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Aliases for LRRC14 Gene

Aliases for LRRC14 Gene

  • Leucine Rich Repeat Containing 14 2 3 5
  • Leucine-Rich Repeat-Containing Protein 14 3
  • KIAA0014 4
  • LRRC14A 3

External Ids for LRRC14 Gene

Previous GeneCards Identifiers for LRRC14 Gene

  • GC08P145748
  • GC08P145714
  • GC08P140856
  • GC08P145743

Summaries for LRRC14 Gene

Entrez Gene Summary for LRRC14 Gene

  • This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

GeneCards Summary for LRRC14 Gene

LRRC14 (Leucine Rich Repeat Containing 14) is a Protein Coding gene. An important paralog of this gene is LRRC14B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC14 Gene

Genomics for LRRC14 Gene

Regulatory Elements for LRRC14 Gene

Enhancers for LRRC14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F144455 0.8 Ensembl ENCODE 50.9 -61.5 -61519 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F143914 1.3 FANTOM5 Ensembl ENCODE 44.8 -580.8 -580835 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F143731 1.1 FANTOM5 ENCODE 30.4 -780.7 -780718 11.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A ZNF143 FOS SP3 SP5 ZHX2 LRRC14 ZNF696 LOC105375803 ENSG00000254548 VPS28 FAM83H-AS1 FAM83H ARHGAP39 ADCK5 ZNF623
GH08F144101 0.4 ENCODE 28.1 -414.1 -414054 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF623 ZNF250 ZNF251 ZNF517 LRRC14 TMED10P1 ENSG00000255164 WDR97 ZNF696 VPS28
GH08F144770 1.5 FANTOM5 Ensembl ENCODE 16.6 +252.6 252636 1.2 KLF1 LEF1 ESRRA HINFP ZNF175 PTRF PYGO2 ZNF644 NCOR1 NR2F6 RPL8 LRRC14 COMMD5 ZNF517 ZNF250 ADCK5 VPS28 LOC105375803 ZNF251 ZNF34
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRRC14 on UCSC Golden Path with GeneCards custom track

Promoters for LRRC14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001404460 -65 1801 ATF1 CREB3L1 ARID4B SIN3A BRCA1 GLIS2 ELK1 ZNF143 ZNF207 FOS

Genomic Location for LRRC14 Gene

Chromosome:
8
Start:
144,517,965 bp from pter
End:
144,525,178 bp from pter
Size:
7,214 bases
Orientation:
Plus strand

Genomic View for LRRC14 Gene

Genes around LRRC14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC14 Gene

Proteins for LRRC14 Gene

  • Protein details for LRRC14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15048-LRC14_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 14
    Protein Accession:
    Q15048
    Secondary Accessions:
    • A8K0A8
    • D3DWM8

    Protein attributes for LRRC14 Gene

    Size:
    493 amino acids
    Molecular mass:
    54513 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04946.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC14 Gene

Post-translational modifications for LRRC14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRRC14 Gene

Domains & Families for LRRC14 Gene

Protein Domains for LRRC14 Gene

Suggested Antigen Peptide Sequences for LRRC14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15048

UniProtKB/Swiss-Prot:

LRC14_HUMAN :
  • Belongs to the PRAME family. LRRC14 subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
Family:
  • Belongs to the PRAME family. LRRC14 subfamily.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC14: view

No data available for Gene Families for LRRC14 Gene

Function for LRRC14 Gene

Phenotypes for LRRC14 Gene

genes like me logo Genes that share phenotypes with LRRC14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRRC14

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRRC14 Gene

Localization for LRRC14 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRRC14 Gene COMPARTMENTS Subcellular localization image for LRRC14 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
mitochondrion 2
plasma membrane 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRRC14 Gene

Pathways & Interactions for LRRC14 Gene

SuperPathways for LRRC14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC14 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRRC14 Gene

Transcripts for LRRC14 Gene

Unigene Clusters for LRRC14 Gene

Leucine rich repeat containing 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC14 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
SP1:
SP2: - -
SP3: -

Relevant External Links for LRRC14 Gene

GeneLoc Exon Structure for
LRRC14
ECgene alternative splicing isoforms for
LRRC14

Expression for LRRC14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRRC14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LRRC14 Gene

This gene is overexpressed in Cervix (51.4) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRRC14 Gene



Protein tissue co-expression partners for LRRC14 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRRC14 Gene:

LRRC14

SOURCE GeneReport for Unigene cluster for LRRC14 Gene:

Hs.459391
genes like me logo Genes that share expression patterns with LRRC14: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRRC14 Gene

Orthologs for LRRC14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC14 34 35
  • 98.85 (n)
cow
(Bos Taurus)
Mammalia LRRC14 34 35
  • 89.18 (n)
dog
(Canis familiaris)
Mammalia LRRC14 34 35
  • 87.49 (n)
rat
(Rattus norvegicus)
Mammalia Lrrc14 34
  • 86.21 (n)
mouse
(Mus musculus)
Mammalia Lrrc14 34 16 35
  • 85.19 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 57 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia LRRC14 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489989 34
  • 60.11 (n)
zebrafish
(Danio rerio)
Actinopterygii CU695007.1 35
  • 27 (a)
ManyToMany
Species where no ortholog for LRRC14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC14 Gene

ENSEMBL:
Gene Tree for LRRC14 (if available)
TreeFam:
Gene Tree for LRRC14 (if available)

Paralogs for LRRC14 Gene

(1) SIMAP similar genes for LRRC14 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for LRRC14 Gene

genes like me logo Genes that share paralogs with LRRC14: view

Variants for LRRC14 Gene

Sequence variations from dbSNP and Humsavar for LRRC14 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs137853231 Pathogenic 144,516,313(-) GCCCT(A/C/G)GGAGA nc-transcript-variant, upstream-variant-2KB, reference, missense, stop-gained, utr-variant-5-prime
rs746636748 Pathogenic 144,516,070(+) TGCCC(-/CT)GTCAT nc-transcript-variant, upstream-variant-2KB, reference, splice-acceptor-variant, frameshift-variant, utr-variant-5-prime
rs794726912 Pathogenic 144,517,703(-) CGAGC(C/T)AGGTG nc-transcript-variant, upstream-variant-2KB, reference, stop-gained, utr-variant-5-prime
rs375568877 Likely benign 144,517,118(+) GCTCC(G/T)CCCTG nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime
rs377485079 Likely benign 144,516,672(+) AAGGA(A/G)GGGAC nc-transcript-variant, upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for LRRC14 Gene

Variant ID Type Subtype PubMed ID
dgv1207n67 CNV gain 20364138
dgv12439n54 CNV loss 21841781
dgv12443n54 CNV loss 21841781
dgv907n27 CNV loss 19166990
esv2738067 CNV deletion 23290073
esv29999 CNV loss 17803354
esv3619131 CNV gain 21293372
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv482127 CNV gain 20164927
nsv515809 CNV gain+loss 19592680
nsv522459 CNV loss 19592680
nsv612940 CNV loss 21841781
nsv612951 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for LRRC14 Gene

Residual Variation Intolerance Score: 7.92% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC14 Gene

Disorders for LRRC14 Gene

Relevant External Links for LRRC14

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC14

No disorders were found for LRRC14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC14 Gene

Publications for LRRC14 Gene

  1. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. (PMID: 25201988) Rietveld C.A. … Koellinger P.D. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 64
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  5. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PMID: 19295130) Olma M.H. … Pintard L. (J. Cell. Sci. 2009) 3 64

Products for LRRC14 Gene

Sources for LRRC14 Gene

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