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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRRC10 Gene

protein-coding GIFtS: 40
GCID: GC12M070002

leucine rich repeat containing 10

Search for LRRC10
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leucine Rich Repeat Containing 10¹ ²
HRLRRP¹ ² ⁵
LRRC10A¹ ²
Leucine-Rich Repeat-Containing Protein 10²

External Ids:	HGNC: 20264¹	Entrez Gene: 376132²	Ensembl: ENSG00000198812⁷	OMIM: 610846⁵	UniProtKB: Q5BKY1³

Export aliases for LRRC10 gene to outside databases

Previous GC identifers: GC12U900436 GC12M068288 GC12M067051

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1

Function: May play important roles in cardiac development and/or cardiac function (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRRC10 gene promoter:
AML1a Olf-1 AREB6 CREB SREBP-1a Zic1 deltaCREB NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRRC10 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15

LRRC10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRRC10 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M070002: view genomic region (about GC identifiers)

Start:	70,002,344 bp from pter	End:	70,004,942 bp from pter
Size:	2,599 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1 (See protein sequence)

Recommended Name: Leucine-rich repeat-containing protein 10

Size: 277 amino acids; 31642 Da

Subcellular location: Nucleus (By similarity)

Sequence caution: Sequence=BAC85724.1; Type=Erroneous initiation;

Secondary accessions: Q6ZVY4

Explore the universe of human proteins at neXtProt for LRRC10: NX_Q5BKY1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5BKY1

LRRC10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_963844.2

ENSEMBL proteins:

ENSP00000355166

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Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005739	mitochondrion	IEA	--
GO:0005856	cytoskeleton	IEA	--
GO:0030016	myofibril	IEA	--

LRRC10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRRC10 for domains About GeneDecksing

2 InterPro domains/families:

IPR001611 Leu-rich_rpt

IPR025875 Leu-rich_rpt_4

Graphical View of Domain Structure for InterPro Entry Q5BKY1

ProtoNet protein and cluster: Q5BKY1

1 Blocks protein family: IPB001611 Leucine-rich repeat signature

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1

Similarity: Contains 7 LRR (leucine-rich) repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1

Function: May play important roles in cardiac development and/or cardiac function (By similarity)

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1 GenomeRNAi human phenotype for LRRC10:

Synthetic lethal with Ras

Animal Models:
Mouse knock-out Lrrc10^tm1Sgt for LRRC10
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Lrrc10):

normal

LRRC10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LRRC10

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for LRRC10 gene:

NM_201550.2

Unigene Cluster for LRRC10:

Leucine rich repeat containing 10

Hs.448708 [show with all ESTs]

Unigene Representative Sequence: NM_201550

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000361484(uc001svc.3)

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Additional cDNA sequence:

AK095935.1 AK123908.1 BC090881.1 BC106892.1 BC106893.1

1 DOTS entry:

DT.40303762

6 AceView cDNA sequences:

AK123908 NM_201550 AK095935 CF552292 N70852 W06861

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRRC10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAGTTTAAA

About this image
See LRRC10 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.448708

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LRRC10 gene from 4/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LRRC10¹	leucine rich repeat containing 10	74.28(n) 76.78(a)		427865 XM_425439.1 XP_425439.1
lizard (Anolis carolinensis)	Reptilia	LRRC10⁶	--	70(a)	1 ↔ 1	GL343256.1(1657626-1658453)
zebrafish (Danio rerio)	Actinopterygii	lrrc10¹	leucine rich repeat containing 10	62.67(n) 64.05(a)		798207 NM_001009559.1 NP_001009559.1
fruit fly (Drosophila melanogaster)	Insecta	f-cup⁶	flyers-cup	8(a)	1 → many	3R(9520979-9526560)

ENSEMBL Gene Tree for LRRC10 (if available)
TreeFam Gene Tree for LRRC10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRRC10 gene

LRRC7² LRRC2² ERBB2IP² MFHAS1² LRRC18² LRRC30² LRRC1² PIDD²

LRRIQ4² SCRIB² SHOC2² LRRD1² LRRC10B² LRRC39² LRRC40²

4 SIMAP similar genes for LRRC10 using alignment to 3 protein entries: LRC10_HUMAN (see all proteins):

LRRC10B LRRC39 LRRC30 LRRIQ4

LRRC10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193207443^1,2		--	70001909(+)	`GCTTCC/TGTCAT`	1	--	int¹		0	--	--	--	--
rs185645579^1,2		--	70002024(+)	`AAAGGA/GACCTT`	1	--	int¹		0	--	--	--	--
rs17106822^1,2	C,F,H,	--	70002097(+)	`ATTATG/ACAACA`	1	--	int¹		14		NA NS EA WA	1450
rs7136503^1,2	H	--	70002118(+)	`TCTAGT/GTTAGC`	1	--	int¹		4		NS EA	420
rs39679^1,2	C,F,O,A,H,	--	70002265(+)	`AAGATG/AACACT`	1	--	int¹		16		MN NA WA CSA EA	703
rs188155703^1,2		--	70002308(+)	`TACATA/GAAGAA`	1	--	int¹		0	--	--	--	--
rs35507291^1,2	C,F	--	70002311(+)	`ATAAAG/TAATTG`	1	--	int¹		2		NA	4
rs200125954^1,2	C	--	70002425(+)	`ATTGTA/CAAAAC`	1	--	ut3¹		0	--	--	--	--
rs11177751^1,2	C,F,H,	--	70002488(+)	`GAGGCA/GGAGAC`	1	--	ut3¹		19		NS EA NA WA	2338
rs150859187^1,2		--	70002552(+)	`GAACAC/TATTTC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LRRC10 (70002344 - 70004942 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LRRC10: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LRRC10 for disorders About MalaCards

LRRC10 for disorders About GeneDecksing

OMIM gene information: 610846 OMIM disorders: --

Export disorders for LRRC10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRRC10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC10)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PubMed id 14751244)^{1, 3} Nakane T....Chiba S. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)¹ Gudbjartsson D.F....Stefansson K. (2008)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 376132	HGNC: 20264	AceView: LRRC10	Ensembl:ENSG00000198812	euGenes: HUgn376132
ECgene: LRRC10	H-InvDB: LRRC10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRRC10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LRRC10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LRRC10 gene:
Search GeneIP for patents involving LRRC10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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	Search for Antibodies for LRRC10 at Abcam
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LRRC10 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for LRRC10

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC10

	SwitchGear 3'UTR luciferase reporter plasmids for LRRC10
	SwitchGear Promoter luciferase reporter plasmids for LRRC10

ThermoFisher Antibodies for LRRC10

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC10

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LRRC10 gene at Home site.

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LRRC10 Gene

leucine rich repeat containing 10

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for LRRC10 gene

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for LRRC10 gene

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for LRRC10 gene

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Export list of displayed genes

LRRC10 Gene

leucine rich repeat containing 10

Aliasesfor LRRC10 gene

Summariesfor LRRC10 gene

Genomic Viewsfor LRRC10 gene

Proteinsfor LRRC10 gene

Protein Domains /Familiesfor LRRC10 gene

Functionfor LRRC10 gene

Pathways & Interactionsfor LRRC10 gene

Drugs & Compoundsfor LRRC10 gene

Transcriptsfor LRRC10 gene

Expression for LRRC10 gene

Orthologsfor LRRC10 gene

Paralogsfor LRRC10 gene

Genomic Variantsfor LRRC10 gene

Disorders / Diseasesfor LRRC10 gene

Publicationsfor LRRC10 gene

External Searches for LRRC10 gene

Genome Databases showing LRRC10 gene

Other Databases showing LRRC10 gene

Specialized Databases showing LRRC10 gene

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Productsfor LRRC10 gene

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Aliases
for LRRC10 gene

Summaries
for LRRC10 gene

Genomic Views
for LRRC10 gene

Proteins
for LRRC10 gene

Protein Domains /
Families
for LRRC10 gene

Function
for LRRC10 gene

Pathways & Interactions
for LRRC10 gene

Drugs & Compounds
for LRRC10 gene

Transcripts
for LRRC10 gene

Expression
for LRRC10 gene

Orthologs
for LRRC10 gene

Paralogs
for LRRC10 gene

Genomic Variants
for LRRC10 gene

Disorders / Diseases
for LRRC10 gene

Publications
for LRRC10 gene

Intellectual Property
for LRRC10 gene

Products
for LRRC10 gene