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LRPAP1 Gene

protein-coding   GIFtS: 64
GCID: GC04M003508

Low Density Lipoprotein Receptor-Related Protein Associated...

(Previous name: low density lipoprotein-related protein-associated protein...)
(Previous symbol: A2MRAP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein Associated Protein
11 2
     HBP442
A2MRAP1 2 3 5     MRAP2
Low Density Lipoprotein-Related Protein-Associated Protein 1
(Alpha-2-Macroglobulin Receptor-Associated Protein 1)1 2
     alpha-2-MRAP2
RAP2 3     Alpha-2-Macroglobulin Receptor-Associated Protein2
MYP232 5     Alpha-2-MRAP3
39 KDa Receptor-Associated Protein2     Low Density Lipoprotein Receptor-Related Protein-Associated Protein 13
A2RAP2     

External Ids:    HGNC: 67011   Entrez Gene: 40432   Ensembl: ENSG000001639567   OMIM: 1042255   UniProtKB: P305333   

Export aliases for LRPAP1 gene to outside databases

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRPAP1 Gene:
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and
facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have
been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Dec 2013)

GeneCards Summary for LRPAP1 Gene:
LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) is a protein-coding gene. Diseases associated with LRPAP1 include myopia 23, autosomal recessive, and myopia, high, with cataract and vitreoretinal degeneration. GO annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

Gene Wiki entry for LRPAP1 (LDL-receptor-related protein associated protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRPAP1 gene promoter:
         ER-alpha   AML1a   Sp1   YY1   STAT3   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRPAP1 promoter sequence
   Search Chromatin IP Primers for LRPAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRPAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Start:
3,505,324 bp from pter      End:
3,534,286 bp from pter
Size:
28,963 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin receptor-associated protein precursor  
Size: 357 amino acids; 41466 Da
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains.
Binds LRP1B; binding is followed by internalization and degradation
Selected PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):
1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    
Secondary accessions: D3DVR9 Q2M310 Q53HQ3 Q53HS6

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Explore proteomics data for LRPAP1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Thr134, Asn268, Thr337, Ser346
  • Modification sites at PhosphoSitePlus

  • See LRPAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002328.1  
    ENSEMBL proteins: 
     ENSP00000421922   ENSP00000421648  

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    Cloud-Clone Corp. CLIAs for LRPAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010483 Alpha_2_MRAP_C
     IPR009066 MG_RAP_rcpt_1

    Graphical View of Domain Structure for InterPro Entry P30533

    ProtoNet protein and cluster: P30533

    1 Blocks protein domain: IPB009066 Alpha-2-macroglobulin receptor-associated protein

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
    Similarity: Belongs to the alpha-2-MRAP family


    LRPAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRP_HUMAN, P30533
    Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

         Genatlas biochemistry entry for LRPAP1:
    low density lipoprotein receptor related protein,associated protein 1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS2229028
    GO:0005515protein binding IPI8083232
    GO:0008201heparin binding IEA--
    GO:0035473lipase binding IEA--
    GO:0048019receptor antagonist activity IDA8083232
         
    LRPAP1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrpap1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     normal  other  renal/urinary system  reproductive system 

    LRPAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LRPAP1: Lrpap1tm1Vln Lrpap1tm1Her

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRPAP1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRPAP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRPAP1

    miRNA
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    miRTarBase miRNAs that target LRPAP1:
    hsa-mir-615-3p (MIRT040189), hsa-mir-26b-5p (MIRT029205)

    Block miRNA regulation of human, mouse, rat LRPAP1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate LRPAP1
    SwitchGear 3'UTR luciferase reporter plasmidLRPAP1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRPAP1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for LRPAP1 (see all 6)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    Sino Biological Human cDNA Clone for LRPAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMRP_HUMAN, P30533: Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell
    surface receptors. Found in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular4
    cytoskeleton2
    cytosol2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA8083232
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA16263759
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane TAS1712782

    LRPAP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LRPAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family
    2Reelin signaling pathway
    Reelin signaling pathway
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development


    3 BioSystems Pathways for LRPAP1
        Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway
    Signaling events mediated by the Hedgehog family



        Pathway & Disease-focused RT2 Profiler PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRPAP1

    Selected Interacting proteins for LRPAP1 (P305331, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63655 I2D: score=5 
    RTN4Q9NQC32, 3MINT-63654 I2D: score=5 
    PPM1GO153552, 3MINT-63653 I2D: score=4 
    VLDLRP981551, 3EBI-715927,EBI-9004309 I2D: score=2 
    CWC25Q9NXE83I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8654360
    GO:0006898receptor-mediated endocytosis TAS2229028
    GO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA8083232
    GO:0016192vesicle-mediated transport TAS8654360
    GO:0032091negative regulation of protein binding IDA8083232

    LRPAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRPAP1 (AMRP)

    Selected Novoseek inferred chemical compound relationships for LRPAP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 58.2 3 10326762 (1), 8694779 (1)
    mannan 31.6 1 7579446 (1)
    heparin 30.2 20 11382778 (6), 9253767 (2), 2229028 (2), 12637503 (1) (see all 5)
    lovastatin 20.6 1 7822276 (1)
    suramin 20.3 2 11604390 (2)
    mannose 18.5 1 7579446 (1)
    lysine 12 8 15025528 (3), 12637503 (2)
    cholesterol 0 3 17987404 (1), 9030194 (1), 16704534 (1)
    sucrose 0 1 8322889 (1)
    lipid 0 2 12394648 (1), 18721259 (1)



    LRPAP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LRPAP1 gene: 
    NM_002337.3  

    Unigene Cluster for LRPAP1:

    Low density lipoprotein receptor-related protein associated protein 1
    Hs.40966  [show with all ESTs]
    Unigene Representative Sequence: NM_002337
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500728(uc003ghh.4) ENST00000296325 ENST00000515119 ENST00000509198

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
      QuantiFast Probe-based Assays in human, mouse, rat LRPAP1

    Additional mRNA sequence: 

    AF085973.1 AK128751.1 AK222504.1 AK222527.1 AK292321.1 AK311600.1 AK312698.1 AL365520.1 
    AL365522.1 BC006574.2 BC007841.1 BC013950.2 BC018955.2 BC105074.1 BC112067.1 BX647984.1 
    M63959.1 

    21 DOTS entries:

    DT.91679654  DT.450524  DT.100879558  DT.95104282  DT.311312  DT.91696992  DT.422641  DT.97858164 
    DT.100810443  DT.100879555  DT.100879544  DT.80100088  DT.92450722  DT.100719826  DT.100804237  DT.100879568 
    DT.121225776  DT.40123802  DT.40304725  DT.80100089  DT.95104287 

    Selected AceView cDNA sequences (see all 696):

    BX381548 BM700334 CR621877 BM727205 CA447726 CF265163 BQ575656 BU185055 
    CR595839 CB121214 CR613053 BQ881899 BM987580 BE275512 CD107520 AL518587 
    CR614498 W81715 BQ723211 CF132382 CB129347 BU859335 H98116 BI193075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRPAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -           -                                               -     -                     
    SP2:              -     -           -                       -     -     -           -     -                     
    SP3:              -     -           -                                                                           
    SP4:              -     -           -           -     -                                                         
    SP5:              -     -                                                                                       


    ECgene alternative splicing isoforms for LRPAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRPAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGAGTCC
    LRPAP1 Expression
    About this image


    LRPAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    LRPAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRPAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40966
        Pathway & Disease-focused RT2 Profiler PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRPAP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrpap11 , 5 low density lipoprotein receptor-related protein associated more1, 5 80.58(n)1
    77.18(a)1
      5 (18.01 cM)5
    169761  NM_013587.21  NP_038615.21 
     350914905 
    chicken
    (Gallus gallus)
    Aves LRPAP11 low density lipoprotein receptor-related protein associated more 67.77(n)
    68.28(a)
      395936  NM_205062.1  NP_990393.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRPAP16
    low density lipoprotein receptor-related protein a...
    68(a)
    1 ↔ 1
    GL343585.1(442453-445917)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986432 hypothetical protein LOC398643 72.93(n)    BC054293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrpap12 low density lipoprotein receptor-related protein associated more 72.59(n)   333939  BC049517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85071 , 3 CG85071 35(a)3
    51.5(n)1
    37.5(a)1
      85E93
    412051  NM_141693.31  NP_649950.11 


    ENSEMBL Gene Tree for LRPAP1 (if available)
    TreeFam Gene Tree for LRPAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for LRPAP1 (see all 1041)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348975111,2
    Cuntested13526636(-) CCTCAA/GTGGTA 2 N S mis11Minor allele frequency- G:0.01NA 76
    rs755795991,2
    F--3504859(+) CACCCC/GCTCGG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs28580241,2
    C,F,A,H--3504863(+) CCCTCT/GGTTCA 1 -- ds500111Minor allele frequency- G:0.39NA WA CSA EA 374
    rs1422912371,2
    --3504892(+) CTCTCA/GGCACC 1 -- ds50010--------
    rs1512683151,2
    --3504902(+) CCGTGC/TCACAG 1 -- ds50010--------
    rs1152445971,2
    F--3504933(+) CGAGGC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1393305721,2
    --3504958(+) TGGCAA/CCGCAC 1 -- ds50010--------
    rs1500336261,2
    C--3504969(+) ACTCAC/GGCCCC 1 -- ds50010--------
    rs1453586171,2
    --3504980(+) ACACAC/TGGATG 1 -- ds50010--------
    rs1425919531,2
    --3505008(+) AGCTAC/TCAGCA 1 -- ds50010--------
    rs100280981,2
    C,F,A,H--3505067(+) CCAACG/ACTGGC 1 -- ds50017Minor allele frequency- A:0.28NA WA EA 370
    rs1926117831,2
    --3505075(+) GGCACA/GGGTGA 1 -- ds50010--------
    rs1162627191,2
    C,F--3505096(+) CTCTGG/AGAATA 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs1844906101,2
    --3505104(+) ATACCC/TGTGCC 1 -- ds50010--------
    rs1890211121,2
    --3505105(+) TACCCA/GTGCCA 1 -- ds50010--------
    rs716082841,2
    C,F--3505161(+) AAGCTC/TGTACA 1 -- ds50016Minor allele frequency- T:0.14NA WA 246
    rs26994041,2
    C,F,O,A,H--3505162(-) ATGTAC/TGAGCT 1 -- ds500111Minor allele frequency- T:0.32NA WA CSA EA 374
    rs1469104291,2
    --3505179(+) GGCCCA/GTCTCT 1 -- ds50010--------
    rs622727001,2
    C,F--3505193(+) TGTGAC/TGTGCA 1 -- ds50015Minor allele frequency- T:0.13NA WA 244
    rs679306541,2
    C--3505206(-) GCAGG-/AGGCTGAG 1 -- ds50012Minor allele frequency- AGG:0.25NA 4
    rs1153535781,2
    F--3505233(+) TCCCCC/TCCGCA 1 -- ds50011Minor allele frequency- T:0.01WA 118
    rs780518751,2
    C,F--3505235(+) CCCCCC/GGCAGT 1 -- ds50012Minor allele frequency- G:0.13CSA WA 120
    rs1477631171,2
    --3505246(+) TTCCTA/GAAGTG 1 -- ds50010--------
    rs1932964001,2
    --3505374(+) ATGGCA/GGTGAA 1 -- ut310--------
    rs34681,2
    C,F,O,A,H--3505448(+) CTCACG/ACGCTT 1 -- ut3126Minor allele frequency- A:0.33MN NS EA NA WA 2964
    rs1849088461,2
    --3505449(+) TCACGC/TGCTTG 1 -- ut310--------
    rs1891893871,2
    --3505470(+) CAACAA/GCAGAC 1 -- ut310--------
    rs1411118381,2
    --3505476(+) CAGACA/GACAGA 1 -- ut310--------
    rs1434614171,2
    --3505490(+) TTCCAA/TCTCCA 1 -- ut310--------
    rs1816420621,2
    --3505509(+) AGGCTA/GGGGTA 1 -- ut310--------
    rs560277441,2
    C--3505604(+) GAAGGT/CAGAAA 1 -- ut312Minor allele frequency- C:0.10WA 120
    rs1171352971,2
    F--3505636(+) AGGGGC/TCCAGG 1 -- ut311Minor allele frequency- T:0.02EA 120
    rs1480074031,2
    C--3505648(+) AGGTCA/GTGAGC 1 -- ut310--------
    rs1407808541,2
    --3505657(+) GCGCCA/CAGCAC 1 -- ut310--------
    rs1859760811,2
    --3505733(+) CAGCAA/GGGTGG 1 -- ut310--------
    rs562982181,2
    --3505750(+) CACCAG/TGCTCC 1 -- ut310--------
    rs1386908471,2
    --3505768(+) CCTCAC/GGTGAG 1 -- ut310--------
    rs117230711,2
    C,F,H--3505847(+) CAACCC/ACCTCG 1 -- ut317Minor allele frequency- A:0.13NA WA CSA EA 366
    rs1898456541,2
    --3505890(+) ACCTGA/GCAAGA 1 -- ut310--------
    rs1811196741,2
    C--3505898(+) AGATCC/TGGCCT 1 -- ut310--------
    rs1418146621,2
    --3505962(+) AACCCA/GGTCTC 1 -- ut310--------
    rs99996971,2
    C,F--3505989(+) TCTCCA/GGGAGG 1 -- ut315Minor allele frequency- G:0.14NA WA 244
    rs1862443671,2
    --3506106(+) GCAGCC/TGAGGT 1 -- ut310--------
    rs1907684361,2
    --3506130(+) GAGGTC/GAGGAA 1 -- ut310--------
    rs563582671,2
    C,F--3506182(+) CTAAAA/GACAGA 1 -- ut318Minor allele frequency- G:0.31WA NA CSA EA 366
    rs68360641,2
    C,F--3506214(+) gctcaC/Tgccta 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1381506331,2
    --3506303(+) GAAACA/CCTGTC 1 -- ut310--------
    rs28580251,2
    C,F--3506440(+) CCATTG/CCACTG 1 -- ut315Minor allele frequency- C:0.50NA WA 10
    rs2002427821,2
    --3506461(+) ATTGA-/GTGATTC 1 -- ut310--------
    rs711801901,2
    C--3506491(-) TTTGG-/T/TTT 
            
    TTTTT
    2 -- ut311NA 2
    rs1447011761,2
    --3506653(+) TGGGCA/GACAGA 1 -- ut310--------
    rs793806561,2
    C--3506681(+) GAAAAA/TAATAA 1 -- ut310--------
    rs2010576701,2
    --3506681(+) AAAAA-/AATAATAA 1 -- cds10--------
    rs772052351,2
    C--3506684(+) AAAAAG/TAAATA 1 -- ut310--------
    rs347650331,2
    C--3506685(+) AAATA-/AA    
       G
    /GAA
    AATAA
    2 -- cds10--------
    rs730809861,2
    C,F--3506762(+) GACTTT/CAGGGA 1 -- ut312Minor allele frequency- C:0.07WA 120
    rs28580261,2
    C,F,A,H--3506811(+) TACCAC/TGCACG 1 -- ut3117Minor allele frequency- T:0.15NS EA WA NA CSA 765
    rs1485238621,2
    --3506847(+) ACGCAC/TGCAGC 1 -- ut310--------
    rs1841594021,2
    C--3506867(+) CTGGCA/TAAGCT 1 -- ut310--------
    rs1428729771,2
    --3506893(+) GCTCAC/TGGACA 1 -- ut310--------
    rs28580271,2
    C,F,O,A,H--3506933(+) AGCCCG/AGCTCG 1 -- ut3115Minor allele frequency- A:0.20NA EA WA 738
    rs1120215001,2
    C,F--3506977(+) GCAGCG/AGCTGC 1 -- ut312Minor allele frequency- A:0.08WA 120
    rs730809911,2
    C,F--3507121(+) TGGGAT/AGGAGT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs737939651,2
    C,F--3507180(+) GCATGG/ACTCCG 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs168444881,2
    C,F--3507187(+) TCCGAG/ACGGCA 1 -- ut315Minor allele frequency- A:0.08NA WA 260
    rs1829590941,2
    --3507205(+) CACACC/TGCGCA 1 -- ut310--------
    rs1472917151,2
    --3507218(+) TGCCTA/GTGCCT 1 -- ut310--------
    rs28580281,2
    C,F,H--3507248(+) CGGAAG/CGTCCC 1 -- ut3112Minor allele frequency- C:0.24NA WA CSA EA 377
    rs1409392431,2
    --3507320(+) CAGCCC/TACACG 1 -- ut310--------
    rs1448606571,2
    --3507324(+) CCACAC/GGCCTC 1 -- ut310--------
    rs1479514401,2
    C--3507381(+) CCAAGA/CCCGTC 1 -- ut310--------
    rs1406532731,2
    --3507383(+) AAGACC/TGTCTA 1 -- ut310--------
    rs1498670391,2
    C--3507386(+) ACCGTA/CTATAC 1 -- ut310--------
    rs1490510421,2
    --3507480(+) AGACCA/GTCTAT 1 -- ut310--------
    rs772983951,2
    C,F--3507521(+) TGCTGG/TGGAGG 1 -- ut311Minor allele frequency- T:0.05NA 120
    rs1430862861,2
    --3507567(+) CTGGGC/TAGAGA 1 -- ut310--------
    rs596141851,2
    C--3507742(+) AAAAA-/ATCACT 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs747179411,2
    C--3507808(+) TTTTTG/TAGACA 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs788690141,2
    C,F--3507852(+) TGGCAC/TGATTT 1 -- ut312Minor allele frequency- T:0.03NA EA 240
    rs782944841,2
    C,F--3507996(+) TGATGC/TTGGCC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1872157931,2
    --3508000(+) GTTGGC/GCAGGC 1 -- ut310--------
    rs1929364891,2
    C--3508122(+) TGAGGC/TGAAGT 1 -- ut310--------
    rs1829711571,2
    --3508151(+) CCGGAG/TTGCAA 1 -- ut310--------
    rs593330611,2
    C,F--3508173(+) CGGCTC/TACTGC 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs1880585511,2
    --3508288(+) GAGATA/GGGGTT 1 -- ut310--------
    rs1922422301,2
    C--3508334(+) CCTCAC/TGTGAT 1 -- ut310--------
    rs68201911,2
    C,F--3508342(+) gatccG/Acccac 1 -- ut313Minor allele frequency- A:0.50NA WA CSA 6
    rs1836560761,2
    --3508405(+) GCTCGA/GGCTGT 1 -- ut310--------
    rs1381190541,2
    --3508421(+) AGAGGA/CTATAT 1 -- ut310--------
    rs1895438741,2
    --3508454(+) TCCCCA/GAAGTC 1 -- ut310--------
    rs559161361,2
    C,F--3508591(+) AGGATC/TGGAAA 1 -- ut314Minor allele frequency- T:0.42NA EA 244
    rs26994031,2
    C,F,A,H--3508671(-) gagccA/Gccaca 1 -- ut3113Minor allele frequency- G:0.35NS EA NA WA CSA 781
    rs1923463561,2
    --3508701(+) CACTCC/TGCGAG 1 -- ut310--------
    rs1845595901,2
    --3508727(+) TCACTG/TGAGAC 1 -- ut310--------
    rs1899463501,2
    --3508742(+) ACTCCA/GAGACC 1 -- ut310--------
    rs1997282001,2
    --3508780(+) TCTAT-/AAAAAA 1 -- ut310--------
    rs1815918171,2
    --3508789(+) AAAAAA/CCTTTT 1 -- ut310--------
    rs1508121941,2
    --3508865(+) AGGCTA/CGCTTG 1 -- ut310--------
    rs1381625851,2
    --3508917(+) CTGCAA/CTCCAA 1 -- ut310--------
    rs1495798081,2
    --3508924(+) CCAAGC/GCTGTG 1 -- ut310--------
    rs2008133211,2
    --3508947(+) GACTC-/AAAAAA 1 -- ut310--------
    rs284101661,2
    C,F--3509097(+) AAAACG/TAAAAC 1 -- ut315Minor allele frequency- T:0.33NA CSA WA EA 362
    rs1846527211,2
    --3509134(+) TTTTTG/TTTACT 1 -- ut310--------
    rs285475701,2
    C,F--3509153(+) CCTCAA/GTTGCA 1 -- ut317Minor allele frequency- G:0.34NA CSA WA EA 366
    rs106253291,2
    C--3509209(+) ATTTATACAT/
            
    TACAT
    1 -- ut311Minor allele frequency- -:0.50CSA 2
    rs339634221,2
    C--3509210(+) TTTAT-/TACAT 
            
    ACATT
    1 -- ut310--------
    rs1137817521,2
    C--3509215(+) TACATC/TATCAT 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs28580291,2
    C,F,O,A,H--3509259(+) TACCTC/TGTCCA 1 -- ut3110Minor allele frequency- T:0.31NA WA CSA EA 373
    rs716082851,2
    C,F--3509260(+) ACCTCG/ATCCAT 1 -- ut316Minor allele frequency- A:0.14NA WA 246
    rs1420519741,2
    C--3509321(+) GTAGA-/CCAAGTTTTT
    AACTGTATTATC
    CCATT
    1 -- ut310--------
    rs770814411,2
    F--3509401(+) AACAAG/TGACAG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1408472471,2
    --3509403(+) CAAGGA/GCAGCA 1 -- ut310--------
    rs1448217981,2
    --3509418(+) GAACAC/GAAAAT 1 -- ut310--------
    rs1895884691,2
    --3509481(+) AACAAC/TAGAAA 1 -- ut310--------
    rs343363831,2
    C--3509483(+) AAAAAA/-TCAAT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs117275591,2
    H--3509517(+) GGTTTC/TTTTGG 1 -- ut310--------
    rs1809094471,2
    --3509599(+) GAGCAC/GGAATG 1 -- ut310--------
    rs1475215221,2
    --3509680(+) TTCTGC/TGACAA 1 -- ut310--------
    rs1849736631,2
    --3509738(+) CCTCAC/TGTCTT 1 -- ut310--------
    rs1909047221,2
    --3509743(+) TGTCTC/TTTTTT 1 -- ut310--------
    rs117293691,2
    C,F,H--3509962(+) tcctgC/Acctca 1 -- ut315Minor allele frequency- A:0.25NA WA CSA 8
    rs1408654161,2
    C--3510237(+) CATCC-/AAAGCC 1 -- ut310--------
    rs754580811,2
    C,F--3510269(+) CTACAC/TAGGAG 1 -- ut312Minor allele frequency- T:0.08NA 122
    rs17307661,2
    C--3510304(-) GGCCAG/AATGAG 1 -- ut316Minor allele frequency- A:0.44MN NA WA EA 546
    rs1429859041,2
    C--3510331(+) AATGCA/GCCATG 1 -- ut310--------
    rs1509217841,2
    C--3510368(+) AGGTCA/GTCTTG 1 -- ut310--------
    rs795953151,2
    C,F--3510415(+) GGTAAG/CGAAGT 1 -- ut312Minor allele frequency- C:0.08NA 122
    rs1817538311,2
    --3510460(+) CAGCTG/TACCAC 1 -- ut310--------
    rs1871479561,2
    --3510462(+) GCTGAA/CCACAT 1 -- ut310--------
    rs31841,2
    C,F,O,A,H--3510514(-) CAGGCG/AGAAGA 1 -- ut3129Minor allele frequency- A:0.29NS EA NA WA CSA 2486
    rs1141267111,2
    C,F--3510581(+) CGAGAC/TTGGGA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1915782451,2
    --3510587(+) TGGGAA/GTAAGA 1 -- ut310--------
    rs31821,2
    C,F,A,H--3510598(-) GCGCTT/CGCTAA 1 -- ut3137Minor allele frequency- C:0.34EA NA NS WA CSA 3410
    rs1406884011,2
    --3510604(+) AGCGCC/TGGCTC 1 -- ut310--------
    rs31831,2
    C,F,O,A,H--3510615(-) ACTGGC/TGAGGT 1 -- ut3128Minor allele frequency- T:0.29MN NS EA NA WA CSA 2716
    rs1833876751,2
    --3510642(+) GCACAA/GACTGA 1 -- ut310--------
    rs1140487701,2
    C,F--3510646(+) AGACTG/AACAAG 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1431950821,2
    --3510670(+) ACTGTC/TAGACA 1 -- ut310--------
    rs1466939941,2
    C--3510684(+) GACACA/GCGTGT 1 -- ut310--------
    rs1162139461,2
    F--3510685(+) ACACGC/TGTGTG 1 -- ut311Minor allele frequency- T:0.01WA 118
    rs1879283501,2
    --3510729(+) GCCATA/GGCCAA 1 -- ut310--------
    rs1913046281,2
    --3510738(+) AAGGCA/GGGAGT 1 -- ut310--------
    rs1403101511,2
    --3510768(+) CACCAC/TGCACA 1 -- ut310--------
    rs100019751,2
    C,F,A--3510769(+) ACCACG/ACACAG 1 -- ut316Minor allele frequency- A:0.13NA WA 246
    rs1823018781,2
    --3510789(+) GAAATA/TAAAAT 1 -- ut310--------
    rs1866269171,2
    --3510800(+) ACACAA/GTCCTC 1 -- ut310--------
    rs1454094221,2
    C--3510847(+) AAAACA/CTGCCA 1 -- ut310--------
    rs1926412951,2
    --3510908(+) ACTCAA/GTACCT 1 -- ut310--------
    rs1849017881,2
    --3510921(+) AGTCAC/TACATG 1 -- ut310--------
    rs586736261,2
    C--3510925(+) ATACAC/TGGCAG 1 -- ut310--------
    rs1166198321,2
    F--3510926(+) TACATG/AGCAGT 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1887712941,2
    --3510938(+) AACGCA/GTGGAC 1 -- ut310--------
    rs17307651,2
    C,F,H--3510954(-) CTCAAC/TAGTCT 1 -- ut3113Minor allele frequency- T:0.29EA NS NA WA CSA 1111
    rs100021081,2
    C,F,A,H--3510957(+) CTGTTG/AAGACG 1 -- ut317Minor allele frequency- A:0.32NS NA WA CSA 105
    rs68214001,2
    C,A,H--3511010(+) GACTGC/TTGAGA 1 -- ut312Minor allele frequency- T:0.33NA CSA 3
    rs17307641,2
    C,F,A,H--3511065(-) TCTCAG/ACAGTC 1 -- ut319Minor allele frequency- A:0.33NA 18
    rs97615831,2
    C,F--3511120(+) GACTGC/TTGAGA 1 -- ut312Minor allele frequency- T:0.50NA 4
    rs16105791,2
    C--3511175(-) TCTCAG/ACAGTC 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs1386316111,2
    C--3511230(+) GACTGC/TTGAGA 1 -- ut310--------
    rs622727011,2
    C--3511285(+) GACTGC/TTGAGA 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs716082861,2
    C,F--3511340(+) GACTGC/TTGAGA 1 -- ut313Minor allele frequency- T:0.33NA 6
    rs348988171,2
    C,F--3511395(+) GACTGT/CTGAGA 1 -- ut313Minor allele frequency- C:0.33NA 6
    rs17944391,2
    C--3511441(+) GACACC/TGGAGA 1 -- ut313Minor allele frequency- T:0.00NA 6
    rs100115451,2
    C,F,A--3511450(+) GACTGT/CTGAGA 1 -- ut313Minor allele frequency- C:0.33NA 6
    rs100209941,2
    C,F,A--3511496(+) GACACC/TGGAGA 1 -- ut313Minor allele frequency- T:0.33NA 6
    rs100138911,2
    C,F,A--3511505(+) GACTGT/CTGAGA 1 -- ut313Minor allele frequency- C:0.33NA 6
    rs100210141,2
    C,F--3511551(+) GACACC/TGGAGA 1 -- ut313Minor allele frequency- T:0.33NA 6
    rs1129196051,2
    C--3511570(+) ACGCCA/GACTGG 1 -- ut310--------
    rs1851423911,2
    --3511597(+) CAACGA/CGTGGA 1 -- ut310--------
    rs1431112631,2
    --3511622(+) AAGACA/GCCGAT 1 -- ut310--------
    rs1896749771,2
    --3511672(+) CAAAAA/CTGCGT 1 -- ut310--------
    rs107106871,2
    C,F--3511713(+) GCATGT/-TTTTT 1 -- ut313Minor allele frequency- -:0.50NA 6
    rs1810432521,2
    --3511777(+) AAACAA/GCCACA 1 -- ut310--------
    rs556547221,2
    C,F--3511791(+) ATCTTG/TAAAAA 1 -- ut311Minor allele frequency- T:0.50WA 2
    rs575371031,2
    C,F--3511943(+) CACTTG/AAGCCC 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs353501831,2
    F--3511984(+) AACCCC/TGTCTC 1 -- ut311Minor allele frequency- T:0.50NA 4
    rs1496229621,2
    --3512079(+) GAGGCA/GAGGGG 1 -- ut310--------
    rs100144661,2
    C,F,A,H--3512137(+) tactgC/Tactcc 1 -- ut316Minor allele frequency- T:0.14NA WA 248
    rs1881263551,2
    --3512148(+) AGCCTA/GAGGGA 1 -- ut310--------
    rs1443777751,2
    --3512273(+) AAGCCC/TATGCA 1 -- ut310--------
    rs1820393751,2
    --3512296(+) AAAGTA/TAAGGG 1 -- ut310--------
    rs100146741,2
    C,F--3512336(+) GGAAAC/TGTACA 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs755776961,2
    F--3512369(+) ACACGC/TGGCAC 1 -- ut311Minor allele frequency- T:0.01NA 120
    rs1488094561,2
    --3512392(+) CAGGCC/TGCCAC 1 -- ut310--------
    rs1871150591,2
    --3512393(+) AGGCCA/GCCACG 1 -- ut310--------
    rs731971251,2
    --3512428(+) TCCACA/GCAAAA 1 -- ut310--------
    rs1390789261,2
    C--3512469(+) TAAGC-/AGAT  
            
    AGATA
    1 -- ut310--------
    rs1920296861,2
    --3512479(+) ACACGC/GAGACA 1 -- ut310--------
    rs68185221,2
    C,F,A,H--3512489(+) ATACAC/GAGACG 1 -- ut3116Minor allele frequency- G:0.02NS EA NA WA 1640
    rs1818004161,2
    --3512518(+) GCCCAA/GAGCCA 1 -- ut310--------
    rs68480391,2
    C,F--3512529(+) TGCACG/TTGGAA 1 -- ut312Minor allele frequency- T:0.03WA 120
    rs17944231,2
    C,F,A,H--3512563(+) AGCTGC/TGGTGG 1 -- ut318Minor allele frequency- T:0.44NA WA EA 370
    rs1867730361,2
    --3512612(+) CGGAGC/TGGAGG 1 -- ut310--------
    rs1431547691,2
    C--3512644(+) AGTGCA/GCACCA 1 -- ut310--------
    rs17944241,2
    C,F,A,H--3512690(+) CTGGGC/TTTTTT 1 -- ut3114Minor allele frequency- T:0.26NA WA CSA EA 380
    rs1466680931,2
    C--3512850(+) CTAGTA/GTTCTC 1 -- ut310--------
    rs765982711,2
    F--3513038(+) CAACTG/CAAATA 1 -- ut311Minor allele frequency- C:0.50CSA 2
    rs1440539671,2
    --3513104(+) TACTAC/TACAGC 1 -- ut310--------
    rs17415561,2
    C,F,A,H--3513125(-) AGAAGC/TGTGTT 1 -- ut3125Minor allele frequency- T:0.28NS EA NA WA CSA 2347
    rs17415551,2
    C--3513205(-) TTCTGG/CTTCTT 1 -- ut314Minor allele frequency- C:0.15NA EA 244
    rs1902699291,2
    --3513218(+) CACCCA/CCCGCC 1 -- ut310--------
    rs1139604001,2
    C,F--3513254(+) ACAAAG/AGAACA 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs1826345171,2
    --3513373(+) GGCAGA/CTCTCA 1 -- ut310--------
    rs1509752101,2
    --3513423(+) CGCCTG/TGTGGA 1 -- ut310--------
    rs1408211211,2
    --3513441(+) CCAGGC/TTCAAA 1 -- ut310--------
    rs1869679861,2
    --3513445(+) GTTCAA/GACACG 1 -- ut310--------
    rs787121381,2
    C--3513449(+) GGGAA-/GGGAA 
            
    CCACG
    1 -- ut310--------
    rs1897556731,2
    --3513474(+) GGACCC/GGGACC 1 -- ut310--------
    rs1835214951,2
    C--3513480(+) GGACCC/TGAGCC 1 -- ut310--------
    rs361010761,2
    C,F--3513570(+) CGCCCG/AGAGCC 1 -- ut312Minor allele frequency- A:0.50NA 4
    rs20144401,2
    C,F,A--3513621(+) CACGCC/TCGGAG 1 -- ut313Minor allele frequency- T:0.33NA 6
    rs38977061,2
    A--3513623(+) CGCTCA/GGAGCC 1 -- ut310--------
    rs286996061,2
    C--3513658(+) GACACG/AGGAAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs131120541,2
    C--3513674(+) CACGCC/TCGGAG 1 -- ut313Minor allele frequency- T:0.17NA 6
    rs74420351,2
    C,A--3513701(+) TCCAGG/ACTCAG 1 -- ut311Minor allele frequency- A:0.50NA 2
    rs7318191,2
    C,F,A--3513711(+) GACACG/AGGAAG 1 -- ut312Minor allele frequency- A:0.50NA 4
    rs131120881,2
    C,F--3513727(+) CACGCC/TCGGAG 1 -- ut313Minor allele frequency- T:0.50NA WA 6
    rs131267921,2
    C,F--3513735(+) GAGCCG/AGACCC 1 -- ut312Minor allele frequency- A:0.50NA WA 4
    rs17944321,2
    C,F,A--3513754(+) TCCAGG/ACTCAG 1 -- ut315Minor allele frequency- A:0.30NA WA 10
    rs17307611,2
    C,F,A--3513780(-) CTCCGG/AGCGTG 1 -- ut312Minor allele frequency- A:0.50NA WA 4
    rs74369981,2
    A--3513781(+) ACGCTC/TGGAGC 1 -- ut310--------
    rs74420711,2
    C,F,A--3513788(+) GAGCCG/AGACCC 1 -- ut312Minor allele frequency- A:0.50NA WA 4
    rs20930981,2
    C,F--3513834(-) GCTCCA/GGGCGT 1 -- ut319Minor allele frequency- G:0.39NA WA EA 372
    rs1932263841,2
    --3513887(+) GGAGCC/TGGACC 1 -- ut310--------
    rs1115584131,2
    C,F--3513901(+) GCAACC/TGCCAG 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs1127503201,2
    C,F--3513936(+) GCCTCC/TGTGGC 1 -- ut312Minor allele frequency- T:0.01NA EA 240
    rs1851839751,2
    --3513943(+) TGGCTA/GTCTCT 1 -- ut310--------
    rs1885055471,2
    --3514048(+) GAGAGG/TTGAAA 1 -- ut310--------
    rs622727021,2
    F--3514049(+) AGAGTC/TGAAAG 1 -- ut311Minor allele frequency- T:0.50NA 2
    rs7307481,2
    C,F--3514086(+) ACTGTC/ACACAG 1 -- ut318Minor allele frequency- A:0.16NA EA WA CSA 520
    rs1166229901,2
    F--3514133(+) CAAGCG/ACTCTT 1 -- ut311Minor allele frequency- A:0.01WA 118
    rs1918531111,2
    --3514227(+) GACGCA/GATCCC 1 -- ut310--------
    rs20771301,2
    C,F,A--3514229(+) CGCGAT/CCCCTT 1 -- ut3110Minor allele frequency- C:0.50NA EA CSA WA 1712
    rs17944381,2
    C,F,A--3514237(-) TGCTCG/TTGAAG 1 -- ut3113Minor allele frequency- T:0.26NA WA CSA EA 378
    rs99956851,2
    C--3514316(+) TCTATA/TTTTTA 1 -- ut310--------
    rs1390574511,2
    C--3514344(+) ATTTCC/TGGTGG 1 -- ut310--------
    rs777684791,2
    F--3514368(+) TTTTTT/AATGTA 1 -- ut312Minor allele frequency- A:0.04NA WA 120
    rs178482811,2
    C--3514414(-) CCAGCG/TGCTGT 1 -- ut31 ese30--------
    rs10495741,2
    C,F,A,H--3514539(-) CGTCGC/TGACAC 1 -- ut3122Minor allele frequency- T:0.36EA MN NS NA WA CSA 4024
    rs1139533971,2
    C--3514602(+) GCCCCA/TGCCAC 1 -- ut310--------
    rs556835541,2
    C--3514613(+) CCTGAC/TGGCGG 1 -- ut312Minor allele frequency- T:0.04WA 120
    rs1839835951,2
    --3514614(+) CTGACA/GGCGGG 1 -- ut310--------
    rs2001273651,2
    C--3514662(+) TTCACA/GCTGGC 1 -- ut310--------
    rs769836281,2
    C,F--3514668(+) CTGGCC/TTCTTC 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1882712521,2
    C--3514680(+) CTGCCA/GGGCTG 1 -- ut310--------
    rs18004951,2
    C,F--3514689(-) TGGGGA/GGCCCA 1 -- ut31 ese33Minor allele frequency- G:0.01NA WA EU 503
    rs67891,2
    C,F,A,H--3514695(-) AGGCAT/CTGGGG 1 -- ut3127Minor allele frequency- C:0.36MN EA NS WA NA CSA EU 4695
    rs1481208091,2
    C--3514696(+) CCCAAT/CGCCTT 1 -- ut311Minor allele frequency- C:0.00EU 489
    rs1419434821,2
    C--3514710(+) AGTTCA/GTTGTG 2 N syn10--------
    rs1438415601,2
    C,F--3514715(+) GTTGTG/CCCGAG 2 /H /D mis12Minor allele frequency- C:0.00NA EU 5285
    rs2008589801,2
    C--3514778(+) GAAACA/GTCTCA 1 -- int10--------
    rs1506774841,2
    --3514843(+) GGAGAC/TGCGCG 1 -- int10--------
    rs1144763571,2
    F--3514879(+) TGCACA/GTCTGA 1 -- int11Minor allele frequency- G:0.03WA 118
    rs17415531,2
    C,F,A,H--3514938(-) GTTAGC/TACTGA 1 -- int118Minor allele frequency- T:0.22NA EA WA CSA 744
    rs1912312031,2
    --3515044(+) TATTTA/GTTTAC 1 -- int10--------
    rs1843233541,2
    --3515106(+) CTCAGC/TTCACT 1 -- int10--------
    rs622727031,2
    C,F--3515148(+) TCCCAC/TCTCAG 1 -- int13Minor allele frequency- T:0.50NA 6
    rs1903868771,2
    --3515186(+) CCCACC/TGCCAC 1 -- int10--------
    rs1160325391,2
    C,F--3515217(+) TTTTGG/ATAGAG 1 -- int11Minor allele frequency- A:0.07NA 120
    rs1822185171,2
    --3515277(+) ATGATC/TCACCC 1 -- int10--------
    rs17415521,2
    C,F,H--3515318(-) TGGCTC/TACACC 1 -- int18Minor allele frequency- T:0.29NA WA CSA 17
    rs1461748181,2
    --3515464(+) CCAGAA/GCATCC 1 -- int10--------
    rs1869336631,2
    --3515511(+) CAGCCC/TAGCCT 1 -- int10--------
    rs763162561,2
    C--3515598(+) AGCCCG/ATGGCT 1 -- int14Minor allele frequency- A:0.04CSA WA NA 241
    rs1890512211,2
    --3515616(+) AATAAC/GTCACC 1 -- int10--------
    rs1813625241,2
    --3515633(+) CCCTTC/TTCTCA 1 -- int10--------
    rs1856364511,2
    --3515641(+) TCAGCA/GGCCCT 1 -- int10--------
    rs737939791,2
    C,F--3515708(+) AACACC/TGAGCT 1 -- int11Minor allele frequency- T:0.50WA 2
    rs1440079291,2
    C--3515718(+) TTTGCC/TGTGGT 1 -- int10--------
    rs37897401,2
    F--3515841(+) GCCACA/GGGCTG 1 -- int11Minor allele frequency- G:0.01EA 1494
    rs17944401,2
    C,F,A,H--3515928(+) CCTTTC/GCTATT 1 -- int117Minor allele frequency- G:0.25NS EA NA WA CSA 794
    rs1486508451,2
    --3515931(+) TTGCTA/CTTTTT 1 -- int10--------
    rs769184141,2
    C--3515955(+) ATGCCA/TGCAGT 1 -- int10--------
    rs359492591,2
    C--3516154(+) GGCTG-/GAGAGTG 1 -- int10--------
    rs105490831,2
    C--3516155(+) TGGAGAG/-TGCCC 1 -- int11Minor allele frequency- -:0.50NA 2
    rs725987841,2
    C--3516157(+) CTGGR-/A/AG  
            
    GTGCC
    1 -- int10--------
    rs1901077891,2
    --3516170(+) GACTCA/CTGGGC 1 -- int10--------
    rs580593361,2
    C,F--3516187(+) TGGGTC/ATCCAG 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1859000151,2
    --3516225(+) ACGAGA/GCAGTG 1 -- int10--------
    rs17944411,2
    C,F,A,H--3516369(+) AGACAA/GCAGCG 1 -- int116Minor allele frequency- G:0.27EA NA WA CSA 481
    rs3714256991,2
    C--3516431(+) CATCTC/TTCCTG 1 -- int10--------
    rs22850881,2
    C,F,A,H--3516448(+) AACTGT/CGGCCT 1 -- int111Minor allele frequency- C:0.41EA NA WA CSA EU 2501
    rs178482861,2
    C--3516457(-) GGACCA/GGGGAG 1 -- int10--------
    rs2005635591,2
    --3516470(+) GAACCC/TGTGCG 1 -- int10--------
    rs1421631671,2
    C--3516476(+) GTGCGC/TACCGT 1 -- int10--------
    rs1405655431,2
    C,F--3516480(+) GCACCA/C/GTGTAG 3 T R M mis12NA EU 5703
    rs1437143101,2
    C,F--3516501(+) TGGTCC/TGCCCC 2 Q R mis11Minor allele frequency- T:0.00NA 4520
    rs2001595691,2
    C--3516511(+) CTCCAC/GCAGGG 2 L V mis10--------
    rs1480772681,2
    C,F--3516517(+) CAGGGC/TGTGCT 2 T A mis11Minor allele frequency- T:0.00NA 4530
    rs1409471051,2
    C--3516528(+) TCTCGC/TGGCTG 2 H R mis11Minor allele frequency- T:0.00NA 4528
    rs2004245261,2
    C,F--3516529(+) CTCGCG/AGCTGC 2 /R /C mis11Minor allele frequency- A:0.00EU 1317
    rs2014966521,2
    --3516539(+) CGGCTC/TACACG 2 V syn10--------
    rs359196941,2
    C,F--3516551(-) GGCGAC/TGGCGA 2 D syn12Minor allele frequency- T:0.01NA 4624
    rs18004931,2,,4
    C,F--3516559(-) AGAGCG/ATGGGC 2 /M /V mis14Minor allele frequency- A:0.01NA MN EU 6057
    rs115495121,2
    C,F,H--3516560(-) GAGAGC/TGTGGG 2 S syn19Minor allele frequency- T:0.03NS NA EU 6671
    rs2005327991,2
    C--3516587(+) TCGTGA/C/TGCAAT 3 A syn10--------
    rs2013844511,2
    C--3516588(+) CGTGCG/ACAATC 2 /A /V mis11Minor allele frequency- A:0.00EU 1323
    rs1453038521,2
    C--3516658(+) CTCCTA/GGAACA 1 -- int10--------
    rs25159671,2
    C,F,H--3516689(+) TCCCTC/TCCCGT 1 -- int1 trp313Minor allele frequency- T:0.01NA WA CSA EA 380
    rs1476498961,2
    C--3516703(+) CGCCAC/TGCCAT 1 -- int10--------
    rs17944421,2
    C,F,A,H--3516742(+) GCCAAG/AGGACG 1 -- int114Minor allele frequency- A:0.24NA WA CSA EA 381
    rs1415204651,2
    --3516777(+) CCTTGC/TGGTGA 1 -- int10--------
    rs17415501,2
    C,F--3517049(-) AGGGCA/GCCTAC 1 -- int110Minor allele frequency- G:0.42EA NA WA CSA 1858
    rs1504148671,2
    --3517132(+) CCTGCA/GGCCAG 1 -- int10--------
    rs769114131,2
    C,F--3517175(+) GACCCC/GTTTCT 1 -- int11Minor allele frequency- G:0.13WA 118
    rs17944431,2
    C,F--3517339(+) CCCCGC/ATGGAC 1 -- int113Minor allele frequency- A:0.25NA WA CSA EA 376
    rs737939801,2
    C,F--3517361(+) CACAGC/TCCTGC 1 -- int11Minor allele frequency- T:0.50WA 2
    rs131292121,2
    C,F--3517389(+) GATGAA/GTTCTC 1 -- int17Minor allele frequency- G:0.14NA WA 248
    rs1491673371,2
    C--3517454(+) GTGGTA/CTCCTT 1 -- int10--------
    rs31351651,2
    C,F,A--3517483(+) CTCAGG/CAAGTG 1 -- int17Minor allele frequency- C:0.32NA CSA WA EA 366
    rs744639011,2
    C,F--3517485(+) CAGGAA/CGTGGT 1 -- int11Minor allele frequency- C:0.02EA 120
    rs2016742211,2
    C--3517509(+) GATCCC/TGGTAG 1 -- int10--------
    rs1840201831,2
    --3517570(+) GACCAC/TCCACA 1 -- int1