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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRPAP1 Gene

protein-coding   GIFtS: 63
GCID: GC04M003508

Low Density Lipoprotein Receptor-Related Protein Associated...

(Previous name: low density lipoprotein-related protein-associated protein...)
(Previous symbol: A2MRAP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Low Density Lipoprotein Receptor-Related Protein Associated Protein
11 2
     MRAP2
A2MRAP1 2 3 5     alpha-2-MRAP2
Low Density Lipoprotein-Related Protein-Associated Protein 1
(Alpha-2-Macroglobulin Receptor-Associated Protein 1)1 2
     Alpha-2-Macroglobulin Receptor-Associated Protein2
Low Density Lipoprotein Receptor-Related Protein-Associated Protein 12 3     Alpha-2-Macroglobulin Receptor-Associated Protein 12
RAP2 3     Lipoprotein Receptor Associated Protein2
A2RAP2     Alpha-2-MRAP3
HBP442     

External Ids:    HGNC: 67011   Entrez Gene: 40432   Ensembl: ENSG000001639567   OMIM: 1042255   UniProtKB: P305333   

Export aliases for LRPAP1 gene to outside databases

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRPAP1 Gene: 
LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) is a protein-coding gene. Diseases associated with LRPAP1 include von willebrand's disease, and biliary tract cancer. GO annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

Gene Wiki entry for LRPAP1 (LDL-receptor-related protein associated protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRPAP1 gene promoter:
         ER-alpha   AML1a   Sp1   YY1   STAT3   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRPAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRPAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRPAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Start:
3,505,324 bp from pter      End:
3,534,286 bp from pter
Size:
28,963 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin receptor-associated protein precursor  
Size: 357 amino acids; 41466 Da
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains.
Binds LRP1B; binding is followed by internalization and degradation
Subcellular location: Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell
surface receptors. Found in the endoplasmic reticulum
6/9 PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):
1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    
Secondary accessions: D3DVR9 Q2M310 Q53HQ3 Q53HS6

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Explore proteomics data for LRPAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30533

  • LRPAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRPAP1 Protein Expression
    REFSEQ proteins: NP_002328.1  
    ENSEMBL proteins: 
     ENSP00000421922   ENSP00000421648  

    Human Recombinant Protein Products for LRPAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LRPAP1 (LRPAP)
    Enzo Life Sciences proteins for LRPAP1
    OriGene Purified Protein for LRPAP1
    OriGene Protein Over-expression Lysate for LRPAP1
    OriGene MassSpec for LRPAP1 
    OriGene Custom Protein Services for LRPAP1
    GenScript Custom Purified and Recombinant Proteins Services for LRPAP1
    Novus Biologicals LRPAP1 Proteins
    Novus Biologicals LRPAP1 Lysate
    Sino Biological Recombinant Protein for LRPAP1
    Sino Biological Cell Lysate for LRPAP1 
    ProSpec Recombinant Protein for LRPAP1
    Cloud-Clone Corp. Proteins for LRPAP1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA8083232
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA16263759
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane TAS1712782

    LRPAP1 for ontologies           About GeneDecksing



    LRPAP1 Antibody Products: 
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    Abcam antibodies for LRPAP1
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    LSBio Antibodies in human, mouse, rat for LRPAP1 

    Assay Products for LRPAP1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR010483 Alpha_2_MRAP_C
     IPR009066 MG_RAP_rcpt_1

    Graphical View of Domain Structure for InterPro Entry P30533

    ProtoNet protein and cluster: P30533

    1 Blocks protein domain: IPB009066 Alpha-2-macroglobulin receptor-associated protein

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
    Similarity: Belongs to the alpha-2-MRAP family


    LRPAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRP_HUMAN, P30533
    Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

         Genatlas biochemistry entry for LRPAP1:
    low density lipoprotein receptor related protein,associated protein 1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS2229028
    GO:0008201heparin binding IEA--
    GO:0035473lipase binding IEA--
    GO:0048019receptor antagonist activity IDA8083232
    GO:0050750low-density lipoprotein particle receptor binding IDA16263759
         
    LRPAP1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrpap1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     normal  other  renal/urinary system  reproductive system 

    LRPAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LRPAP1: Lrpap1tm1Vln Lrpap1tm1Her

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRPAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRPAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRPAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRPAP1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
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    SwitchGear 3'UTR luciferase reporter plasmidLRPAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRPAP1
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    Gene Editing
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    Clone
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
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                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 

    Cell Line
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    Search LifeMap BioReagents cell lines for LRPAP1
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LRPAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family
    2Reelin signaling pathway
    Reelin signaling pathway
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development


    3 BioSystems Pathways for LRPAP1
        Signaling events mediated by the Hedgehog family
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRPAP1

    5/28 Interacting proteins for LRPAP1 (P305332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63655 I2D: score=5 
    RTN4Q9NQC32, 3MINT-63654 I2D: score=5 
    PPM1GO153552, 3MINT-63653 I2D: score=4 
    CWC25Q9NXE83I2D: score=4 
    LRP1Q079543I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8654360
    GO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA8083232
    GO:0016192vesicle-mediated transport TAS8654360
    GO:0032091negative regulation of protein binding IDA8083232
    GO:1900116extracellular negative regulation of signal transduction IDA8083232

    LRPAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRPAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRPAP1 (AMRP)

    10/13 Novoseek inferred chemical compound relationships for LRPAP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 58.2 3 10326762 (1), 8694779 (1)
    mannan 31.6 1 7579446 (1)
    heparin 30.2 20 11382778 (6), 9253767 (2), 2229028 (2), 12637503 (1) (see all 5)
    lovastatin 20.6 1 7822276 (1)
    suramin 20.3 2 11604390 (2)
    mannose 18.5 1 7579446 (1)
    lysine 12 8 15025528 (3), 12637503 (2)
    cholesterol 0 3 17987404 (1), 9030194 (1), 16704534 (1)
    sucrose 0 1 8322889 (1)
    lipid 0 2 12394648 (1), 18721259 (1)

    Search CenterWatch for drugs/clinical trials and news about LRPAP1 / AMRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRPAP1 gene: 
    NM_002337.3  

    Unigene Cluster for LRPAP1:

    Low density lipoprotein receptor-related protein associated protein 1
    Hs.40966  [show with all ESTs]
    Unigene Representative Sequence: NM_002337
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500728(uc003ghh.4) ENST00000296325 ENST00000515119 ENST00000509198


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LRPAP1
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
    Sirion Biotech Customized lentivirus for stable overexpression of LRPAP1 
                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1

    Additional mRNA sequence: 

    AF085973.1 AK128751.1 AK222504.1 AK222527.1 AK292321.1 AK311600.1 AK312698.1 AL365520.1 
    AL365522.1 BC006574.2 BC007841.1 BC013950.2 BC018955.2 BC105074.1 BC112067.1 BX647984.1 
    M63959.1 

    21 DOTS entries:

    DT.91679654  DT.450524  DT.100879558  DT.95104282  DT.311312  DT.91696992  DT.422641  DT.97858164 
    DT.100810443  DT.100879555  DT.100879544  DT.80100088  DT.92450722  DT.100719826  DT.100804237  DT.100879568 
    DT.121225776  DT.40123802  DT.40304725  DT.80100089  DT.95104287 

    24/696 AceView cDNA sequences (see all 696):

    BQ723211 W81715 CR607197 BQ434613 BX381548 AL577900 H98116 BQ668698 
    AI151446 BX399454 BU579630 BQ575656 CR591537 CD107520 CB157694 CB129347 
    AA311422 BQ675077 CR614498 BE275512 AW514873 BM711920 CR596948 AI815082 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LRPAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -           -                                               -     -                     
    SP2:              -     -           -                       -     -     -           -     -                     
    SP3:              -     -           -                                                                           
    SP4:              -     -           -           -     -                                                         
    SP5:              -     -                                                                                       


    ECgene alternative splicing isoforms for LRPAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRPAP1 expression in normal human tissues (normalized intensities)      LRPAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGAGTCC
    LRPAP1 Expression
    About this image


    LRPAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See LRPAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRPAP1

    SOURCE GeneReport for Unigene cluster: Hs.40966
        SABiosciences Expression via Pathway-Focused PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRPAP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrpap11 , 5 low density lipoprotein receptor-related protein associated more1, 5 79.55(n)1
    76.19(a)1
      5 (18.01 cM)5
    169761  NM_013587.21  NP_038615.21 
     350914905 
    chicken
    (Gallus gallus)
    Aves LRPAP11 low density lipoprotein receptor-related protein associated more 67.88(n)
    68.69(a)
      395936  NM_205062.1  NP_990393.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRPAP16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343585.1(442453-445917)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986432 hypothetical protein LOC398643 72.93(n)    BC054293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrpap12 low density lipoprotein receptor-related protein associated more 72.59(n)   333939  BC049517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85071 , 3 CG85071 35(a)3
    50.55(n)1
    36.56(a)1
      85E93
    412051  NM_141693.21  NP_649950.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C15C8.41 Protein C15C8.4 42.97(n)
    33.59(a)
      179745  NM_073786.3  NP_506187.2 


    ENSEMBL Gene Tree for LRPAP1 (if available)
    TreeFam Gene Tree for LRPAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in LRPAP1 are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348975111,2
    Cuntested13526636(-) CCTCAA/GTGGTA 2 N S mis11Minor allele frequency- G:0.01NA 76
    rs755795991,2
    F--3504859(+) CACCCC/GCTCGG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs28580241,2
    C,F,A,H--3504863(+) CCCTCT/GGTTCA 1 -- ds500111Minor allele frequency- G:0.39NA WA CSA EA 374
    rs1422912371,2
    --3504892(+) CTCTCA/GGCACC 1 -- ds50010--------
    rs1512683151,2
    --3504902(+) CCGTGC/TCACAG 1 -- ds50010--------
    rs1152445971,2
    F--3504933(+) CGAGGC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1393305721,2
    --3504958(+) TGGCAA/CCGCAC 1 -- ds50010--------
    rs1500336261,2
    C--3504969(+) ACTCAC/GGCCCC 1 -- ds50010--------
    rs1453586171,2
    --3504980(+) ACACAC/TGGATG 1 -- ds50010--------
    rs1425919531,2
    --3505008(+) AGCTAC/TCAGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRPAP1 (3505324 - 3534286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for LRPAP1 (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726908CNV Deletion23290073
    esv2726905CNV Deletion23290073
    esv2726904CNV Deletion23290073
    esv1183049CNV Deletion17803354
    esv2726902CNV Deletion23290073
    esv2726900CNV Deletion23290073
    esv1102085CNV Deletion17803354
    esv2726907CNV Deletion23290073
    esv1447823CNV Deletion17803354
    esv2726903CNV Deletion23290073


    Human Gene Mutation Database (HGMD): LRPAP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRPAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRPAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104225    OMIM disorders: --

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
  • Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane
    glomerular nephritis

  • 20/22 diseases for LRPAP1 (see all 22):    About MalaCards
    von willebrand's disease    biliary tract cancer    gallbladder cancer    tuberous sclerosis
    liposarcoma    lissencephaly    hypothyroidism    thrombosis
    nephritis    wilms tumor    glomerulonephritis    alzheimer's disease
    endometrial carcinoma    peritonitis    dementia    myocardial infarction
    atherosclerosis    retinitis    colorectal cancer    thyroiditis


    LRPAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for LRPAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy membranous 66.8 1 9207124 (1)
    glomerulonephritis 56.4 8 8238258 (2), 9207124 (1), 10886254 (1), 7579068 (1) (see all 7)
    alzheimers disease 25.6 2 16650578 (1), 16938309 (1)
    carcinoma embryonal 23 2 2229028 (1), 7615664 (1)
    atherosclerosis 0 1 7959795 (1)
    tumors 0 4 8640836 (2), 7957939 (1)
    carcinoma 0 2 8238258 (1), 7957939 (1)

    Genetic Association Database (GAD): LRPAP1
    Human Genome Epidemiology (HuGE) Navigator: LRPAP1 (21 documents)

    Export disorders for LRPAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRPAP1 gene, integrated from 9 sources (see all 201) (see top 10):
    (articles sorted by number of sources associating them with LRPAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. (PubMed id 9782079)1, 2, 4, 9 Van Leuven F.... Nelissen B. (1998)
    2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. (PubMed id 1712782)1, 2, 3 Strickland D.K.... Argraves W.S. (1991)
    3. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. (PubMed id 7774585)1, 2, 9 Bu G.... Schwartz A.L. (1995)
    4. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor- associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (PubMed id 7789983)1, 2, 9 Van Leuven F.... Van den Berghe H. (1995)
    5. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. (PubMed id 1400426)1, 2, 9 Kounnas M.Z.... Strickland D.K. (1992)
    6. Lipoprotein Receptor Associated Protein (LRPAP1) Insertion/Deletion Polymorphism: Association with Gallbladder Cancer Susceptibility. (PubMed id 17987404)1, 4, 9 Pandey S.N....Mittal B. (2006)
    7. Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (PubMed id 16650578)1, 4, 9 Depboylu C....Dodel R.C. (2006)
    8. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. (PubMed id 17913606)1, 4, 9 Juzyszyn Z....Drozdzik M. (2008)
    9. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. (PubMed id 16704534)1, 4, 9 Dixit M....Mittal B. (2006)
    10. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. (PubMed id 18721259)1, 4, 9 Pandey P....Mittal B. (2008)
    11. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)1, 4, 9 Cunningham N....O'Donnell J.S. (2005)
    12. The solution structure of the N-terminal domain of alpha2- macroglobulin receptor-associated protein. (PubMed id 9207124)1, 2, 9 Nielsen P.R.... Poulsen F.M. (1997)
    13. Variation in the lipoprotein receptor-related protein, alpha2-macroglobulin and lipoprotein receptor-associated protein genes in relation to plasma lipid levels and risk of early myocardial infarction. (PubMed id 12394648)1, 4, 9 Gonzalez P....Coto E. (2002)
    14. Cholesterol Metabolism Gene Polymorphisms and the Ris k of Biliary Tract Cancers and Stones: A Population-Based Case-Control Study in Shanghai, China. (PubMed id 21062971)1, 4 Xu H.L....Hsing A.W. (2010)
    15. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    16. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (2010)
    17. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (2010)
    18. ACE and LRPAP1 insertion-deletion polymorphisms in a northern Ivory Coast population. (PubMed id 18494379)1, 4 Santovito A....Delpero M. (2007)
    19. Sequencing of the entire coding region of the receptor associated protein (RAP) in patients with primary hypothyroidism of unknown origin. (PubMed id 18075286)1, 4 Lisi S....Marino M. (2007)
    20. Allelic frequencies at the ACE and LRPAP1 loci suggest age-related relationships in a northern Italian population. (PubMed id 17536759)1, 4 Santovito A....Delpero M. (2007)
    21. Association of lipoprotein receptor, receptor-associated protein, and metabolizing enzyme gene polymorphisms with gallstone disease: A case-control study. (PubMed id 16837242)1, 4 Dixit M....Mittal B. (2006)
    22. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    23. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    24. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. (PubMed id 11793025)1, 4 Hashim Y....Cull C.A. (2001)
    25. Variation in the LRP-associated protein gene (LRPAP1) is associated with late-onset Alzheimer disease. (PubMed id 11425005)1, 4 Sanchez L....Coto E. (2001)
    26. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PubMed id 11384978)1, 2 Liu C.-X.... Bu G. (2001)
    27. The 39-kDa receptor-associated protein modulates lipoprotein catabolism by binding to LDL receptors. (PubMed id 7822276)1, 9 Medh J.D....Chappell D.A. (1995)
    28. ERD2 proteins mediate ER retention of the HNEL signal of LRP's receptor-associated protein (RAP). (PubMed id 9010785)1, 9 Bu G....Geuze H.J. (1997)
    29. TSH-Dependent expression of the LDL receptor-associated protein (RAP) in thyroid epithelial cells. (PubMed id 17123336)1, 9 Botta R....Marino M. (2006)
    30. Interaction of lipoprotein lipase and receptor-associated protein. (PubMed id 16517593)1, 9 Page S....Bensadoun A. (2006)
    31. Allosteric modulation of ligand binding to low density lipoprotein receptor-related protein by the receptor-associated protein requires critical lysine residues within its carboxyl-terminal domain. (PubMed id 12637503)1, 9 Migliorini M.M....Strickland D.K. (2003)
    32. A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein. (PubMed id 1374383)1, 9 Williams S.E....Strickland D.K. (1992)
    33. A heparin binding protein whose expression increases during differentiation of embryonal carcinoma cells to parietal endoderm cells: cDNA cloning and sequence analysis. (PubMed id 2229028)1, 9 Furukawa T....Muramatsu T. (1990)
    34. RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. (PubMed id 16678114)2, 9 Lee D.... Wang Y.-X. (2006)
    35. Structural organization of the receptor associated protein. (PubMed id 14674767)1, 9 Lazic A....Gettins P.G. (2003)
    36. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PubMed id 7959795)1, 9 Korenberg J.R....Argraves W.S. (1994)
    37. NMR structural studies of domain 1 of receptor-associated protein. (PubMed id 15213425)1, 9 Wu Y....Wang Y.X. (2004)
    38. Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif. (PubMed id 16938309)2, 9 Jensen G.A.... Kragelund B.B. (2006)
    39. Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein. (PubMed id 8940146)1, 9 Jacobsen L.... Petersen C.M. (1996)
    40. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. (PubMed id 9013611)1, 9 Petersen C.M.... Moestrup S.K. (1997)
    41. The very low density lipoprotein receptor mediates the cellular catabolism of lipoprotein lipase and urokinase-plasminogen activator inhibitor type I complexes. (PubMed id 7592875)1, 9 Argraves K.M....Strickland D.K. (1995)
    42. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    43. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    44. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    45. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    46. Genetic variation in 3-hydroxy-3-methylglutaryl CoA r eductase modifies the chemopreventive activity of statins for colorectal cancer . (PubMed id 20403997)1 Lipkin S.M....Gruber S.B. (2010)
    47. Lack of interaction between LRP1 and A2M polymorphism s for the risk of Alzheimer disease. (PubMed id 20637261)1 Bruno E....Zappia M. (2010)
    48. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)
    49. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    50. Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
    51. Genetic analysis of Alzheimer's disease in the Uppsala Longitudinal Study of Adult Men. (PubMed id 19141999)4 Giedraitis V....Glaser A. (2009)
    52. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. (PubMed id 19098903)1 Bell R.D....Zlokovic B.V. (2009)
    53. Receptor-associated protein interacts with amyloid-be ta peptide and promotes its cellular uptake. (PubMed id 19826010)1 Kanekiyo T. and Bu G. (2009)
    54. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    55. Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. (PubMed id 18055545)1 Wilhelmus M.M....Verbeek M.M. (2007)
    56. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. (PubMed id 16630895)2 Fisher C.... Blacklow S.C. (2006)
    57. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    58. Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1. (PubMed id 16798736)1 Wang L....Lawrence J.C. (2006)
    59. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. (PubMed id 17000644)1 Vertegaal A.C....Lamond A.I. (2006)
    60. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    61. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. (PubMed id 16263759)1 Li Y....Bu G. (2005)
    62. A universal strategy for proteomic studies of SUMO an d other ubiquitin-like modifiers. (PubMed id 15576338)1 Rosas-Acosta G....Wilson V.G. (2005)
    63. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. (PubMed id 15342917)1 Roux P.P....Blenis J. (2004)
    64. Differential binding of ligands to the apolipoprotein E receptor 2. (PubMed id 12899622)1 Andersen O.M.... Willnow T.E. (2003)
    65. 1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein. (PubMed id 12766414)2 Wu Y.... Wang Y.-X. (2003)
    66. Recombinant von Willebrand factor-insight into structure and function through infusion studies in animals with severe von Willebrand disease. (PubMed id 11992244)1 Schwarz H.P....Turecek P.L. (2002)
    67. GAIP, GIPC and Galphai3 are concentrated in endocytic compartments of proximal tubule cells: putative role in regulating megalin's function. (PubMed id 11912251)1 Lou X....Farquhar M.G. (2002)
    68. Evidence of functional modulation of the MEKK/JNK/cJun signaling cascade by the low density lipoprotein receptor-related protein (LRP). (PubMed id 12193592)1 Lutz C....Baier G. (2002)
    69. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    70. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
    71. LR11, a mosaic LDL receptor family member, mediates the uptake of ApoE-rich lipoproteins in vitro. (PubMed id 11557679)1 Taira K....Saito Y. (2001)
    72. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. (PubMed id 11167825)1 Grumbach I.M....Platanias L.C. (2001)
    73. The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. (PubMed id 10783161)1 Li W.... Guan K.-L. (2000)
    74. The YXXL motif, but not the two NPXY motifs, serves as the dominant endocytosis signal for low density lipoprotein receptor-related protein. (PubMed id 10747918)1 Li Y....Bu G. (2000)
    75. Differential expression of the alpha(2)-macroglobulin receptor and the receptor associated protein in normal human endometrium and endometrial carcinoma. (PubMed id 11006321)1 Foca C....Rice G.E. (2000)
    76. Relation between the insertion/deletion polymorphism in the gene coding for receptor associated protein (RAP) and plasma apolipoprotein AI (apoAI) and high-density lipoprotein cholesterol (HDL) levels. (PubMed id 10845573)4 Benes P....Vacha J. (2000)
    77. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. (PubMed id 10571241)1 Hiesberger T....Herz J. (1999)
    78. RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors. (PubMed id 8654360)1 Willnow T.E....Herz J. (1996)
    79. Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP). (PubMed id 7510321)1 Zheng G....McCluskey R.T. (1994)
    80. Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection. (PubMed id 7535288)1 Jou Y.S....Myers R.M. (1994)
    81. Functional domains of the receptor-associated protein (RAP). (PubMed id 7512726)1 Orlando R.A. and Farquhar M.G. (1994)
    82. The 39-kDa receptor-associated protein regulates ligand binding by the very low density lipoprotein receptor. (PubMed id 8083232)1 Battey F.D....Strickland D.K. (1994)
    83. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
    84. 39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 1718973)1 Herz J....Brown M.S. (1991)
    85. Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor. (PubMed id 3266596)1 Herz J....Stanley K.K. (1988)
    86. Dominant thermodynamic role of the third independent receptor binding site in the receptor-associated protein RAP. (PubMed id 11735425)9 Andersen O.M....Thogersen H.C. (2001)
    87. Role of receptor-associated 39/45 kD protein in active Heymann nephritis. (PubMed id 7723231)9 Huang J. and Makker S.P. (1995)
    88. Receptor-associated protein (RAP) has two high-affini ty binding sites for the low-density lipoprotein receptor-related protein (LRP) : consequences for the chaperone functions of RAP. (PubMed id 19397492)9 Jensen J.K....Gettins P.G. (2009)
    89. Impaired thyroglobulin (Tg) secretion by FRTL-5 cells transfected with soluble receptor associated protein (RAP): evidence for a role of RAP in the Tg biosynthetic pathway. (PubMed id 15008249)9 Lisi S....Marino M. (2003)
    90. Differential functions of triplicated repeats suggest two independent roles for the receptor-associated protein as a molecular chaperone. (PubMed id 9099728)9 Obermoeller L.M....Bu G. (1997)
    91. High affinity binding of receptor-associated protein to heparin and low density lipoprotein receptor-related protein requires similar basic amino acid sequence motifs. (PubMed id 11382778)9 Melman L....Bu G. (2001)
    92. Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site. (PubMed id 7559542)9 Nielsen M.S....Gliemann J. (1995)
    93. Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts. (PubMed id 7508685)9 Coukos G....Coutifaris C. (1994)
    94. The carboxyl-terminal domain of receptor-associated protein facilitates proper folding and trafficking of the very low density lipoprotein receptor by interaction with the three amino-terminal ligand-binding repeats of the receptor. (PubMed id 10464330)9 Savonen R....Bu G. (1999)
    95. Receptor-associated protein is a folding chaperone for low density lipoprotein receptor-related protein. (PubMed id 8703036)9 Bu G. and Rennke S. (1996)
    96. The chicken oocyte receptor for yolk precursors as a model for studying the action of receptor-associated protein and lactoferrin. (PubMed id 7543099)9 Hiesberger T....Nimpf J. (1995)
    97. Heparin binding protein-44 (HBP-44)/receptor-associated protein (RAP)mediates cell-substratum adhesion of mouse NIH/3T3 cells through its binding to low density lipoprotein (LDL) receptor-related protein (LRP). (PubMed id 9253767)9 Terada H....Ozawa M. (1997)
    98. The expression of megalin (gp330) and LRP diverges during F9 cell differentiation. (PubMed id 7615664)9 Czekay R.P....Farquhar M.G. (1995)
    99. Transcription and translation of gp600 and receptor-associated protein (RAP) in active Heymann nephritis. (PubMed id 7778686)9 Makker S.P....Huang J. (1995)
    100. Gene transfer into human hepatoma cells by receptor-associated protein/polylysine conjugates. (PubMed id 15025528)9 Kim T.G....Kim J.S. (2004)
    101. Adenovirus-mediated transfer of the 39 kD receptor-associated protein increases fibrinolytic capacity. (PubMed id 11422743)9 Goedde M.F....Kooistra T. (2001)
    102. The receptor-associated protein (RAP) interacts with several resident proteins of the endoplasmic reticulum including a glycoprotein related to actin. (PubMed id 11035914)9 Sarti M....Orlando R.A. (2000)
    103. Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells. (PubMed id 8238258)9 Lundstrom M....Farquhar M.G. (1993)
    104. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. (PubMed id 18177055)9 Estrada K....Blacklow S.C. (2008)
    105. The structure of receptor-associated protein (RAP). (PubMed id 17656581)9 Lee D....Wang Y.X. (2007)
    106. Receptor-associated protein is important for normal processing of megalin in kidney proximal tubules. (PubMed id 10665926)9 Birn H....Christensen E.I. (2000)
    107. Molecular analysis of ligand binding to the second cluster of complement-type repeats of the low density lipoprotein receptor-related protein. Evidence for an allosteric component in receptor-associated protein-mediated inhibition of ligand binding. (PubMed id 9153209)9 Horn I.R....van Zonneveld A.J. (1997)
    108. Functional mimicry of the LDL receptor-associated protein through multimerization of a minimized third domain. (PubMed id 17963731)9 Isbell S.L....Zankel T.C. (2007)
    109. Three complement-type repeats of the low-density lipoprotein receptor-related protein define a common binding site for RAP, PAI-1, and lactoferrin. (PubMed id 9787164)9 Vash B....DeCamp D. (1998)
    110. Dissection of the domain architecture of the alpha2macroglobulin-receptor-associated protein. (PubMed id 9119022)9 Ellgaard L....Thogersen H.C. (1997)
    111. Receptor-associated protein and members of the low density lipoprotein receptor family share a common epitope. An extended model for the development of passive Heymann nephritis. (PubMed id 8910522)9 Hiesberger T....Nimpf J. (1996)
    112. Decreased expression of both the low-density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor and its receptor-associated protein in late stages of cutaneous melanocytic tumor progression. (PubMed id 8640836)9 de Vries T.J....van Muijen G.N. (1996)
    113. Immunohistochemical localization of alpha-2 macroglobulin receptor/low-density lipoprotein receptor-related protein, receptor-associated protein, and Gp330 in the human endometrium. (PubMed id 9420885)9 Sayegh R.A....Isaacson K.B. (1995)
    114. Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. (PubMed id 15823038)9 McCormick L.M....Bu G. (2005)
    115. Domain organization of the 39-kDa receptor-associated protein. (PubMed id 9873007)9 Medved L.V....Strickland D.K. (1999)
    116. Ca2+ and receptor-associated protein are independently required for proper folding and disulfide bond formation of the low density lipoprotein receptor-related protein. (PubMed id 9712858)9 Obermoeller L.M....Bu G. (1998)
    117. Ligand-toxin hybrids directed to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein exhibit lower toxicity than native Pseudomonas exotoxin. (PubMed id 8626399)9 Zdanovsky A.G....FitzGerald D.J. (1996)
    118. Induction of passive Heymann nephritis with antibodies specific for a synthetic peptide derived from the receptor-associated protein. (PubMed id 8642311)9 Kerjaschki D....Farquhar M.G. (1996)
    119. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. (PubMed id 7579068)9 Farquhar M.G....Orlando R.A. (1995)
    120. gp330 and RAP: the Heymann nephritis antigenic complex. (PubMed id 7944157)9 Farquhar M.G....Orlando R.A. (1994)
    121. Functional duplication of ligand-binding domains within low-density lipoprotein receptor-related protein for interaction with receptor associated protein, alpha2-macroglobulin, factor IXa and factor VIII. (PubMed id 17512806)9 Meijer A.B....Mertens K. (2007)
    122. The single ligand-binding repeat of Tva, a low densit y lipoprotein receptor-related protein, contains two ligand-binding surfaces. (PubMed id 16769730)9 Contreras-Alcantara S....Delos S.E. (2006)
    123. Low-density lipoprotein receptor-related protein mediates in PC12 cell cultures the inhibition of nerve growth factor-promoted neurite outgrowth by pregnancy zone protein and alpha2-macroglobulin. (PubMed id 12237864)9 Chiabrando G.A....Koo P.H. (2002)
    124. The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. (PubMed id 11604390)9 Vassiliou G....McPherson R. (2001)
    125. Involvement of low-density lipoprotein receptor-related protein (LRP) in the clearance of factor VIII in von Willebrand factor-deficient mice. (PubMed id 10688827)9 Schwarz H.P....Turecek P.L. (2000)
    126. The second and fourth cluster of class A cysteine-rich repeats of the low density lipoprotein receptor-related protein share ligand-binding properties. (PubMed id 10531329)9 Neels J.G....van Zonneveld A.J. (1999)
    127. Different expression of the alpha2-macroglobulin rece ptor/low-density lipoprotein receptor-related protein in human keratinocytes an d fibroblasts. (PubMed id 9836507)9 Birkenmeier G....Reissig D. (1998)
    128. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. (PubMed id 9188102)9 Czekay R.P....Farquhar M.G. (1997)
    129. Breast carcinoma epithelial cells express a very low-density lipoprotein receptor variant lacking the O-linked glycosylation domain encoded by exon 16, but with full binding activity for serine proteinase/serpin complexes and Mr-40,000 receptor-associated protein. (PubMed id 9346319)9 Martensen P.M....Andreasen P.A. (1997)
    130. Low density lipoprotein receptor-related protein modulates the expression of tissue-type plasminogen activator in human colon fibroblasts. (PubMed id 9045716)9 Hardy M.M....Bu G. (1997)
    131. Characterization of alpha 2-macroglobulin binding to human trabecular meshwork cells: presence of the alpha 2-macroglobulin signaling receptor. (PubMed id 8806749)9 Howard G.C....Pizzo S.V. (1996)
    132. Up-regulation of the low density lipoprotein receptor-related protein by dexamethasone in HepG2 cells. (PubMed id 8664331)9 Kancha R.K. and Hussain M.M. (1996)
    133. Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. (PubMed id 8322889)9 Biemesderfer D....Farquhar M.G. (1993)
    134. Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death. (PubMed id 19414325)9 Hayashi S....Fukushima T. (2009)
    135. [Characterization of the interaction between low density lipoprotein receptor-related protein-associated protein 1 and the cancer and embryo expression protein 65] (PubMed id 15968324)9 Jin G.L....Shou C.C. (2005)
    136. All three LDL receptor homology regions of the LDL receptor-related protein bind multiple ligands. (PubMed id 14596620)9 Croy J.E....Komives E.A. (2003)
    137. The role of the low-density lipoprotein receptor-related protein (LRP1) in Alzheimer's A beta generation: development of a cell-based model system. (PubMed id 12212791)9 Goto J.J. and Tanzi R.E. (2002)
    138. Human alpha-defensin regulates smooth muscle cell contraction: a role for low-density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. (PubMed id 12393692)9 Nassar T....Higazi A.A. (2002)
    139. Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65. (PubMed id 11606623)9 Kinoshita A....Hyman B.T. (2001)
    140. Receptor-associated protein binding blocks ubiquitinylation of the low density lipoprotein receptor-related protein. (PubMed id 11716468)9 Misra U.K. and Pizzo S.V. (2001)
    141. Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor. (PubMed id 11278770)9 Sousa M.M. and Saraiva M.J. (2001)
    142. Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells. (PubMed id 9880335)9 Vilhardt F....van Deurs B. (1999)
    143. Fibrinolytic activity of human mesothelial cells is counteracted by rapid uptake of tissue-type plasminogen activator. (PubMed id 9893120)9 Sitter T....Kooistra T. (1999)
    144. Characterization of alpha 2-macroglobulin receptor low density lipoprotein receptor-related protein (alpha 2 MR/LRP) in White Carneau pigeon peritoneal macrophages: its role in lipoprotein metabolism. (PubMed id 9030194)9 Seo T....St Clair R.W. (1997)
    145. Native and non-glycosylated recombinant single-chain urokinase-type plasminogen activator are recognized by different receptor systems on rat parenchymal liver cells. (PubMed id 8585013)9 van der Kaaden M.E....Kuiper J. (1995)
    146. Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1. (PubMed id 7775583)9 Godyna S....Argraves W.S. (1995)
    147. Evidence for a second alpha 2-macroglobulin receptor. (PubMed id 7513689)9 Misra U.K....Pizzo S.V. (1994)
    148. Very low density lipoprotein receptor from mammary gland and mammary epithelial cell lines binds and mediates endocytosis of M(r) 40,000 receptor associated protein. (PubMed id 7957939)9 Simonsen A.C....Andreasen P.A. (1994)
    149. Low density lipoprotein receptor-related protein (LRP 1) regulates Rac1 and RhoA reciprocally to control Schwann cell adhesion and mi gration. (PubMed id 20197276)9 Mantuano E....Campana W.M. (2010)
    150. Metalloproteinase-dependent shedding of low-density l ipoprotein receptor-related protein-1 ectodomain decreases endocytic clearance of endometrial matrix metalloproteinase-2 and -9 at menstruation. (PubMed id 19406945)9 Selvais C....Emonard H. (2009)
    151. Gene delivery targeted to the brain using an Angiopep -conjugated polyethyleneglycol-modified polyamidoamine dendrimer. (PubMed id 19765819)9 Ke W....Jiang C. (2009)
    152. ApoE 4 reduces the expression of Abeta degrading enzy me IDE by activating the NMDA receptor in hippocampal neurons. (PubMed id 19616072)9 Du J....Wang Z. (2009)
    153. Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. (PubMed id 19150883)9 Lu J....Chen C.H. (2009)
    154. Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes. (PubMed id 19605848)9 Lambert M.P....Poncz M. (2009)
    155. Structural insights into recognition of beta2-glycopr otein I by the lipoprotein receptors. (PubMed id 19676115)9 Beglov D....Beglova N. (2009)
    156. Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2. (PubMed id 18489431)9 White T.C....McCarty O.J. (2008)
    157. Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. (PubMed id 19036954)9 Kim H.J....Thayer S.A. (2008)
    158. A unique function for LRP-1: a component of a two-receptor system mediating specific endocytosis of plasma-derived factor V by megakaryocytes. (PubMed id 18194421)9 Bouchard B.A....Tracy P.B. (2008)
    159. LRP1 controls biosynthetic and endocytic trafficking of neuronal prion protein. (PubMed id 18285446)9 Parkyn C.J....Morris R.J. (2008)
    160. The hemopexin domain of matrix metalloproteinase-9 activates cell signaling and promotes migration of schwann cells by binding to low-density lipoprotein receptor-related protein. (PubMed id 18987193)9 Mantuano E....Campana W.M. (2008)
    161. Mechanisms regulating plasminogen activators in transformed retinal ganglion cells. (PubMed id 18243176)9 Rock N. and Chintala S.K. (2008)
    162. Minimization of the third domain of the LDL receptor-associated protein (RAP). (PubMed id 17678622)9 Isbell S.L....Zankel T.C. (2007)
    163. Differential capacity of anti-RAP and anti-megalin an tibodies to produce progressive passive Heymann nephritis - implications for th e pathogenesis of idiopathic human membranous glomerulonephritis. (PubMed id 16981232)9 Makker S.P. and Tramontano A. (2006)
    164. Decrease in LDL receptor-related protein expression and function correlates with advanced stages of Wilms tumors. (PubMed id 16106426)9 Desrosiers R.R....Annabi B. (2006)
    165. Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor. (PubMed id 17055779)9 Zhou H....Jiang X.C. (2006)
    166. Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. (PubMed id 15489233)9 Emonard H....Courtoy P.J. (2004)
    167. Tyrosine phosphorylation of the LDL receptor-related protein (LRP) and activation of the ERK pathway are required for connective tissue growth factor to potentiate myofibroblast differentiation. (PubMed id 15469966)9 Yang M....Wang H. (2004)
    168. A novel efflux-recapture process underlies the mechanism of high-density lipoprotein cholesteryl ester-selective uptake mediated by the low-density lipoprotein receptor-related protein. (PubMed id 15178567)9 Vassiliou G. and McPherson R. (2004)
    169. Differential RNA interference: replacement of endogenous with recombinant low density lipoprotein receptor-related protein (LRP). (PubMed id 15202569)9 Laatsch A....Joerg H. (2004)
    170. Role of LRP in TGFbeta2-mediated neuronal uptake of Abeta and effects on memory. (PubMed id 15211588)9 Harris-White M.E....Frautschy S.A. (2004)
    171. Low density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced collagen gel contractile activity of human fibroblasts. (PubMed id 12672816)9 Takayama Y....Takezawa T. (2003)
    172. Insect lipoprotein follows a transferrin-like recycli ng pathway that is mediated by the insect LDL receptor homologue. (PubMed id 12356906)9 Van Hoof D....Van der Horst D.J. (2002)
    173. Integrin clustering induces kinectin accumulation. (PubMed id 11973345)9 Tran H.... Yamada K.M. (2002)
    174. Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein. (PubMed id 11844476)9 Nathan B.P....Struble R.G. (2002)
    175. Calcium coordination and pH dependence of the calcium affinity of ligand-binding repeat CR7 from the LRP. Comparison with related domains from the LRP and the LDL receptor. (PubMed id 11735395)9 Simonovic M....Gettins P.G. (2001)
    176. Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro. (PubMed id 11379818)9 Qiu Z....Rebeck G.W. (2001)
    177. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. (PubMed id 11751384)9 Biliran H. and Sheng S. (2001)
    178. A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation. (PubMed id 11180402)9 Benezra M....Vlodavsky I. (2001)
    179. Expression and folding of human very-low-density lipoprotein receptor fragments: neutralization capacity toward human rhinovirus HRV2. (PubMed id 11118376)9 Ronacher B....Blaas D. (2000)
    180. T cell lines specific for a synthetic Heymann nephritis peptide derived from the receptor-associated protein. (PubMed id 10886254)9 Wu H....Knight J.F. (2000)
    181. Evolutionary conservation of circulating soluble low density lipoprotein receptor-related protein-like ('LRP-like') molecules. (PubMed id 10326762)9 Grimsley P.G....Owensby D.A. (1999)
    182. Monoclonal antibodies as context-specific reagents: differential antigen reactivity of MAb 58K-9 during immunoprecipitation, immunoblotting, and immunofluorescence analyses. (PubMed id 10626676)9 Gao Y.S. and Sztul E. (1999)
    183. Rap1B and Rap2B translocation to the cytoskeleton by von Willebrand factor involves FcgammaII receptor-mediated protein tyrosine phosphorylation. (PubMed id 10224142)9 Torti M....Balduini C. (1999)
    184. Analysis of a novel mechanism of neuronal toxicity produced by an apolipoprotein E-derived peptide. (PubMed id 10037478)9 Moulder K.L....Johnson E.M. (1999)
    185. Increased clearance explains lower plasma levels of tissue-type plasminogen activator by estradiol: evidence for potently enhanced mannose receptor expression in mice. (PubMed id 10438721)9 Lansink M....Kooistra T. (1999)
    186. Platelet sarco/endoplasmic reticulum Ca2+ATPase isofo rm 3b and Rap 1b: interrelation and regulation in physiopathology. (PubMed id 9576865)9 Lacabaratz-Porret C....Enouf J. (1998)
    187. Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation. (PubMed id 9846982)9 Rudling M....Angelin B. (1998)
    188. Characterization of a kidney proximal tubule cell line, LLC-PK1, expressing endocytotic active megalin. (PubMed id 9773777)9 Nielsen R....Christensen E.I. (1998)
    189. Low density lipoprotein receptor-related protein (LRP) expression varies among Hep G2 cell lines. (PubMed id 9610960)9 Grimsley P.G....Owensby D.A. (1997)
    190. Alpha2-macroglobulin complexes with and mediates the endocytosis of beta-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. (PubMed id 9349534)9 Narita M....Bu G. (1997)
    191. Nickel is a specific antagonist for the catabolism of activated alpha 2-macroglobulin. (PubMed id 9060994)9 Kancha R.K. and Hussain M.M. (1997)
    192. Heparan sulfate proteoglycan-mediated uptake of apolipoprotein E-triglyceride-rich lipoprotein particles: a major pathway at physiological particle concentrations. (PubMed id 9335533)9 Al-Haideri M....Deckelbaum R.J. (1997)
    193. Ligand selectivity of 105 kDa and 130 kDa lipoprotein-binding proteins in vascular-smooth-muscle-cell membranes is unique. (PubMed id 8694779)9 Bochkov V.N....Resink T.J. (1996)
    194. Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis) (PubMed id 8989729)9 Kerjaschki D. and Neale T.J. (1996)
    195. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). (PubMed id 8973792)9 Knauer M.F....Glabe C.G. (1996)
    196. alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor. (PubMed id 8522616)9 Conese M....Blasi F. (1995)
    197. Degradation of tissue-type plasminogen activator by human monocyte-derived macrophages is mediated by the mannose receptor and by the low-density lipoprotein receptor-related protein. (PubMed id 7579446)9 Noorman F....Rijken D.C. (1995)

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    Entrez Gene: 4043 HGNC: 6701 AceView: LRPAP1 Ensembl:ENSG00000163956 euGenes: HUgn4043
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