LRRC10 Gene
protein-coding GIFtS: 40
GCID: GC12M070002
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Leucine Rich Repeat Containing 10
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Aliases
for LRRC10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Leucine Rich Repeat Containing 101 2 | | HRLRRP2 5 | | LRRC10A2 | | Leucine-Rich Repeat-Containing Protein 102 |
Export aliases for LRRC10 gene to outside databasesPrevious GC identifers: GC12U900436 GC12M068288 GC12M067051 |
Summaries
for LRRC10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
GeneCards Summary for LRRC10 Gene: 
LRRC10 (leucine rich repeat containing 10) is a protein-coding gene. An important paralog of this gene is LRRC7.
UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1Function: May play important roles in cardiac development and/or cardiac function (By similarity)
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Genomic Views
for LRRC10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.2 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LRRC10 gene promoter:
AML1a Olf-1 AREB6 CREB SREBP-1a Zic1 deltaCREB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LRRC10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15LRRC10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M070002: view genomic region
(about GC identifiers)
Start:
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70,002,344 bp from pter |
End:
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70,004,942 bp from pter |
Size:
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2,599 bases |
Orientation:
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minus strand |
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Proteins
for LRRC10 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1 (See
protein sequence)Recommended Name: Leucine-rich repeat-containing protein 10 Size: 277 amino acids; 31642 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAC85724.1; Type=Erroneous initiation;
Secondary accessions: Q6ZVY4Explore the universe of human proteins at neXtProt for LRRC10: NX_Q5BKY1
Explore proteomics data for LRRC10 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q5BKY1
LRRC10 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_963844.2
ENSEMBL proteins: ENSP00000355166
Human Recombinant Protein Products for LRRC10:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
LRRC10 for ontologies About GeneDecksing
LRRC10 Antibody Products:
Assay Products for LRRC10: |
Protein
Domains /
Families
for LRRC10 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| 2 InterPro protein domains:Graphical View of Domain Structure for InterPro Entry Q5BKY1 ProtoNet protein and cluster: Q5BKY1 1 Blocks protein domain: IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: LRC10_HUMAN, Q5BKY1Similarity: Contains 7 LRR (leucine-rich) repeats
LRRC10 for domains About GeneDecksing
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Function
for LRRC10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LRC10_HUMAN, Q5BKY1Function: May play important roles in cardiac development and/or cardiac function (By similarity) Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
LRRC10 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for LRRC10:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Lrrc10):
LRRC10 for phenotypes About GeneDecksing
Animal Models:
MGI mouse knock-out Lrrc10tm1Sgt for LRRC10
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for LRRC10 | |  | Search LifeMap BioReagents cell lines for LRRC10 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC10 |
Pathways & Interactions
for LRRC10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LRRC10
|
Drugs & Compounds
for LRRC10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LRRC10 (LRC10)
Search CenterWatch for drugs/clinical trials and news about LRRC10 / LRC10
|
Transcripts
for LRRC10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LRRC10 gene: NM_201550.2 Unigene Cluster for LRRC10: Leucine rich repeat containing 10 Hs.448708 [show with all ESTs]Unigene Representative Sequence: NM_2015501 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000361484(uc001svc.3)
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for LRRC10
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC10 |
Additional mRNA sequence: AK095935.1 AK123908.1 BC090881.1 BC106892.1 BC106893.1 1 DOTS entry: DT.40303762 6 AceView cDNA sequences: NM_201550 AK123908 CF552292 AK095935 N70852 W06861
GeneLoc Exon Structure
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Expression
for LRRC10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LRRC10 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTAGTTTAAA
About this image
See LRRC10 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.448708
SABiosciences Custom PCR Arrays for LRRC10
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for LRRC10
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRRC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC10 |
Orthologs
for LRRC10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for LRRC10 gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for LRRC10 (if available)
TreeFam Gene Tree for LRRC10 (if available) |
Paralogs
for LRRC10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LRRC10 gene
- LRRC72 LRRC22 ERBB2IP2 MFHAS12 LRRC12 LRRC302 LRRIQ42 SCRIB2
- SHOC22 LRRD12 LRRC10B2 LRRC392 LRRC402
4 SIMAP similar genes for LRRC10 using alignment to 3 protein entries: LRC10_HUMAN (see all proteins):LRRC10B LRRC39 LRRC30 LRRIQ4
LRRC10 for paralogs About GeneDecksing
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Genomic Variants
for LRRC10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LRRC10 (70002344 - 70004942 bp)
Structural Variations
Database of Genomic Variants (DGV) variations for LRRC10: --
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing LRRC10 |
|
Disorders
/ Diseases
for LRRC10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 LRRC10 for disorders About MalaCards
OMIM gene information: 610846
OMIM disorders: --
LRRC10 for disorders About GeneDecksing
Genetic Association Database (GAD): LRRC10
Export disorders for LRRC10 gene to outside databases
|
Publications
for LRRC10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LRRC10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with LRRC10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Molecular cloning and expression of HRLRRP, a novel heart-restricted leucine-rich repeat protein. (PubMed id 14751244)1, 3 Nakane T....Chiba S. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for LRRC10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing LRRC10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing LRRC10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LRRC10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LRRC10 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for LRRC10 gene:
Search GeneIP for patents involving LRRC10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LRRC10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRRC10 | | | QIAGEN SeqTarget long-range PCR primers for resequencing LRRC10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRRC10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRRC10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRRC10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRRC10 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRRC10 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for LRRC10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRRC10 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for LRRC10 |
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