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LRP3 Gene

protein-coding   GIFtS: 53
GCID: GC19P033685

Low Density Lipoprotein Receptor-Related Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein 31 2
105 KDa Low-Density Lipoprotein Receptor-Related Protein2 3
LRP-32 3
hLRp1052 3
CTD-2540B15.132
Low-Density Lipoprotein Receptor-Related Protein 32

External Ids:    HGNC: 66951   Entrez Gene: 40372   Ensembl: ENSG000001308817   OMIM: 6031595   UniProtKB: O750743   

Export aliases for LRP3 gene to outside databases

Previous GC identifers: GC19P034303 GC19P034134 GC19P038361 GC19P038377 GC19P030187


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRP3 Gene:
LRP3 (low density lipoprotein receptor-related protein 3) is a protein-coding gene. An important paralog of this gene is LRP12.

UniProtKB/Swiss-Prot: LRP3_HUMAN, O75074
Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal
transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL)
or to LRPAP1 in vitro

Gene Wiki entry for LRP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRP3 gene promoter:
         Pax-5   RREB-1   HNF-4alpha2   E47   HNF-4alpha1   Egr-2   PPAR-gamma1   Hand1   PPAR-gamma2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRP3 promoter sequence
   Search Chromatin IP Primers for LRP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.11

LRP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P033685:  view genomic region     (about GC identifiers)

Start:
33,668,509 bp from pter      End:
33,699,773 bp from pter
Size:
31,265 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRP3_HUMAN, O75074 (See protein sequence)
Recommended Name: Low-density lipoprotein receptor-related protein 3 precursor  
Size: 770 amino acids; 82884 Da
Subunit: Binds GGA1 and GGA2 (By similarity)
Sequence caution: Sequence=BAG51998.1; Type=Erroneous initiation; Sequence=BAG59164.1; Type=Erroneous initiation;
Secondary accessions: B3KQD6 B4DKF2

Explore the universe of human proteins at neXtProt for LRP3: NX_O75074

Explore proteomics data for LRP3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn71, Asn199, Asn359

  • See LRP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002324.2  
    ENSEMBL proteins: 
     ENSP00000476735   ENSP00000253193  

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    antibodies-online proteins for LRP3 (6 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LDLR: Low density lipoprotein receptors

    3 InterPro protein domains:
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR023415 LDLR_class-A_CS

    Graphical View of Domain Structure for InterPro Entry O75074

    ProtoNet protein and cluster: O75074

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: LRP3_HUMAN, O75074
    Similarity: Belongs to the LDLR family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 4 LDL-receptor class A domains


    Find genes that share domains with LRP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRP3_HUMAN, O75074
    Function: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal
    transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL)
    or to LRPAP1 in vitro

         Genatlas biochemistry entry for LRP3:
    low density lipoprotein receptor related protein 3,LDLR superfamily

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRP3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for LRP3:
     Decreased cilium length  Decreased cilium length after   Upregulation of Wnt/beta-caten 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for LRP3

    miRNA
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    miRTarBase miRNAs that target LRP3:
    hsa-mir-93-5p (MIRT048793), hsa-mir-10a-5p (MIRT047679), hsa-mir-10b-5p (MIRT047486), hsa-mir-296-3p (MIRT038495), hsa-mir-744-5p (MIRT037564), hsa-mir-93-3p (MIRT038820), hsa-mir-331-3p (MIRT043332)

    Block miRNA regulation of human, mouse, rat LRP3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRP3 (see all 21):
    hsa-miR-146b-3p hsa-miR-875-3p hsa-miR-3938 hsa-miR-1226 hsa-miR-185* hsa-miR-520d-5p hsa-miR-2110 hsa-miR-409-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRP3_HUMAN, O75074: Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    plasma membrane3
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005905coated pit IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LRP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRP3
    Interactions:

        Search GeneGlobe Interaction Network for LRP3

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LRP3 (O750742, 3 ENSP000002531934) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GGA1Q9UJY52, 3, ENSP000003413444MINT-18135 I2D: score=2 STRING: ENSP00000341344
    GGA2Q9UJY42, 3, ENSP000003119624MINT-18407 I2D: score=3 STRING: ENSP00000311962
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS9693042

    Find genes that share ontologies with LRP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRP3 gene: 
    NM_002333.3  

    Unigene Cluster for LRP3:

    Low density lipoprotein receptor-related protein 3
    Hs.515340  [show with all ESTs]
    Unigene Representative Sequence: NM_002333
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592484 ENST00000253193(uc010edh.3 uc010xrp.1 uc002nuk.4)
    ENST00000590275 ENST00000590278
    miRNA
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    hsa-miR-146b-3p hsa-miR-875-3p hsa-miR-3938 hsa-miR-1226 hsa-miR-185* hsa-miR-520d-5p hsa-miR-2110 hsa-miR-409-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat LRP3
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    Additional mRNA sequence: 

    AB009462.1 AF085860.1 AK074751.1 AK126750.1 AK129963.1 AK130330.1 AK295505.1 AK296536.1 
    AK316314.1 BC007408.2 

    12 DOTS entries:

    DT.435766  DT.406649  DT.99963022  DT.121496317  DT.40195166  DT.100835548  DT.121496291  DT.65288771 
    DT.100813074  DT.121496300  DT.95364437  DT.97860369 

    Selected AceView cDNA sequences (see all 175):

    BM728356 BE909019 BU630231 BF724566 CR602048 BI757057 BC007408 BM694492 
    BM771054 BE395935 BU738781 AA326386 AA351797 BM766510 BQ929643 CA395541 
    BU195375 BX284080 W84566 BU542519 BF516316 AA335242 CK904423 BQ722249 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for LRP3    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:                          -                           
    SP2:                          -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for LRP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACACAGGCA
    LRP3 Expression
    About this image

    LRP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515340

    UniProtKB/Swiss-Prot: LRP3_HUMAN, O75074
    Tissue specificity: Widely expressed. Highly expressed in skeletal muscle and ovary. Expressed at intermediate
    level in heart, brain, liver, pancreas, prostate and small intestine. Weakly expressed in testis, colon and
    leukocyte

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for LRP3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrp31 , 5 low density lipoprotein receptor-related protein 31, 5 86.09(n)1
    92.98(a)1
      7 (21.15 cM)5
    4359651  NM_001024707.11  NP_001019878.11 
     352000275 
    chicken
    (Gallus gallus)
    Aves LRP31 low density lipoprotein receptor-related protein 3 66.57(n)
    71.49(a)
      415773  XM_414135.4  XP_414135.2 
    lizard
    (Anolis carolinensis)
    Reptilia LRP36
    low density lipoprotein receptor-related protein 3...
    71(a)
    1 ↔ 1
    GL343469.1(643177-652143)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrp31 low density lipoprotein receptor-related protein 3 66.67(n)
    73.42(a)
      100494496  XM_002935794.2  XP_002935840.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lrp31 low density lipoprotein receptor-related protein 3 69.8(n)
    70.73(a)
      100170796  NM_001130634.1  NP_001124106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG65536
    --
    22(a)
    1 → many
    2R(9742083-9743270)
    worm
    (Caenorhabditis elegans)
    Secernentea M03E7.46
    Protein M03E7.4 (M03E7.4) mRNA, complete cds
    18(a)
    1 → many
    V(5609414-5613219) WBGene00019756
    wheat
    (Triticum aestivum)
    Liliopsida Ta.142 Triticum aestivum transcribed sequence with moderate more 74.43(n)    CK194148.1 


    ENSEMBL Gene Tree for LRP3 (if available)
    TreeFam Gene Tree for LRP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRP3 gene
    LRP122  LDLRAD32  LRP102  
    2 SIMAP similar genes for LRP3 using alignment to 2 protein entries:     LRP3_HUMAN (see all proteins):
    LRP12    LRP10

    Find genes that share paralogs with LRP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRP3 (see all 407)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1439026411,2
    --33683741(+) GCAGTG/TAGCCG 1 -- us2k10--------
    rs10354461,2
    C--33683746(-) GATCAC/TGGCTC 1 -- us2k1 tfbs30--------
    rs1113912131,2
    C,F--33683772(+) AGCCTG/CGGCAA 1 -- us2k11Minor allele frequency- C:0.50CSA 2
    rs595533971,2
    C--33683956(+) GAGACC/TGTCTC 1 -- us2k10--------
    rs1118239881,2
    C--33683992(+) CAGCAG/ACAACA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs72532361,2
    C,F,A,H--33683995(+) CAGCAA/GCAACA 1 -- us2k110Minor allele frequency- G:0.38NA CSA EA 256
    rs1814321421,2
    --33684303(+) TCCCCC/GCATTT 1 -- us2k10--------
    rs1996309021,2
    C--33684556(+) TCCCC-/CTGTCTC 1 -- us2k10--------
    rs1858553311,2
    --33684642(+) GGCCTC/TCTCCC 1 -- us2k10--------
    rs126095491,2
    C,A,H--33684895(+) TAAGCA/CGTCCT 1 -- us2k18Minor allele frequency- C:0.30NA WA CSA EA 367

    HapMap Linkage Disequilibrium report for LRP3 (33668509 - 33699773 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for LRP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3841n71CNV Loss21882294
    dgv3840n71CNV Loss21882294
    nsv911579CNV Loss21882294
    dgv3842n71CNV Loss21882294
    nsv833808CNV Loss17160897
    esv24627CNV Loss19812545
    dgv3839n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603159    OMIM disorders: --


    Find genes that share disorders with LRP3           About GenesLikeMe


    Export disorders for LRP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRP3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LRP3)
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    1. cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2. (PubMed id 9693042)1, 2, 3, 9 Ishii H.... Yamamoto T.T. (Genomics 1998)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PubMed id 7959795)1, 3 Korenberg J.R....Argraves W.S. (Genomics 1994)
    6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains. (PubMed id 11390366)1 Takatsu H.... Nakayama K. (J. Biol. Chem. 2001)
    9. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4037 HGNC: 6695 AceView: LRP3 Ensembl:ENSG00000130881 euGenes: HUgn4037
    ECgene: LRP3 H-InvDB: LRP3

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRP3 gene:
    Search GeneIP for patents involving LRP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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