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Aliases for LRRC17 Gene

Aliases for LRRC17 Gene

  • Leucine Rich Repeat Containing 17 2 3 5
  • P37NB 3 4
  • 37 KDa Leucine-Rich Repeat (LRR) Protein 3

External Ids for LRRC17 Gene

Previous GeneCards Identifiers for LRRC17 Gene

  • GC07P102100
  • GC07P102113
  • GC07P102147
  • GC07P102340
  • GC07P102553
  • GC07P096915

Summaries for LRRC17 Gene

GeneCards Summary for LRRC17 Gene

LRRC17 (Leucine Rich Repeat Containing 17) is a Protein Coding gene. Diseases associated with LRRC17 include Neuroblastoma. An important paralog of this gene is NOTCH2NL.

UniProtKB/Swiss-Prot for LRRC17 Gene

  • Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Gene Wiki entry for LRRC17 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC17 Gene

Genomics for LRRC17 Gene

Regulatory Elements for LRRC17 Gene

Enhancers for LRRC17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC17 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRRC17 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC17 Gene

Chromosome:
7
Start:
102,912,897 bp from pter
End:
102,945,111 bp from pter
Size:
32,215 bases
Orientation:
Plus strand

Genomic View for LRRC17 Gene

Genes around LRRC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC17 Gene

Proteins for LRRC17 Gene

  • Protein details for LRRC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6Y2-LRC17_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 17
    Protein Accession:
    Q8N6Y2
    Secondary Accessions:
    • Q13288
    • Q6UWA7
    • Q75MG5

    Protein attributes for LRRC17 Gene

    Size:
    441 amino acids
    Molecular mass:
    51800 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC17 Gene

Proteomics data for LRRC17 Gene at MOPED

Post-translational modifications for LRRC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC17 Gene

No data available for DME Specific Peptides for LRRC17 Gene

Domains & Families for LRRC17 Gene

Protein Domains for LRRC17 Gene

Suggested Antigen Peptide Sequences for LRRC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6Y2

UniProtKB/Swiss-Prot:

LRC17_HUMAN :
  • Contains 2 LRRCT domains.
  • Contains 6 LRR (leucine-rich) repeats.
Domain:
  • Contains 2 LRRCT domains.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC17: view

No data available for Gene Families for LRRC17 Gene

Function for LRRC17 Gene

Molecular function for LRRC17 Gene

UniProtKB/Swiss-Prot Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).
genes like me logo Genes that share phenotypes with LRRC17: view

Animal Model Products

miRNA for LRRC17 Gene

miRTarBase miRNAs that target LRRC17

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC17 Gene

Localization for LRRC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC17 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC17 Gene COMPARTMENTS Subcellular localization image for LRRC17 gene
Compartment Confidence
extracellular 5
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for LRRC17 Gene

Pathways & Interactions for LRRC17 Gene

SuperPathways for LRRC17 Gene

No Data Available

Interacting Proteins for LRRC17 Gene

Gene Ontology (GO) - Biological Process for LRRC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 NOT osteoblast differentiation ISS --
GO:0033687 NOT osteoblast proliferation ISS --
genes like me logo Genes that share ontologies with LRRC17: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC17 Gene

Drugs & Compounds for LRRC17 Gene

No Compound Related Data Available

Transcripts for LRRC17 Gene

Unigene Clusters for LRRC17 Gene

Leucine rich repeat containing 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC17 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for LRRC17 Gene

GeneLoc Exon Structure for
LRRC17
ECgene alternative splicing isoforms for
LRRC17

Expression for LRRC17 Gene

mRNA expression in normal human tissues for LRRC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC17 Gene

This gene is overexpressed in Ovary (x11.0), Artery - Coronary (x5.5), and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for LRRC17 Gene

This gene is overexpressed in Ovary (22.7), Monocytes (21.0), Tlymphocyte (10.8), and Neutrophil (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC17 Gene



SOURCE GeneReport for Unigene cluster for LRRC17 Gene Hs.567412

mRNA Expression by UniProt/SwissProt for LRRC17 Gene

Q8N6Y2-LRC17_HUMAN
Tissue specificity: Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.
genes like me logo Genes that share expression patterns with LRRC17: view

Primer Products

No data available for Protein tissue co-expression partners for LRRC17 Gene

Orthologs for LRRC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC17 35
  • 90.02 (n)
  • 91.61 (a)
LRRC17 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC17 35
  • 85.51 (n)
  • 87.15 (a)
LRRC17 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc17 35
  • 84.13 (n)
  • 87.53 (a)
Lrrc17 16
Lrrc17 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC17 35
  • 99.55 (n)
  • 99.32 (a)
LRRC17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc17 35
  • 82.31 (n)
  • 87.3 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC17 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC17 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC17 35
  • 73.49 (n)
  • 74.02 (a)
P37NB 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC17 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc17 35
  • 66.35 (n)
  • 63.93 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc17 35
  • 56.41 (n)
  • 54.62 (a)
lrrc17 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sli 36
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for LRRC17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC17 Gene

ENSEMBL:
Gene Tree for LRRC17 (if available)
TreeFam:
Gene Tree for LRRC17 (if available)

Paralogs for LRRC17 Gene

Paralogs for LRRC17 Gene

genes like me logo Genes that share paralogs with LRRC17: view

Variants for LRRC17 Gene

Sequence variations from dbSNP and Humsavar for LRRC17 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_051103 -
VAR_051104 -
VAR_051105 -

Structural Variations from Database of Genomic Variants (DGV) for LRRC17 Gene

Variant ID Type Subtype PubMed ID
esv2752138 CNV Loss 17911159
nsv464667 CNV Loss 19166990
esv2452928 CNV Insertion 19546169
esv1748254 CNV Insertion 17803354

Variation tolerance for LRRC17 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LRRC17 Gene

Disorders for LRRC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC17 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LRRC17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC17
genes like me logo Genes that share disorders with LRRC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC17 Gene

Publications for LRRC17 Gene

  1. A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution. (PMID: 8982252) Kim D. … Yang S.Y. (Biochim. Biophys. Acta 1996) 2 3 4 23 67
  2. Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. (PMID: 19336404) Kim T. … Choi Y. (J. Biol. Chem. 2009) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3

Products for LRRC17 Gene

Sources for LRRC17 Gene

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