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Aliases for LRP5L Gene

Aliases for LRP5L Gene

  • LDL Receptor Related Protein 5 Like 2 3 5
  • Low Density Lipoprotein Receptor-Related Protein 5-Like 2 3
  • LRP-5-Like 3 4
  • Low-Density Lipoprotein Receptor-Related Protein 5-Like Protein 3

External Ids for LRP5L Gene

Previous GeneCards Identifiers for LRP5L Gene

  • GC22M024072
  • GC22M024077
  • GC22M025747
  • GC22M008694

Summaries for LRP5L Gene

GeneCards Summary for LRP5L Gene

LRP5L (LDL Receptor Related Protein 5 Like) is a Protein Coding gene. GO annotations related to this gene include Wnt-protein binding and Wnt-activated receptor activity. An important paralog of this gene is NID2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP5L Gene

Genomics for LRP5L Gene

Regulatory Elements for LRP5L Gene

Enhancers for LRP5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F025402 1.1 ENCODE 21.9 +0.8 768 5.0 MLX WRNIP1 ZNF133 ARID4B SIN3A DMAP1 ZNF48 YY1 ZNF121 ELK1 LRP5L LRRC75B LOC100419673 LOC105372966 PIR32639
GH22F025398 1 Ensembl ENCODE 21.3 +6.7 6735 1.3 CTCF BMI1 ZNF121 ZFHX2 PATZ1 EED PRDM10 CREM EGR2 MTA2 LRP5L PIR32639
GH22F025385 1.2 Ensembl ENCODE 16.4 +16.6 16577 6.8 ELF3 MLX ARID4B DMAP1 THRB ZNF48 RAD21 RARA MIXL1 THAP11 LRP5L PIR32639
GH22F024548 1.8 FANTOM5 Ensembl ENCODE 9.8 +851.9 851916 8.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF70 SNRPD3 GGTLC4P POM121L9P MIF-AS1 ARL5AP4 LOC100421614 CRIP1P4 RPS10P29 ENSG00000228039
GH22F025418 1.6 FANTOM5 Ensembl ENCODE 9.5 -14.6 -14629 4.0 FEZF1 GLIS2 REST TSHZ1 PPARG GLIS1 KDM1A SP7 CTCF SUZ12 LOC105372966 ENSG00000272798 LRP5L GRK3 GC22P025419 PIR33644
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRP5L on UCSC Golden Path with GeneCards custom track

Promoters for LRP5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000616083 477 2601 TBL1XR1 ZNF133 SIN3A FEZF1 RARA ELK1 SCRT2 CREM ZNF263 ZBTB11

Genomic Location for LRP5L Gene

25,351,418 bp from pter
25,405,377 bp from pter
53,960 bases
Minus strand

Genomic View for LRP5L Gene

Genes around LRP5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP5L Gene

Proteins for LRP5L Gene

  • Protein details for LRP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 5-like protein
    Protein Accession:
    Secondary Accessions:
    • B0QYF3
    • B0QYF4
    • B2RPI5

    Protein attributes for LRP5L Gene

    252 amino acids
    Molecular mass:
    28483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP5L Gene


neXtProt entry for LRP5L Gene

Post-translational modifications for LRP5L Gene

No Post-translational modifications

No data available for DME Specific Peptides for LRP5L Gene

Domains & Families for LRP5L Gene

Protein Domains for LRP5L Gene

Suggested Antigen Peptide Sequences for LRP5L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 5 LDL-receptor class B repeats.
  • Contains 5 LDL-receptor class B repeats.
genes like me logo Genes that share domains with LRP5L: view

No data available for Gene Families for LRP5L Gene

Function for LRP5L Gene

Gene Ontology (GO) - Molecular Function for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017147 Wnt-protein binding IBA --
GO:0042813 Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with LRP5L: view
genes like me logo Genes that share phenotypes with LRP5L: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRP5L Gene

Localization for LRP5L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP5L gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0043235 receptor complex IBA --
genes like me logo Genes that share ontologies with LRP5L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for LRP5L Gene

Pathways & Interactions for LRP5L Gene

SuperPathways for LRP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IBA --
GO:0060070 canonical Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with LRP5L: view

No data available for Pathways by source and SIGNOR curated interactions for LRP5L Gene

Transcripts for LRP5L Gene

Unigene Clusters for LRP5L Gene

Low density lipoprotein receptor-related protein 5-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP5L Gene

No ASD Table

Relevant External Links for LRP5L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP5L Gene

Protein differential expression in normal tissues from HIPED for LRP5L Gene

This gene is overexpressed in Breast (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP5L Gene

Protein tissue co-expression partners for LRP5L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP5L Gene:


SOURCE GeneReport for Unigene cluster for LRP5L Gene:

genes like me logo Genes that share expression patterns with LRP5L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP5L Gene

Orthologs for LRP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP5L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP5L 35
  • 94 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
-- 35
  • 7 (a)
-- 35
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 21 (a)
(Bos Taurus)
Mammalia LRP5 35
  • 12 (a)
(Canis familiaris)
Mammalia LRP5 35
  • 12 (a)
(Gallus gallus)
Aves LRP5 35
  • 12 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 10 (a)
(Danio rerio)
Actinopterygii lrp5 35
  • 10 (a)
fruit fly
(Drosophila melanogaster)
Insecta arr 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 35 (a)
Species where no ortholog for LRP5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP5L Gene

Gene Tree for LRP5L (if available)
Gene Tree for LRP5L (if available)

Paralogs for LRP5L Gene

Paralogs for LRP5L Gene

(12) SIMAP similar genes for LRP5L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP5L: view

Variants for LRP5L Gene

Sequence variations from dbSNP and Humsavar for LRP5L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs10222259 -- 25,390,455(+) CTGCT(A/G)GGGCG intron-variant
rs10222306 -- 25,388,438(+) AACGA(A/C)CCTAA intron-variant
rs10222309 -- 25,388,217(+) GGGCA(A/G)CTGGA intron-variant
rs10427987 -- 25,379,643(+) GCTGC(A/G)CCACC intron-variant
rs10696144 -- 25,382,291(+) AAAAA(-/A/AAA)GAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRP5L Gene

Variant ID Type Subtype PubMed ID
dgv100e203 CNV gain+loss 21179565
nsv471190 CNV loss 18288195
nsv471189 CNV gain 18288195
nsv469659 CNV gain+loss 16826518
nsv469622 CNV gain+loss 16826518
nsv459856 CNV loss 19166990
nsv459855 CNV gain 19166990
nsv459853 CNV loss 19166990
nsv459716 CNV gain 19166990
nsv442794 CNV gain+loss 18776908
nsv438341 CNV loss 16468122
nsv437193 CNV loss 16327808
nsv437190 CNV loss 16327808
nsv436865 CNV insertion 17901297
nsv436354 CNV deletion 17901297
nsv436347 CNV deletion 17901297
nsv433458 CNV gain 18776910
nsv428388 CNV loss 18775914
nsv1160747 OTHER complex 26073780
nsv1160745 CNV deletion 26073780
nsv1126013 CNV deletion 24896259
nsv1110863 OTHER inversion 24896259
nsv1067300 CNV gain 25217958
nsv1065248 CNV loss 25217958
nsv1062814 CNV gain 25217958
nsv1056779 CNV loss 25217958
nsv1055442 CNV gain 25217958
esv3893467 CNV gain 25118596
esv3893466 CNV gain 25118596
esv3893465 CNV gain+loss 25118596
esv3647461 CNV loss 21293372
esv3647457 CNV loss 21293372
esv32873 CNV gain+loss 17666407
esv2758829 CNV gain+loss 17122850
esv2751952 CNV gain 17911159
esv2496250 CNV gain 19546169
esv2421729 OTHER complex 20811451
esv23681 CNV gain+loss 19812545
dgv831e214 CNV gain 21293372
dgv830e214 CNV gain 21293372
dgv828e199 CNV deletion 23128226
dgv8079n54 CNV loss 21841781
dgv8078n54 CNV gain 21841781
dgv8077n54 CNV loss 21841781
dgv8076n54 CNV loss 21841781
dgv8075n54 CNV loss 21841781
dgv8074n54 CNV gain 21841781
dgv8073n54 CNV gain+loss 21841781
dgv8072n54 CNV gain 21841781
dgv8071n54 CNV gain 21841781
dgv756n67 CNV gain 20364138
dgv731e201 CNV deletion 23290073
dgv68n17 CNV loss 16327808
dgv578n27 CNV loss 19166990
dgv577n27 CNV gain 19166990
dgv576n27 CNV gain 19166990
dgv575n27 CNV loss 19166990
dgv45n64 CNV loss 17921354
dgv4557n100 CNV gain 25217958
dgv4556n100 CNV gain+loss 25217958
dgv4555n100 CNV gain 25217958
dgv4554n100 CNV loss 25217958
dgv4552n100 CNV loss 25217958
dgv4550n100 CNV gain 25217958
dgv4549n100 CNV gain+loss 25217958
dgv4548n100 CNV loss 25217958
dgv4547n100 CNV gain 25217958
dgv4545n100 CNV loss 25217958
dgv44n64 CNV gain 17921354
dgv44e213 CNV gain 24956385
dgv24e196 CNV duplication 17116639
dgv177e55 CNV loss 17911159
dgv176e55 CNV loss 17911159
dgv175e55 CNV gain 17911159
dgv1307e212 CNV gain 25503493
dgv1306e212 CNV loss 25503493
dgv1305e212 CNV loss 25503493
dgv1304e212 CNV gain 25503493
nsv9890 CNV gain+loss 18304495
nsv962871 CNV duplication 23825009
nsv834164 CNV gain+loss 17160897
nsv834163 CNV gain+loss 17160897
nsv829134 CNV gain 20364138
nsv821696 CNV gain 15273396
nsv820110 CNV gain 19587683
nsv817983 CNV gain+loss 17921354
nsv7350 OTHER inversion 18451855
nsv588839 CNV loss 21841781
nsv588831 CNV loss 21841781
nsv588827 CNV gain 21841781
nsv588756 CNV gain+loss 21841781
nsv517205 CNV gain+loss 19592680
nsv514967 CNV gain+loss 21397061

Variation tolerance for LRP5L Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP5L Gene

Disorders for LRP5L Gene

Relevant External Links for LRP5L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP5L Gene

Publications for LRP5L Gene

  1. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for LRP5L Gene

Sources for LRP5L Gene

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