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Aliases for LRRC14 Gene

Aliases for LRRC14 Gene

  • Leucine Rich Repeat Containing 14 2 3
  • Leucine-Rich Repeat-Containing Protein 14 3
  • KIAA0014 4
  • LRRC14A 3

External Ids for LRRC14 Gene

Previous GeneCards Identifiers for LRRC14 Gene

  • GC08P145748
  • GC08P145714
  • GC08P140856
  • GC08P145743

Summaries for LRRC14 Gene

Entrez Gene Summary for LRRC14 Gene

  • This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for LRRC14 Gene

LRRC14 (Leucine Rich Repeat Containing 14) is a Protein Coding gene. An important paralog of this gene is PRAMEF20.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC14 Gene

Genomics for LRRC14 Gene

Regulatory Elements for LRRC14 Gene

Transcription factor binding sites by QIAGEN in the LRRC14 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRRC14 Gene

144,517,965 bp from pter
144,525,178 bp from pter
7,214 bases
Plus strand

Genomic View for LRRC14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC14 Gene

Proteins for LRRC14 Gene

  • Protein details for LRRC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 14
    Protein Accession:
    Secondary Accessions:
    • A8K0A8
    • D3DWM8

    Protein attributes for LRRC14 Gene

    493 amino acids
    Molecular mass:
    54513 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA04946.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC14 Gene

Proteomics data for LRRC14 Gene at MOPED

Post-translational modifications for LRRC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC14 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for LRRC14

No data available for DME Specific Peptides for LRRC14 Gene

Domains for LRRC14 Gene

Protein Domains for LRRC14 Gene


Suggested Antigen Peptide Sequences for LRRC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PRAME family. LRRC14 subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
  • Belongs to the PRAME family. LRRC14 subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC14: view

No data available for Gene Families for LRRC14 Gene

Function for LRRC14 Gene

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC14

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC14 Gene

Localization for LRRC14 Gene

Subcellular locations from

Jensen Localization Image for LRRC14 Gene COMPARTMENTS Subcellular localization image for LRRC14 gene
Compartment Confidence
cytosol 2
mitochondrion 2
golgi apparatus 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC14 Gene

Pathways for LRRC14 Gene

SuperPathways for LRRC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC14 Gene


No data available for Pathways by source for LRRC14 Gene

Transcripts for LRRC14 Gene

Unigene Clusters for LRRC14 Gene

Leucine rich repeat containing 14:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP2: - -
SP3: -

Relevant External Links for LRRC14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC14 Gene

mRNA expression in normal human tissues for LRRC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LRRC14 Gene

This gene is overexpressed in Cervix (51.4) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC14 Gene

SOURCE GeneReport for Unigene cluster for LRRC14 Gene Hs.459391

genes like me logo Genes that share expressions with LRRC14: view

Expression partners for LRRC14 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC14 Gene

Orthologs for LRRC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC14 35
  • 89.18 (n)
  • 95.74 (a)
LRRC14 36
  • 96 (a)
(Canis familiaris)
Mammalia LRRC14 35
  • 87.49 (n)
  • 96.35 (a)
LRRC14 36
  • 86 (a)
(Mus musculus)
Mammalia Lrrc14 35
  • 85.19 (n)
  • 94.12 (a)
Lrrc14 16
Lrrc14 36
  • 94 (a)
(Pan troglodytes)
Mammalia LRRC14 35
  • 98.85 (n)
  • 99.39 (a)
LRRC14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrrc14 35
  • 86.21 (n)
  • 92.7 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
-- 36
  • 49 (a)
-- 36
  • 57 (a)
(Anolis carolinensis)
Reptilia LRRC14 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489989 35
  • 60.11 (n)
  • 48.88 (a)
(Danio rerio)
Actinopterygii CU695007.1 36
  • 27 (a)
Species with no ortholog for LRRC14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC14 Gene

Gene Tree for LRRC14 (if available)
Gene Tree for LRRC14 (if available)

Paralogs for LRRC14 Gene

(1) SIMAP similar genes for LRRC14 Gene using alignment to 4 proteins: Pseudogenes for LRRC14 Gene

genes like me logo Genes that share paralogs with LRRC14: view

Variants for LRRC14 Gene

Sequence variations from dbSNP and Humsavar for LRRC14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2721190 Benign 144,517,130(-) CACAG(C/T)CTACG upstream-variant-2KB
rs3735854 - 144,521,306(-) GCAAG(C/T)CCTCA missense, reference
rs60812033 -- 144,521,394(+) CACCA(A/G)CTGCT synonymous-codon, reference
rs77726980 -- 144,521,692(+) TCATC(G/T)GTGGG utr-variant-3-prime
rs79312814 -- 144,520,715(+) GATGG(C/T)GAGGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for LRRC14 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
nsv891846 CNV Loss 21882294
nsv831489 CNV Loss 17160897
dgv7966n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
dgv7972n71 CNV Loss 21882294
dgv907n27 CNV Loss 19166990
dgv7975n71 CNV Loss 21882294
dgv7976n71 CNV Loss 21882294
dgv7977n71 CNV Loss 21882294
dgv7978n71 CNV Loss 21882294
nsv891897 CNV Loss 21882294
esv29999 CNV Loss 17803354
nsv891912 CNV Loss 21882294
dgv7982n71 CNV Loss 21882294
dgv1207n67 CNV Gain 20364138
dgv7984n71 CNV Loss 21882294
nsv482127 CNV Gain 20164927
nsv522459 CNV Loss 19592680
esv2738067 CNV Deletion 23290073

Relevant External Links for LRRC14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC14 Gene

Disorders for LRRC14 Gene

No disorders were found for LRRC14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for LRRC14 Gene

Publications for LRRC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3
  4. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PMID: 19295130) Olma M.H. … Pintard L. (J. Cell. Sci. 2009) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for LRRC14 Gene

Sources for LRRC14 Gene

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