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LRPAP1 Gene

protein-coding   GIFtS: 64
GCID: GC04M003508

Low Density Lipoprotein Receptor-Related Protein Associated...

(Previous name: low density lipoprotein-related protein-associated protein...)
(Previous symbol: A2MRAP)
  See LRPAP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein Associated Protein
11 2
     HBP442
A2MRAP1 2 3 5     MRAP2
Low Density Lipoprotein-Related Protein-Associated Protein 1
(Alpha-2-Macroglobulin Receptor-Associated Protein 1)1 2
     alpha-2-MRAP2
RAP2 3     Alpha-2-Macroglobulin Receptor-Associated Protein2
MYP232 5     Alpha-2-MRAP3
39 KDa Receptor-Associated Protein2     Low Density Lipoprotein Receptor-Related Protein-Associated Protein 13
A2RAP2     

External Ids:    HGNC: 67011   Entrez Gene: 40432   Ensembl: ENSG000001639567   OMIM: 1042255   UniProtKB: P305333   

Export aliases for LRPAP1 gene to outside databases

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRPAP1 Gene:
This gene encodes a protein that interacts with the low density lipoprotein (LDL) receptor-related protein and
facilitates its proper folding and localization by preventing the binding of ligands. Mutations in this gene have
been identified in individuals with myopia 23. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Dec 2013)

GeneCards Summary for LRPAP1 Gene:
LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) is a protein-coding gene. Diseases associated with LRPAP1 include myopia 23, autosomal recessive, and myopia, high, with cataract and vitreoretinal degeneration. GO annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

Gene Wiki entry for LRPAP1 (LDL-receptor-related protein associated protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_006051.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRPAP1 gene promoter:
         ER-alpha   AML1a   Sp1   YY1   STAT3   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRPAP1 promoter sequence
   Search Chromatin IP Primers for LRPAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRPAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Start:
3,505,324 bp from pter      End:
3,534,286 bp from pter
Size:
28,963 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin receptor-associated protein precursor  
Size: 357 amino acids; 41466 Da
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains.
Binds LRP1B; binding is followed by internalization and degradation
Selected PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):
1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    
Secondary accessions: D3DVR9 Q2M310 Q53HQ3 Q53HS6

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Explore proteomics data for LRPAP1 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Thr134, Asn268, Thr337, Ser346
  • Modification sites at PhosphoSitePlus

  • See LRPAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002328.1  
    ENSEMBL proteins: 
     ENSP00000421922   ENSP00000421648  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR010483 Alpha_2_MRAP_C
     IPR009066 MG_RAP_rcpt_1

    Graphical View of Domain Structure for InterPro Entry P30533

    ProtoNet protein and cluster: P30533

    1 Blocks protein domain: IPB009066 Alpha-2-macroglobulin receptor-associated protein

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
    Similarity: Belongs to the alpha-2-MRAP family


    Find genes that share domains with LRPAP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRP_HUMAN, P30533
    Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

         Genatlas biochemistry entry for LRPAP1:
    low density lipoprotein receptor related protein,associated protein 1

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS2229028
    GO:0005515protein binding IPI8083232
    GO:0008201heparin binding IEA--
    GO:0035473lipase binding IEA--
    GO:0048019receptor antagonist activity IDA8083232
         
    Find genes that share ontologies with LRPAP1           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrpap1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     normal  other  renal/urinary system  reproductive system 

    Find genes that share phenotypes with LRPAP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LRPAP1: Lrpap1tm1Vln Lrpap1tm1Her

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRPAP1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AMRP_HUMAN, P30533: Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell
    surface receptors. Found in the endoplasmic reticulum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    extracellular4
    cytoskeleton2
    cytosol2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA8083232
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA16263759
    GO:0009986cell surface IEA--
    GO:0016021integral component of membrane TAS1712782

    Find genes that share ontologies with LRPAP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LRPAP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family
    2Reelin signaling pathway
    Reelin signaling pathway
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development


    3 BioSystems Pathways for LRPAP1
        Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway
    Signaling events mediated by the Hedgehog family



        Pathway & Disease-focused RT2 Profiler PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRPAP1

    Selected Interacting proteins for LRPAP1 (P305331, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63655 I2D: score=5 
    RTN4Q9NQC32, 3MINT-63654 I2D: score=5 
    PPM1GO153552, 3MINT-63653 I2D: score=4 
    VLDLRP981551, 3EBI-715927,EBI-9004309 I2D: score=2 
    CWC25Q9NXE83I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8654360
    GO:0006898receptor-mediated endocytosis TAS2229028
    GO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA8083232
    GO:0016192vesicle-mediated transport TAS8654360
    GO:0032091negative regulation of protein binding IDA8083232

    Find genes that share ontologies with LRPAP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRPAP1 (AMRP)

    Selected Novoseek inferred chemical compound relationships for LRPAP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 58.2 3 10326762 (1), 8694779 (1)
    mannan 31.6 1 7579446 (1)
    heparin 30.2 20 11382778 (6), 9253767 (2), 2229028 (2), 12637503 (1) (see all 5)
    lovastatin 20.6 1 7822276 (1)
    suramin 20.3 2 11604390 (2)
    mannose 18.5 1 7579446 (1)
    lysine 12 8 15025528 (3), 12637503 (2)
    cholesterol 0 3 17987404 (1), 9030194 (1), 16704534 (1)
    sucrose 0 1 8322889 (1)
    lipid 0 2 12394648 (1), 18721259 (1)



    Find genes that share compounds with LRPAP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRPAP1 gene: 
    NM_002337.3  

    Unigene Cluster for LRPAP1:

    Low density lipoprotein receptor-related protein associated protein 1
    Hs.40966  [show with all ESTs]
    Unigene Representative Sequence: NM_002337
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500728(uc003ghh.4) ENST00000296325 ENST00000515119 ENST00000509198

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      QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
      QuantiFast Probe-based Assays in human, mouse, rat LRPAP1

    Additional mRNA sequence: 

    AF085973.1 AK128751.1 AK222504.1 AK222527.1 AK292321.1 AK311600.1 AK312698.1 AL365520.1 
    AL365522.1 BC006574.2 BC007841.1 BC013950.2 BC018955.2 BC105074.1 BC112067.1 BX647984.1 
    M63959.1 

    21 DOTS entries:

    DT.91679654  DT.450524  DT.100879558  DT.95104282  DT.311312  DT.91696992  DT.422641  DT.97858164 
    DT.100810443  DT.100879555  DT.100879544  DT.80100088  DT.92450722  DT.100719826  DT.100804237  DT.100879568 
    DT.121225776  DT.40123802  DT.40304725  DT.80100089  DT.95104287 

    Selected AceView cDNA sequences (see all 696):

    BX381548 BM700334 CR621877 BM727205 CA447726 CF265163 BQ575656 BU185055 
    CR595839 CB121214 CR613053 BQ881899 BM987580 BE275512 CD107520 AL518587 
    CR614498 W81715 BQ723211 CF132382 CB129347 BU859335 H98116 BI193075 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRPAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -           -                                               -     -                     
    SP2:              -     -           -                       -     -     -           -     -                     
    SP3:              -     -           -                                                                           
    SP4:              -     -           -           -     -                                                         
    SP5:              -     -                                                                                       


    ECgene alternative splicing isoforms for LRPAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRPAP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGAGTCC
    LRPAP1 Expression
    About this image


    LRPAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    LRPAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRPAP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40966
        Pathway & Disease-focused RT2 Profiler PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRPAP1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrpap11 , 5 low density lipoprotein receptor-related protein associated more1, 5 80.58(n)1
    77.18(a)1
      5 (18.01 cM)5
    169761  NM_013587.21  NP_038615.21 
     350914905 
    chicken
    (Gallus gallus)
    Aves LRPAP11 low density lipoprotein receptor-related protein associated more 67.77(n)
    68.28(a)
      395936  NM_205062.1  NP_990393.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRPAP16
    low density lipoprotein receptor-related protein a...
    68(a)
    1 ↔ 1
    GL343585.1(442453-445917)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986432 hypothetical protein LOC398643 72.93(n)    BC054293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrpap12 low density lipoprotein receptor-related protein associated more 72.59(n)   333939  BC049517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85071 , 3 CG85071 35(a)3
    51.5(n)1
    37.5(a)1
      85E93
    412051  NM_141693.31  NP_649950.11 


    ENSEMBL Gene Tree for LRPAP1 (if available)
    TreeFam Gene Tree for LRPAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for LRPAP1 (see all 1041)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348975111,2
    Cuntested13526636(-) CCTCAA/GTGGTA 2 N S mis11Minor allele frequency- G:0.01NA 76
    rs755795991,2
    F--3504859(+) CACCCC/GCTCGG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs28580241,2
    C,F,A,H--3504863(+) CCCTCT/GGTTCA 1 -- ds500111Minor allele frequency- G:0.39NA WA CSA EA 374
    rs1422912371,2
    --3504892(+) CTCTCA/GGCACC 1 -- ds50010--------
    rs1512683151,2
    --3504902(+) CCGTGC/TCACAG 1 -- ds50010--------
    rs1152445971,2
    F--3504933(+) CGAGGC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1393305721,2
    --3504958(+) TGGCAA/CCGCAC 1 -- ds50010--------
    rs1500336261,2
    C--3504969(+) ACTCAC/GGCCCC 1 -- ds50010--------
    rs1453586171,2
    --3504980(+) ACACAC/TGGATG 1 -- ds50010--------
    rs1425919531,2
    --3505008(+) AGCTAC/TCAGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRPAP1 (3505324 - 3534286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRPAP1 (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726908CNV Deletion23290073
    esv2726905CNV Deletion23290073
    esv2726904CNV Deletion23290073
    esv1183049CNV Deletion17803354
    esv2726902CNV Deletion23290073
    esv2726900CNV Deletion23290073
    esv1102085CNV Deletion17803354
    esv2726907CNV Deletion23290073
    esv1447823CNV Deletion17803354
    esv2726903CNV Deletion23290073

    Human Gene Mutation Database (HGMD): LRPAP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRPAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRPAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 104225   
    OMIM disorders: 615431  
    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
  • Myopia 23, autosomal recessive (MYP23) [MIM:615431]: A refractive error of the eye, in which parallel
    rays from a distant object come to focus in front of the retina, vision being better for near objects than for
    far. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane
    glomerular nephritis

  • 3 diseases for LRPAP1:    
    About MalaCards
    myopia 23, autosomal recessive    myopia, high, with cataract and vitreoretinal degeneration    myopia


    Find genes that share disorders with LRPAP1           About GenesLikeMe

    7 Novoseek inferred disease relationships for LRPAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy membranous 66.8 1 9207124 (1)
    glomerulonephritis 56.4 8 8238258 (2), 9207124 (1), 10886254 (1), 7579068 (1) (see all 7)
    alzheimers disease 25.6 2 16650578 (1), 16938309 (1)
    carcinoma embryonal 23 2 2229028 (1), 7615664 (1)
    atherosclerosis 0 1 7959795 (1)
    tumors 0 4 8640836 (2), 7957939 (1)
    carcinoma 0 2 8238258 (1), 7957939 (1)

    Genetic Association Database (GAD): LRPAP1
    Human Genome Epidemiology (HuGE) Navigator: LRPAP1 (21 documents)

    Export disorders for LRPAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for LRPAP1 gene, integrated from 10 sources (see all 211) (see top 10):
    (articles sorted by number of sources associating them with LRPAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. (PubMed id 9782079)1, 2, 4, 9 Van Leuven F.... Nelissen B. (Genomics 1998)
    2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. (PubMed id 1712782)1, 2, 3 Strickland D.K.... Argraves W.S. (J. Biol. Chem. 1991)
    3. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. (PubMed id 7774585)1, 2, 9 Bu G.... Schwartz A.L. (EMBO J. 1995)
    4. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor- associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (PubMed id 7789983)1, 2, 9 Van Leuven F.... Van den Berghe H. (Genomics 1995)
    5. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. (PubMed id 1400426)1, 2, 9 Kounnas M.Z.... Strickland D.K. (J. Biol. Chem. 1992)
    6. Lipoprotein receptor associated protein (LRPAP1) insertion/deletion polymorphism: association with gallbladder cancer susceptibility. (PubMed id 17987404)1, 4, 9 Pandey S.N....Mittal B. (Int J Gastrointest Cancer 2006)
    7. Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (PubMed id 16650578)1, 4, 9 Depboylu C....Dodel R.C. (Neurosci. Lett. 2006)
    8. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. (PubMed id 17913606)1, 4, 9 Juzyszyn Z....DroA_dzik M. (Dig Liver Dis 2008)
    9. RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. (PubMed id 16678114)1, 2, 9 Lee D.... Wang Y.-X. (Mol. Cell 2006)
    10. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. (PubMed id 16704534)1, 4, 9 Dixit M....Mittal B. (J. Gastroenterol. Hepatol. 2006)
    11. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. (PubMed id 18721259)1, 4, 9 Pandey P....Mittal B. (Genes Brain Behav. 2008)
    12. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)1, 4, 9 Cunningham N....O'Donnell J.S. (amp 2005)
    13. The solution structure of the N-terminal domain of alpha2- macroglobulin receptor-associated protein. (PubMed id 9207124)1, 2, 9 Nielsen P.R.... Poulsen F.M. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    14. Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif. (PubMed id 16938309)1, 2, 9 Jensen G.A.... Kragelund B.B. (J. Mol. Biol. 2006)
    15. Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. (PubMed id 12394648)1, 4, 9 GonzA!lez P....Coto E. (Coron. Artery Dis. 2002)
    16. Mutations in LRPAP1 are associated with severe myopia in humans. (PubMed id 23830514)1, 2 Aldahmesh M.A....Alkuraya F.S. (Am. J. Hum. Genet. 2013)
    17. Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. (PubMed id 21062971)1, 4 Xu H.L....Hsing A.W. (Carcinogenesis 2011)
    18. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    19. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    20. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    21. ACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population. (PubMed id 18494379)1, 4 Santovito A....Delpero M. (Hum. Biol. 2007)
    22. Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. (PubMed id 18075286)1, 4 Lisi S....MarinA^ M. (J. Endocrinol. Invest. 2007)
    23. Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a northern Italian population. (PubMed id 17536759)1, 4 Santovito A....Delpero M. (Ann. Hum. Biol. 2007)
    24. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. (PubMed id 16630895)1, 2 Fisher C.... Blacklow S.C. (Mol. Cell 2006)
    25. Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study. (PubMed id 16837242)1, 4 Dixit M....Mittal B. (Hepatol. Res. 2006)
    26. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    27. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    28. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. (PubMed id 11793025)1, 4 Hashim Y....Cull C.A. (Diabetologia 2001)
    29. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. (PubMed id 11425005)1, 4 SA!nchez L....Coto E. (Am. J. Med. Genet. 2001)
    30. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PubMed id 11384978)1, 2 Liu C.-X.... Bu G. (J. Biol. Chem. 2001)
    31. Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP. (PubMed id 11735425)1, 9 Andersen O.M....gersen H.C. (Biochemistry 2001)
    32. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone. (PubMed id 9099728)1, 9 Obermoeller L.M....Bu G. (J. Biol. Chem. 1997)
    33. High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs. (PubMed id 11382778)1, 9 Melman L....Bu G. (J. Biol. Chem. 2001)
    34. The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors. (PubMed id 7822276)1, 9 Medh J.D....Chappell D.A. (J. Biol. Chem. 1995)
    35. The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor. (PubMed id 10464330)1, 9 Savonen R....Bu G. (J. Biol. Chem. 1999)
    36. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). (PubMed id 9010785)1, 9 Bu G....Geuze H.J. (J. Cell. Sci. 1997)
    37. TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells. (PubMed id 17123336)1, 9 Botta R....MarinA^ M. (Thyroid 2006)
    38. Interaction of lipoprotein lipase and receptor-associated protein. (PubMed id 16517593)1, 9 Page S....Bensadoun A. (J. Biol. Chem. 2006)
    39. Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain. (PubMed id 12637503)1, 9 Migliorini M.M....Strickland D.K. (J. Biol. Chem. 2003)
    40. A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. (PubMed id 1374383)1, 9 Williams S.E....Strickland D.K. (J. Biol. Chem. 1992)
    41. A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. (PubMed id 2229028)1, 9 Furukawa T....Muramatsu T. (J. Biochem. 1990)
    42. Structural organization of the receptor associated protein. (PubMed id 14674767)1, 9 Lazic A....Gettins P.G. (Biochemistry 2003)
    43. Domain organization of the 39-kDa receptor-associated protein. (PubMed id 9873007)1, 9 Medved L.V....Strickland D.K. (J. Biol. Chem. 1999)
    44. Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein. (PubMed id 9712858)1, 9 Obermoeller L.M....Bu G. (J. Biol. Chem. 1998)
    45. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PubMed id 7959795)1, 9 Korenberg J.R....Argraves W.S. (Genomics 1994)
    46. NMR structural studies of domain 1 of receptor-associated protein. (PubMed id 15213425)1, 9 Wu Y....Wang Y.X. (J. Biomol. NMR 2004)
    47. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. (PubMed id 8940146)1, 9 Jacobsen L.... Petersen C.M. (J. Biol. Chem. 1996)
    48. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. (PubMed id 9013611)1, 9 Petersen C.M.... Moestrup S.K. (J. Biol. Chem. 1997)
    49. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. (PubMed id 7592875)1, 9 Argraves K.M....Strickland D.K. (J. Biol. Chem. 1995)
    50. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    51. Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. (PubMed id 23969696)1 Sabater-Lleal M....O'Donnell C.J. (Circulation 2013)
    52. Mapping the binding region on the low density lipoprotein receptor for blood coagulation factor VIII. (PubMed id 23754288)1 Kurasawa J.H....Sarafanov A.G. (J. Biol. Chem. 2013)
    53. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    54. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    55. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    56. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    57. Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein. (PubMed id 20002523)1 Kerr M.L....Small D.H. (J. Neurochem. 2010)
    58. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. (PubMed id 20403997)1 Lipkin S.M....Gruber S.B. (Cancer Prev Res (Phila) 2010)
    59. Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease. (PubMed id 20637261)1 Bruno E....Zappia M. (Neurosci. Lett. 2010)
    60. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)
    61. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    62. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (J. Proteome Res. 2009)
    63. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (Dement Geriatr Cogn Disord 2009)
    64. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. (PubMed id 19098903)1 Bell R.D....Zlokovic B.V. (Nat. Cell Biol. 2009)
    65. Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake. (PubMed id 19826010)1 Kanekiyo T. and Bu G. (J. Biol. Chem. 2009)
    66. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    67. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. (PubMed id 18055545)1 Wilhelmus M.M....Verbeek M.M. (Am. J. Pathol. 2007)
    68. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    69. Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. (PubMed id 16798736)1 Wang L....Lawrence J.C. (J. Biol. Chem. 2006)
    70. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)1 Vertegaal A.C....Lamond A.I. (amp 2006)
    71. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    72. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. (PubMed id 16263759)1 Li Y....Bu G. (J. Cell. Sci. 2005)
    73. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (amp 2005)
    74. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)1 Roux P.P.... Blenis J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    75. Differential binding of ligands to the apolipoprotein E receptor 2. (PubMed id 12899622)1 Andersen O.M.... Willnow T.E. (Biochemistry 2003)
    76. 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. (PubMed id 12766414)2 Wu Y.... Wang Y.-X. (J. Biomol. NMR 2003)
    77. A LRPAP1 intronic insertion/deletion polymorphism and phenotypic variability in Alzheimer disease. (PubMed id 14959998)1 Schutte D.L....Buckwalter K.C. (Res Theory Nurs Pract 2003)
    78. Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease. (PubMed id 11992244)1 Schwarz H.P....Turecek P.L. (Semin. Thromb. Hemost. 2002)
    79. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. (PubMed id 11912251)1 Lou X....Farquhar M.G. (J. Am. Soc. Nephrol. 2002)
    80. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    81. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (Science 2001)
    82. LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. (PubMed id 11557679)1 Taira K....Saito Y. (Arterioscler. Thromb. Vasc. Biol. 2001)
    83. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. (PubMed id 11167825)1 Grumbach I.M....Platanias L.C. (Br. J. Haematol. 2001)
    84. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PubMed id 10783161)1 Li W.... Guan K.-L. (Genes Dev. 2000)
    85. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. (PubMed id 10747918)1 Li Y....Bu G. (J. Biol. Chem. 2000)
    86. Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma. (PubMed id 11006321)1 Foca C....Rice G.E. (Mol. Hum. Reprod. 2000)
    87. Relation between the insertion/deletion polymorphism in the gene coding for receptor associated protein (RAP) and plasma apolipoprotein AI (apoAI) and high-density lipoprotein cholesterol (HDL) levels. (PubMed id 10845573)4 Benes P....VA!cha J. (Clin. Genet. 2000)
    88. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. (PubMed id 10571241)1 Hiesberger T....Herz J. (Neuron 1999)
    89. Localization of a single transglutaminase-reactive glutamine in the third domain of RAP, the alpha2-macroglobulin receptor-associated protein. (PubMed id 10071930)1 Rasmussen L.K....rensen E.S. (J. Protein Chem. 1999)
    90. The domain structure of human receptor-associated protein. Protease sensitivity and guanidine HCl denaturation. (PubMed id 9727037)1 Rall S.C....Wardell M.R. (J. Biol. Chem. 1998)
    91. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. (PubMed id 8654360)1 Willnow T.E....Herz J. (EMBO J. 1996)
    92. In situ hybridization studies of alpha 2-macroglobulin receptor and receptor-associated protein in human prostate carcinoma. (PubMed id 8610058)1 McGarvey T....Stearns M.E. (Prostate 1996)
    93. Inhibitory effect on the lipolysis-stimulated receptor of the 39-kDa receptor-associated protein. (PubMed id 7615497)1 Troussard A.A....Yen F.T. (J. Biol. Chem. 1995)
    94. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. (PubMed id 7538675)1 Willnow T.E....Herz J. (Proc. Natl. Acad. Sci. U.S.A. 1995)
    95. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). (PubMed id 7510321)1 Zheng G....McCluskey R.T. (J. Histochem. Cytochem. 1994)
    96. Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection. (PubMed id 7535288)1 Jou Y.S....Myers R.M. (Genomics 1994)
    97. Functional domains of the receptor-associated protein (RAP). (PubMed id 7512726)1 Orlando R.A. and Farquhar M.G. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    98. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. (PubMed id 8083232)1 Battey F.D....Strickland D.K. (J. Biol. Chem. 1994)
    99. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    100. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 1718973)1 Herz J....Brown M.S. (J. Biol. Chem. 1991)
    101. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. (PubMed id 3266596)1 Herz J....Stanley K.K. (EMBO J. 1988)
    102. Role of receptor-associated 39/45 kD protein in active Heymann nephritis. (PubMed id 7723231)9 Huang J. and Makker S.P. (Kidney Int. 1995)
    103. Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP. (PubMed id 19397492)9 Jensen J.K....Gettins P.G. (Biochem. J. 2009)
    104. Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway. (PubMed id 15008249)9 Lisi S....MarinA^ M. (J. Endocrinol. Invest. 2003)
    105. Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site. (PubMed id 7559542)9 Nielsen M.S....Gliemann J. (J. Biol. Chem. 1995)
    106. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts. (PubMed id 7508685)9 Coukos G....Coutifaris C. (Am. J. Pathol. 1994)
    107. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. (PubMed id 8703036)9 Bu G. and Rennke S. (J. Biol. Chem. 1996)
    108. The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrin. (PubMed id 7543099)9 Hiesberger T....Nimpf J. (J. Biol. Chem. 1995)
    109. Heparin binding protein-44 (HBP-44)/receptor-associated protein (RAP)mediates cell-substratum adhesion of mouse NIH/3T3 cells through its binding to low density lipoprotein (LDL) receptor-related protein (LRP). (PubMed id 9253767)9 Terada H....Ozawa M. (Mol. Membr. Biol. 1997)
    110. The expression of megalin (gp330) and LRP diverges during F9 cell differentiation. (PubMed id 7615664)9 Czekay R.P....Farquhar M.G. (J. Cell. Sci. 1995)
    111. Transcription and translation of gp600 and receptor-associated protein (RAP) in active Heymann nephritis. (PubMed id 7778686)9 Makker S.P....Huang J. (Am. J. Pathol. 1995)
    112. Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates. (PubMed id 15025528)9 Kim T.G....Kim J.S. (Bioconjug. Chem. 2004)
    113. Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity. (PubMed id 11422743)9 Goedde M.F....Kooistra T. (Kidney Int. 2001)
    114. The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin. (PubMed id 11035914)9 Sarti M....Orlando R.A. (Exp. Cell Res. 2000)
    115. Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells. (PubMed id 8238258)9 Lundstrom M....Farquhar M.G. (Am. J. Pathol. 1993)
    116. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. (PubMed id 18177055)9 Estrada K....Blacklow S.C. (Biochemistry 2008)
    117. The structure of receptor-associated protein (RAP). (PubMed id 17656581)9 Lee D....Wang Y.X. (Protein Sci. 2007)
    118. Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. (PubMed id 10665926)9 Birn H....Christensen E.I. (J. Am. Soc. Nephrol. 2000)
    119. Molecular analysis of ligand binding to the second cluster of complement-type repeats of the low density lipoprotein receptor-related protein. Evidence for an allosteric component in receptor-associated protein-mediated inhibition of ligand binding. (PubMed id 9153209)9 Horn I.R....van Zonneveld A.J. (J. Biol. Chem. 1997)
    120. Functional mimicry of the LDL receptor-associated protein through multimerization of a minimized third domain. (PubMed id 17963731)9 Isbell S.L....Zankel T.C. (Biochem. Biophys. Res. Commun. 2007)
    121. Three complement-type repeats of the low-density lipoprotein receptor-related protein define a common binding site for RAP, PAI-1, and lactoferrin. (PubMed id 9787164)9 Vash B....DeCamp D. (Blood 1998)
    122. Dissection of the domain architecture of the alpha2macroglobulin-receptor-associated protein. (PubMed id 9119022)9 Ellgaard L....gersen H.C. (Eur. J. Biochem. 1997)
    123. Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritis. (PubMed id 8910522)9 Hiesberger T....Nimpf J. (J. Biol. Chem. 1996)
    124. Decreased expression of both the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression. (PubMed id 8640836)9 de Vries T.J....van Muijen G.N. (Cancer Res. 1996)
    125. Immunohistochemical localization of alpha-2 macroglobulin receptor/low-density lipoprotein receptor-related protein, receptor-associated protein, and Gp330 in the human endometrium. (PubMed id 9420885)9 Sayegh R.A....Isaacson K.B. (J. Soc. Gynecol. Investig. 1995)
    126. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. (PubMed id 15823038)9 McCormick L.M....Bu G. (Biochemistry 2005)
    127. Ligand-toxin hybrids directed to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin. (PubMed id 8626399)9 Zdanovsky A.G....FitzGerald D.J. (J. Biol. Chem. 1996)
    128. Induction of passive Heymann nephritis with antibodies specific for a synthetic peptide derived from the receptor-associated protein. (PubMed id 8642311)9 Kerjaschki D....Farquhar M.G. (J. Exp. Med. 1996)
    129. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. (PubMed id 7579068)9 Farquhar M.G....Orlando R.A. (J. Am. Soc. Nephrol. 1995)
    130. gp330 and RAP: the Heymann nephritis antigenic complex. (PubMed id 7944157)9 Farquhar M.G....Orlando R.A. (Ann. N. Y. Acad. Sci. 1994)
    131. Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII. (PubMed id 17512806)9 Meijer A.B....Mertens K. (Biochim. Biophys. Acta 2007)
    132. The single ligand-binding repeat of Tva, a low density lipoprotein receptor-related protein, contains two ligand-binding surfaces. (PubMed id 16769730)9 Contreras-Alcantara S....Delos S.E. (J. Biol. Chem. 2006)
    133. Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin. (PubMed id 12237864)9 Chiabrando G.A....Koo P.H. (J. Neurosci. Res. 2002)
    134. The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. (PubMed id 11604390)9 Vassiliou G....McPherson R. (J. Biol. Chem. 2001)
    135. Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. (PubMed id 10688827)9 Schwarz H.P....Turecek P.L. (Blood 2000)
    136. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. (PubMed id 10531329)9 Neels J.G....van Zonneveld A.J. (J. Biol. Chem. 1999)
    137. Different expression of the alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein in human keratinocytes and fibroblasts. (PubMed id 9836507)9 Birkenmeier G....Reissig D. (Arch. Dermatol. Res. 1998)
    138. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. (PubMed id 9188102)9 Czekay R.P....Farquhar M.G. (Mol. Biol. Cell 1997)
    139. Breast carcinoma epithelial cells express a very low-density lipoprotein receptor variant lacking the O-linked glycosylation domain encoded by exon 16, but with full binding activity for serine proteinase/serpin complexes and Mr-40,000 receptor-associated protein. (PubMed id 9346319)9 Martensen P.M....Andreasen P.A. (Eur. J. Biochem. 1997)
    140. Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts. (PubMed id 9045716)9 Hardy M.M....Bu G. (J. Biol. Chem. 1997)
    141. Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. (PubMed id 8806749)9 Howard G.C....Pizzo S.V. (Arch. Biochem. Biophys. 1996)
    142. Up-regulation of the low density lipoprotein receptor-related protein by dexamethasone in HepG2 cells. (PubMed id 8664331)9 Kancha R.K. and Hussain M.M. (Biochim. Biophys. Acta 1996)
    143. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. (PubMed id 8322889)9 Biemesderfer D....Farquhar M.G. (Am. J. Physiol. 1993)
    144. Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. (PubMed id 19414325)9 Hayashi S....Fukushima T. (Anticancer Res. 2009)
    145. [Characterization of the interaction between low density lipoprotein receptor-related protein-associated protein 1 and the cancer and embryo expression protein 65]. (PubMed id 15968324)9 Jin G.L....Shou C.C. (Beijing Da Xue Xue Bao 2005)
    146. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands. (PubMed id 14596620)9 Croy J.E....Komives E.A. (Biochemistry 2003)
    147. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. (PubMed id 12212791)9 Goto J.J. and Tanzi R.E. (J. Mol. Neurosci. 2002)
    148. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 12393692)9 Nassar T....Higazi A.A. (Blood 2002)
    149. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. (PubMed id 11606623)9 Kinoshita A....Hyman B.T. (J. Neurosci. 2001)
    150. Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein. (PubMed id 11716468)9 Misra U.K. and Pizzo S.V. (Arch. Biochem. Biophys. 2001)
    151. Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor. (PubMed id 11278770)9 Sousa M.M. and Saraiva M.J. (J. Biol. Chem. 2001)
    152. Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells. (PubMed id 9880335)9 Vilhardt F....van Deurs B. (Mol. Biol. Cell 1999)
    153. Fibrinolytic activity of human mesothelial cells is counteracted by rapid uptake of tissue-type plasminogen activator. (PubMed id 9893120)9 Sitter T....Kooistra T. (Kidney Int. 1999)
    154. Characterization of alpha 2-macroglobulin receptor low density lipoprotein receptor-related protein (alpha 2 MR/LRP) in White Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism. (PubMed id 9030194)9 Seo T....St Clair R.W. (Biochim. Biophys. Acta 1997)
    155. Native and non-glycosylated recombinant single-chain urokinase-type plasminogen activator are recognized by different receptor systems on rat parenchymal liver cells. (PubMed id 8585013)9 van der Kaaden M.E....Kuiper J. (Thromb. Haemost. 1995)
    156. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. (PubMed id 7775583)9 Godyna S....Argraves W.S. (J. Cell Biol. 1995)
    157. Evidence for a second alpha 2-macroglobulin receptor. (PubMed id 7513689)9 Misra U.K....Pizzo S.V. (J. Biol. Chem. 1994)
    158. Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M(r) 40,000 receptor associated protein. (PubMed id 7957939)9 Simonsen A.C....Andreasen P.A. (FEBS Lett. 1994)
    159. Low density lipoprotein receptor-related protein (LRP1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and migration. (PubMed id 20197276)9 Mantuano E....Campana W.M. (J. Biol. Chem. 2010)
    160. Metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinase-2 and -9 at menstruation. (PubMed id 19406945)9 Selvais C....Emonard H. (Endocrinology 2009)
    161. Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer. (PubMed id 19765819)9 Ke W....Jiang C. (Biomaterials 2009)
    162. ApoE 4 reduces the expression of Abeta degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons. (PubMed id 19616072)9 Du J....Wang Z. (Neurosci. Lett. 2009)
    163. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. (PubMed id 19150883)9 Lu J....Chen C.H. (Circ. Res. 2009)
    164. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. (PubMed id 19605848)9 Lambert M.P....Poncz M. (Blood 2009)
    165. Structural insights into recognition of beta2-glycoprotein I by the lipoprotein receptors. (PubMed id 19676115)9 Beglov D....Beglova N. (Proteins 2009)
    166. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. (PubMed id 18489431)9 White T.C....McCarty O.J. (J. Thromb. Haemost. 2008)
    167. Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. (PubMed id 19036954)9 Kim H.J....Thayer S.A. (J. Neurosci. 2008)
    168. A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes. (PubMed id 18194421)9 Bouchard B.A....Tracy P.B. (J. Thromb. Haemost. 2008)
    169. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. (PubMed id 18285446)9 Parkyn C.J....Morris R.J. (J. Cell. Sci. 2008)
    170. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. (PubMed id 18987193)9 Mantuano E....Campana W.M. (J. Neurosci. 2008)
    171. Mechanisms regulating plasminogen activators in transformed retinal ganglion cells. (PubMed id 18243176)9 Rock N. and Chintala S.K. (Exp. Eye Res. 2008)
    172. Minimization of the third domain of the LDL receptor-associated protein (RAP). (PubMed id 17678622)9 Isbell S.L....Zankel T.C. (Biochem. Biophys. Res. Commun. 2007)
    173. Differential capacity of anti-RAP and anti-megalin antibodies to produce progressive passive Heymann nephritis - implications for the pathogenesis of idiopathic human membranous glomerulonephritis. (PubMed id 16981232)9 Makker S.P. and Tramontano A. (J. Pathol. 2006)
    174. Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumors. (PubMed id 16106426)9 Desrosiers R.R....Annabi B. (amp 2006)
    175. Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor. (PubMed id 17055779)9 Zhou H....Jiang X.C. (Biochim. Biophys. Acta 2006)
    176. Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. (PubMed id 15489233)9 Emonard H....Courtoy P.J. (J. Biol. Chem. 2004)
    177. Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. (PubMed id 15469966)9 Yang M....Wang H. (FASEB J. 2004)
    178. A novel efflux-recapture process underlies the mechanism of high-density lipoprotein cholesteryl ester-selective uptake mediated by the low-density lipoprotein receptor-related protein. (PubMed id 15178567)9 Vassiliou G. and McPherson R. (Arterioscler. Thromb. Vasc. Biol. 2004)
    179. Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). (PubMed id 15202569)9 Laatsch A....Joerg H. (Eur. J. Cell Biol. 2004)
    180. Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory. (PubMed id 15211588)9 Harris-White M.E....Frautschy S.A. (J. Neurosci. Res. 2004)
    181. Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts. (PubMed id 12672816)9 Takayama Y....Takezawa T. (J. Biol. Chem. 2003)
    182. Insect lipoprotein follows a transferrin-like recycling pathway that is mediated by the insect LDL receptor homologue. (PubMed id 12356906)9 Van Hoof D....Van der Horst D.J. (J. Cell. Sci. 2002)
    183. Integrin clustering induces kinectin accumulation. (PubMed id 11973345)9 Tran H.... Yamada K.M. (J. Cell Sci. 2002)
    184. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. (PubMed id 11844476)9 Nathan B.P....Struble R.G. (Brain Res. 2002)
    185. Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor. (PubMed id 11735395)9 Simonovic M....Gettins P.G. (Biochemistry 2001)
    186. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. (PubMed id 11379818)9 Qiu Z....Rebeck G.W. (J. Neuropathol. Exp. Neurol. 2001)
    187. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)9 Biliran H. and Sheng S. (Cancer Res. 2001)
    188. A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation. (PubMed id 11180402)9 Benezra M....Vlodavsky I. (J. Cell. Biochem. 2001)
    189. Expression and folding of human very-low-density lipoprotein receptor fragments: neutralization capacity toward human rhinovirus HRV2. (PubMed id 11118376)9 Ronacher B....Blaas D. (Virology 2000)
    190. T cell lines specific for a synthetic Heymann nephritis peptide derived from the receptor-associated protein. (PubMed id 10886254)9 Wu H....Knight J.F. (Clin. Exp. Immunol. 2000)
    191. Evolutionary conservation of circulating soluble low density lipoprotein receptor-related protein-like (&quot;LRP-like&quot;) molecules. (PubMed id 10326762)9 Grimsley P.G....Owensby D.A. (Thromb. Res. 1999)
    192. Monoclonal antibodies as context-specific reagents: differential antigen reactivity of MAb 58K-9 during immunoprecipitation, immunoblotting, and immunofluorescence analyses. (PubMed id 10626676)9 Gao Y.S. and Sztul E. (Hybridoma 1999)
    193. Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation. (PubMed id 10224142)9 Torti M....Balduini C. (J. Biol. Chem. 1999)
    194. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. (PubMed id 10037478)9 Moulder K.L....Johnson E.M. (J. Neurochem. 1999)
    195. Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in mice. (PubMed id 10438721)9 Lansink M....Kooistra T. (Blood 1999)
    196. Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology. (PubMed id 9576865)9 Lacabaratz-Porret C....Enouf J. (Biochem. J. 1998)
    197. Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation. (PubMed id 9846982)9 Rudling M....Angelin B. (Am. J. Pathol. 1998)

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     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRPAP1
     LSBio Antibodies in human, mouse, rat for LRPAP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for LRPAP1
      Search eBioscience for proteins for LRPAP1
      Search eBioscience for elisas for LRPAP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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