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Aliases for LRRC1 Gene

Aliases for LRRC1 Gene

  • Leucine Rich Repeat Containing 1 2 3
  • LANO 3 4 6
  • Leucine-Rich Repeat-Containing 1 2 3
  • LAP And No PDZ Protein 3 4
  • LANO Adapter Protein 3 4
  • LAP (Leucine-Rich Repeats And PDZ) And No PDZ Protein 3
  • Leucine-Rich Repeat-Containing Protein 1 3
  • DJ523E19.1 3

External Ids for LRRC1 Gene

Previous GeneCards Identifiers for LRRC1 Gene

  • GC00U990863
  • GC06P053660
  • GC06P053706
  • GC06P053492

Summaries for LRRC1 Gene

GeneCards Summary for LRRC1 Gene

LRRC1 (Leucine Rich Repeat Containing 1) is a Protein Coding gene. An important paralog of this gene is MFHAS1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRRC1 Gene

Genomics for LRRC1 Gene

Regulatory Elements for LRRC1 Gene

Genomic Location for LRRC1 Gene

53,794,497 bp from pter
53,924,121 bp from pter
129,625 bases
Plus strand

Genomic View for LRRC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRRC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRRC1 Gene

Proteins for LRRC1 Gene

  • Protein details for LRRC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q5TGN3
    • Q9HAC0
    • Q9NVF1

    Protein attributes for LRRC1 Gene

    524 amino acids
    Molecular mass:
    59242 Da
    Quaternary structure:
    • Interacts with DLG1 and DLG4. May form a complex with DLG1 and ERBB2IP, where interaction between LRRC1 and ERBB2IP is indirect.
    • Sequence=BAA91801.1; Type=Frameshift; Positions=262; Evidence={ECO:0000305};

    Alternative splice isoforms for LRRC1 Gene


neXtProt entry for LRRC1 Gene

Proteomics data for LRRC1 Gene at MOPED

Post-translational modifications for LRRC1 Gene

  • Ubiquitination at Lys60, Lys63, and Lys381
  • Modification sites at PhosphoSitePlus

Other Protein References for LRRC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRRC1 Gene

Domains for LRRC1 Gene

Protein Domains for LRRC1 Gene


Suggested Antigen Peptide Sequences for LRRC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 17 LRR (leucine-rich) repeats.
  • Contains 17 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRRC1: view

No data available for Gene Families for LRRC1 Gene

Function for LRRC1 Gene

Gene Ontology (GO) - Molecular Function for LRRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRRC1: view

Phenotypes for LRRC1 Gene

GenomeRNAi human phenotypes for LRRC1:
genes like me logo Genes that share phenotypes with LRRC1: view

Animal Model Products

miRNA for LRRC1 Gene

miRTarBase miRNAs that target LRRC1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRRC1 Gene

Localization for LRRC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRRC1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized at the basolateral side of epithelial cells.

Subcellular locations from

Jensen Localization Image for LRRC1 Gene COMPARTMENTS Subcellular localization image for LRRC1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for LRRC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with LRRC1: view

Pathways for LRRC1 Gene

SuperPathways for LRRC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRRC1 Gene


No data available for Pathways by source for LRRC1 Gene

Transcripts for LRRC1 Gene

Unigene Clusters for LRRC1 Gene

Leucine rich repeat containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRRC1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRRC1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b
SP1: - - -
SP2: -

Relevant External Links for LRRC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRRC1 Gene

mRNA expression in normal human tissues for LRRC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for LRRC1 Gene

This gene is overexpressed in Cervix (18.7) and Salivary gland (12.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRRC1 Gene

SOURCE GeneReport for Unigene cluster for LRRC1 Gene Hs.606493

mRNA Expression by UniProt/SwissProt for LRRC1 Gene

Tissue specificity: Expressed strongly in testis and placenta, followed by heart, lung, kidney, thyroid, trachea, colon, prostate and pancreas.
genes like me logo Genes that share expressions with LRRC1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for LRRC1 Gene

Orthologs for LRRC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRRC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRRC1 35
  • 88.8 (n)
  • 94.66 (a)
LRRC1 36
  • 95 (a)
(Canis familiaris)
Mammalia LRRC1 35
  • 93.32 (n)
  • 97.13 (a)
LRRC1 36
  • 97 (a)
(Mus musculus)
Mammalia Lrrc1 35
  • 88.68 (n)
  • 93.13 (a)
Lrrc1 16
Lrrc1 36
  • 91 (a)
(Pan troglodytes)
Mammalia LRRC1 35
  • 99.43 (n)
  • 99.81 (a)
LRRC1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrrc1 35
  • 88.3 (n)
  • 92.37 (a)
(Monodelphis domestica)
Mammalia LRRC1 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia LRRC1 36
  • 84 (a)
(Gallus gallus)
Aves LRRC1 35
  • 81.99 (n)
  • 87.87 (a)
LRRC1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia LRRC1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrrc1 35
  • 74.68 (n)
  • 82.44 (a)
MGC75617 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.15200 35
(Danio rerio)
Actinopterygii Dr.10955 35
lrrc1 35
  • 70.17 (n)
  • 76.1 (a)
lrrc1 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta scrib 36
  • 11 (a)
(Caenorhabditis elegans)
Secernentea let-413 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7054 36
  • 20 (a)
Species with no ortholog for LRRC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRRC1 Gene

Gene Tree for LRRC1 (if available)
Gene Tree for LRRC1 (if available)

Paralogs for LRRC1 Gene

(10) SIMAP similar genes for LRRC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRRC1: view

Variants for LRRC1 Gene

Sequence variations from dbSNP and Humsavar for LRRC1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1543356 -- 53,923,563(+) ATATC(A/G)GTTGA utr-variant-3-prime
rs1883632 -- 53,915,634(+) TTTAC(A/G)TGAAT intron-variant
rs2050159 -- 53,908,355(+) TTTCA(A/G)TCAGG intron-variant
rs2223617 -- 53,910,606(+) TTTTA(C/T)TTCCT intron-variant
rs2294789 -- 53,920,478(+) TAAAG(A/C)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRRC1 Gene

Variant ID Type Subtype PubMed ID
nsv830664 CNV Gain 17160897
esv2667284 CNV Deletion 23128226
nsv5306 CNV Insertion 18451855
esv5680 CNV Gain 19470904

Relevant External Links for LRRC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRRC1 Gene

Disorders for LRRC1 Gene

(1) University of Copenhagen DISEASES for LRRC1 Gene

Relevant External Links for LRRC1

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with LRRC1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for LRRC1 Gene

Publications for LRRC1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells. (PMID: 11440998) Saito H. … Borg J.-P. (J. Biol. Chem. 2001) 3 4
  4. Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5. (PMID: 12200217) Suzuki T. … Yamakawa K. (Epilepsy Res. 2002) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for LRRC1 Gene

Sources for LRRC1 Gene

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