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Aliases for LRRC16A Gene

Aliases for LRRC16A Gene

  • Leucine Rich Repeat Containing 16A 2 3
  • Leucine Rich Repeat Containing 16 2 3
  • CARMIL Homolog 3 4
  • CARMIL1a 3 4
  • LRRC16 3 4
  • CARMIL 3 4
  • Capping Protein, Arp2/3, And Myosin-I Linker Homolog 1 3
  • And Myosin-I Linker Homolog 1 (Dictyostelium) 2
  • Capping Protein 2
  • DJ501N12.1 3
  • DJ501N12.5 3
  • CARMIL1 3
  • Arp2/3 2

External Ids for LRRC16A Gene

Previous HGNC Symbols for LRRC16A Gene

  • LRRC16

Previous GeneCards Identifiers for LRRC16A Gene

  • GC06P025389
  • GC06P025222

Summaries for LRRC16A Gene

GeneCards Summary for LRRC16A Gene

LRRC16A (Leucine Rich Repeat Containing 16A) is a Protein Coding gene. Diseases associated with LRRC16A include acute urate nephropathy and gout. Among its related pathways are Hemostasis and Factors involved in megakaryocyte development and platelet production. GO annotations related to this gene include protein complex binding. An important paralog of this gene is RLTPR.

UniProtKB/Swiss-Prot for LRRC16A Gene

  • Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration.

Gene Wiki entry for LRRC16A Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC16A Gene

Genomics for LRRC16A Gene

Regulatory Elements for LRRC16A Gene

Genomic Location for LRRC16A Gene

Chromosome:
6
Start:
25,279,078 bp from pter
End:
25,620,530 bp from pter
Size:
341,453 bases
Orientation:
Plus strand

Genomic View for LRRC16A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC16A Gene

Proteins for LRRC16A Gene

  • Protein details for LRRC16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZK9-LR16A_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 16A
    Protein Accession:
    Q5VZK9
    Secondary Accessions:
    • B8X1J0
    • Q6ZUH5
    • Q6ZW07
    • Q9NXU7

    Protein attributes for LRRC16A Gene

    Size:
    1371 amino acids
    Molecular mass:
    151557 Da
    Quaternary structure:
    • Interacts via its C-terminus with CAPZA2 in cytoplasm; interaction is essential for lamellipodial protrusion and cell translocation (By similarity). Homodimer.
    SequenceCaution:
    • Sequence=BAA90912.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for LRRC16A Gene

    Alternative splice isoforms for LRRC16A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC16A Gene

Proteomics data for LRRC16A Gene at MOPED

Post-translational modifications for LRRC16A Gene

  • Ubiquitination at Lys 593
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC16A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC16A Gene

Domains & Families for LRRC16A Gene

Protein Domains for LRRC16A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC16A Gene

Graphical View of Domain Structure for InterPro Entry

Q5VZK9

UniProtKB/Swiss-Prot:

LR16A_HUMAN :
  • Belongs to the CARMIL family.
  • Contains 11 LRR (leucine-rich) repeats.
Family:
  • Belongs to the CARMIL family.
Similarity:
  • Contains 11 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC16A: view

No data available for Gene Families for LRRC16A Gene

Function for LRRC16A Gene

Molecular function for LRRC16A Gene

UniProtKB/Swiss-Prot Function:
Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity). May control actin dynamics in lamellipodia. Required for cell migration.

Gene Ontology (GO) - Molecular Function for LRRC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 16054028
genes like me logo Genes that share ontologies with LRRC16A: view

Phenotypes for LRRC16A Gene

GenomeRNAi human phenotypes for LRRC16A:
genes like me logo Genes that share phenotypes with LRRC16A: view

Animal Model Products

CRISPR Products

miRNA for LRRC16A Gene

miRTarBase miRNAs that target LRRC16A

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC16A Gene

Localization for LRRC16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC16A Gene

Cell projection, lamellipodium. Cytoplasm. Note=Colocalized with F-actin in lamellipodia but not with F-actin in stress fibers. Also found on macropinosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC16A Gene COMPARTMENTS Subcellular localization image for LRRC16A gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for LRRC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0030027 lamellipodium IDA 19846667
GO:0031941 filamentous actin ISS --
genes like me logo Genes that share ontologies with LRRC16A: view

Pathways & Interactions for LRRC16A Gene

genes like me logo Genes that share pathways with LRRC16A: view

Pathways by source for LRRC16A Gene

Gene Ontology (GO) - Biological Process for LRRC16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007015 actin filament organization NAS 19846667
GO:0007596 blood coagulation TAS --
GO:0016477 cell migration IMP 19846667
GO:0030032 lamellipodium assembly IMP 19846667
GO:0030335 positive regulation of cell migration IMP 16054028
genes like me logo Genes that share ontologies with LRRC16A: view

No data available for SIGNOR curated interactions for LRRC16A Gene

Drugs & Compounds for LRRC16A Gene

No Compound Related Data Available

Transcripts for LRRC16A Gene

mRNA/cDNA for LRRC16A Gene

(9) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC16A Gene

Leucine rich repeat containing 16A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC16A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC16A Gene

No ASD Table

Relevant External Links for LRRC16A Gene

GeneLoc Exon Structure for
LRRC16A
ECgene alternative splicing isoforms for
LRRC16A

Expression for LRRC16A Gene

mRNA expression in normal human tissues for LRRC16A Gene

Protein differential expression in normal tissues from HIPED for LRRC16A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (24.7) and Serum (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC16A Gene



SOURCE GeneReport for Unigene cluster for LRRC16A Gene Hs.649550

mRNA Expression by UniProt/SwissProt for LRRC16A Gene

Q5VZK9-LR16A_HUMAN
Tissue specificity: Expressed in lung, placenta, small intestine, liver, thymus, colon, skeletal muscle, heart and brain. Higher expression in kidney.
genes like me logo Genes that share expression patterns with LRRC16A: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for LRRC16A Gene

Orthologs for LRRC16A Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC16A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC16A 35
  • 90.53 (n)
  • 91.94 (a)
LRRC16A 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC16A 35
  • 90.1 (n)
  • 93.65 (a)
LRRC16A 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc16a 35
  • 84.66 (n)
  • 89.76 (a)
Lrrc16a 16
Lrrc16a 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC16A 35
  • 99.61 (n)
  • 99.71 (a)
LRRC16A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc16a 35
  • 85.03 (n)
  • 89.9 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC16A 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRRC16A 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC16A 35
  • 79.41 (n)
  • 87.96 (a)
LRRC16A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC16A 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc16a 35
  • 77.76 (n)
  • 87.52 (a)
Str.17185 35
zebrafish
(Danio rerio)
Actinopterygii LRRC16A 36
  • 66 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004841 35
  • 49.03 (n)
  • 42.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1399 35
  • 49.16 (n)
  • 42.22 (a)
CG1399 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea crml-1 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
ManyToMany
Species with no ortholog for LRRC16A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC16A Gene

ENSEMBL:
Gene Tree for LRRC16A (if available)
TreeFam:
Gene Tree for LRRC16A (if available)

Paralogs for LRRC16A Gene

Paralogs for LRRC16A Gene

(2) SIMAP similar genes for LRRC16A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRC16A: view

Variants for LRRC16A Gene

Sequence variations from dbSNP and Humsavar for LRRC16A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs118855 -- 25,551,654(+) ACTTT(A/T)CTGAA intron-variant
rs140854 -- 25,531,332(-) TTTCA(-/TTCT)AAGAA intron-variant
rs150533 -- 25,535,384(-) TCTTC(C/T)AGTGA intron-variant
rs150551 -- 25,533,702(-) TGCAT(C/T)GGGGA intron-variant
rs169946 -- 25,551,915(-) TTTTT(C/G)GCTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC16A Gene

Variant ID Type Subtype PubMed ID
nsv883484 CNV Gain 21882294
dgv6439n71 CNV Gain 21882294
nsv883487 CNV Gain 21882294
esv24399 CNV Loss 19812545
esv8827 CNV Gain 19470904
nsv830612 CNV Gain 17160897
esv275059 CNV Loss 21479260
esv271205 CNV Insertion 20981092
esv26089 CNV Gain 19812545
nsv819937 CNV Loss 19587683
esv27936 CNV Loss 19812545
esv2731721 CNV Deletion 23290073
esv27920 CNV Gain 19812545
nsv823458 CNV Gain 20364138
esv2731722 CNV Deletion 23290073
esv1982720 CNV Deletion 18987734
esv2676638 CNV Deletion 23128226
nsv349286 CNV Loss 16902084
esv2731723 CNV Deletion 23290073
nsv883488 CNV Gain 21882294

Variation tolerance for LRRC16A Gene

Residual Variation Intolerance Score: 53.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC16A Gene

HapMap Linkage Disequilibrium report
LRRC16A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC16A Gene

Disorders for LRRC16A Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRRC16A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
acute urate nephropathy
  • uric acid nephrolithiasis
gout
  • gouty arthritis
- elite association

Relevant External Links for LRRC16A

Genetic Association Database (GAD)
LRRC16A
Human Genome Epidemiology (HuGE) Navigator
LRRC16A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC16A
genes like me logo Genes that share disorders with LRRC16A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC16A Gene

Publications for LRRC16A Gene

  1. Distinct roles for CARMIL isoforms in cell migration. (PMID: 19846667) Liang Y. … Cooper J.A. (Mol. Biol. Cell 2009) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Platelet count mediates the contribution of a genetic variant in LRRC16A to ARDS risk. (PMID: 25254322) Wei Y. … Christiani D.C. (Chest 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for LRRC16A Gene

Sources for LRRC16A Gene

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