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Aliases for LRP3 Gene

Aliases for LRP3 Gene

  • LDL Receptor Related Protein 3 2 3 5
  • 105 KDa Low-Density Lipoprotein Receptor-Related Protein 3 4
  • Low Density Lipoprotein Receptor-Related Protein 3 2 3
  • HLRp105 3 4
  • LRP-3 3 4
  • CTD-2540B15.13 3

External Ids for LRP3 Gene

Previous GeneCards Identifiers for LRP3 Gene

  • GC19P034303
  • GC19P034134
  • GC19P038361
  • GC19P038377
  • GC19P033685
  • GC19P030187

Summaries for LRP3 Gene

GeneCards Summary for LRP3 Gene

LRP3 (LDL Receptor Related Protein 3) is a Protein Coding gene. An important paralog of this gene is LRP10.

UniProtKB/Swiss-Prot for LRP3 Gene

  • Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.

Gene Wiki entry for LRP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP3 Gene

Genomics for LRP3 Gene

Regulatory Elements for LRP3 Gene

Enhancers for LRP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRP3 Gene

33,177,603 bp from pter
33,208,867 bp from pter
31,265 bases
Plus strand

Genomic View for LRP3 Gene

Genes around LRP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP3 Gene

Proteins for LRP3 Gene

  • Protein details for LRP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 3
    Protein Accession:
    Secondary Accessions:
    • B3KQD6
    • B4DKF2

    Protein attributes for LRP3 Gene

    770 amino acids
    Molecular mass:
    82884 Da
    Quaternary structure:
    • Binds GGA1 and GGA2.
    • Sequence=BAG51998.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG59164.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for LRP3 Gene

Proteomics data for LRP3 Gene at MOPED

Post-translational modifications for LRP3 Gene

  • Glycosylation at Asn 71, Asn 199, and Asn 359
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LRP3 Gene

Domains & Families for LRP3 Gene

Gene Families for LRP3 Gene

Suggested Antigen Peptide Sequences for LRP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CUB domains.
  • Belongs to the LDLR family.
  • Contains 2 CUB domains.
  • Contains 4 LDL-receptor class A domains.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP3: view

Function for LRP3 Gene

Molecular function for LRP3 Gene

GENATLAS Biochemistry:
low density lipoprotein receptor related protein 3,LDLR superfamily
UniProtKB/Swiss-Prot Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.
genes like me logo Genes that share phenotypes with LRP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP3 Gene

Localization for LRP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP3 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

Jensen Localization Image for LRP3 Gene COMPARTMENTS Subcellular localization image for LRP3 gene
Compartment Confidence
extracellular 3
plasma membrane 3
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LRP3 Gene

Pathways & Interactions for LRP3 Gene

SuperPathways for LRP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for LRP3 Gene

Drugs & Compounds for LRP3 Gene

(1) Drugs for LRP3 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COG 133 Pharma ApoE mimetic peptide, ApoE peptide fragment 0

(1) ApexBio Compounds for LRP3 Gene

Compound Action Cas Number
COG 133 ApoE mimetic peptide 514200-66-9
genes like me logo Genes that share compounds with LRP3: view

Transcripts for LRP3 Gene

Unigene Clusters for LRP3 Gene

Low density lipoprotein receptor-related protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP3 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for LRP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP3 Gene

mRNA expression in normal human tissues for LRP3 Gene

Protein differential expression in normal tissues from HIPED for LRP3 Gene

This gene is overexpressed in Bone marrow stromal cell (66.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP3 Gene

SOURCE GeneReport for Unigene cluster for LRP3 Gene Hs.515340

mRNA Expression by UniProt/SwissProt for LRP3 Gene

Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and leukocyte.
genes like me logo Genes that share expression patterns with LRP3: view

Protein tissue co-expression partners for LRP3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LRP3 Gene

Orthologs for LRP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for LRP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRP3 35
  • 88.69 (n)
  • 92.72 (a)
LRP3 36
  • 93 (a)
(Mus musculus)
Mammalia Lrp3 35
  • 86.09 (n)
  • 92.98 (a)
Lrp3 16
Lrp3 36
  • 91 (a)
(Pan troglodytes)
Mammalia LRP3 35
  • 99.09 (n)
  • 99.22 (a)
LRP3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Lrp3 35
  • 86.28 (n)
  • 93.12 (a)
(Canis familiaris)
Mammalia LRP3 36
  • 86 (a)
(Monodelphis domestica)
Mammalia LRP3 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia LRP3 36
  • 62 (a)
(Gallus gallus)
Aves LRP3 35
  • 66.57 (n)
  • 71.49 (a)
LRP3 36
  • 65 (a)
(Anolis carolinensis)
Reptilia LRP3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp3 35
  • 66.67 (n)
  • 73.42 (a)
(Danio rerio)
Actinopterygii lrp3 35
  • 69.8 (n)
  • 70.73 (a)
LRP3 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6553 36
  • 22 (a)
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 18 (a)
(Triticum aestivum)
Liliopsida Ta.14 35
Species with no ortholog for LRP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for LRP3 Gene

Gene Tree for LRP3 (if available)
Gene Tree for LRP3 (if available)

Paralogs for LRP3 Gene

Paralogs for LRP3 Gene

(2) SIMAP similar genes for LRP3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP3: view

Variants for LRP3 Gene

Sequence variations from dbSNP and Humsavar for LRP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3745974 - 33,207,385(-) CGTCT(A/G)CCAGT reference, missense
rs3745978 - 33,205,409(-) CCCCC(A/G)GGGCA reference, synonymous-codon
rs7259840 -- 33,206,575(+) AGTCA(A/T)GTCGC intron-variant, reference, missense
rs12975724 -- 33,197,153(+) ATAGG(A/G)GTATG intron-variant
rs8100642 -- 33,204,335(+) GCTTC(A/G/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP3 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
nsv911579 CNV Loss 21882294
dgv3839n71 CNV Loss 21882294
dgv3840n71 CNV Loss 21882294
dgv3841n71 CNV Loss 21882294
esv24627 CNV Loss 19812545
dgv3842n71 CNV Loss 21882294

Variation tolerance for LRP3 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.62; 56.57% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LRP3 Gene

Disorders for LRP3 Gene

Relevant External Links for LRP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP3 Gene

Publications for LRP3 Gene

  1. cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2. (PMID: 9693042) Ishii H. … Yamamoto T.T. (Genomics 1998) 2 3 4 23 67
  2. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PMID: 7959795) Korenberg J.R. … Argraves W.S. (Genomics 1994) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for LRP3 Gene

Sources for LRP3 Gene