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Aliases for LRP5L Gene

Aliases for LRP5L Gene

  • Low Density Lipoprotein Receptor-Related Protein 5-Like 2 3
  • LRP-5-Like 3 4
  • Low-Density Lipoprotein Receptor-Related Protein 5-Like Protein 3

External Ids for LRP5L Gene

Previous GeneCards Identifiers for LRP5L Gene

  • GC22M024072
  • GC22M024077
  • GC22M025747
  • GC22M008694

Summaries for LRP5L Gene

GeneCards Summary for LRP5L Gene

LRP5L (Low Density Lipoprotein Receptor-Related Protein 5-Like) is a Protein Coding gene. GO annotations related to this gene include Wnt-protein binding and Wnt-activated receptor activity. An important paralog of this gene is LRP1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP5L Gene

Genomics for LRP5L Gene

Regulatory Elements for LRP5L Gene

Genomic Location for LRP5L Gene

Start:
25,351,418 bp from pter
End:
25,405,377 bp from pter
Size:
53,960 bases
Orientation:
Minus strand

Genomic View for LRP5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP5L Gene

Proteins for LRP5L Gene

  • Protein details for LRP5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A4QPB2-LRP5L_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 5-like protein
    Protein Accession:
    A4QPB2
    Secondary Accessions:
    • B0QYF3
    • B0QYF4
    • B2RPI5

    Protein attributes for LRP5L Gene

    Size:
    252 amino acids
    Molecular mass:
    28483 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP5L Gene

Proteomics data for LRP5L Gene at MOPED

Post-translational modifications for LRP5L Gene

No Post-translational modifications

Other Protein References for LRP5L Gene

No data available for DME Specific Peptides for LRP5L Gene

Domains for LRP5L Gene

Protein Domains for LRP5L Gene

Suggested Antigen Peptide Sequences for LRP5L Gene

Graphical View of Domain Structure for InterPro Entry

A4QPB2

UniProtKB/Swiss-Prot:

LRP5L_HUMAN :
  • A4QPB2
Similarity:
  • Contains 5 LDL-receptor class B repeats.
genes like me logo Genes that share domains with LRP5L: view

No data available for Gene Families for LRP5L Gene

Function for LRP5L Gene

Gene Ontology (GO) - Molecular Function for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017147 Wnt-protein binding IBA --
GO:0042813 Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with LRP5L: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for LRP5L Gene

Localization for LRP5L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP5L Gene COMPARTMENTS Subcellular localization image for LRP5L gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for LRP5L Gene

Pathways for LRP5L Gene

SuperPathways for LRP5L Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IBA --
GO:0060070 canonical Wnt signaling pathway IBA --
genes like me logo Genes that share ontologies with LRP5L: view

No data available for Pathways by source for LRP5L Gene

Transcripts for LRP5L Gene

Unigene Clusters for LRP5L Gene

Low density lipoprotein receptor-related protein 5-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRP5L

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP5L Gene

No ASD Table

Relevant External Links for LRP5L Gene

GeneLoc Exon Structure for
LRP5L
ECgene alternative splicing isoforms for
LRP5L

Expression for LRP5L Gene

mRNA expression in normal human tissues for LRP5L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRP5L Gene

SOURCE GeneReport for Unigene cluster for LRP5L Gene Hs.634058

genes like me logo Genes that share expressions with LRP5L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP5L Gene

Orthologs for LRP5L Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP5L 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP5 36
  • 12 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LRP5 36
  • 12 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 7 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LRP5 36
  • 12 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 10 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lrp5 36
  • 10 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta arr 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for LRP5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP5L Gene

ENSEMBL:
Gene Tree for LRP5L (if available)
TreeFam:
Gene Tree for LRP5L (if available)

Paralogs for LRP5L Gene

Paralogs for LRP5L Gene

Selected SIMAP similar genes for LRP5L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP5L: view

Variants for LRP5L Gene

Sequence variations from dbSNP and Humsavar for LRP5L Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6489 -- 25,355,750(-) CTCAC(-/TCAC)GTGTC intron-variant
rs16388 -- 25,354,849(-) TGGCC(-/ATTGCC)CTGGC intron-variant
rs133187 -- 25,352,036(+) TAGGT(-/GT)AGGGT intron-variant
rs133188 -- 25,352,751(+) TTAGT(A/G)TTAAA intron-variant
rs133189 -- 25,354,906(+) CAAAC(A/G)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP5L Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
dgv1392e1 CNV Complex 17122850
dgv24e196 CNV Duplication 17116639
nsv428388 CNV Loss 18775914
dgv1393e1 CNV Complex 17122850
nsv469659 CNV Complex 16826518
dgv175e55 CNV Gain 17911159
dgv1394e1 CNV Complex 17122850
nsv834163 CNV Gain+Loss 17160897
esv23681 CNV Gain+Loss 19812545
dgv575n27 CNV Loss 19166990
dgv576n27 CNV Gain 19166990
dgv778e201 CNV Deletion 23290073
dgv4914n71 CNV Gain 21882294
nsv436354 CNV Deletion 17901297
dgv44n64 CNV Gain 17921354
dgv4915n71 CNV Loss 21882294
dgv577n27 CNV Gain 19166990
nsv517205 CNV Gain+Loss 19592680
dgv176e55 CNV Loss 17911159
nsv471189 CNV Gain 18288195
dgv4916n71 CNV Loss 21882294
dgv4917n71 CNV Gain 21882294
dgv4918n71 CNV Gain+Loss 21882294
dgv4919n71 CNV Gain 21882294
dgv1395e1 CNV Complex 17122850
dgv756n67 CNV Gain 20364138
dgv4921n71 CNV Gain 21882294
dgv4922n71 CNV Gain 21882294
esv32873 CNV Gain+Loss 17666407
nsv436865 CNV Insertion 17901297
esv2751952 CNV Gain 17911159
dgv828e199 CNV Deletion 23128226
nsv9890 CNV Gain+Loss 18304495
dgv4923n71 CNV Gain 21882294
dgv4924n71 CNV Gain+Loss 21882294
nsv459716 CNV Gain 19166990
dgv4925n71 CNV Loss 21882294
dgv4926n71 CNV Gain+Loss 21882294
nsv433458 CNV Gain 18776910
dgv45n64 CNV Loss 17921354
esv2421729 OTHER Complex 20811451
nsv442794 CNV CNV 18776908
nsv471190 CNV Loss 18288195
nsv817983 CNV Gain+Loss 17921354
nsv514967 CNV Complex 21397061
nsv436347 CNV Deletion 17901297
nsv914777 CNV Gain+Loss 21882294
dgv4927n71 CNV Gain 21882294
dgv4928n71 CNV Gain 21882294
nsv459853 CNV Loss 19166990
nsv834164 CNV Gain+Loss 17160897
nsv914818 CNV Gain 21882294
nsv437190 CNV Loss 16327808
dgv177e55 CNV Loss 17911159
nsv459855 CNV Gain 19166990
esv2496250 CNV Gain 19546169
nsv469622 CNV Loss 16826518
nsv821696 CNV Gain 15273396
nsv459856 CNV Loss 19166990
dgv4929n71 CNV Gain 21882294
nsv914825 CNV Gain 21882294
dgv4930n71 CNV Gain 21882294
nsv829134 CNV Gain 20364138
dgv4931n71 CNV Gain 21882294
dgv578n27 CNV Loss 19166990
dgv4932n71 CNV Loss 21882294
nsv438341 CNV Loss 16468122
nsv914845 CNV Gain 21882294
nsv437193 CNV Loss 16327808
dgv68n17 CNV Loss 16327808
nsv820110 CNV Gain 19587683
dgv4933n71 CNV Gain 21882294
dgv4934n71 CNV Gain 21882294

Relevant External Links for LRP5L Gene

HapMap Linkage Disequilibrium report
LRP5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP5L Gene

Disorders for LRP5L Gene

No disorders were found for LRP5L Gene.

No data available for UniProtKB/Swiss-Prot for LRP5L Gene

Publications for LRP5L Gene

  1. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PMID: 7566098) Adams M.D. … White O. (Nature 1995) 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3
  5. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 4

Products for LRP5L Gene

Sources for LRP5L Gene

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