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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LRPAP1 Gene

protein-coding   GIFtS: 63
GCID: GC04M003508

Low Density Lipoprotein Receptor-Related Protein Associated...

(Previous name: low density lipoprotein-related protein-associated protein...)
(Previous symbol: A2MRAP)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Low Density Lipoprotein Receptor-Related Protein Associated Protein
11 2
     MRAP2
A2MRAP1 2 3 5     alpha-2-MRAP2
Low Density Lipoprotein-Related Protein-Associated Protein 1
(Alpha-2-Macroglobulin Receptor-Associated Protein 1)1 2
     Alpha-2-Macroglobulin Receptor-Associated Protein2
Low Density Lipoprotein Receptor-Related Protein-Associated Protein 12 3     Alpha-2-Macroglobulin Receptor-Associated Protein 12
RAP2 3     Lipoprotein Receptor Associated Protein2
A2RAP2     Alpha-2-MRAP3
HBP442     

External Ids:    HGNC: 67011   Entrez Gene: 40432   Ensembl: ENSG000001639567   OMIM: 1042255   UniProtKB: P305333   

Export aliases for LRPAP1 gene to outside databases

Previous GC identifers: GC04M003517 GC04M003420 GC04M003545 GC04M003551


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for LRPAP1 Gene: 
LRPAP1 (low density lipoprotein receptor-related protein associated protein 1) is a protein-coding gene. Diseases associated with LRPAP1 include von willebrand's disease, and biliary tract cancer. GO annotations related to this gene include heparin binding and low-density lipoprotein particle receptor binding.

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

Gene Wiki entry for LRPAP1 (LDL-receptor-related protein associated protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LRPAP1 gene promoter:
         ER-alpha   AML1a   Sp1   YY1   STAT3   FOXO1a   FOXO1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRPAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LRPAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRPAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.3   Ensembl cytogenetic band:  4p16.3   HGNC cytogenetic band: 4p16.3

LRPAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRPAP1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M003508:  view genomic region     (about GC identifiers)

Start:
3,505,324 bp from pter      End:
3,534,286 bp from pter
Size:
28,963 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533 (See protein sequence)
Recommended Name: Alpha-2-macroglobulin receptor-associated protein precursor  
Size: 357 amino acids; 41466 Da
Subunit: Present on cell surface forming a complex with the alpha-2-macroglobulin receptor heavy and light chains.
Binds LRP1B; binding is followed by internalization and degradation
Subcellular location: Endoplasmic reticulum. Cytoplasm. Cell surface. Note=Intracellular and associated with cell
surface receptors. Found in the endoplasmic reticulum
6/9 PDB 3D structures from and Proteopedia for LRPAP1 (see all 9):
1LRE (3D)        1NRE (3D)        1OP1 (3D)        1OV2 (3D)        2FCW (3D)        2FTU (3D)    
Secondary accessions: D3DVR9 Q2M310 Q53HQ3 Q53HS6

Explore the universe of human proteins at neXtProt for LRPAP1: NX_P30533

Explore proteomics data for LRPAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30533

  • LRPAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LRPAP1 Protein Expression
    REFSEQ proteins: NP_002328.1  
    ENSEMBL proteins: 
     ENSP00000421922   ENSP00000421648  

    Human Recombinant Protein Products for LRPAP1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LRPAP1 (LRPAP)
    Enzo Life Sciences proteins for LRPAP1
    OriGene Purified Protein for LRPAP1
    OriGene Protein Over-expression Lysate for LRPAP1
    OriGene MassSpec for LRPAP1 
    OriGene Custom Protein Services for LRPAP1
    GenScript Custom Purified and Recombinant Proteins Services for LRPAP1
    Novus Biologicals LRPAP1 Proteins
    Novus Biologicals LRPAP1 Lysate
    Sino Biological Recombinant Protein for LRPAP1
    Sino Biological Cell Lysate for LRPAP1 
    ProSpec Recombinant Protein for LRPAP1
    Cloud-Clone Corp. Proteins for LRPAP1 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA8083232
    GO:0005783endoplasmic reticulum IDA--
    GO:0005886plasma membrane IDA16263759
    GO:0009986cell surface IEA--
    GO:0016021integral to membrane TAS1712782

    LRPAP1 for ontologies           About GeneDecksing



    LRPAP1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LRPAP1 (LRPAP)
    OriGene Antibodies for LRPAP1
    OriGene Custom Antibody Services for LRPAP1
    GenScript Custom Superior Antibodies Services for LRPAP1
    Novus Biologicals LRPAP1 Antibodies
    Abcam antibodies for LRPAP1
    Cloud-Clone Corp. Antibodies for LRPAP1 
    ThermoFisher Antibodies for LRPAP1
    LSBio Antibodies in human, mouse, rat for LRPAP1 

    Assay Products for LRPAP1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRPAP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRPAP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRPAP1 
    Cloud-Clone Corp. CLIAs for LRPAP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR010483 Alpha_2_MRAP_C
     IPR009066 MG_RAP_rcpt_1

    Graphical View of Domain Structure for InterPro Entry P30533

    ProtoNet protein and cluster: P30533

    1 Blocks protein domain: IPB009066 Alpha-2-macroglobulin receptor-associated protein

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
    Similarity: Belongs to the alpha-2-MRAP family


    LRPAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AMRP_HUMAN, P30533
    Function: Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330

         Genatlas biochemistry entry for LRPAP1:
    low density lipoprotein receptor related protein,associated protein 1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004873asialoglycoprotein receptor activity TAS2229028
    GO:0008201heparin binding IEA--
    GO:0035473lipase binding IEA--
    GO:0048019receptor antagonist activity IDA8083232
    GO:0050750low-density lipoprotein particle receptor binding IDA16263759
         
    LRPAP1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lrpap1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     normal  other  renal/urinary system  reproductive system 

    LRPAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for LRPAP1: Lrpap1tm1Vln Lrpap1tm1Her

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LRPAP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LRPAP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRPAP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRPAP1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LRPAP1
    SwitchGear 3'UTR luciferase reporter plasmidLRPAP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRPAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRPAP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRPAP1
    Sirion Biotech Customized adenovirus for overexpression of LRPAP1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for LRPAP1 (see all 7)
    OriGene ORF clones in mouse, rat for LRPAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    Sino Biological Human cDNA Clone for LRPAP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
    Sirion Biotech Customized lentivirus for stable overexpression of LRPAP1 
                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRPAP1
    Search LifeMap BioReagents cell lines for LRPAP1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for LRPAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling events mediated by the Hedgehog family
    Signaling events mediated by the Hedgehog family
    2Reelin signaling pathway
    Reelin signaling pathway
    3Lissencephaly gene (LIS1) in neuronal migration and development
    Lissencephaly gene (LIS1) in neuronal migration and development


    3 BioSystems Pathways for LRPAP1
        Signaling events mediated by the Hedgehog family
    Lissencephaly gene (LIS1) in neuronal migration and development
    Reelin signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LRPAP1

    5/28 Interacting proteins for LRPAP1 (P305332, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLA2Q141812, 3MINT-63655 I2D: score=5 
    RTN4Q9NQC32, 3MINT-63654 I2D: score=5 
    PPM1GO153552, 3MINT-63653 I2D: score=4 
    CWC25Q9NXE83I2D: score=4 
    LRP1Q079543I2D: score=4 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding TAS8654360
    GO:0010916negative regulation of very-low-density lipoprotein particle clearance IDA8083232
    GO:0016192vesicle-mediated transport TAS8654360
    GO:0032091negative regulation of protein binding IDA8083232
    GO:1900116extracellular negative regulation of signal transduction IDA8083232

    LRPAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LRPAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LRPAP1 (AMRP)

    10/13 Novoseek inferred chemical compound relationships for LRPAP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    exotoxin-a 58.2 3 10326762 (1), 8694779 (1)
    mannan 31.6 1 7579446 (1)
    heparin 30.2 20 11382778 (6), 9253767 (2), 2229028 (2), 12637503 (1) (see all 5)
    lovastatin 20.6 1 7822276 (1)
    suramin 20.3 2 11604390 (2)
    mannose 18.5 1 7579446 (1)
    lysine 12 8 15025528 (3), 12637503 (2)
    cholesterol 0 3 17987404 (1), 9030194 (1), 16704534 (1)
    sucrose 0 1 8322889 (1)
    lipid 0 2 12394648 (1), 18721259 (1)

    Search CenterWatch for drugs/clinical trials and news about LRPAP1 / AMRP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LRPAP1 gene: 
    NM_002337.3  

    Unigene Cluster for LRPAP1:

    Low density lipoprotein receptor-related protein associated protein 1
    Hs.40966  [show with all ESTs]
    Unigene Representative Sequence: NM_002337
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000500728(uc003ghh.4) ENST00000296325 ENST00000515119 ENST00000509198


    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRPAP1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate LRPAP1
    SwitchGear 3'UTR luciferase reporter plasmidLRPAP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for LRPAP1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRPAP1
    Clone
    Products:
         
    OriGene clones in human, mouse for LRPAP1 (see all 7)
    OriGene ORF clones in mouse, rat for LRPAP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRPAP1 (NM_002337)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRPAP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRPAP1
    Sirion Biotech Customized lentivirus for stable overexpression of LRPAP1 
                         Customized lentivirus expression plasmids for stable overexpression of LRPAP1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for LRPAP1
    OriGene qSTAR qPCR primer pairs in human, mouse for LRPAP1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat LRPAP1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRPAP1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRPAP1

    Additional mRNA sequence: 

    AF085973.1 AK128751.1 AK222504.1 AK222527.1 AK292321.1 AK311600.1 AK312698.1 AL365520.1 
    AL365522.1 BC006574.2 BC007841.1 BC013950.2 BC018955.2 BC105074.1 BC112067.1 BX647984.1 
    M63959.1 

    21 DOTS entries:

    DT.91679654  DT.450524  DT.100879558  DT.95104282  DT.311312  DT.91696992  DT.422641  DT.97858164 
    DT.100810443  DT.100879555  DT.100879544  DT.80100088  DT.92450722  DT.100719826  DT.100804237  DT.100879568 
    DT.121225776  DT.40123802  DT.40304725  DT.80100089  DT.95104287 

    696 AceView cDNA sequences (see top 24):

    BQ723211 W81715 CR607197 BQ434613 BX381548 AL577900 H98116 BQ668698 
    AI151446 BX399454 BU579630 BQ575656 CR591537 CD107520 CB157694 CB129347 
    AA311422 BQ675077 CR614498 BE275512 AW514873 BM711920 CR596948 AI815082 
    CR624552 CR617514 BM924592 CR605976 BU675722 BG281808 CF265163 BQ683366 
    BI193075 BU185055 CA447726 BG323249 BE383858 BQ881899 BU859335 BG333801 
    BQ689723 CR595839 AI572479 CF132382 BM987580 AA770339 BE796768 CR613053 
    BM700334 AL518587 CR619388 AA088229 CR604735 CR625424 AI583516 BM852714 
    BX334930 CD517573 BQ637162 CD106275 AL520928 AI867074 CR619887 AI754943 
    CR611476 BQ669156 CR591442 BQ897642 BU156740 AA909714 BQ128256 BQ720360 
    BM709427 AU118613 BF025878 BX424900 BU179046 CF529220 CR606004 CB155075 
    BU186892 BQ950417 CF264726 AA346285 BU579870 CD251666 BU150674 BI913337 
    AA126097 BQ673271 AI537007 CF265155 BM314081 BQ067447 AA487306 CD675693 
    CA777028 BM829185 CR599568 CF242842 BQ646733 BX379126 CR597384 CR603866 
    CR607312 R32206 BQ677169 CR626102 AA364822 CR603821 BX458886 BU739271 
    CF131155 BI910583 H93142 AI624250 BM699312 BQ919623 CD368695 CR601277 
    AA315401 BQ708990 BX642367 CR616455 BU845958 BU155418 BX283931 CR618610 
    BG745392 BQ672325 CN481187 BM973798 BM700235 BG745631 BU180312 CR601788 
    AA954128 CA427917 CF264849 CF126327 BU149808 BU624312 CR607263 BQ681486 
    BQ008423 BM925025 BQ711429 R32165 BF724449 BM796862 BU161097 BI771239 
    CR625232 BU740767 CA432162 BU733368 CD106780 BU155748 BQ680640 BQ008640 
    BF724850 CD108126 BG334406 BM313801 CR625692 F07402 AI089128 CB121214 
    CA428688 BM727205 CD513115 BQ950420 CR604363 CR621877 AA324002 CA307021 
    BG163545 BX337024 BM906307 BP382038 BU737988 BM996574 AL555377 AI272361 
    L34966 BE877426 BQ923632 BU737964 BP353134 BM544005 BE540944 BE909994 
    CB129968 AA478255 BU173677 BP381629 AA080928 CA449229 BI160867 AA535235 
    BV190196 BI916857 BE730977 BG745757 BG820093 AA313744 BI834575 BM791746 
    BG331403 BU543816 CA426974 AW247481 BI862113 BQ215032 AI079780 CA487951 
    BX355802 BI763226 BM984672 BG746209 AA975677 BQ924135 AA374462 H52483 
    AA345319 BM263629 BQ674900 BG822403 BX375284 BX357911 BX353713 BQ674357 
    BM975054 BM850877 BP369520 BP362260 CB120898 CA419552 AI188104 BG477274 
    AA401020 BV190061 BE275900 CB137049 AI811118 BG825886 BF036684 BG110949 
    BE274218 AA595072 BG167320 BI912626 BE386418 BQ016049 AA563744 BM046593 
    BF984627 BX438827 BQ677459 BX492422 CB107134 AA583031 BP431946 BG430812 
    AW473343 BQ681160 AA365751 BG326979 F19128 CB161688 BU838910 CB148643 
    BQ682241 CA776747 BM711472 BM852155 BM310089 BI161041 AW247344 AW167361 
    BF347265 BM742353 AL580222 AW026266 BQ070364 AA829299 CF128084 BI669036 
    BM665720 BF342458 CD692683 CA424932 BM263338 BM826334 AA349095 BI754878 
    F08754 BM555362 AA594775 BF727197 BM091573 BI601792 BU171461 AW473267 
    BG722951 BM723833 BX357722 CF265009 CD614665 BX335156 NM_002337 AI589536 
    BM507200 BU163394 BX396548 CA438848 BX335155 BI601948 BF968932 BF034916 
    AA668921 BX355803 BQ683217 BG323705 AI368068 BE385001 BX337825 BF529652 
    BQ943219 CA748866 BU163148 BG282176 BG761204 BP381599 BI670330 BU683409 
    AL550423 AW006761 BM545224 AA322094 BG678989 BQ420620 BE645847 AV694332 
    BI602314 BE741320 AI129756 BX647984 CF131044 BQ684498 BU185712 BX399382 
    BP367523 BP336419 AW207565 AW190672 AI539861 BI763803 BE167478 BQ710363 
    BQ694313 BQ008372 AA975056 BF726664 BQ956089 CB123400 BX337934 BQ445888 
    BQ011634 CF126445 AA703528 AI890820 BX329562 BG168453 BU838233 BM857161 
    AW516952 BQ068386 AA165603 BG703958 AA487155 AL558387 AV684684 BE620421 
    BQ683934 BX357261 AL709309 BU167180 BG280920 BQ008982 BG701512 CF243155 
    BG168512 BG545725 BU194192 CA416735 BX376228 BX337935 BQ945010 BG539610 
    BQ948629 BQ072910 BM310352 BM686256 AI202759 BX476525 BF724494 BX380288 
    BQ045468 BQ776096 BQ448007 BQ054042 M63959 BG623450 BU190831 CB306089 
    AI131173 BI092977 BX357910 BP352597 BI827186 BQ682814 BQ001629 BQ012505 
    BI759002 AW304741 BU185293 BF313017 CA777238 BQ127993 BM669531 BX385618 
    CA395818 AA676602 AA630483 BF038402 T28875 BG926728 AL518777 AA122233 
    CF140462 BU192808 BF445926 AW276644 AW117804 CD579407 AI922920 BG282032 
    AI300414 BU728056 BI824970 AL547550 BI818941 BX490082 W60426 BM091277 
    F03638 BG105098 BE905094 AV694545 AW250582 AA622227 AA040390 BG402558 
    AI627592 AI693244 BM008390 AK128751 BC006574 AW672885 BQ710391 AU099889 
    AL035999 R01169 AA886301 BP370882 BF315181 BX375436 BX386966 AL518778 
    BQ677407 N79580 BG704282 AA151981 BU071491 BF529883 AA160306 BP381150 
    N90264 BC007841 AI784287 AL574287 BI602018 BX385617 BX337023 AL558992 
    BF347234 BF448985 AA348801 H46924 AA532777 AA595075 BG767447 BX642368 
    BC013950 AI149523 AA303462 AL548347 T15923 BQ678045 BC018955 AA299554 
    BI087739 AA146618 AL561929 BX340859 BX337824 BG231593 AW148499 W74711 
    BF125470 AA654302 BM686699 BG002462 BG015933 AA121311 AI032610 BE327982 
    AI093757 AA364673 CB956055 AI185129 AI932567 AI919544 T97998 BF173199 
    AI445446 H50380 CD614662 BE047622 BE540382 AA121449 AA323943 H50347 
    AA384484 AA563728 W46142 BI763151 BE727620 AA295569 AA885967 AA121454 
    BQ673436 BP353096 AU159628 AW515346 AW962060 BX376227 AW974976 AA088374 
    AV701777 W81252 AW275902 AU135239 CD614664 AI279861 CF141488 BI824306 
    AA223554 H47028 AW961997 AW262768 AA679106 AA844540 AI668871 AW250525 
    AA401029 CA776953 CD579573 AA293764 AI279643 AA478254 AI313206 N34241 
    AA855172 CA944454 T80641 BF812549 BF694098 AA486209 AA243045 BG483519 
    AI559856 CD579826 AA588088 BI768691 BX380723 AA165484 N93206 AL046867 
    BG948944 AI089127 AI783812 BQ354685 AI356099 BF347800 AA617902 BE548236 
    AL580674 W74680 AA411319 AI077804 BE967657 N99909 L34970 N25642 
    AA917574 BG015938 BM477919 AA143549 BX386965 AL572435 BM714639 BE732050 
    BX357260 AA917572 AA595267 AA576384 W46154 AI693789 BG951603 BE929303 
    BX417360 AA876903 W16615 AA771905 CA434866 AA132375 BF871998 AA533736 
    BE298537 BM914761 BG702698 AL529267 CF139856 W39205 BU174324 BE281604 
    BI057918 BF058604 AA121317 BI552821 W56164 BI910608 AA829566 W25287 
    AI869746 AW675563 AA150529 BX377274 AL558964 AA040494 H93173 BE707518 
    BG769388 BI058182 AA132619 BX351653 AI160555 AA622989 AA075750 AL544047 
    H46923 AL563400 AA776413 H46489 AL572938 T98076 T72463 AA555162 
    W38958 BQ369239 AW577008 AA126171 BQ369034 AA121110 CF264763 AA552040 
    H52482 BG236822 BG960046 BI763024 AA243044 BX445233 R01280 AI186093 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for LRPAP1 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11
    SP1:              -     -           -                                               -     -                     
    SP2:              -     -           -                       -     -     -           -     -                     
    SP3:              -     -           -                                                                           
    SP4:              -     -           -           -     -                                                         
    SP5:              -     -                                                                                       


    ECgene alternative splicing isoforms for LRPAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LRPAP1 expression in normal human tissues (normalized intensities)      LRPAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACAGAGTCC
    LRPAP1 Expression
    About this image


    LRPAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/forebrain/telencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   

    See LRPAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LRPAP1

    SOURCE GeneReport for Unigene cluster: Hs.40966
        SABiosciences Expression via Pathway-Focused PCR Array including LRPAP1: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRPAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for LRPAP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrpap11 , 5 low density lipoprotein receptor-related protein associated more1, 5 79.55(n)1
    76.19(a)1
      5 (18.01 cM)5
    169761  NM_013587.21  NP_038615.21 
     350914905 
    chicken
    (Gallus gallus)
    Aves LRPAP11 low density lipoprotein receptor-related protein associated more 67.88(n)
    68.69(a)
      395936  NM_205062.1  NP_990393.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRPAP16
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343585.1(442453-445917)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986432 hypothetical protein LOC398643 72.93(n)    BC054293.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrpap12 low density lipoprotein receptor-related protein associated more 72.59(n)   333939  BC049517.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85071 , 3 CG85071 35(a)3
    50.55(n)1
    36.56(a)1
      85E93
    412051  NM_141693.21  NP_649950.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C15C8.41 Protein C15C8.4 42.97(n)
    33.59(a)
      179745  NM_073786.3  NP_506187.2 


    ENSEMBL Gene Tree for LRPAP1 (if available)
    TreeFam Gene Tree for LRPAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1041 SNPs in LRPAP1 are shown (see all 1041)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs348975111,2
    Cuntested13526636(-) CCTCAA/GTGGTA 2 N S mis11Minor allele frequency- G:0.01NA 76
    rs755795991,2
    F--3504859(+) CACCCC/GCTCGG 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs28580241,2
    C,F,A,H--3504863(+) CCCTCT/GGTTCA 1 -- ds500111Minor allele frequency- G:0.39NA WA CSA EA 374
    rs1422912371,2
    --3504892(+) CTCTCA/GGCACC 1 -- ds50010--------
    rs1512683151,2
    --3504902(+) CCGTGC/TCACAG 1 -- ds50010--------
    rs1152445971,2
    F--3504933(+) CGAGGC/TGAGGC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1393305721,2
    --3504958(+) TGGCAA/CCGCAC 1 -- ds50010--------
    rs1500336261,2
    C--3504969(+) ACTCAC/GGCCCC 1 -- ds50010--------
    rs1453586171,2
    --3504980(+) ACACAC/TGGATG 1 -- ds50010--------
    rs1425919531,2
    --3505008(+) AGCTAC/TCAGCA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for LRPAP1 (3505324 - 3534286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for LRPAP1 (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2726908CNV Deletion23290073
    esv2726905CNV Deletion23290073
    esv2726904CNV Deletion23290073
    esv1183049CNV Deletion17803354
    esv2726902CNV Deletion23290073
    esv2726900CNV Deletion23290073
    esv1102085CNV Deletion17803354
    esv2726907CNV Deletion23290073
    esv1447823CNV Deletion17803354
    esv2726903CNV Deletion23290073


    Human Gene Mutation Database (HGMD): LRPAP1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing LRPAP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRPAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 104225    OMIM disorders: --

    UniProtKB/Swiss-Prot: AMRP_HUMAN, P30533
  • Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane
    glomerular nephritis

  • 20/22 diseases for LRPAP1 (see all 22):    About MalaCards
    von willebrand's disease    biliary tract cancer    gallbladder cancer    tuberous sclerosis
    liposarcoma    lissencephaly    hypothyroidism    thrombosis
    nephritis    wilms tumor    glomerulonephritis    alzheimer's disease
    endometrial carcinoma    peritonitis    dementia    myocardial infarction
    atherosclerosis    retinitis    colorectal cancer    thyroiditis


    LRPAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    7 Novoseek inferred disease relationships for LRPAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nephropathy membranous 66.8 1 9207124 (1)
    glomerulonephritis 56.4 8 8238258 (2), 9207124 (1), 10886254 (1), 7579068 (1) (see all 7)
    alzheimers disease 25.6 2 16650578 (1), 16938309 (1)
    carcinoma embryonal 23 2 2229028 (1), 7615664 (1)
    atherosclerosis 0 1 7959795 (1)
    tumors 0 4 8640836 (2), 7957939 (1)
    carcinoma 0 2 8238258 (1), 7957939 (1)

    Genetic Association Database (GAD): LRPAP1
    Human Genome Epidemiology (HuGE) Navigator: LRPAP1 (21 documents)

    Export disorders for LRPAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LRPAP1 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with LRPAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of the human LRPAP1 gene coding for the lipoprotein receptor-associated protein: identification of 22 polymorphisms and one mutation. (PubMed id 9782079)1, 2, 4, 9 Van Leuven F.... Nelissen B. (1998)
    2. Primary structure of alpha 2-macroglobulin receptor-associated protein. Human homologue of a Heymann nephritis antigen. (PubMed id 1712782)1, 2, 3 Strickland D.K.... Argraves W.S. (1991)
    3. 39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein. (PubMed id 7774585)1, 2, 9 Bu G.... Schwartz A.L. (1995)
    4. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor- associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. (PubMed id 7789983)1, 2, 9 Van Leuven F.... Van den Berghe H. (1995)
    5. The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330. (PubMed id 1400426)1, 2, 9 Kounnas M.Z.... Strickland D.K. (1992)
    6. Lipoprotein Receptor Associated Protein (LRPAP1) Insertion/Deletion Polymorphism: Association with Gallbladder Cancer Susceptibility. (PubMed id 17987404)1, 4, 9 Pandey S.N....Mittal B. (2006)
    7. Alpha2-macroglobulin, lipoprotein receptor-related protein and lipoprotein receptor-associated protein and the genetic risk for developing Alzheimer's disease. (PubMed id 16650578)1, 4, 9 Depboylu C....Dodel R.C. (2006)
    8. Low-density lipoprotein receptor-related protein-associated protein (LRPAP1) gene IVS5 insertion/deletion polymorphism is not a risk factor for gallstone disease in a Polish population. (PubMed id 17913606)1, 4, 9 Juzyszyn Z....Drozdzik M. (2008)
    9. Association of low density lipoprotein receptor related protein-associated protein (LRPAP1) gene insertion/deletion polymorphism with gallstone disease. (PubMed id 16704534)1, 4, 9 Dixit M....Mittal B. (2006)
    10. LRP-associated protein gene (LRPAP1) and susceptibility to degenerative dementia. (PubMed id 18721259)1, 4, 9 Pandey P....Mittal B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4043 HGNC: 6701 AceView: LRPAP1 Ensembl:ENSG00000163956 euGenes: HUgn4043
    ECgene: LRPAP1 H-InvDB: LRPAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LRPAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LRPAP1 gene:
    Search GeneIP for patents involving LRPAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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