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LRRC10 Gene(Protein Coding)

Leucine Rich Repeat Containing 10

GCID:
GC12M069608
GIFtS:
48
Genes Participants
UDN Logo

Aliases for LRRC10 Gene

Aliases for LRRC10 Gene

  • Leucine Rich Repeat Containing 10 2 3 5
  • Leucine-Rich Repeat-Containing Protein 10 3
  • LRRC10A 3
  • HRLRRP 3

External Ids for LRRC10 Gene

Previous GeneCards Identifiers for LRRC10 Gene

  • GC12U900436
  • GC12M068288
  • GC12M070002
  • GC12M067051

Summaries for LRRC10 Gene

GeneCards Summary for LRRC10 Gene

LRRC10 (Leucine Rich Repeat Containing 10) is a Protein Coding gene. Diseases associated with LRRC10 include Dilated Cardiomyopathy. GO annotations related to this gene include actin binding and alpha-actinin binding. An important paralog of this gene is LRRC10B.

UniProtKB/Swiss-Prot for LRRC10 Gene

  • May play important roles in cardiac development and/or cardiac function.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC10 Gene

Genomics for LRRC10 Gene

Products:

  1. Regulatory Element

Regulatory Elements for LRRC10 Gene

Enhancers for LRRC10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G069655 1.2 Ensembl ENCODE 12 -45.8 -45769 3.9 PKNOX1 ATF1 TCF12 GATA2 FOS TBX21 ZNF592 CREB3 SMARCA4 PBX2 BEST3 RAB3IP LRRC10 LOC101928002 ENSG00000279551 LOC105369823
GH12G069613 0.3 FANTOM5 11.4 -2.3 -2262 0.2 LRRC10 LOC105369823
GH12G069624 1 ENCODE 0.4 -13.1 -13074 0.2 PKNOX1 ATF1 CREB3L1 ARNT SIN3A E2F7 TCF12 ZNF766 CBX5 ELK1 LYZ LOC105369823 LRRC10
GH12G069616 0.5 Ensembl 0.7 -4.9 -4939 0.2 POLR2A SMARCA4 SPI1 LRRC10 LOC105369823
GH12G069584 1.1 ENCODE 0.3 +25.5 25517 1.8 HDGF PKNOX1 MLX CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A DMAP1 FRS2 NUP107 LYZ CCT2 LRRC10
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRRC10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the LRRC10 gene promoter:

Genomic Location for LRRC10 Gene

Chromosome:
12
Start:
69,608,564 bp from pter
End:
69,611,162 bp from pter
Size:
2,599 bases
Orientation:
Minus strand

Genomic View for LRRC10 Gene

Genes around LRRC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC10 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for LRRC10 Gene

Proteins for LRRC10 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for LRRC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKY1-LRC10_HUMAN
    Recommended name:
    Leucine-rich repeat-containing protein 10
    Protein Accession:
    Q5BKY1
    Secondary Accessions:
    • Q6ZVY4

    Protein attributes for LRRC10 Gene

    Size:
    277 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC10 Gene

Protein Expression for LRRC10 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for LRRC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC10 Gene

Domains & Families for LRRC10 Gene

Protein Domains for LRRC10 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for LRRC10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRRC10: view

No data available for Gene Families and UniProtKB/Swiss-Prot for LRRC10 Gene

Function for LRRC10 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for LRRC10 Gene

UniProtKB/Swiss-Prot Function:
May play important roles in cardiac development and/or cardiac function.

Gene Ontology (GO) - Molecular Function for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0051393 alpha-actinin binding IEA --
genes like me logo Genes that share ontologies with LRRC10: view

Phenotypes for LRRC10 Gene

MGI mutant phenotypes for LRRC10:
inferred from 1 alleles
GenomeRNAi human phenotypes for LRRC10:
genes like me logo Genes that share phenotypes with LRRC10: view

Animal Models for LRRC10 Gene

MGI Knock Outs for LRRC10:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC10 Gene

Localization for LRRC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC10 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRRC10 gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3
cytoskeleton 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA --
GO:0005856 cytoskeleton IEA --
GO:0030016 myofibril IEA --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with LRRC10: view

Pathways & Interactions for LRRC10 Gene

SuperPathways for LRRC10 Gene

PathCards logo More details on SuperPathways for LRRC10
No Data Available

Gene Ontology (GO) - Biological Process for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055013 cardiac muscle cell development IEA --
genes like me logo Genes that share ontologies with LRRC10: view

No data available for Pathways by source and SIGNOR curated interactions for LRRC10 Gene

Drugs & Compounds for LRRC10 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for LRRC10 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for LRRC10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC10 Gene

Leucine rich repeat containing 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC10 Gene

No ASD Table

Relevant External Links for LRRC10 Gene

GeneLoc Exon Structure for
LRRC10
ECgene alternative splicing isoforms for
LRRC10

Expression for LRRC10 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRRC10 Gene

mRNA expression in normal human tissues for LRRC10 Gene
mRNA expression by BioGPS for LRRC10 GenemRNA expression by GTEx for LRRC10 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC10 Gene

This gene is overexpressed in Heart - Left Ventricle (x35.6) and Heart - Atrial Appendage (x15.6).

Protein differential expression in normal tissues from HIPED for LRRC10 Gene

This gene is overexpressed in Heart (39.0) and Fetal heart (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC10 Gene



Protein tissue co-expression partners for LRRC10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRRC10 Gene:

LRRC10

SOURCE GeneReport for Unigene cluster for LRRC10 Gene:

Hs.448708

Evidence on tissue expression from TISSUES for LRRC10 Gene

  • Heart(4.4)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with LRRC10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRRC10 Gene

Orthologs for LRRC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LRRC10 34 35
  • 99.52 (n)
cow
(Bos Taurus)
 Mammalia LRRC10 34 35
  • 91.1 (n)
mouse
(Mus musculus)
 Mammalia Lrrc10 34 16 35
  • 85.64 (n)
rat
(Rattus norvegicus)
 Mammalia Lrrc10 34
  • 84.86 (n)
dog
(Canis familiaris)
 Mammalia LRRC10 34 35
  • 83.15 (n)
oppossum
(Monodelphis domestica)
 Mammalia LRRC10 35
  • 80 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves LRRC10 34 35
  • 76.46 (n)
lizard
(Anolis carolinensis)
 Reptilia LRRC10 35
  • 70 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia lrrc10 34
  • 64.96 (n)
zebrafish
(Danio rerio)
 Actinopterygii lrrc10 34 35
  • 61.33 (n)
Species where no ortholog for LRRC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC10 Gene

ENSEMBL:
Gene Tree for LRRC10 (if available)
TreeFam:
Gene Tree for LRRC10 (if available)

Paralogs for LRRC10 Gene

Paralogs for LRRC10 Gene

(4) SIMAP similar genes for LRRC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRC10: view

Variants for LRRC10 Gene

Sequence variations from dbSNP and Humsavar for LRRC10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1002033341 -- 69,609,026(+) CAAAC(C/T)TTTTA utr-variant-3-prime
rs1002467555 -- 69,608,684(+) CAAAG(G/T)CAGAG utr-variant-3-prime
rs1003705541 -- 69,610,424(+) GACCA(C/T)ATCCG reference, missense
rs1003792881 -- 69,608,462(+) ACTTG(G/T)TACTG downstream-variant-500B
rs1003895625 -- 69,608,963(+) CTCTT(C/T)TCCAG utr-variant-3-prime

Variation tolerance for LRRC10 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC10 Gene

Human Gene Mutation Database (HGMD)
LRRC10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRRC10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC10 Gene

Disorders for LRRC10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRRC10 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy
  • congestive cardiomyopathy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for LRRC10

Genetic Association Database (GAD)
LRRC10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRRC10
genes like me logo Genes that share disorders with LRRC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRRC10 Gene

Publications for LRRC10 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 46 64
  2. Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PMID: 14751244) Nakane T. … Chiba S. (Biochem. Biophys. Res. Commun. 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy. (PMID: 26017719) Qu X.K. … Qiu X.B. (Mol Med Rep 2015) 3 64

Products for LRRC10 Gene

Sources for LRRC10 Gene

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