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Aliases for LRRC15 Gene

Aliases for LRRC15 Gene

  • Leucine Rich Repeat Containing 15 2 3 5
  • Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog 3 4
  • HLib 3 4
  • LIB 3 4
  • Leucine-Rich Repeat Protein Induced By Beta Amyloid 3
  • Leucine-Rich Repeat-Containing Protein 15 3

External Ids for LRRC15 Gene

Previous GeneCards Identifiers for LRRC15 Gene

  • GC03M195480
  • GC03M195399
  • GC03M195396
  • GC03M195557
  • GC03M194075
  • GC03M191455

Summaries for LRRC15 Gene

GeneCards Summary for LRRC15 Gene

LRRC15 (Leucine Rich Repeat Containing 15) is a Protein Coding gene. GO annotations related to this gene include collagen binding and laminin binding. An important paralog of this gene is GP5.

Additional gene information for LRRC15 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC15 Gene

Genomics for LRRC15 Gene

Regulatory Elements for LRRC15 Gene

Enhancers for LRRC15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H194364 1 Ensembl ENCODE 35.7 +4.6 4571 1 PKNOX1 INSM2 FEZF1 ZIC2 HIC1 ZNF664 GLIS2 RCOR1 FOS ZNF600 LRRC15 CPN2
GH03H194129 2.1 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +233.1 233149 14 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D LSG1 ENSG00000229964 LINC01972 ENSG00000233987 ENSG00000238031 LRRC15 OPA1-AS1 ENSG00000272707 ENSG00000232874 HES1
GH03H195100 2 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -733.9 -733879 7 HDGF FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B XXYLT1-AS2 LRRC15 LSG1 RN7SL36P FAM43A PPP1R2 ACAP2 XXYLT1-AS1 MIR3137
GH03H193868 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.5 +498.0 498025 6 PKNOX1 ATF1 ZFP64 SIN3A GLI4 ZBTB7B TCF12 GATA2 ATF7 FOS LSG1 LRRC15 ENSG00000232874 HES1 OPA1-AS1 LOC105374286 LINC02038
GH03H194069 1.4 ENCODE dbSUPER 16 +298.5 298517 4 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 LSG1 LRRC15 OPA1-AS1 ENSG00000232874 HES1 FAM43A LINC02028 ENSG00000229334 ENSG00000229964
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC15 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC15 Gene

Chromosome:
3
Start:
194,355,247 bp from pter
End:
194,369,743 bp from pter
Size:
14,497 bases
Orientation:
Minus strand

Genomic View for LRRC15 Gene

Genes around LRRC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC15 Gene

Proteins for LRRC15 Gene

  • Protein details for LRRC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF66-LRC15_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 15
    Protein Accession:
    Q8TF66
    Secondary Accessions:
    • Q495Q6
    • Q7RTN7

    Protein attributes for LRRC15 Gene

    Size:
    581 amino acids
    Molecular mass:
    64366 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01065.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01740.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC15 Gene

Post-translational modifications for LRRC15 Gene

  • Glycosylation at posLast=7575 and posLast=369369
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC15 Gene

Domains & Families for LRRC15 Gene

Gene Families for LRRC15 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for LRRC15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC15: view

No data available for UniProtKB/Swiss-Prot for LRRC15 Gene

Function for LRRC15 Gene

Phenotypes From GWAS Catalog for LRRC15 Gene

Gene Ontology (GO) - Molecular Function for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding IDA 16098915
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005518 collagen binding IDA 16098915
GO:0043236 laminin binding IDA 16098915
genes like me logo Genes that share ontologies with LRRC15: view
genes like me logo Genes that share phenotypes with LRRC15: view

Animal Models for LRRC15 Gene

MGI Knock Outs for LRRC15:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC15

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC15 Gene

Localization for LRRC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC15 gene
Compartment Confidence
extracellular 5
plasma membrane 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LRRC15: view

Pathways & Interactions for LRRC15 Gene

SuperPathways for LRRC15 Gene

No Data Available

Interacting Proteins for LRRC15 Gene

Gene Ontology (GO) - Biological Process for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0030335 positive regulation of cell migration IMP 16098915
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:0046813 receptor-mediated virion attachment to host cell IMP 18385238
genes like me logo Genes that share ontologies with LRRC15: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC15 Gene

Drugs & Compounds for LRRC15 Gene

(3) Drugs for LRRC15 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 107
Hydrochlorothiazide Approved, Vet_approved Pharma Inhibition, Inhibitor 421
Metoprolol Approved, Investigational Pharma Antagonist 214
genes like me logo Genes that share compounds with LRRC15: view

Transcripts for LRRC15 Gene

mRNA/cDNA for LRRC15 Gene

Unigene Clusters for LRRC15 Gene

Leucine rich repeat containing 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRRC15
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for LRRC15 Gene

GeneLoc Exon Structure for
LRRC15
ECgene alternative splicing isoforms for
LRRC15

Expression for LRRC15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC15 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.0) and Skin - Sun Exposed (Lower leg) (x6.5).

Protein differential expression in normal tissues from HIPED for LRRC15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.2), Breast (25.3), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC15 Gene



NURSA nuclear receptor signaling pathways regulating expression of LRRC15 Gene:

LRRC15

SOURCE GeneReport for Unigene cluster for LRRC15 Gene:

Hs.288467

mRNA Expression by UniProt/SwissProt for LRRC15 Gene:

Q8TF66-LRC15_HUMAN
Tissue specificity: Brain and placenta.

Evidence on tissue expression from TISSUES for LRRC15 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LRRC15: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC15 Gene

Orthologs for LRRC15 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC15 33 34
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia LRRC15 33 34
  • 88.74 (n)
cow
(Bos Taurus)
Mammalia LRRC15 33 34
  • 86.16 (n)
mouse
(Mus musculus)
Mammalia Lrrc15 33 16 34
  • 81.55 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc15 33
  • 81.43 (n)
oppossum
(Monodelphis domestica)
Mammalia LRRC15 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC15 33 34
  • 62.8 (n)
lizard
(Anolis carolinensis)
Reptilia LRRC15 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc15 33
  • 52.71 (n)
zebrafish
(Danio rerio)
Actinopterygii lrrc15 33 34
  • 44.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16974 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-1 33
  • 40.11 (n)
Species where no ortholog for LRRC15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC15 Gene

ENSEMBL:
Gene Tree for LRRC15 (if available)
TreeFam:
Gene Tree for LRRC15 (if available)

Paralogs for LRRC15 Gene

(5) SIMAP similar genes for LRRC15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC15: view

Variants for LRRC15 Gene

Sequence variations from dbSNP and Humsavar for LRRC15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000376702 -- 194,369,105(+) GTTAC(A/T)CTTGC intron-variant
rs1001136357 -- 194,356,564(+) ACCAC(C/T)CTGAT utr-variant-3-prime
rs1001198789 -- 194,357,888(+) CAGAT(A/G)CAGGC utr-variant-3-prime
rs1001201698 -- 194,366,839(+) AGGGA(G/T)CAGAG intron-variant
rs1001209736 -- 194,361,942(+) CAGCC(C/T)TGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC15 Gene

Variant ID Type Subtype PubMed ID
esv2726432 CNV deletion 23290073
esv3599194 CNV loss 21293372
esv995002 CNV deletion 20482838
nsv1112389 CNV deletion 24896259
nsv4178 CNV insertion 18451855
nsv472950 CNV novel sequence insertion 20440878
nsv480650 CNV novel sequence insertion 20440878

Variation tolerance for LRRC15 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.91; 87.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC15 Gene

Disorders for LRRC15 Gene

Relevant External Links for LRRC15

Human Genome Epidemiology (HuGE) Navigator
LRRC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC15

No disorders were found for LRRC15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC15 Gene

Publications for LRRC15 Gene

  1. Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. (PMID: 12923058) Reynolds PA … Haber DA (Genes & development 2003) 2 3 4 60
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny DM … Gibbs RA (Nature 2006) 3 4 60
  3. A novel member of the leucine-rich repeat superfamily induced in rat astrocytes by beta-amyloid. (PMID: 11785964) Satoh K … Yokota H (Biochemical and biophysical research communications 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Human gingiva transcriptome during wound healing. (PMID: 28005267) Wang Y … Tatakis DN (Journal of clinical periodontology 2016) 3 60

Products for LRRC15 Gene

Sources for LRRC15 Gene

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