Aliases for LRP6 Gene
External Ids for LRP6 Gene
Previous GeneCards Identifiers for LRP6 Gene
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
GeneCards Summary for LRP6 Gene
LRP6 (Low Density Lipoprotein Receptor-Related Protein 6) is a Protein Coding gene. Diseases associated with LRP6 include coronary artery disease, autosomal dominant, 2 and coronary artery disease - hyperlipidemia - hypertension - diabetes - osteoporosis. Among its related pathways are ERK Signaling and MicroRNAs in cardiomyocyte hypertrophy. GO annotations related to this gene include protein homodimerization activity and frizzled binding. An important paralog of this gene is LRP1B.
UniProtKB/Swiss-Prot for LRP6 Gene
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).