Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRPAP1 Gene

protein-coding   GIFtS: 63
GCID: GC04M003508

Low Density Lipoprotein Receptor-Related Protein Associated...

(Previous name: low density lipoprotein-related protein-associated protein...)
(Previous symbol: A2MRAP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at
MalaCards
 

Aliases
for LRPAP1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section
Aliases
Low Density Lipoprotein Receptor-Related Protein Associated Protein
11 2
     MRAP2
A2MRAP1 2 3 5     alpha-2-MRAP2
Low Density Lipoprotein-Related Protein-Associated Protein 1
(Alpha-2-Macroglobulin Receptor-Associated Protein 1)1 2
     Alpha-2-Macroglobulin Receptor-Associated Protein2
Low Density Lipoprotein Receptor-Related Protein-Associated Protein 12 3     Alpha-2-Macroglobulin Receptor-Associated Protein 12
RAP2 3     Lipoprotein Receptor Associated Protein2
A2RAP2     Alpha-2-MRAP3
HBP442     

External Ids:    HGNC: 67011   Entrez Gene: 40432   Ensembl: ENSG000001639567   OMIM: 1042255   UniProtKB: P305333   

Export aliases for LRPAP1 gene to outside databases

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551


Summaries
for LRPAP1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
GeneCards Summary for LRPAP1 Gene: 
LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) is a protein-coding gene. Diseases associated with LRPAP1 include von willebrand's disease, and biliary tract cancer. GO annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

Gene Wiki entry for LRPAP1 (LDL-receptor-related protein associated protein) Gene


Genomic Views
for LRPAP1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRPAP1 gene promoter:
         ER-alpha   AML1a   Sp1   YY1   STAT3   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LRPAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRPAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRPAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Start:
 3,505,324 bp from pter      End:
 3,534,286 bp from pter
Size:
 28,963 bases      Orientation:
 minus strand

Proteins
for LRPAP1 gene

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section
UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin receptor-associated protein precursor  
Size: 357 amino acids; 41466 Da
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains.
Binds LRP1B; binding is followed by internalization and degradation
Subcellular location: Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell
surface receptors. Found in the endoplasmic reticulum
6/9 PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):
1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    
Secondary accessions: D3DVR9 Q2M310 Q53HQ3 Q53HS6

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Explore proteomics data for LRPAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30533

    • LRPAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRPAP1 Protein Expression
    REFSEQ proteins: NP_002328.1  
    ENSEMBL proteins: 
     ENSP00000421922   ENSP00000421648  

    Human Recombinant Protein Products for LRPAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LRPAP1 (LRPAP)
    Enzo Life Sciences proteins for LRPAP1
    OriGene Purified Protein for LRPAP1
    OriGene Protein Over-expression Lysate for LRPAP1
    OriGene MassSpec for LRPAP1 
    OriGene Custom Protein Services for LRPAP1
    GenScript Custom Purified and Recombinant Proteins Services for LRPAP1
    Novus Biologicals LRPAP1 Proteins
    Novus Biologicals LRPAP1 Lysate
    Sino Biological Recombinant Protein for LRPAP1
    Sino Biological Cell Lysate for LRPAP1 
    ProSpec Recombinant Protein for LRPAP1
    Cloud-Clone Corp. Proteins for LRPAP1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA8083232
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA16263759
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane TAS1712782

    LRPAP1 for ontologies           About GeneDecksing



    LRPAP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LRPAP1 (LRPAP)
    OriGene Antibodies for LRPAP1
    OriGene Custom Antibody Services for LRPAP1
    GenScript Custom Superior Antibodies Services for LRPAP1
    Novus Biologicals LRPAP1 Antibodies
    Abcam antibodies for LRPAP1
    Cloud-Clone Corp. Antibodies for LRPAP1 
    ThermoFisher Antibodies for LRPAP1
    LSBio Antibodies in human, mouse, rat for LRPAP1 

    Assay Products for LRPAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRPAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRPAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRPAP1 
    Cloud-Clone Corp. CLIAs for LRPAP1

    Protein Domains /
    Families
    for LRPAP1 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    		 2 InterPro protein domains:
     IPR010483 Alpha_2_MRAP_C
     IPR009066 MG_RAP_rcpt_1

    Graphical View of Domain Structure for InterPro Entry P30533

    ProtoNet protein and cluster: P30533

    1 Blocks protein domain: IPB009066 Alpha-2-macroglobulin receptor-associated protein

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
    Similarity: Belongs to the alpha-2-MRAP family


    LRPAP1 for domains           About GeneDecksing


    Function
    for LRPAP1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRP_HUMAN, P30533
    Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

         Genatlas biochemistry entry for LRPAP1:
    low density lipoprotein receptor related protein,associated protein 1

         Gene Ontology (GO): 7 molecular function terms (GO ID links to tree view) (see first 5):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS2229028
    GO:0008201heparin binding IEA--
    GO:0035473lipase binding IEA--
    GO:0048019receptor antagonist activity IDA8083232
    GO:0050750low-density lipoprotein particle receptor binding IDA16263759
    GO:0051082unfolded protein binding TAS8654360
    GO:0070326very-low-density lipoprotein particle receptor binding IPI8083232
         
    LRPAP1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Lrpap1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     normal  other  renal/urinary system  reproductive system 

    LRPAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LRPAP1: Lrpap1tm1Vln Lrpap1tm1Her

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRPAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRPAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRPAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRPAP1 

    miRNA
    Products:            		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LRPAP1
    SwitchGear 3'UTR luciferase reporter plasmid: LRPAP1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRPAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRPAP1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for LRPAP1
    Sirion Biotech Customized adenovirus for overexpression of LRPAP1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LRPAP1 (see all 7)
    OriGene ORF clones in mouse, rat for LRPAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    Sino Biological Human cDNA Clone for LRPAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
    Sirion Biotech Customized lentivirus for stable overexpression of LRPAP1 
                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for LRPAP1
    Search LifeMap BioReagents cell lines for LRPAP1
    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1


    Pathways & Interactions
    for LRPAP1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LRPAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by the Hedgehog family
    		Signaling events mediated by the Hedgehog family
    2Reelin signaling pathway
    		Reelin signaling pathway
    3Lissencephaly gene (LIS1) in neuronal migration and development
    		Lissencephaly gene (LIS1) in neuronal migration and development


    3 BioSystems Pathways for LRPAP1
        Signaling events mediated by the Hedgehog family
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRPAP1

    5/28 Interacting proteins for LRPAP1 (P305332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63655 I2D: score=5 
    RTN4Q9NQC32, 3MINT-63654 I2D: score=5 
    PPM1GO153552, 3MINT-63653 I2D: score=4 
    CWC25Q9NXE83I2D: score=4 
    LRP1Q079543I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8654360
    GO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA8083232
    GO:0016192vesicle-mediated transport TAS8654360
    GO:0032091negative regulation of protein binding IDA8083232
    GO:1900116extracellular negative regulation of signal transduction IDA8083232

    LRPAP1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for LRPAP1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRPAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRPAP1 (AMRP)

    10/13 Novoseek inferred chemical compound relationships for LRPAP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 58.2 3 10326762 (1), 8694779 (1)
    mannan 31.6 1 7579446 (1)
    heparin 30.2 20 11382778 (6), 9253767 (2), 2229028 (2), 12637503 (1) (see all 5)
    lovastatin 20.6 1 7822276 (1)
    suramin 20.3 2 11604390 (2)
    mannose 18.5 1 7579446 (1)
    lysine 12 8 15025528 (3), 12637503 (2)
    cholesterol 0 3 17987404 (1), 9030194 (1), 16704534 (1)
    sucrose 0 1 8322889 (1)
    lipid 0 2 12394648 (1), 18721259 (1)

    Search CenterWatch for drugs/clinical trials and news about LRPAP1 / AMRP

    Transcripts
    for LRPAP1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for LRPAP1 gene: 
    NM_002337.3  

    Unigene Cluster for LRPAP1:

    Low density lipoprotein receptor-related protein associated protein 1
    Hs.40966  [show with all ESTs]
    Unigene Representative Sequence: NM_002337
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500728(uc003ghh.4) ENST00000296325 ENST00000515119 ENST00000509198


    miRNA
    Products:             		 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LRPAP1
    SwitchGear 3'UTR luciferase reporter plasmid: LRPAP1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRPAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRPAP1
    Clone
    Products:             		 OriGene clones in human, mouse for LRPAP1 (see all 7)
    OriGene ORF clones in mouse, rat for LRPAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
    Sirion Biotech Customized lentivirus for stable overexpression of LRPAP1 
                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 
    Primer
    Products:            		OriGene qPCR primer pairs and template standards for LRPAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRPAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRPAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1

    Additional mRNA sequence: 

    AF085973.1 AK128751.1 AK222504.1 AK222527.1 AK292321.1 AK311600.1 AK312698.1 AL365520.1 
    AL365522.1 BC006574.2 BC007841.1 BC013950.2 BC018955.2 BC105074.1 BC112067.1 BX647984.1 
    M63959.1 

    21 DOTS entries:

    DT.91679654  DT.450524  DT.100879558  DT.95104282  DT.311312  DT.91696992  DT.422641  DT.97858164 
    DT.100810443  DT.100879555  DT.100879544  DT.80100088  DT.92450722  DT.100719826  DT.100804237  DT.100879568 
    DT.121225776  DT.40123802  DT.40304725  DT.80100089  DT.95104287 

    24/696 AceView cDNA sequences (see all 696):

    BQ723211 W81715 CR607197 BQ434613 BX381548 AL577900 H98116 BQ668698 
    AI151446 BX399454 BU579630 BQ575656 CR591537 CD107520 CB157694 CB129347 
    AA311422 BQ675077 CR614498 BE275512 AW514873 BM711920 CR596948 AI815082 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LRPAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -           -                                               -     -                     
    SP2:              -     -           -                       -     -     -           -     -                     
    SP3:              -     -           -                                                                           
    SP4:              -     -           -           -     -                                                         
    SP5:              -     -                                                                                       


    ECgene alternative splicing isoforms for LRPAP1

    Expression
    for LRPAP1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRPAP1 expression in normal human tissues (normalized intensities)      LRPAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGAGTCC
    LRPAP1 Expression
    About this image


    LRPAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See LRPAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRPAP1

    SOURCE GeneReport for Unigene cluster: Hs.40966
        SABiosciences Expression via Pathway-Focused PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:    		OriGene qPCR primer pairs and template standards for LRPAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRPAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRPAP1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

    Orthologs
    for LRPAP1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for LRPAP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Lrpap11 , 5 low density lipoprotein receptor-related protein associated more1, 5 79.55(n)1
    76.19(a)1    		   5 (18.01 cM)5
    169761  NM_013587.21  NP_038615.21 
     350914905 
    chicken
    (Gallus gallus)    		 Aves LRPAP11 low density lipoprotein receptor-related protein associated more 67.88(n)
    68.69(a)    		   395936  NM_205062.1  NP_990393.1 
    lizard
    (Anolis carolinensis)    		 Reptilia LRPAP16
    		 Uncharacterized protein
    		 68(a)
    		 1 ↔ 1
    		 GL343585.1(442453-445917)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3986432 hypothetical protein LOC398643 72.93(n)    BC054293.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii lrpap12 low density lipoprotein receptor-related protein associated more 72.59(n)   333939  BC049517.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG85071 , 3 CG85071 35(a)3
    50.55(n)1
    36.56(a)1    		   85E93
    412051  NM_141693.21  NP_649950.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C15C8.41 Protein C15C8.4 42.97(n)
    33.59(a)    		   179745  NM_073786.3  NP_506187.2 


    ENSEMBL Gene Tree for LRPAP1 (if available)
    TreeFam Gene Tree for LRPAP1 (if available)

    Paralogs
    for LRPAP1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for LRPAP1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in LRPAP1 are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs348975111,2
    		Cuntested13526636(-) CCTCAA/GTGGTA 2 N S mis11Minor allele frequency- G:0.01NA 76
    rs755795991,2
    		F--3504859(+) CACCCC/GCTCGG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs28580241,2
    		C,F,A,H--3504863(+) CCCTCT/GGTTCA 1 -- ds500111Minor allele frequency- G:0.39NA WA CSA EA 374
    rs1422912371,2
    		--3504892(+) CTCTCA/GGCACC 1 -- ds50010--------
    rs1512683151,2
    		--3504902(+) CCGTGC/TCACAG 1 -- ds50010--------
    rs1152445971,2
    		F--3504933(+) CGAGGC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1393305721,2
    		--3504958(+) TGGCAA/CCGCAC 1 -- ds50010--------
    rs1500336261,2
    		C--3504969(+) ACTCAC/GGCCCC 1 -- ds50010--------
    rs1453586171,2
    		--3504980(+) ACACAC/TGGATG 1 -- ds50010--------
    rs1425919531,2
    		--3505008(+) AGCTAC/TCAGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRPAP1 (3505324 - 3534286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for LRPAP1 (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726908CNV Deletion23290073
    esv2726905CNV Deletion23290073
    esv2726904CNV Deletion23290073
    esv1183049CNV Deletion17803354
    esv2726902CNV Deletion23290073
    esv2726900CNV Deletion23290073
    esv1102085CNV Deletion17803354
    esv2726907CNV Deletion23290073
    esv1447823CNV Deletion17803354
    esv2726903CNV Deletion23290073


    Human Gene Mutation Database (HGMD): LRPAP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRPAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRPAP1

    Disorders / Diseases
    for LRPAP1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		 OMIM gene information: 104225    OMIM disorders: --

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
  • Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane
    glomerular nephritis

    • 20/22 diseases for LRPAP1 (see all 22):    About MalaCards
    von willebrand's disease    biliary tract cancer    gallbladder cancer    tuberous sclerosis
    liposarcoma    lissencephaly    hypothyroidism    thrombosis
    nephritis    wilms tumor    glomerulonephritis    alzheimer's disease
    endometrial carcinoma    peritonitis    dementia    myocardial infarction
    atherosclerosis    retinitis    colorectal cancer    thyroiditis


    LRPAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for LRPAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy membranous 66.8 1 9207124 (1)
    glomerulonephritis 56.4 8 8238258 (2), 9207124 (1), 10886254 (1), 7579068 (1) (see all 7)
    alzheimers disease 25.6 2 16650578 (1), 16938309 (1)
    carcinoma embryonal 23 2 2229028 (1), 7615664 (1)
    atherosclerosis 0 1 7959795 (1)
    tumors 0 4 8640836 (2), 7957939 (1)
    carcinoma 0 2 8238258 (1), 7957939 (1)

    Genetic Association Database (GAD): LRPAP1
    Human Genome Epidemiology (HuGE) Navigator: LRPAP1 (21 documents)

    Export disorders for LRPAP1 gene to outside databases

    Publications
    for LRPAP1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRPAP1 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with LRPAP1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. (PubMed id 9782079)1, 2, 4, 9 Van Leuven F.... Nelissen B. (1998)
    2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. (PubMed id 1712782)1, 2, 3 Strickland D.K.... Argraves W.S. (1991)
    3. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. (PubMed id 7774585)1, 2, 9 Bu G.... Schwartz A.L. (1995)
    4. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor- associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (PubMed id 7789983)1, 2, 9 Van Leuven F.... Van den Berghe H. (1995)
    5. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. (PubMed id 1400426)1, 2, 9 Kounnas M.Z.... Strickland D.K. (1992)
    6. Lipoprotein Receptor Associated Protein (LRPAP1) Insertion/Deletion Polymorphism: Association with Gallbladder Cancer Susceptibility. (PubMed id 17987404)1, 4, 9 Pandey S.N....Mittal B. (2006)
    7. Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (PubMed id 16650578)1, 4, 9 Depboylu C....Dodel R.C. (2006)
    8. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. (PubMed id 17913606)1, 4, 9 Juzyszyn Z....Drozdzik M. (2008)
    9. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. (PubMed id 16704534)1, 4, 9 Dixit M....Mittal B. (2006)
    10. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. (PubMed id 18721259)1, 4, 9 Pandey P....Mittal B. (2008)

    External Searches for LRPAP1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LRPAP1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4043 HGNC: 6701 AceView: LRPAP1 Ensembl:ENSG00000163956 euGenes: HUgn4043
    ECgene: LRPAP1 H-InvDB: LRPAP1

    Other Databases showing LRPAP1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing LRPAP1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRPAP1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for LRPAP1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for LRPAP1 gene:
    Search GeneIP for patents involving LRPAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for LRPAP1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for LRPAP1 (LRPAP)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for LRPAP1 (LRPAP)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LRPAP1   OriGene RNAi products in human, mouse, rat for LRPAP1  
     OriGene qPCR primer pairs and template standards for LRPAP1   OriGene Protein Over-expression Lysate for LRPAP1  
     OriGene MassSpec something-or-other for LRPAP1   OriGene clones in human, mouse for LRPAP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRPAP1   OriGene Purified Protein for LRPAP1  
     OriGene ORF clones in mouse, rat for LRPAP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRPAP1   OriGene Custom Protein Services for LRPAP1  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LRPAP1
     QIAGEN SeqTarget long-range PCR primers for resequencing LRPAP1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRPAP1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRPAP1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
     GenScript Custom Purified and Recombinant Proteins Services for LRPAP1 GenScript cDNA clones with any tag delivered in your preferred vector for LRPAP1
     GenScript Custom Assay Services for LRPAP1 GenScript Custom Superior Antibodies Services for LRPAP1
     GenScript Custom overexpressing Cell Line Services for LRPAP1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in LRPAP1 promoter
     Search Chromatin IP Primers for LRPAP1
     RT2 qPCR Primer Assay in human, mouse, rat LRPAP1
     GNC Network for LRPAP1
     SABiosciences PCR Arrays including human, mouse, rat LRPAP1
     Search Tocris compounds for LRPAP1 (AMRP)
     Proteins and Antibodies for LRPAP1
     Cell Lysates for LRPAP1
     cDNA Clones for LRPAP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for LRPAP1
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     LRPAP1 antibodies
     LRPAP1 proteins
     LRPAP1 lysates
     Antibodies for LRPAP1
     See all of Abcam's Antibodies, Kits and Proteins for LRPAP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for LRPAP1




     Proteins for LRPAP1
     Antibodies for LRPAP1
     ELISAs for LRPAP1
     CLIAs for LRPAP1
     Search LifeMap BioReagents cell lines for LRPAP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1
     SwitchGear 3'UTR luciferase reporter plasmids for LRPAP1
     SwitchGear Promoter luciferase reporter plasmids for LRPAP1
     ThermoFisher Antibodies for LRPAP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for LRPAP1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRPAP1
    Customized:
     lentivirus for stable overexpression of LRPAP1
     lentivirus expression plasmids for stable overexpression of LRPAP1
     adenovirus for overexpression of LRPAP1
     LSBio Antibodies in human, mouse, rat for LRPAP1
    		Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2014 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      LRPAP1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4