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Aliases for LRRC15 Gene

Aliases for LRRC15 Gene

  • Leucine Rich Repeat Containing 15 2 3 5
  • Leucine-Rich Repeat Protein Induced By Beta-Amyloid Homolog 3 4
  • HLib 3 4
  • LIB 3 4
  • Leucine-Rich Repeat Protein Induced By Beta Amyloid 3

External Ids for LRRC15 Gene

Previous GeneCards Identifiers for LRRC15 Gene

  • GC03M195480
  • GC03M195399
  • GC03M195396
  • GC03M195557
  • GC03M194075
  • GC03M191455

Summaries for LRRC15 Gene

GeneCards Summary for LRRC15 Gene

LRRC15 (Leucine Rich Repeat Containing 15) is a Protein Coding gene. Diseases associated with LRRC15 include waterhouse-friderichsen syndrome. GO annotations related to this gene include collagen binding and laminin binding. An important paralog of this gene is LRRTM2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC15 Gene

Genomics for LRRC15 Gene

Regulatory Elements for LRRC15 Gene

Genomic Location for LRRC15 Gene

Chromosome:
3
Start:
194,355,247 bp from pter
End:
194,369,743 bp from pter
Size:
14,497 bases
Orientation:
Minus strand

Genomic View for LRRC15 Gene

Genes around LRRC15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC15 Gene

Proteins for LRRC15 Gene

  • Protein details for LRRC15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF66-LRC15_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 15
    Protein Accession:
    Q8TF66
    Secondary Accessions:
    • Q495Q6
    • Q7RTN7

    Protein attributes for LRRC15 Gene

    Size:
    581 amino acids
    Molecular mass:
    64366 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI01065.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=DAA01740.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRRC15 Gene

Proteomics data for LRRC15 Gene at MOPED

Post-translational modifications for LRRC15 Gene

  • Glycosylation at Asn 75 and Asn 369
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC15 Gene

Domains & Families for LRRC15 Gene

Suggested Antigen Peptide Sequences for LRRC15 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TF66

UniProtKB/Swiss-Prot:

LRC15_HUMAN :
  • Contains 1 LRRCT domain.
  • Contains 15 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Similarity:
  • Contains 15 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC15: view

No data available for Gene Families for LRRC15 Gene

Function for LRRC15 Gene

Gene Ontology (GO) - Molecular Function for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005518 collagen binding IDA 16098915
genes like me logo Genes that share ontologies with LRRC15: view
genes like me logo Genes that share phenotypes with LRRC15: view

Animal Models for LRRC15 Gene

MGI Knock Outs for LRRC15:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC15 Gene

Localization for LRRC15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC15 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC15 Gene COMPARTMENTS Subcellular localization image for LRRC15 gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with LRRC15: view

Pathways & Interactions for LRRC15 Gene

SuperPathways for LRRC15 Gene

No Data Available

Interacting Proteins for LRRC15 Gene

Selected Interacting proteins: Q8TF66-LRC15_HUMAN for LRRC15 Gene via I2D

Gene Ontology (GO) - Biological Process for LRRC15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:1904030 negative regulation of cyclin-dependent protein kinase activity IBA --
genes like me logo Genes that share ontologies with LRRC15: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC15 Gene

Drugs & Compounds for LRRC15 Gene

(3) Drugs for LRRC15 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 99
Hydrochlorothiazide Approved Pharma Inhibition, Inhibitor 387
Metoprolol Approved, Investigational Pharma Antagonist 193
genes like me logo Genes that share compounds with LRRC15: view

Transcripts for LRRC15 Gene

mRNA/cDNA for LRRC15 Gene

Unigene Clusters for LRRC15 Gene

Leucine rich repeat containing 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2: -

Relevant External Links for LRRC15 Gene

GeneLoc Exon Structure for
LRRC15
ECgene alternative splicing isoforms for
LRRC15

Expression for LRRC15 Gene

mRNA expression in normal human tissues for LRRC15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRRC15 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x25.0) and Skin - Sun Exposed (Lower leg) (x6.5).

Protein differential expression in normal tissues from HIPED for LRRC15 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.2), Breast (25.3), and Urine (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LRRC15 Gene



SOURCE GeneReport for Unigene cluster for LRRC15 Gene Hs.288467

mRNA Expression by UniProt/SwissProt for LRRC15 Gene

Q8TF66-LRC15_HUMAN
Tissue specificity: Brain and placenta.
genes like me logo Genes that share expression patterns with LRRC15: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for LRRC15 Gene

Orthologs for LRRC15 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRRC15 35
  • 86.16 (n)
  • 86.85 (a)
LRRC15 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRRC15 35
  • 88.74 (n)
  • 90.86 (a)
LRRC15 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrrc15 35
  • 81.55 (n)
  • 82.7 (a)
Lrrc15 16
Lrrc15 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRRC15 35
  • 99.14 (n)
  • 98.8 (a)
LRRC15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrrc15 35
  • 81.43 (n)
  • 84.08 (a)
oppossum
(Monodelphis domestica)
Mammalia LRRC15 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRRC15 35
  • 62.8 (n)
  • 55.25 (a)
LRRC15 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRRC15 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc15 35
  • 52.71 (n)
  • 48.08 (a)
zebrafish
(Danio rerio)
Actinopterygii lrrc15 35
  • 44.65 (n)
  • 36.9 (a)
lrrc15 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16974 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lron-1 35
  • 40.11 (n)
  • 33.97 (a)
Species with no ortholog for LRRC15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC15 Gene

ENSEMBL:
Gene Tree for LRRC15 (if available)
TreeFam:
Gene Tree for LRRC15 (if available)

Paralogs for LRRC15 Gene

(5) SIMAP similar genes for LRRC15 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRRC15: view

Variants for LRRC15 Gene

Sequence variations from dbSNP and Humsavar for LRRC15 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs13060627 - 194,360,254(+) GAAGA(C/T)GCTGG reference, missense
rs13070515 - 194,360,187(+) TCCCC(A/G)GAGAG reference, missense
rs6578 -- 194,355,277(-) GTGTA(C/T)AGAAT utr-variant-3-prime
rs8513 -- 194,355,482(-) AGATT(A/G)TTCTC utr-variant-3-prime
rs903329 -- 194,365,964(-) GAAGG(C/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC15 Gene

Variant ID Type Subtype PubMed ID
esv2726432 CNV Deletion 23290073
esv995002 CNV Deletion 20482838
nsv4178 CNV Insertion 18451855

Variation tolerance for LRRC15 Gene

Residual Variation Intolerance Score: 92.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.91; 87.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC15 Gene

HapMap Linkage Disequilibrium report
LRRC15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC15 Gene

Disorders for LRRC15 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC15 Gene - From: DISEASES

Disorder Aliases PubMed IDs
waterhouse-friderichsen syndrome
  • wolfram syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LRRC15

Human Genome Epidemiology (HuGE) Navigator
LRRC15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC15
genes like me logo Genes that share disorders with LRRC15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC15 Gene

Publications for LRRC15 Gene

  1. Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein. (PMID: 12923058) Reynolds P.A. … Haber D.A. (Genes Dev. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for LRRC15 Gene

Sources for LRRC15 Gene

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