LRPAP1 Gene

Aliases
for LRPAP1 gene

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551

Summaries
for LRPAP1 gene

Genomic Views
for LRPAP1 gene

RefSeq DNA sequence:

NC_000004.11  NC_018915.1  NT_006051.18  

SwitchGear Promoter luciferase reporter plasmid: LRPAP1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRPAP1

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Proteins
for LRPAP1 gene

6/9 PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):

1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Post-translational modifications:

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	OriGene Purified Protein: LRPAP1 OriGene Protein Over-expression Lysate: LRPAP1 OriGene Custom Protein Services for LRPAP1
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	Novus Biologicals LRPAP1 Proteins Novus Biologicals LRPAP1 Lysate
	Sino Biological Recombinant Protein for LRPAP1
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	Uscn Proteins for LRPAP1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

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	Abcam antibodies for LRPAP1
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Protein Domains /
Families
for LRPAP1 gene

ProtoNet protein and cluster: P30533

Function
for LRPAP1 gene

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Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for LRPAP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRPAP1 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRPAP1 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 2 alleles) (MGI details for Lrpap1)

Pathways & Interactions
for LRPAP1 gene

	Super-pathway	contained gene-specific pathways
1	Reelin signaling pathway	Reelin signaling pathway 1.00
2	Signaling events mediated by the Hedgehog family	Signaling events mediated by the Hedgehog family 1.00
3	Lissencephaly gene (LIS1) in neuronal migration and development	Lissencephaly gene (LIS1) in neuronal migration and development 1.00

3 BioSystems Pathways for LRPAP1

	Reelin signaling pathway
	Lissencephaly gene (LIS1) in neuronal migration and development
	Signaling events mediated by the Hedgehog family

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

Drugs & Compounds
for LRPAP1 gene

Transcripts
for LRPAP1 gene

Expression
for LRPAP1 gene

LRPAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CACAGAGTCC

5 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainCerebral Cortex			Brain
	BrainChoroid Plexus			Brain
	BrainMedulla Oblongata			Brain
	Neural TubeDiencephalic Roof Plate			Neural Tube
	Neural TubeMetencephalon			Neural Tube
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	Extraembryonic endoderm-like cells (Generation of extrae...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRPAP1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

Orthologs
for LRPAP1 gene

Paralogs
for LRPAP1 gene

Genomic Variants
for LRPAP1 gene

Disorders / Diseases
for LRPAP1 gene

20/25 diseases for LRPAP1

7 Novoseek disease relationships for LRPAP1 gene    About this table

Publications
for LRPAP1 gene

PubMed articles for LRPAP1 gene, integrated from 9 sources (see all 198) (see top 10): (articles sorted by number of sources associating them with LRPAP1)

Utopia: connect your pdf to the dynamic world of online information

1. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. (PubMed id 9782079)^{1, 2, 4, 9} Van Leuven F.... Nelissen B. (1998)
2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. (PubMed id 1712782)^{1, 2, 3} Strickland D.K.... Argraves W.S. (1991)
3. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. (PubMed id 7774585)^{1, 2, 9} Bu G.... Schwartz A.L. (1995)
4. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor- associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (PubMed id 7789983)^{1, 2, 9} Van Leuven F.... Van den Berghe H. (1995)
5. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. (PubMed id 1400426)^{1, 2, 9} Kounnas M.Z.... Strickland D.K. (1992)
6. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)^{1, 4, 9} Cunningham N....O'Donnell J.S. (2005)
7. The solution structure of the N-terminal domain of alpha2- macroglobulin receptor-associated protein. (PubMed id 9207124)^{1, 2, 9} Nielsen P.R.... Poulsen F.M. (1997)
8. Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. (PubMed id 12394648)^{1, 4, 9} Gonzalez P....Coto E. (2002)
9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
11. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. (PubMed id 11793025)^{1, 4} Hashim Y....Cull C.A. (2001)
12. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. (PubMed id 11425005)^{1, 4} Sanchez L....Coto E. (2001)
13. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PubMed id 11384978)^{1, 2} Liu C.-X.... Bu G. (2001)
14. The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors. (PubMed id 7822276)^{1, 9} Medh J.D....Chappell D.A. (1995)
15. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). (PubMed id 9010785)^{1, 9} Bu G....Geuze H.J. (1997)
16. TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells. (PubMed id 17123336)^{1, 9} Botta R....Marino M. (2006)
17. Interaction of lipoprotein lipase and receptor-associated protein. (PubMed id 16517593)^{1, 9} Page S....Bensadoun A. (2006)
18. Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain. (PubMed id 12637503)^{1, 9} Migliorini M.M....Strickland D.K. (2003)
19. Lipoprotein Receptor Associated Protein (LRPAP1) Insertion/Deletion Polymorphism: Association with Gallbladder Cancer Susceptibility. (PubMed id 17987404)^{1, 9} Pandey S.N....Mittal B. (2006)
20. Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (PubMed id 16650578)^{1, 9} Depboylu C....Dodel R.C. (2006)
21. A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. (PubMed id 1374383)^{1, 9} Williams S.E....Strickland D.K. (1992)
22. A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. (PubMed id 2229028)^{1, 9} Furukawa T....Muramatsu T. (1990)
23. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. (PubMed id 17913606)^{1, 9} Juzyszyn Z....Drozdzik M. (2008)
24. RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. (PubMed id 16678114)^{2, 9} Lee D.... Wang Y.-X. (2006)
25. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. (PubMed id 16704534)^{1, 9} Dixit M....Mittal B. (2006)
26. Structural organization of the receptor associated protein. (PubMed id 14674767)^{1, 9} Lazic A....Gettins P.G. (2003)
27. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PubMed id 7959795)^{1, 9} Korenberg J.R....Argraves W.S. (1994)
28. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. (PubMed id 18721259)^{1, 9} Pandey P....Mittal B. (2008)
29. NMR structural studies of domain 1 of receptor-associated protein. (PubMed id 15213425)^{1, 9} Wu Y....Wang Y.X. (2004)
30. Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif. (PubMed id 16938309)^{2, 9} Jensen G.A.... Kragelund B.B. (2006)
31. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. (PubMed id 8940146)^{1, 9} Jacobsen L.... Petersen C.M. (1996)
32. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. (PubMed id 9013611)^{1, 9} Petersen C.M.... Moestrup S.K. (1997)
33. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. (PubMed id 7592875)^{1, 9} Argraves K.M....Strickland D.K. (1995)
34. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
35. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
36. Cholesterol Metabolism Gene Polymorphisms and the Ris k of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China. (PubMed id 21062971)¹ Xu H.L....Hsing A.W. (2010)
37. Genetic variation in 3-hydroxy-3-methylglutaryl CoA r eductase modifies the chemopreventive activity of statins for colorectal cancer . (PubMed id 20403997)¹ Lipkin S.M....Gruber S.B. (2010)
38. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
39. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)¹ Yoshida T....Yamada Y. (2010)
40. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)¹ Oguri M....Yamada Y. (2010)
41. Lack of interaction between LRP1 and A2M polymorphism s for the risk of Alzheimer disease. (PubMed id 20637261)¹ Bruno E....Zappia M. (2010)
42. A human MAP kinase interactome. (PubMed id 20936779)¹ Bandyopadhyay S....Ideker T. (2010)
43. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
44. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)² Chen R.... Zou H. (2009)
45. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. (PubMed id 19098903)¹ Bell R.D....Zlokovic B.V. (2009)
46. Receptor-associated protein interacts with amyloid-be ta peptide and promotes its cellular uptake. (PubMed id 19826010)¹ Kanekiyo T. and Bu G. (2009)
47. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
48. ACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population. (PubMed id 18494379)¹ Santovito A....Delpero M. (2007)
49. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. (PubMed id 18055545)¹ Wilhelmus M.M....Verbeek M.M. (2007)
50. Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. (PubMed id 18075286)¹ Lisi S....Marino M. (2007)
51. Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a northern Italian population. (PubMed id 17536759)¹ Santovito A....Delpero M. (2007)
52. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. (PubMed id 16630895)² Fisher C.... Blacklow S.C. (2006)
53. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
54. Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study. (PubMed id 16837242)¹ Dixit M....Mittal B. (2006)
55. Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. (PubMed id 16798736)¹ Wang L....Lawrence J.C. (2006)
56. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)¹ Vertegaal A.C....Lamond A.I. (2006)
57. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
58. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. (PubMed id 16263759)¹ Li Y....Bu G. (2005)
59. A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)¹ Rosas-Acosta G....Wilson V.G. (2005)
60. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)¹ Roux P.P....Blenis J. (2004)
61. Differential binding of ligands to the apolipoprotein E receptor 2. (PubMed id 12899622)¹ Andersen O.M.... Willnow T.E. (2003)
62. 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. (PubMed id 12766414)² Wu Y.... Wang Y.-X. (2003)
63. Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease. (PubMed id 11992244)¹ Schwarz H.P....Turecek P.L. (2002)
64. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. (PubMed id 11912251)¹ Lou X....Farquhar M.G. (2002)
65. Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). (PubMed id 12193592)¹ Lutz C....Baier G. (2002)
66. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
67. The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)
68. LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. (PubMed id 11557679)¹ Taira K....Saito Y. (2001)
69. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. (PubMed id 11167825)¹ Grumbach I.M....Platanias L.C. (2001)
70. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PubMed id 10783161)¹ Li W.... Guan K.-L. (2000)
71. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. (PubMed id 10747918)¹ Li Y....Bu G. (2000)
72. Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma. (PubMed id 11006321)¹ Foca C....Rice G.E. (2000)
73. Relation between the insertion/deletion polymorphism in the gene coding for receptor associated protein (RAP) and plasma apolipoprotein AI (apoAI) and high-density lipoprotein cholesterol (HDL) levels. (PubMed id 10845573)⁴ Benes P....Vacha J. (2000)
74. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. (PubMed id 10571241)¹ Hiesberger T....Herz J. (1999)
75. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. (PubMed id 8654360)¹ Willnow T.E....Herz J. (1996)
76. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). (PubMed id 7510321)¹ Zheng G....McCluskey R.T. (1994)
77. Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection. (PubMed id 7535288)¹ Jou Y.S....Myers R.M. (1994)
78. Functional domains of the receptor-associated protein (RAP). (PubMed id 7512726)¹ Orlando R.A. and Farquhar M.G. (1994)
79. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. (PubMed id 8083232)¹ Battey F.D....Strickland D.K. (1994)
80. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
81. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 1718973)¹ Herz J....Brown M.S. (1991)
82. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. (PubMed id 3266596)¹ Herz J....Stanley K.K. (1988)
83. Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP. (PubMed id 11735425)⁹ Andersen O.M....Thogersen H.C. (2001)
84. Role of receptor-associated 39/45 kD protein in active Heymann nephritis. (PubMed id 7723231)⁹ Huang J. and Makker S.P. (1995)
85. Receptor-associated protein (RAP) has two high-affini ty binding sites for the low-density lipoprotein receptor-related protein (LRP) : consequences for the chaperone functions of RAP. (PubMed id 19397492)⁹ Jensen J.K....Gettins P.G. (2009)
86. Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway. (PubMed id 15008249)⁹ Lisi S....Marino M. (2003)
87. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone. (PubMed id 9099728)⁹ Obermoeller L.M....Bu G. (1997)
88. High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs. (PubMed id 11382778)⁹ Melman L....Bu G. (2001)
89. Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site. (PubMed id 7559542)⁹ Nielsen M.S....Gliemann J. (1995)
90. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts. (PubMed id 7508685)⁹ Coukos G....Coutifaris C. (1994)
91. The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor. (PubMed id 10464330)⁹ Savonen R....Bu G. (1999)
92. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. (PubMed id 8703036)⁹ Bu G. and Rennke S. (1996)
93. The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrin. (PubMed id 7543099)⁹ Hiesberger T....Nimpf J. (1995)
94. Heparin binding protein-44 (HBP-44)/receptor-associated protein (RAP)mediates cell-substratum adhesion of mouse NIH/3T3 cells through its binding to low density lipoprotein (LDL) receptor-related protein (LRP). (PubMed id 9253767)⁹ Terada H....Ozawa M. (1997)
95. The expression of megalin (gp330) and LRP diverges during F9 cell differentiation. (PubMed id 7615664)⁹ Czekay R.P....Farquhar M.G. (1995)
96. Transcription and translation of gp600 and receptor-associated protein (RAP) in active Heymann nephritis. (PubMed id 7778686)⁹ Makker S.P....Huang J. (1995)
97. Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates. (PubMed id 15025528)⁹ Kim T.G....Kim J.S. (2004)
98. Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity. (PubMed id 11422743)⁹ Goedde M.F....Kooistra T. (2001)
99. The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin. (PubMed id 11035914)⁹ Sarti M....Orlando R.A. (2000)
100. Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells. (PubMed id 8238258)⁹ Lundstrom M....Farquhar M.G. (1993)
101. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. (PubMed id 18177055)⁹ Estrada K....Blacklow S.C. (2008)
102. The structure of receptor-associated protein (RAP). (PubMed id 17656581)⁹ Lee D....Wang Y.X. (2007)
103. Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. (PubMed id 10665926)⁹ Birn H....Christensen E.I. (2000)
104. Molecular analysis of ligand binding to the second cluster of complement-type repeats of the low density lipoprotein receptor-related protein. Evidence for an allosteric component in receptor-associated protein-mediated inhibition of ligand binding. (PubMed id 9153209)⁹ Horn I.R....van Zonneveld A.J. (1997)
105. Functional mimicry of the LDL receptor-associated protein through multimerization of a minimized third domain. (PubMed id 17963731)⁹ Isbell S.L....Zankel T.C. (2007)
106. Three complement-type repeats of the low-density lipoprotein receptor-related protein define a common binding site for RAP, PAI-1, and lactoferrin. (PubMed id 9787164)⁹ Vash B....DeCamp D. (1998)
107. Dissection of the domain architecture of the alpha2macroglobulin-receptor-associated protein. (PubMed id 9119022)⁹ Ellgaard L....Thogersen H.C. (1997)
108. Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritis. (PubMed id 8910522)⁹ Hiesberger T....Nimpf J. (1996)
109. Decreased expression of both the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression. (PubMed id 8640836)⁹ de Vries T.J....van Muijen G.N. (1996)
110. Immunohistochemical localization of alpha-2 macroglobulin receptor/low-density lipoprotein receptor-related protein, receptor-associated protein, and Gp330 in the human endometrium. (PubMed id 9420885)⁹ Sayegh R.A....Isaacson K.B. (1995)
111. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. (PubMed id 15823038)⁹ McCormick L.M....Bu G. (2005)
112. Domain organization of the 39-kDa receptor-associated protein. (PubMed id 9873007)⁹ Medved L.V....Strickland D.K. (1999)
113. Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein. (PubMed id 9712858)⁹ Obermoeller L.M....Bu G. (1998)
114. Ligand-toxin hybrids directed to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin. (PubMed id 8626399)⁹ Zdanovsky A.G....FitzGerald D.J. (1996)
115. Induction of passive Heymann nephritis with antibodies specific for a synthetic peptide derived from the receptor-associated protein. (PubMed id 8642311)⁹ Kerjaschki D....Farquhar M.G. (1996)
116. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. (PubMed id 7579068)⁹ Farquhar M.G....Orlando R.A. (1995)
117. gp330 and RAP: the Heymann nephritis antigenic complex. (PubMed id 7944157)⁹ Farquhar M.G....Orlando R.A. (1994)
118. Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII. (PubMed id 17512806)⁹ Meijer A.B....Mertens K. (2007)
119. The single ligand-binding repeat of Tva, a low densit y lipoprotein receptor-related protein, contains two ligand-binding surfaces. (PubMed id 16769730)⁹ Contreras-Alcantara S....Delos S.E. (2006)
120. Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin. (PubMed id 12237864)⁹ Chiabrando G.A....Koo P.H. (2002)
121. The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. (PubMed id 11604390)⁹ Vassiliou G....McPherson R. (2001)
122. Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. (PubMed id 10688827)⁹ Schwarz H.P....Turecek P.L. (2000)
123. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. (PubMed id 10531329)⁹ Neels J.G....van Zonneveld A.J. (1999)
124. Different expression of the alpha2-macroglobulin rece ptor/low-density lipoprotein receptor-related protein in human keratinocytes an d fibroblasts. (PubMed id 9836507)⁹ Birkenmeier G....Reissig D. (1998)
125. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. (PubMed id 9188102)⁹ Czekay R.P....Farquhar M.G. (1997)
126. Breast carcinoma epithelial cells express a very low-density lipoprotein receptor variant lacking the O-linked glycosylation domain encoded by exon 16, but with full binding activity for serine proteinase/serpin complexes and Mr-40,000 receptor-associated protein. (PubMed id 9346319)⁹ Martensen P.M....Andreasen P.A. (1997)
127. Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts. (PubMed id 9045716)⁹ Hardy M.M....Bu G. (1997)
128. Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. (PubMed id 8806749)⁹ Howard G.C....Pizzo S.V. (1996)
129. Up-regulation of the low density lipoprotein receptor-related protein by dexamethasone in HepG2 cells. (PubMed id 8664331)⁹ Kancha R.K. and Hussain M.M. (1996)
130. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. (PubMed id 8322889)⁹ Biemesderfer D....Farquhar M.G. (1993)
131. Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. (PubMed id 19414325)⁹ Hayashi S....Fukushima T. (2009)
132. [Characterization of the interaction between low density lipoprotein receptor-related protein-associated protein 1 and the cancer and embryo expression protein 65] (PubMed id 15968324)⁹ Jin G.L....Shou C.C. (2005)
133. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands. (PubMed id 14596620)⁹ Croy J.E....Komives E.A. (2003)
134. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. (PubMed id 12212791)⁹ Goto J.J. and Tanzi R.E. (2002)
135. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 12393692)⁹ Nassar T....Higazi A.A. (2002)
136. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. (PubMed id 11606623)⁹ Kinoshita A....Hyman B.T. (2001)
137. Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein. (PubMed id 11716468)⁹ Misra U.K. and Pizzo S.V. (2001)
138. Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor. (PubMed id 11278770)⁹ Sousa M.M. and Saraiva M.J. (2001)
139. Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells. (PubMed id 9880335)⁹ Vilhardt F....van Deurs B. (1999)
140. Fibrinolytic activity of human mesothelial cells is counteracted by rapid uptake of tissue-type plasminogen activator. (PubMed id 9893120)⁹ Sitter T....Kooistra T. (1999)
141. Characterization of alpha 2-macroglobulin receptor low density lipoprotein receptor-related protein (alpha 2 MR/LRP) in White Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism. (PubMed id 9030194)⁹ Seo T....St Clair R.W. (1997)
142. Native and non-glycosylated recombinant single-chain urokinase-type plasminogen activator are recognized by different receptor systems on rat parenchymal liver cells. (PubMed id 8585013)⁹ van der Kaaden M.E....Kuiper J. (1995)
143. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. (PubMed id 7775583)⁹ Godyna S....Argraves W.S. (1995)
144. Evidence for a second alpha 2-macroglobulin receptor. (PubMed id 7513689)⁹ Misra U.K....Pizzo S.V. (1994)
145. Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M(r) 40,000 receptor associated protein. (PubMed id 7957939)⁹ Simonsen A.C....Andreasen P.A. (1994)
146. Low density lipoprotein receptor-related protein (LRP 1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and mi gration. (PubMed id 20197276)⁹ Mantuano E....Campana W.M. (2010)
147. Metalloproteinase-dependent shedding of low-density l ipoprotein receptor-related protein-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinase-2 and -9 at menstruation. (PubMed id 19406945)⁹ Selvais C....Emonard H. (2009)
148. Gene delivery targeted to the brain using an Angiopep -conjugated polyethyleneglycol-modified polyamidoamine dendrimer. (PubMed id 19765819)⁹ Ke W....Jiang C. (2009)
149. ApoE 4 reduces the expression of Abeta degrading enzy me IDE by activating the NMDA receptor in hippocampal neurons. (PubMed id 19616072)⁹ Du J....Wang Z. (2009)
150. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. (PubMed id 19150883)⁹ Lu J....Chen C.H. (2009)
151. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. (PubMed id 19605848)⁹ Lambert M.P....Poncz M. (2009)
152. Structural insights into recognition of beta2-glycopr otein I by the lipoprotein receptors. (PubMed id 19676115)⁹ Beglov D....Beglova N. (2009)
153. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. (PubMed id 18489431)⁹ White T.C....McCarty O.J. (2008)
154. Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. (PubMed id 19036954)⁹ Kim H.J....Thayer S.A. (2008)
155. A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes. (PubMed id 18194421)⁹ Bouchard B.A....Tracy P.B. (2008)
156. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. (PubMed id 18285446)⁹ Parkyn C.J....Morris R.J. (2008)
157. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. (PubMed id 18987193)⁹ Mantuano E....Campana W.M. (2008)
158. Mechanisms regulating plasminogen activators in transformed retinal ganglion cells. (PubMed id 18243176)⁹ Rock N. and Chintala S.K. (2008)
159. Minimization of the third domain of the LDL receptor-associated protein (RAP). (PubMed id 17678622)⁹ Isbell S.L....Zankel T.C. (2007)
160. Differential capacity of anti-RAP and anti-megalin an tibodies to produce progressive passive Heymann nephritis - implications for th e pathogenesis of idiopathic human membranous glomerulonephritis. (PubMed id 16981232)⁹ Makker S.P. and Tramontano A. (2006)
161. Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumors. (PubMed id 16106426)⁹ Desrosiers R.R....Annabi B. (2006)
162. Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor. (PubMed id 17055779)⁹ Zhou H....Jiang X.C. (2006)
163. Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. (PubMed id 15489233)⁹ Emonard H....Courtoy P.J. (2004)
164. Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. (PubMed id 15469966)⁹ Yang M....Wang H. (2004)
165. A novel efflux-recapture process underlies the mechanism of high-density lipoprotein cholesteryl ester-selective uptake mediated by the low-density lipoprotein receptor-related protein. (PubMed id 15178567)⁹ Vassiliou G. and McPherson R. (2004)
166. Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). (PubMed id 15202569)⁹ Laatsch A....Joerg H. (2004)
167. Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory. (PubMed id 15211588)⁹ Harris-White M.E....Frautschy S.A. (2004)
168. Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts. (PubMed id 12672816)⁹ Takayama Y....Takezawa T. (2003)
169. Insect lipoprotein follows a transferrin-like recycli ng pathway that is mediated by the insect LDL receptor homologue. (PubMed id 12356906)⁹ Van Hoof D....Van der Horst D.J. (2002)
170. Integrin clustering induces kinectin accumulation. (PubMed id 11973345)⁹ Tran H.... Yamada K.M. (2002)
171. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. (PubMed id 11844476)⁹ Nathan B.P....Struble R.G. (2002)
172. Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor. (PubMed id 11735395)⁹ Simonovic M....Gettins P.G. (2001)
173. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. (PubMed id 11379818)⁹ Qiu Z....Rebeck G.W. (2001)
174. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)⁹ Biliran H. and Sheng S. (2001)
175. A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation. (PubMed id 11180402)⁹ Benezra M....Vlodavsky I. (2001)
176. Expression and folding of human very-low-density lipoprotein receptor fragments: neutralization capacity toward human rhinovirus HRV2. (PubMed id 11118376)⁹ Ronacher B....Blaas D. (2000)
177. T cell lines specific for a synthetic Heymann nephritis peptide derived from the receptor-associated protein. (PubMed id 10886254)⁹ Wu H....Knight J.F. (2000)
178. Evolutionary conservation of circulating soluble low density lipoprotein receptor-related protein-like ('LRP-like') molecules. (PubMed id 10326762)⁹ Grimsley P.G....Owensby D.A. (1999)
179. Monoclonal antibodies as context-specific reagents: differential antigen reactivity of MAb 58K-9 during immunoprecipitation, immunoblotting, and immunofluorescence analyses. (PubMed id 10626676)⁹ Gao Y.S. and Sztul E. (1999)
180. Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation. (PubMed id 10224142)⁹ Torti M....Balduini C. (1999)
181. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. (PubMed id 10037478)⁹ Moulder K.L....Johnson E.M. (1999)
182. Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in mice. (PubMed id 10438721)⁹ Lansink M....Kooistra T. (1999)
183. Platelet sarco/endoplasmic reticulum Ca2+ATPase isofo rm 3b and Rap 1b: interrelation and regulation in physiopathology. (PubMed id 9576865)⁹ Lacabaratz-Porret C....Enouf J. (1998)
184. Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation. (PubMed id 9846982)⁹ Rudling M....Angelin B. (1998)
185. Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin. (PubMed id 9773777)⁹ Nielsen R....Christensen E.I. (1998)
186. Low density lipoprotein receptor-related protein (LRP) expression varies among Hep G2 cell lines. (PubMed id 9610960)⁹ Grimsley P.G....Owensby D.A. (1997)
187. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. (PubMed id 9349534)⁹ Narita M....Bu G. (1997)
188. Nickel is a specific antagonist for the catabolism of activated alpha 2-macroglobulin. (PubMed id 9060994)⁹ Kancha R.K. and Hussain M.M. (1997)
189. Heparan sulfate proteoglycan-mediated uptake of apolipoprotein E-triglyceride-rich lipoprotein particles: a major pathway at physiological particle concentrations. (PubMed id 9335533)⁹ Al-Haideri M....Deckelbaum R.J. (1997)
190. Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique. (PubMed id 8694779)⁹ Bochkov V.N....Resink T.J. (1996)
191. Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis) (PubMed id 8989729)⁹ Kerjaschki D. and Neale T.J. (1996)
192. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). (PubMed id 8973792)⁹ Knauer M.F....Glabe C.G. (1996)
193. alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor. (PubMed id 8522616)⁹ Conese M....Blasi F. (1995)
194. Degradation of tissue-type plasminogen activator by human monocyte-derived macrophages is mediated by the mannose receptor and by the low-density lipoprotein receptor-related protein. (PubMed id 7579446)⁹ Noorman F....Rijken D.C. (1995)
195. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. (PubMed id 7543026)⁹ Kounnas M.Z....Strickland D.K. (1995)
196. Urokinase/urokinase receptor system: internalization/degradation of urokinase-serpin complexes: mechanism and regulation. (PubMed id 7612191)⁹ Conese M. and Blasi F. (1995)
197. Identification of a lipolysis-stimulated receptor that is distinct from the LDL receptor and the LDL receptor-related protein. (PubMed id 7509190)⁹ Yen F.T....Bihain B.E. (1994)

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