRRC18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRRC18 for disorders About GeneDecksing
3  diseases for LRRC18: About MalaCardssystemic lupus erythematosus lupus erythematosus atherosclerosis
Export disorders for LRRC18 gene to outside databases
|
Publications
for LRRC18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Genome-wide association study in a Chinese Han popula tion identifies nine new susceptibility loci for systemic lupus erythematosus. (PubMed id 19838193)1 Han J.W....Zhang X.J. (2009)
- Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study. (PubMed id 17903303)1 O'Donnell C.J....Demissie S. (2007)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Identification of a novel testis-specific gene mtLR1, which is expressed at specific stages of mouse spermatogenesis. (PubMed id 15707978)1 Nie D.S....Lu G.X. (2005)
- Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for LRRC18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC18 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for LRRC18 gene:
Search GeneIP for patents involving LRRC18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC18 | | | OriGene Protein Over-expression Lysate for LRRC18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC18 | | OriGene 3'-UTR Clone for LRRC18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LRRC18 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC18 | | OriGene Custom Protein Services for LRRC18 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC18 |
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 | | | LRRC18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC18 |
|  |  |  | | | | ThermoFisher Antibodies for LRRC18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC18 |
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