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LRRC10 Gene

protein-coding GIFtS: 41
GCID: GC12M070002

Leucine Rich Repeat Containing 10

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MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Leucine Rich Repeat Containing 10¹ ²
HRLRRP² ⁵
LRRC10A²
Leucine-Rich Repeat-Containing Protein 10²

External Ids:	HGNC: 20264¹	Entrez Gene: 376132²	Ensembl: ENSG00000198812⁷	OMIM: 610846⁵	UniProtKB: Q5BKY1³

Export aliases for LRRC10 gene to outside databases

Previous GC identifers: GC12U900436 GC12M068288 GC12M067051

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRRC10 Gene:

LRRC10 (leucine rich repeat containing 10) is a protein-coding gene. An important paralog of this gene is LRRC2.

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1

Function: May play important roles in cardiac development and/or cardiac function (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the LRRC10 gene promoter:
AML1a Olf-1 AREB6 CREB SREBP-1a Zic1 deltaCREB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRRC10 promoter sequence

Search Chromatin IP Primers for LRRC10

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRRC10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15

LRRC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC10 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M070002: view genomic region (about GC identifiers)

Start:	70,002,344 bp from pter	End:	70,004,942 bp from pter
Size:	2,599 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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About This Section

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1 (See protein sequence)

Recommended Name: Leucine-rich repeat-containing protein 10

Size: 277 amino acids; 31642 Da

Sequence caution: Sequence=BAC85724.1; Type=Erroneous initiation;

Secondary accessions: Q6ZVY4

Explore the universe of human proteins at neXtProt for LRRC10: NX_Q5BKY1

Explore proteomics data for LRRC10 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See LRRC10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_963844.2

ENSEMBL proteins:

ENSP00000355166

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

Graphical View of Domain Structure for InterPro Entry Q5BKY1

ProtoNet protein and cluster: Q5BKY1

1 Blocks protein domain: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1

Similarity: Contains 7 LRR (leucine-rich) repeats

Find genes that share domains with LRRC10 About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LRC10_HUMAN, Q5BKY1

Function: May play important roles in cardiac development and/or cardiac function (By similarity)

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	--	--
GO:0051393	alpha-actinin binding	IEA	--

Find genes that share ontologies with LRRC10 About GenesLikeMe

Phenotypes:
1 GenomeRNAi human phenotype for LRRC10:

Synthetic lethal with Ras

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Lrrc10):

normal

Find genes that share phenotypes with LRRC10 About GenesLikeMe

Animal Models:
MGI mouse knock-out Lrrc10^tm1Sgt for LRRC10

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

LRC10_HUMAN, Q5BKY1: Nucleus (By similarity)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	2
mitochondrion	2
nucleus	2
cytosol	1
extracellular	1
peroxisome	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0030016	myofibril	--	--
GO:0030017	sarcomere	IEA	--

Find genes that share ontologies with LRRC10 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for LRRC10
Interactions:

Search GeneGlobe Interaction Network for LRRC10

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for LRRC10 (ENSP00000355166⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CAB39	ENSP00000258418⁴	STRING: ENSP00000258418
CAB39L	ENSP00000261669⁴	STRING: ENSP00000261669

About this table

Gene Ontology (GO): 1 biological process term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0055013	cardiac muscle cell development	IEA	--

Find genes that share ontologies with LRRC10 About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
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About This Section

REFSEQ mRNAs for LRRC10 gene:

NM_201550.2

Unigene Cluster for LRRC10:

Leucine rich repeat containing 10

Hs.448708 [show with all ESTs]

Unigene Representative Sequence: NM_201550

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000361484(uc001svc.3)

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Additional mRNA sequence:

AK095935.1 AK123908.1 BC090881.1 BC106892.1 BC106893.1

1 DOTS entry:

DT.40303762

6 AceView cDNA sequences:

NM_201550 AK123908 CF552292 AK095935 N70852 W06861

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRRC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TTAGTTTAAA

About this image

LRRC10 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

LRRC10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.448708

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LRRC10 gene from Selected species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lrrc10^{1 , 5}	leucine rich repeat containing 10^{1, 5}	85.64(n)¹ 88.69(a)¹		10 (65.06 cM)⁵ 237560¹ NM_146242.2¹ NP_666354.1¹ 117045341⁵
chicken (Gallus gallus)	Aves	LRRC10¹	leucine rich repeat containing 10	76.46(n) 79.76(a)		427865 XM_004937565.1 XP_004937622.1
lizard (Anolis carolinensis)	Reptilia	LRRC10⁶	leucine rich repeat containing 10	70(a)	1 ↔ 1	GL343256.1(1657626-1658453)
tropical clawed frog (Xenopus tropicalis)	Amphibia	lrrc10¹	leucine rich repeat containing 10	64.96(n) 69.6(a)		100492390 XM_002938506.2 XP_002938552.2
zebrafish (Danio rerio)	Actinopterygii	lrrc10¹	leucine rich repeat containing 10	61.33(n) 62.5(a)		798207 NM_001009559.1 NP_001009559.1

ENSEMBL Gene Tree for LRRC10 (if available)
TreeFam Gene Tree for LRRC10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRRC10 gene

LRRC2² LRCH2² LRRC18² LRSAM1² LRRC30² PIDD² LRCH3² LRRC57²

LRRC10B² LRRC39² LRCH4² LRCH1²

4 SIMAP similar genes for LRRC10 using alignment to 3 protein entries: LRC10_HUMAN (see all proteins):

LRRC10B LRRC39 LRRC30 LRRIQ4

Find genes that share paralogs with LRRC10 About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193207443^1,2		--	70001909(+)	`GCTTCC/TGTCAT`	1	--	int¹		0	--	--	--	--
rs185645579^1,2		--	70002024(+)	`AAAGGA/GACCTT`	1	--	int¹		0	--	--	--	--
rs17106822^1,2	C,F,H	--	70002097(+)	`ATTATG/ACAACA`	1	--	int¹		14		NA NS EA WA	1450
rs7136503^1,2	H	--	70002118(+)	`TCTAGT/GTTAGC`	1	--	int¹		4		NS EA	420
rs39679^1,2	C,F,O,A,H	--	70002265(+)	`AAGATG/AACACT`	1	--	int¹		16		MN NA WA CSA EA	703
rs188155703^1,2		--	70002308(+)	`TACATA/GAAGAA`	1	--	int¹		0	--	--	--	--
rs35507291^1,2	C,F	--	70002311(+)	`ATAAAG/TAATTG`	1	--	int¹		2		NA	4
rs200125954^1,2	C	--	70002425(+)	`ATTGTA/CAAAAC`	1	--	ut3¹		0	--	--	--	--
rs11177751^1,2	C,F,H	--	70002488(+)	`GAGGCA/GGAGAC`	1	--	ut3¹		19		NS EA NA WA	2338
rs150859187^1,2	C	--	70002552(+)	`GAACAC/TATTTC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LRRC10 (70002344 - 70004942 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for LRRC10: --

Site Specific Mutation Identification with PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OMIM gene information: 610846 OMIM disorders: --

Find genes that share disorders with LRRC10 About GenesLikeMe

Genetic Association Database (GAD): LRRC10

Export disorders for LRRC10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRRC10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with LRRC10)

Utopia: connect your pdf to the dynamic
world of online information

Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)^{1, 4} Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PubMed id 14751244)^{1, 3} Nakane T....Chiba S. (Biochem. Biophys. Res. Commun. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 376132	HGNC: 20264	AceView: LRRC10	Ensembl:ENSG00000198812	euGenes: HUgn376132
ECgene: LRRC10	H-InvDB: LRRC10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRRC10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LRRC10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LRRC10 gene:
Search GeneIP for patents involving LRRC10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	QuantiFast Probe-based Assays in human, mouse, rat LRRC10		QuantiTect SYBR Green Assays in human, mouse, rat LRRC10
	Custom PCR Arrays for LRRC10		Search Chromatin IP Primers for LRRC10
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat LRRC10		Search GeneGlobe Interaction Network for LRRC10
	Regulatory tfbs in LRRC10 promoter

	GenScript Custom Purified and Recombinant Proteins Services for LRRC10		GenScript cDNA clones with any tag delivered in your preferred vector for LRRC10
	GenScript Custom Assay Services for LRRC10		GenScript Custom overexpressing Cell Line Services for LRRC10
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC10

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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

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Hot genes Disease genes LRRC10 gene at Home site.

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LRRC10 Gene

Leucine Rich Repeat Containing 10

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LRRC10 Gene

Leucine Rich Repeat Containing 10

Aliasesfor LRRC10 gene

Summariesfor LRRC10 gene

Genomic Viewsfor LRRC10 gene

Proteinsfor LRRC10 gene

LRRC10 Human Recombinant Protein Products:

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Expression for LRRC10 gene

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External Searches for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

Expression
for LRRC10 gene

Orthologs
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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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