Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



LRP5 Gene

protein-coding   GIFtS: 68
GCID: GC11P068080

Low Density Lipoprotein Receptor-Related Protein 5

(Previous names: osteoporosis pseudoglioma syndrome, exudative vitreoretinopathy...)
(Previous symbols: LRP7, OPPG, EVR1)
  See LRP5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Low Density Lipoprotein Receptor-Related Protein 51 2     OPTA12 5
LRP71 2 3 5     VBCH22 5
OPPG1 2 5     Exudative Vitreoretinopathy 11
LR32 3 5     Osteoporosis Pseudoglioma Syndrome1
EVR11 2     HBM2
LRP-52 3     OPS2
BMND12 5     Low Density Lipoprotein Receptor-Related Protein 72
EVR42 5     Low-Density Lipoprotein Receptor-Related Protein 52

External Ids:    HGNC: 66971   Entrez Gene: 40412   Ensembl: ENSG000001623377   OMIM: 6035065   UniProtKB: O751973   

Export aliases for LRP5 gene to outside databases

Previous GC identifers: GC11P070603 GC11P069776 GC11P068330 GC11P067855 GC11P067836 GC11P064451


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for LRP5 Gene:
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the
process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family
members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with
type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density
related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative
vitreoretinopathy. (provided by RefSeq, Nov 2009)

GeneCards Summary for LRP5 Gene:
LRP5 (low density lipoprotein receptor-related protein 5) is a protein-coding gene. Diseases associated with LRP5 include exudative vitreoretinopathy 4, and hyperostosis, endosteal. GO annotations related to this gene include Wnt-activated receptor activity and Wnt-protein binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: LRP5_HUMAN, O75197
Function: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing
aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of
Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor
complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the
cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and
destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye.
Required for posterior patterning of the epiblast during gastrulation

Gene Wiki entry for LRP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRP5 gene promoter:
         TBP   RP58   AML1a   FOXI1   S8   FOXO4   HSF2   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRP5 promoter sequence
   Search Chromatin IP Primers for LRP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.4

LRP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P068080:  view genomic region     (about GC identifiers)

Start:
68,080,077 bp from pter      End:
68,216,743 bp from pter
Size:
136,667 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: LRP5_HUMAN, O75197 (See protein sequence)
Recommended Name: Low-density lipoprotein receptor-related protein 5 precursor  
Size: 1615 amino acids; 179145 Da
Subunit: Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling (By similarity).
Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with
FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif
domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is
enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1;
the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated
phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents
the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases
DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling.
Interacts with APCDD1
Secondary accessions: Q96TD6 Q9UES7 Q9UP66

Explore the universe of human proteins at neXtProt for LRP5: NX_O75197

Explore proteomics data for LRP5 at MOPED

Post-translational modifications: 

  • Phosphorylation of cytoplasmic PPPSP motifs regulates the signal transduction of the Wnt signaling pathway through
    acting as a docking site for AXIN1 (By similarity)1
  • Glycosylation2 at Asn93, Asn138, Asn446, Asn499, Asn705, Asn878
  • Modification sites at PhosphoSitePlus

  • See LRP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002326.2  
    ENSEMBL proteins: 
     ENSP00000294304   ENSP00000436652   ENSP00000435315  
    Reactome Protein details: O75197

    LRP5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRP5
    GenScript Custom Purified and Recombinant Proteins Services for LRP5
    Novus Biologicals LRP5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRP5

     
    Search eBioscience for Proteins for LRP5 

    LRP5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for LRP5 (LRP-5)
    Cell Signaling Technology (CST) Antibodies for LRP5 
    OriGene Antibodies for LRP5
    OriGene Custom Antibody Services for LRP5
    Novus Biologicals LRP5 Antibodies
    Abcam antibodies for LRP5 (O75581, O75197)
    Cloud-Clone Corp. Antibodies for LRP5
    ThermoFisher Antibody for LRP5
    LSBio Antibodies in human, mouse, rat for LRP5

    LRP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRP5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRP5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRP5
    Cloud-Clone Corp. CLIAs for LRP5
    Search eBioscience for ELISAs for LRP5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    LDLR: Low density lipoprotein receptors

    Selected InterPro protein domains (see all 6):
     IPR002172 LDrepeatLR_classA_rpt
     IPR000033 LDLR_classB_rpt
     IPR023415 LDLR_class-A_CS
     IPR000742 EG-like_dom
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry O75197

    ProtoNet protein and cluster: O75197

    1 Blocks protein domain: IPB002172 Low density lipoprotein-receptor

    UniProtKB/Swiss-Prot: LRP5_HUMAN, O75197
    Similarity: Belongs to the LDLR family
    Similarity: Contains 4 EGF-like domains
    Similarity: Contains 3 LDL-receptor class A domains
    Similarity: Contains 20 LDL-receptor class B repeats


    Find genes that share domains with LRP5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRP5_HUMAN, O75197
    Function: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing
    aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of
    Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor
    complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the
    cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and
    destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye.
    Required for posterior patterning of the epiblast during gastrulation

         Genatlas biochemistry entry for LRP5:
    low density lipoprotein receptor related protein 5

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15908424
    GO:0015026coreceptor activity IBA--
    GO:0017147Wnt-protein binding IBA--
    GO:0019534NOT toxin transporter activity IMP18350154
    GO:0042813Wnt-activated receptor activity IBA--
         
    Find genes that share ontologies with LRP5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRP5:
     Proliferating cells 

         Selected MGI mutant phenotypes (inferred from 18 alleles(MGI details for Lrp5) (see all 18):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     limbs/digits/tail  liver/biliary system  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with LRP5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LRP5: Lrp5tm3.2Mawa Lrp5tm1Jsak Lrp5tm1.2Vari Lrp5tm1Grw Lrp5tm1Dgen Lrp5tm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRP5

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRP5:
    hsa-mir-335-5p (MIRT018508)

    Block miRNA regulation of human, mouse, rat LRP5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate LRP5:
    hsa-miR-3163 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-375 hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidLRP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRP5
    Predesigned siRNA for gene silencing in human, mouse, rat LRP5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRP5

    Clone
    Products:
         
    OriGene clones in human, mouse for LRP5 (see all 6)
    OriGene ORF clones in mouse, rat for LRP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP5 (NM_002335)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRP5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRP5
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRP5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    LRP5_HUMAN, O75197: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum (By similarity).
    Note=Chaperoned to the plasma membrane by MESD (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular2
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005886plasma membrane IDA17680723
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA18762581

    Find genes that share ontologies with LRP5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for LRP5 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathways0.40
    2Wnt Signaling Pathway (WikiPathways)
    Wnt Signaling Pathway and Pluripotency0.55
    3ERK Signaling
    Molecular Mechanisms of Cancer0.51
    4Wnt signaling network
    Wnt signaling network
    5WNT Signaling
    WNT Signaling


    Find genes that share SuperPaths with LRP5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for LRP5
        Wnt Signaling Pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for LRP5
        Molecular Mechanisms of Cancer
    Reelin Pathway (Cajal-Retzius cells)
    Colorectal Cancer Metastasis
    WNT Signaling

    1 Cell Signaling Technology (CST) Pathway for LRP5
        Wnt / Hedgehog / Notch

    5 BioSystems Pathways for LRP5
        MicroRNAs in cardiomyocyte hypertrophy
    Wnt Signaling Pathway and Pluripotency
    Wnt Signaling Pathway NetPath
    N-cadherin signaling events
    Wnt signaling network

    4 Reactome Pathways for LRP5
        regulation of FZD by ubiquitination
    disassembly of the destruction complex and recruitment of AXIN to the membrane
    negative regulation of TCF-dependent signaling by WNT ligand antagonists
    TCF dependent signaling in response to WNT


    1 Kegg Pathway  (Kegg details for LRP5):
        Wnt signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP5: 
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRP5 (O751971, 3 ENSP000002943044) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151693, ENSP000002623204I2D: score=5 STRING: ENSP00000262320
    MESDC2Q146963, ENSP000002617584I2D: score=2 STRING: ENSP00000261758
    WNT1P046283, ENSP000002935494I2D: score=2 STRING: ENSP00000293549
    CDH2P190223, ENSP000002691414I2D: score=1 STRING: ENSP00000269141
    DKK1O949073, ENSP000003630814I2D: score=1 STRING: ENSP00000363081
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001702gastrulation with mouth forming second IBA--
    GO:0001944vasculature development ----
    GO:0002053positive regulation of mesenchymal cell proliferation IMP17680723
    GO:0002076osteoblast development IBA--
    GO:0006007glucose catabolic process IMP19673927

    Find genes that share ontologies with LRP5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRP5

    1 HMDB Compound for LRP5    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    9 Novoseek inferred chemical compound relationships for LRP5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    opp-g 93.2 18 18825883 (4), 16252235 (3), 18602879 (3), 20096619 (2) (see all 6)
    vitamin d 37.9 15 16613987 (4), 19810105 (1), 19506792 (1), 15811432 (1) (see all 5)
    1,25 dihydroxy vitamin d3 33.8 1 17293108 (1)
    estrogen 22.9 5 19028354 (1), 15781005 (1), 17241106 (1), 19506792 (1) (see all 5)
    valine 22 3 17223614 (1), 19571442 (1), 15207752 (1)
    cholesterol 0 3 15448002 (1), 18721193 (1), 16723389 (1)
    lipid 0 8 19673927 (3), 19233690 (1), 18721193 (1), 18696049 (1) (see all 6)
    glucose 0 10 19673927 (6), 18493104 (1), 16723389 (1), 18696049 (1) (see all 5)
    calcium 0 2 15781005 (1), 16168727 (1)



    Find genes that share compounds with LRP5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for LRP5 gene: 
    NM_002335.2  

    Unigene Cluster for LRP5:

    Low density lipoprotein receptor-related protein 5
    Hs.6347  [show with all ESTs]
    Unigene Representative Sequence: NM_002335
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294304(uc001ont.3) ENST00000529993(uc009ysg.3) ENST00000528890
    ENST00000528714 ENST00000533695 ENST00000529702 ENST00000529481
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRP5 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate LRP5:
    hsa-miR-3163 hsa-miR-23b hsa-miR-130a* hsa-miR-23a hsa-miR-375 hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmidLRP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRP5
    Predesigned siRNA for gene silencing in human, mouse, rat LRP5
    Clone
    Products:
         
    OriGene clones in human, mouse for LRP5 (see all 6)
    OriGene ORF clones in mouse, rat for LRP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP5 (NM_002335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRP5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP5
      QuantiTect SYBR Green Assays in human, mouse, rat LRP5
      QuantiFast Probe-based Assays in human, mouse, rat LRP5

    Additional mRNA sequence: 

    AB017498.1 AF064548.1 AF077820.1 AF088027.1 BC098397.1 BC150595.1 

    13 DOTS entries:

    DT.455960  DT.100026920  DT.91961498  DT.95233960  DT.100772573  DT.95262124  DT.100664890  DT.100707486 
    DT.100781223  DT.120742825  DT.40317391  DT.91878540  DT.95100675 

    Selected AceView cDNA sequences (see all 221):

    BX439521 AI310060 BF445906 BX102265 BF940511 BX280363 BU732114 AA284502 
    AI583742 AA953315 AW594043 BQ689731 BQ687102 AI193440 BM561582 BX646853 
    BU159392 AI073917 BF811034 AF088027 AI567059 AI540548 BM826335 AB017498 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    LRP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAATGTGA
    LRP5 Expression
    About this image


    LRP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)
             Trachea
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive Streak Cells Primitive Streak
    LRP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6347

    UniProtKB/Swiss-Prot: LRP5_HUMAN, O75197
    Tissue specificity: Widely expressed, with the highest level of expression in the liver and in aorta

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP5: 
              WNT Signaling Pathway in human mouse rat
              Stem Cell Signaling in human mouse rat
              Notch Signaling Pathway in human mouse rat
              Adipogenesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP5
    QuantiTect SYBR Green Assays in human, mouse, rat LRP5
    QuantiFast Probe-based Assays in human, mouse, rat LRP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for LRP5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrp51 , 5 low density lipoprotein receptor-related protein 51, 5 87.1(n)1
    94.71(a)1
      19 (3.33 cM)5
    169731  NM_008513.31  NP_032539.21 
     35848285 
    chicken
    (Gallus gallus)
    Aves LRP51 low density lipoprotein receptor-related protein 5 75.95(n)
    88.53(a)
      423114  NM_001012897.1  NP_001012915.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    84(a)
    1 → many
    1(75392759-75528315)
    African clawed frog
    (Xenopus laevis)
    Amphibia lrp5-A2 low density lipoprotein receptor-related protein 5 75.18(n)    AF508960.1 
    zebrafish
    (Danio rerio)
    Actinopterygii lrp51 low density lipoprotein receptor-related protein 5 72.26(n)
    76.07(a)
      568518  NM_001177458.1  NP_001170929.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta arr3 Wnt receptor signaling pathway
    low-density lipoprotein receptor less
    42(a)
    (best of 2)
        --


    ENSEMBL Gene Tree for LRP5 (if available)
    TreeFam Gene Tree for LRP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for LRP5 gene
    LRP62  LRP22  LRP1B2  EGF2  LDLR2  LRP5L2  LRP42  VLDLR2  
    NID12  NID22  LRP82  LRP12  
    8 SIMAP similar genes for LRP5 using alignment to 3 protein entries:     LRP5_HUMAN (see all proteins):
    LRP6    LRP5L    LDLR    LRP4    LRP1    LRP8
    LRP2    LRP1B

    Find genes that share paralogs with LRP5           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LRP5
    PGOHUM00000259699


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    LRP5_HUMAN, O75197: Genetic variations in LRP5 define the bone mineral density quantitative trait locus 1 (BMND1)
    [MIM:601884]. Variance in bone mineral density influences bone mass and contributes to size determination in the
    general population


    Selected SNPs for LRP5 (see all 3563)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs803583171,2,,4
    CVitreoretinopathy, exudative 4 (EVR4)4 pathogenic168114327(+) TGGACA/GACACA 2 N D mis10--------
    rs289397091,2,,4
    CVitreoretinopathy, exudative 4 (EVR4)4 pathogenic168126153(+) CCGACA/GAGCTC 2 K E mis1 ese30--------
    VAR_0184664
    Vitreoretinopathy, exudative 4 (EVR4)4--see VAR_0184662 Y H mis40--------
    VAR_0639644
    Vitreoretinopathy, exudative 4 (EVR4)4--see VAR_0639642 A T mis40--------
    VAR_0639554
    Osteoporosis-pseudoglioma syndrome (OPPG)4--see VAR_0639552 D N mis40--------
    VAR_0218144
    Osteoporosis-pseudoglioma syndrome (OPPG)4--see VAR_0218142 R Q mis40--------
    VAR_0218124
    Van Buchem disease 2 (VBCH2)4--see VAR_0218122 A T mis40--------
    VAR_0639504
    Osteoporosis-pseudoglioma syndrome (OPPG)4--see VAR_0639502 S L mis40--------
    VAR_0212234
    Vitreoretinopathy, exudative 4 (EVR4)4--see VAR_0212232 R G mis40--------
    VAR_0184654
    Vitreoretinopathy, exudative 4 (EVR4)4--see VAR_0184652 T M mis40--------

    HapMap Linkage Disequilibrium report for LRP5 (68080077 - 68216743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRP5 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744660CNV Deletion23290073
    esv2744658CNV Deletion23290073
    esv2744659CNV Deletion23290073
    esv2744661CNV Deletion23290073
    esv2656496CNV Deletion23128226
    esv2572031CNV Deletion19546169
    nsv509420CNV Insertion20534489
    esv2510779CNV Insertion19546169
    esv1742622CNV Insertion17803354
    esv1780205CNV Insertion17803354

    Human Gene Mutation Database (HGMD): LRP5
    Locus Specific Mutation Databases (LSDB): LRP5

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRP5
    DNA2.0 Custom Variant and Variant Library Synthesis for LRP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603506   
    OMIM disorders: 259770  601884  144750  607636  166710  601813  607634  
    UniProtKB/Swiss-Prot: LRP5_HUMAN, O75197
  • Vitreoretinopathy, exudative 4 (EVR4) [MIM:601813]: A disorder of the retinal vasculature characterized
    by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may
    lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial
    avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by
    scarring, retinal detachment and blindness. Clinical features can be highly variable, even within the same
    family. Patients with mild forms of the disease are asymptomatic, and their only disease related abnormality is
    an arc of avascular retina in the extreme temporal periphery. Note=The disease is caused by mutations affecting
    the gene represented in this entry
  • Osteoporosis (OSTEOP) [MIM:166710]: A systemic skeletal disorder characterized by decreased bone mass and
    deterioration of bone microarchitecture without alteration in the composition of bone. The result is fragile
    bones and an increased risk of fractures, even after minimal trauma. Osteoporosis is a chronic condition of
    multifactorial etiology and is usually clinically silent until a fracture occurs. Note=Disease susceptibility is
    associated with variations affecting the gene represented in this entry
  • Osteoporosis-pseudoglioma syndrome (OPPG) [MIM:259770]: A disease characterized by congenital or
    infancy-onset blindness and severe juvenile-onset osteoporosis and spontaneous fractures. Additional clinical
    manifestations may include microphthalmos, abnormalities of the iris, lens or vitreous, cataracts, short stature,
    microcephaly, ligamental laxity, mental retardation and hypotonia. Note=The disease is caused by mutations
    affecting the gene represented in this entry
  • High bone mass trait (HBM) [MIM:601884]: Rare phenotype characterized by exceptionally dense bones. HBM
    individuals show otherwise a completely normal skeletal structure and no other unusual clinical findings.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Endosteal hyperostosis, Worth type (WENHY) [MIM:144750]: An autosomal dominant sclerosing bone dysplasia
    clinically characterized by elongation of the mandible, increased gonial angle, flattened forehead, and the
    presence of a slowly enlarging osseous prominence of the hard palate (torus palatinus). Serum calcium, phosphorus
    and alkaline phosphatase levels are normal. Radiologically, it is characterized by early thickening of the
    endosteum of long bones, the skull and of the mandible. With advancing age, the trabeculae of the metaphysis
    become thickened. WENHY becomes clinically and radiologically evident by adolescence, does not cause deformity
    except in the skull and mandible, and is not associated with bone pain or fracture. Affected patients have normal
    height, proportion, intelligence and longevity. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Osteopetrosis, autosomal dominant 1 (OPTA1) [MIM:607634]: A rare genetic disease characterized by
    abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe
    autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form
    occurring in adolescence or adulthood. OPTA1 is an autosomal dominant form characterized by generalized
    osteosclerosis most pronounced in the cranial vault. Patients are often asymptomatic, but some suffer from pain
    and hearing loss. It appears to be the only type of osteopetrosis not associated with an increased fracture rate.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Van Buchem disease 2 (VBCH2) [MIM:607636]: VBCH2 is an autosomal dominant sclerosing bone dysplasia
    characterized by cranial osteosclerosis, thickened calvaria and cortices of long bones, enlarged mandible and
    normal serum alkaline phosphatase levels. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • Selected diseases for LRP5 (see all 28):    
    About MalaCards
    exudative vitreoretinopathy 4    hyperostosis, endosteal    high bone mass trait    osteopetrosis autosomal dominant type 1
    osteosclerosis-developmental delay-craniosynostosis syndrome    hyperostosis corticalis generalisata, benign form of worth with torus palatinus    osteoporosis-pseudoglioma syndrome    osteoporosis
    idiopathic juvenile osteoporosis    van buchem disease type 2    lrp5-related familial exudative vitreoretinopathy, autosomal recessive    lrp5-related autosomal dominant osteopetrosis
    osteosclerosis    lrp5-related familial exudative vitreoretinopathy, autosomal dominant    hyperostosis    glanders
    craniodiaphyseal dysplasia    exudative vitreoretinopathy    sost-related sclerosing bone dysplasia    familial exudative vitreoretinopathy, autosomal dominant

    9 diseases from the University of Copenhagen DISEASES database for LRP5:
    Exudative vitreoretinopathy     Osteoporosis     Hyperostosis     Idiopathic juvenile osteoporosis
    Glanders     Osteosclerosis     Blindness     Osteogenesis imperfecta
    Brucellosis

    Find genes that share disorders with LRP5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LRP5 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    osteoporosis-pseudoglioma syndrome 96.8 20 15850991 (2), 12204281 (1), 15775238 (1), 16397351 (1) (see all 18)
    high bone mass 95.1 46 15824861 (4), 12817748 (3), 17295608 (3), 16397351 (2) (see all 27)
    mass phenotype 92.2 14 17295608 (2), 15095618 (1), 16397351 (1), 15824851 (1) (see all 10)
    sclerosteosis 89.4 2 15908424 (1), 14564212 (1)
    pseudoglioma 85.9 5 16679074 (2), 17395706 (1), 19041744 (1)
    van buchem disease 85.6 3 18538647 (1), 12579474 (1), 14564212 (1)
    osteosclerosis, autosomal dominant 84.7 2 12579474 (1), 15940380 (1)
    idiopathic juvenile osteoporosis 81.9 2 15824851 (1), 18602879 (1)
    osteoporosis 78.3 58 15824851 (4), 17395706 (3), 18349089 (3), 16168727 (3) (see all 35)
    torus palatinus 76.4 1 15940380 (1)

    GeneTests: LRP5
    GeneReviews: LRP5
    Genetic Association Database (GAD): LRP5
    Human Genome Epidemiology (HuGE) Navigator: LRP5 (89 documents)

    Export disorders for LRP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for LRP5 gene, integrated from 10 sources (see all 289):
    (articles sorted by number of sources associating them with LRP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complexity of the genotype-phenotype correlation in familial exudative vitreoretinopathy with mutations in the LRP5 and/or FZD4 genes. (PubMed id 15981244)1, 2, 4, 9 Qin M.... Kondo H. (Hum. Mutat. 2005)
    2. Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites. (PubMed id 15077203)1, 2, 4, 9 Ferrari S.L.... Antonarakis S.E. (Am. J. Hum. Genet. 2004)
    3. LRP5, low-density-lipoprotein-receptor-related protein 5, is a determinant for bone mineral density. (PubMed id 14727154)1, 2, 4, 9 Mizuguchi T.... Yoshiura K. (J. Hum. Genet. 2004)
    4. Cloning of a novel member of the low-density lipoprotein receptor family. (PubMed id 9714764)1, 2, 3, 9 Hey P.J.... Hess J.F. (Gene 1998)
    5. Oropharyngeal skeletal disease accompanying high bone mass and novel LRP5 mutation. (PubMed id 15824861)1, 2, 9 Rickels M.R.... Whyte M.P. (J. Bone Miner. Res. 2005)
    6. Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites. (PubMed id 17241106)1, 4, 9 Xiong D.H....Deng H.W. (J. Bone Miner. Res. 2007)
    7. Low density lipoprotein receptor-related protein 5 (LRP5) mutations and osteoporosis, impaired glucose metabolism and hypercholesterolaemia. (PubMed id 19673927)1, 4, 9 Saarinen A....MAokitie O. (Clin. Endocrinol. (Oxf) 2010)
    8. Genetic variation at the low-density lipoprotein receptor-related protein 5 (LRP5) locus modulates Wnt signaling and the relationship of physical activity with bone mineral density in men. (PubMed id 17137849)1, 4, 9 Kiel D.P....Dupuis J. (Bone 2007)
    9. LRP5 gene polymorphisms and idiopathic osteoporosis in men. (PubMed id 16168727)1, 4, 9 Ferrari S.L....de Vernejoul M.C. (Bone 2005)
    10. Contribution of the LRP5 gene to normal variation in peak BMD in women. (PubMed id 15619672)1, 4, 9 Koller D.L....Econs M.J. (J. Bone Miner. Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 4041 HGNC: 6697 AceView: LRP5 Ensembl:ENSG00000162337 euGenes: HUgn4041
    ECgene: LRP5 Kegg: 4041 H-InvDB: LRP5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for LRP5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LRP5 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=LRP5[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for LRP5 gene:
    Search GeneIP for patents involving LRP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for LRP5 (LRP-5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for LRP5   OriGene RNAi products in human, mouse, rat for LRP5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for LRP5  
     OriGene qSTAR qPCR primer pairs in human, mouse for LRP5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for LRP5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for LRP5   OriGene Custom Protein Services for LRP5  

     
     
     Block miRNA regulation of human, mouse, rat LRP5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LRP5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP5 Predesigned siRNA for gene silencing in human, mouse, rat LRP5
     QuantiFast Probe-based Assays in human, mouse, rat LRP5 QuantiTect SYBR Green Assays in human, mouse, rat LRP5
     PCR Arrays including human, mouse, rat LRP5 Search Chromatin IP Primers for LRP5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP5  GeneGlobe Interaction Network for LRP5
     Regulatory tfbs in LRP5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for LRP5 GenScript cDNA clones with any tag delivered in your preferred vector for LRP5
     GenScript Custom Assay Services for LRP5 GenScript Custom overexpressing Cell Line Services for LRP5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for LRP5 

     Search Tocris compounds for LRP5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     LRP5 antibodies
     LRP5 proteins
     Antibodies for LRP5
     See all of Abcam's Antibodies, Kits and Proteins for LRP5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for LRP5
     Antibodies for LRP5
     ELISAs for LRP5
     CLIAs for LRP5



     Browse ESI BIO Cell Lines and PureStem Progenitors for LRP5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP5
     SwitchGear 3'UTR luciferase reporter plasmids for LRP5
     SwitchGear Promoter luciferase reporter plasmids for LRP5
     ThermoFisher Antibody for LRP5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRP5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRP5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRP5
     LSBio Antibodies in human, mouse, rat for LRP5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LRP5
      Search eBioscience for proteins for LRP5
      Search eBioscience for elisas for LRP5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      LRP5 gene at Home site.
    Version: 3.12.216 30 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4