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Aliases for LRRC17 Gene

Aliases for LRRC17 Gene

  • Leucine Rich Repeat Containing 17 2 3 5
  • P37NB 3 4
  • Leucine-Rich Repeat-Containing Protein 17 3
  • 37 KDa Leucine-Rich Repeat (LRR) Protein 3

External Ids for LRRC17 Gene

Previous GeneCards Identifiers for LRRC17 Gene

  • GC07P102100
  • GC07P102113
  • GC07P102147
  • GC07P102340
  • GC07P102553
  • GC07P096915

Summaries for LRRC17 Gene

GeneCards Summary for LRRC17 Gene

LRRC17 (Leucine Rich Repeat Containing 17) is a Protein Coding gene. Diseases associated with LRRC17 include Neuroblastoma. An important paralog of this gene is SLIT3.

UniProtKB/Swiss-Prot for LRRC17 Gene

  • Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Gene Wiki entry for LRRC17 Gene

Additional gene information for LRRC17 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC17 Gene

Genomics for LRRC17 Gene

Regulatory Elements for LRRC17 Gene

Enhancers for LRRC17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H102870 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -38.9 -38904 6 PKNOX1 FOXA2 SIN3A ATF7 FOS RUNX3 JUNB PPARG ZNF592 NFIL3 LRRC17 CRYZP1 FAM185A ENSG00000213385 POLR2J3 UPK3BL1 ARMC10 ORAI2 LRWD1 RN7SKP198
GH07H102987 1.6 Ensembl ENCODE dbSUPER 11 +78.5 78468 6 HDGF PKNOX1 FOXA2 ARNT FEZF1 ZNF2 ZNF766 CBX5 FOS DEK PRKRIP1 ENSG00000213385 CRYZP1 ENSG00000239486 DNAJC2 PMPCB ALKBH4 DPY19L2P2 LRRC17 ARMC10
GH07H102889 1.3 Ensembl ENCODE dbSUPER 12.5 -21.3 -21317 3 HDAC1 PKNOX1 ATF1 JUN CEBPG ZBTB40 FOSL1 GATA2 POLR2A FOS LRRC17 LRWD1 ORAI2 ARMC10 RN7SKP198
GH07H102932 1.2 Ensembl ENCODE dbSUPER 12.3 +21.6 21636 3 HDAC1 PKNOX1 TAL1 CEBPG RAD21 ZNF766 POLR2A FOS RCOR1 SOX6 LRRC17 NAPEPLD ARMC10 LRWD1 NFE4
GH07H102912 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +2.4 2411 6 ELF3 CTCF PKNOX1 JUN RAD21 ZNF316 ZNF366 ZNF547 PATZ1 FOS RNU6-1136P FBXL13 DPY19L2P2 ARMC10 LRRC17 RASA4 RPL23AP95 NFE4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC17 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000216170 503 1601 PKNOX1 ZNF174 CHD1 RAD21 ZNF366 ZNF692 PATZ1 ZNF547 ZNF600 PRDM1

Genomic Location for LRRC17 Gene

Chromosome:
7
Start:
102,912,897 bp from pter
End:
102,945,111 bp from pter
Size:
32,215 bases
Orientation:
Plus strand

Genomic View for LRRC17 Gene

Genes around LRRC17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC17 Gene

Proteins for LRRC17 Gene

  • Protein details for LRRC17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6Y2-LRC17_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 17
    Protein Accession:
    Q8N6Y2
    Secondary Accessions:
    • Q13288
    • Q6UWA7
    • Q75MG5

    Protein attributes for LRRC17 Gene

    Size:
    441 amino acids
    Molecular mass:
    51800 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRRC17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC17 Gene

Post-translational modifications for LRRC17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC17 Gene

No data available for DME Specific Peptides for LRRC17 Gene

Domains & Families for LRRC17 Gene

Gene Families for LRRC17 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for LRRC17 Gene

Suggested Antigen Peptide Sequences for LRRC17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC17: view

No data available for UniProtKB/Swiss-Prot for LRRC17 Gene

Function for LRRC17 Gene

Molecular function for LRRC17 Gene

UniProtKB/Swiss-Prot Function:
Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).

Phenotypes From GWAS Catalog for LRRC17 Gene

genes like me logo Genes that share phenotypes with LRRC17: view

Animal Model Products

CRISPR Products

miRNA for LRRC17 Gene

miRTarBase miRNAs that target LRRC17

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC17 Gene

Localization for LRRC17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC17 Gene

Secreted, extracellular space.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC17 gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space ISS --
genes like me logo Genes that share ontologies with LRRC17: view

Pathways & Interactions for LRRC17 Gene

SuperPathways for LRRC17 Gene

No Data Available

Interacting Proteins for LRRC17 Gene

Gene Ontology (GO) - Biological Process for LRRC17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 NOT osteoblast differentiation ISS --
GO:0033687 NOT osteoblast proliferation ISS --
GO:0045671 negative regulation of osteoclast differentiation ISS --
GO:0048539 bone marrow development ISS --
genes like me logo Genes that share ontologies with LRRC17: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC17 Gene

Drugs & Compounds for LRRC17 Gene

No Compound Related Data Available

Transcripts for LRRC17 Gene

Unigene Clusters for LRRC17 Gene

Leucine rich repeat containing 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC17
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC17 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5
SP1:
SP2: -
SP3:

Relevant External Links for LRRC17 Gene

GeneLoc Exon Structure for
LRRC17
ECgene alternative splicing isoforms for
LRRC17

Expression for LRRC17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC17 Gene

This gene is overexpressed in Ovary (x11.0), Artery - Coronary (x5.5), and Artery - Aorta (x4.4).

Protein differential expression in normal tissues from HIPED for LRRC17 Gene

This gene is overexpressed in Ovary (22.7), Monocytes (21.0), Tlymphocyte (10.8), and Neutrophil (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC17 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC17 Gene:

LRRC17

SOURCE GeneReport for Unigene cluster for LRRC17 Gene:

Hs.567412

mRNA Expression by UniProt/SwissProt for LRRC17 Gene:

Q8N6Y2-LRC17_HUMAN
Tissue specificity: Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.

Evidence on tissue expression from TISSUES for LRRC17 Gene

  • Pancreas(4.1)
  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with LRRC17: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC17 Gene

Orthologs for LRRC17 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC17 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia LRRC17 33 34
  • 90.02 (n)
dog
(Canis familiaris)
Mammalia LRRC17 33 34
  • 85.51 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC17 34
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc17 33 16 34
  • 84.13 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc17 33
  • 82.31 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC17 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC17 33
  • 73.49 (n)
P37NB 34
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC17 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc17 33
  • 66.35 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc17 33 34
  • 56.41 (n)
fruit fly
(Drosophila melanogaster)
Insecta sli 34
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea slt-1 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 12 (a)
OneToMany
Species where no ortholog for LRRC17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC17 Gene

ENSEMBL:
Gene Tree for LRRC17 (if available)
TreeFam:
Gene Tree for LRRC17 (if available)

Paralogs for LRRC17 Gene

genes like me logo Genes that share paralogs with LRRC17: view

Variants for LRRC17 Gene

Sequence variations from dbSNP and Humsavar for LRRC17 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000007686 -- 102,922,871(+) TACTC(A/G)GGAGG intron-variant
rs1000178607 -- 102,929,267(+) GTGCT(A/C)AGTTC intron-variant
rs1000196679 -- 102,936,358(+) GTCTA(C/T)CTGAG intron-variant
rs1000360631 -- 102,915,900(+) TGAGT(A/G)AAAAT intron-variant
rs1000376502 -- 102,944,038(+) ACTTA(C/T)AGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC17 Gene

Variant ID Type Subtype PubMed ID
dgv6538n100 CNV gain 25217958
esv1748254 CNV insertion 17803354
esv2452928 CNV insertion 19546169
esv2752138 CNV loss 17911159
esv3447330 CNV duplication 20981092
esv3614364 CNV loss 21293372
esv3614365 CNV loss 21293372
nsv464667 CNV loss 19166990
nsv608058 CNV gain 21841781
nsv608060 CNV loss 21841781

Variation tolerance for LRRC17 Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.85; 86.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC17 Gene

Disorders for LRRC17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC17 Gene - From: GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LRRC17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC17
genes like me logo Genes that share disorders with LRRC17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC17 Gene

Publications for LRRC17 Gene

  1. A cDNA encoding a putative 37 kDa leucine-rich repeat (LRR) protein, p37NB, isolated from S-type neuroblastoma cell has a differential tissue distribution. (PMID: 8982252) Kim D … Yang SY (Biochimica et biophysica acta 1996) 2 3 4 22 60
  2. Identification of LRRc17 as a negative regulator of receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. (PMID: 19336404) Kim T … Choi Y (The Journal of biological chemistry 2009) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60

Products for LRRC17 Gene

Sources for LRRC17 Gene

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