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Aliases for LRRC10 Gene

Aliases for LRRC10 Gene

  • Leucine Rich Repeat Containing 10 2 3 5
  • LRRC10A 3
  • HRLRRP 3

External Ids for LRRC10 Gene

Previous GeneCards Identifiers for LRRC10 Gene

  • GC12U900436
  • GC12M068288
  • GC12M070002
  • GC12M067051

Summaries for LRRC10 Gene

GeneCards Summary for LRRC10 Gene

LRRC10 (Leucine Rich Repeat Containing 10) is a Protein Coding gene. GO annotations related to this gene include actin binding and alpha-actinin binding. An important paralog of this gene is LRRC8A.

UniProtKB/Swiss-Prot for LRRC10 Gene

  • May play important roles in cardiac development and/or cardiac function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC10 Gene

Genomics for LRRC10 Gene

Regulatory Elements for LRRC10 Gene

Enhancers for LRRC10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRRC10 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRRC10 Gene

69,608,564 bp from pter
69,611,162 bp from pter
2,599 bases
Minus strand

Genomic View for LRRC10 Gene

Genes around LRRC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRRC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRRC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC10 Gene

Proteins for LRRC10 Gene

  • Protein details for LRRC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 10
    Protein Accession:
    Secondary Accessions:
    • Q6ZVY4

    Protein attributes for LRRC10 Gene

    277 amino acids
    Molecular mass:
    31642 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRRC10 Gene

Proteomics data for LRRC10 Gene at MOPED

Post-translational modifications for LRRC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRRC10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC10 Gene

Domains & Families for LRRC10 Gene

Protein Domains for LRRC10 Gene

Suggested Antigen Peptide Sequences for LRRC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 LRR (leucine-rich) repeats.
  • Contains 7 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC10: view

No data available for Gene Families for LRRC10 Gene

Function for LRRC10 Gene

Molecular function for LRRC10 Gene

UniProtKB/Swiss-Prot Function:
May play important roles in cardiac development and/or cardiac function.

Gene Ontology (GO) - Molecular Function for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with LRRC10: view

Phenotypes for LRRC10 Gene

MGI mutant phenotypes for LRRC10:
inferred from 1 alleles
GenomeRNAi human phenotypes for LRRC10:
genes like me logo Genes that share phenotypes with LRRC10: view

Animal Models for LRRC10 Gene

MGI Knock Outs for LRRC10:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRRC10 Gene

Localization for LRRC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC10 Gene

Subcellular locations from

Jensen Localization Image for LRRC10 Gene COMPARTMENTS Subcellular localization image for LRRC10 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3
cytoskeleton 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRRC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with LRRC10: view

Pathways & Interactions for LRRC10 Gene

SuperPathways for LRRC10 Gene

No Data Available

Interacting Proteins for LRRC10 Gene

Gene Ontology (GO) - Biological Process for LRRC10 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRRC10 Gene

Drugs & Compounds for LRRC10 Gene

No Compound Related Data Available

Transcripts for LRRC10 Gene

mRNA/cDNA for LRRC10 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRRC10 Gene

Leucine rich repeat containing 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC10 Gene

No ASD Table

Relevant External Links for LRRC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC10 Gene

mRNA expression in normal human tissues for LRRC10 Gene

mRNA differential expression in normal tissues according to GTEx for LRRC10 Gene

This gene is overexpressed in Heart - Left Ventricle (x35.6) and Heart - Atrial Appendage (x15.6).

Protein differential expression in normal tissues from HIPED for LRRC10 Gene

This gene is overexpressed in Heart (39.0) and Fetal heart (30.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRRC10 Gene

SOURCE GeneReport for Unigene cluster for LRRC10 Gene Hs.448708

genes like me logo Genes that share expression patterns with LRRC10: view

Protein tissue co-expression partners for LRRC10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for LRRC10 Gene

Orthologs for LRRC10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRRC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC10 35
  • 91.1 (n)
  • 92.86 (a)
LRRC10 36
  • 92 (a)
(Canis familiaris)
Mammalia LRRC10 35
  • 83.15 (n)
  • 81.04 (a)
LRRC10 36
  • 79 (a)
(Mus musculus)
Mammalia Lrrc10 35
  • 85.64 (n)
  • 88.69 (a)
Lrrc10 16
Lrrc10 36
  • 88 (a)
(Pan troglodytes)
Mammalia LRRC10 35
  • 99.52 (n)
  • 99.64 (a)
LRRC10 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrrc10 35
  • 84.86 (n)
  • 88.64 (a)
(Monodelphis domestica)
Mammalia LRRC10 36
  • 80 (a)
(Gallus gallus)
Aves LRRC10 35
  • 76.46 (n)
  • 79.76 (a)
LRRC10 36
  • 74 (a)
(Anolis carolinensis)
Reptilia LRRC10 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc10 35
  • 64.96 (n)
  • 69.6 (a)
(Danio rerio)
Actinopterygii lrrc10 35
  • 61.33 (n)
  • 62.5 (a)
lrrc10 36
  • 59 (a)
Species with no ortholog for LRRC10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRRC10 Gene

Gene Tree for LRRC10 (if available)
Gene Tree for LRRC10 (if available)

Paralogs for LRRC10 Gene

(4) SIMAP similar genes for LRRC10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with LRRC10: view

Variants for LRRC10 Gene

Sequence variations from dbSNP and Humsavar for LRRC10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs28203 -- 69,609,659(+) TGAGC(C/T)TCATG utr-variant-3-prime
rs28204 -- 69,609,715(+) CTTTT(A/G)CTCTT utr-variant-3-prime
rs39679 -- 69,608,485(+) AAGAT(A/G)ACACT downstream-variant-500B
rs7136503 -- 69,608,338(+) TCTAG(G/T)TTAGC downstream-variant-500B
rs7295466 -- 69,609,172(+) gaaac(C/T)agctt utr-variant-3-prime

Variation tolerance for LRRC10 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRRC10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRRC10 Gene

Disorders for LRRC10 Gene

Relevant External Links for LRRC10

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRRC10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRRC10 Gene

Publications for LRRC10 Gene

  1. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson D.F. … Stefansson K. (Nat. Genet. 2008) 3 48 67
  2. Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PMID: 14751244) Nakane T. … Chiba S. (Biochem. Biophys. Res. Commun. 2004) 2 3
  3. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for LRRC10 Gene

Sources for LRRC10 Gene