LRRC14 Gene
protein-coding GIFtS: 47
GCID: GC08P145743
|
|
leucine rich repeat containing 14
| |
Aliases
for LRRC14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 141 2 | | LRRC14A1 2 | | KIAA00141 3 | | Leucine-Rich Repeat-Containing Protein 142 |
Export aliases for LRRC14 gene to outside databasesPrevious GC identifers: GC08P145748 GC08P145714 GC08P140856 |
Summaries
for LRRC14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LRRC14:
This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Dec 2012)
|
Genomic Views
for LRRC14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC14 gene promoter:
Sp1 p53 Olf-1 MyoD E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3LRRC14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145743: view genomic region
(about GC identifiers)
Start:
|
145,743,376 bp from pter |
End:
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145,750,557 bp from pter |
Size:
|
7,182 bases |
Orientation:
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plus strand |
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Proteins
for LRRC14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LRC14_HUMAN, Q15048 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 14 Size: 493 amino acids; 54513 Da
Sequence caution: Sequence=BAA04946.2; Type=Erroneous initiation;
Secondary accessions: A8K0A8 D3DWM8Explore the universe of human proteins at neXtProt for LRRC14: NX_Q15048
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15048
LRRC14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001258965.1 NP_055480.1
ENSEMBL proteins: ENSP00000436452 ENSP00000434768 ENSP00000292524 ENSP00000435985 ENSP00000434738
Human Recombinant Protein Products:
LRRC14 Antibody Products:
Assay Products for LRRC14: |
Protein
Domains /
Families
for LRRC14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LRRC14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15048ProtoNet protein and cluster: Q15048 UniProtKB/Swiss-Prot: LRC14_HUMAN, Q15048Similarity: Belongs to the PRAME familySimilarity: Contains 5 LRR (leucine-rich) repeats |
Function
for LRRC14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC14 |
|
Pathways & Interactions
for LRRC14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC14
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for LRRC14 (Q150483 ENSP000002925244) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for LRRC14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC14
Search CenterWatch for drugs/clinical trials and news about LRRC14 / LRC14
|
Transcripts
for LRRC14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC14 gene (2 alternative transcripts): NM_001272036.1 NM_014665.3 Unigene Cluster for LRRC14: Leucine rich repeat containing 14 Hs.459391 [show with all ESTs]Unigene Representative Sequence: NM_0146659 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000527730 ENST00000529022 ENST00000292524(uc003zdk.2 uc003zdl.2)
ENST00000530854 ENST00000525766 ENST00000531310 ENST00000528528 ENST00000530242
ENST00000529995
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LRRC14 (NM_014665) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK289473.1 BC011377.1 D25216.1 9 DOTS entries: DT.113890 DT.100820773 DT.100757585 DT.121469486 DT.100820778 DT.100820781 DT.100804386 DT.86846723 DT.95086015 24/150 AceView cDNA sequences (see all 150): CB054846 BM456583 AI216480 AA293361 AI474263 CR625635 N53287 CA440215 AW169470 CR612338 BU733276 AI890607 BM693175 BQ962722 BX106345 AW613294 AL133903 AW081716 AI095518 AW246675 BM754828 BI769872 BU677483 AA292382
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for LRRC14 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for LRRC14
|
Expression
for LRRC14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTCTCTTCT
About this image
See LRRC14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRRC14
SOURCE GeneReport for Unigene cluster: Hs.459391
SABiosciences Custom PCR Arrays for LRRC14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC14 |
Orthologs
for LRRC14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for LRRC14 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
LRRC146 |
-- |
49(a) |
1 ↔ 1 |
GL343636.1(284468-290490) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
BX697147.12 |
-- |
73.57(n) |
|
BX697147.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CU695007.16 |
-- |
25(a) |
1 ↔ 1 |
7(41486722-41493869) |
ENSEMBL Gene Tree for LRRC14 (if available)
TreeFam Gene Tree for LRRC14 (if available) |
Paralogs
for LRRC14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC14 gene
- PRAMEF192 PRAMEF102 PRAMEF32 PRAMEF202 LOC6453592 PRAMEF182 PRAMEF122 PRAMEF212
- PRAMEF152 PRAMEF222 PRAMEF42 PRAMEF22 PRAMEF132 PRAMEF92 PRAME2 LRRC14B2
- PRAMEF142 PRAMEF72 PRAMEF82 PRAMEF172 PRAMEF52 PRAMEF112 PRAMEF162 PRAMEF12
- PRAMEF62
1 SIMAP similar gene for LRRC14 using alignment to 4 protein entries: LRC14_HUMAN (see all proteins):LRRC14B
LRRC14 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for LRRC14
PGOHUM00000246266 PGOHUM00000241475 PGOHUM00000241916
|
Genomic Variants
for LRRC14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC14 (145743376 - 145750557 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for LRRC14
4 CNVs: 4613 23292 53129 30306 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRRC14 |
|
Disorders
/ Diseases
for LRRC14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LRRC14 for disorders About GeneDecksing
1  disease for LRRC14: About MalaCardsmelanoma
Export disorders for LRRC14 gene to outside databases
|
Publications
for LRRC14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for LRRC14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LRRC14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LRRC14 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing LRRC14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for LRRC14 gene:
Search GeneIP for patents involving LRRC14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LRRC14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRRC14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRRC14 | | | OriGene Protein Over-expression Lysate for LRRC14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LRRC14 | | OriGene 3'-UTR Clone for LRRC14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRRC14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LRRC14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LRRC14 | | OriGene Custom Protein Services for LRRC14 | | | OriGene Custom Immunoassay Development | | |
| |
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| |
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| |  |  |  |  | | | | |
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 |
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 | | | LRRC14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC14 |
|  |  |  | | | | ThermoFisher Antibody for LRRC14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC14 |
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