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Aliases for LRP2BP Gene

Aliases for LRP2BP Gene

  • LRP2 Binding Protein 2 3 5
  • Megalin-Binding Protein 3 4
  • MegBP 3 4
  • KIAA1325 4

External Ids for LRP2BP Gene

Previous GeneCards Identifiers for LRP2BP Gene

  • GC04M186661
  • GC04M186522
  • GC04M186285
  • GC04M182038

Summaries for LRP2BP Gene

GeneCards Summary for LRP2BP Gene

LRP2BP (LRP2 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LRP2BP Gene

  • May act as an adapter that regulates LRP2 function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP2BP Gene

Genomics for LRP2BP Gene

Regulatory Elements for LRP2BP Gene

Promoters for LRP2BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRP2BP on UCSC Golden Path with GeneCards custom track

Genomic Location for LRP2BP Gene

185,363,878 bp from pter
185,396,935 bp from pter
33,058 bases
Minus strand

Genomic View for LRP2BP Gene

Genes around LRP2BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP2BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP2BP Gene

Proteins for LRP2BP Gene

  • Protein details for LRP2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LRP2-binding protein
    Protein Accession:
    Secondary Accessions:
    • A6NJR7
    • A7E219
    • B3KX83
    • Q9NSN6

    Protein attributes for LRP2BP Gene

    347 amino acids
    Molecular mass:
    39780 Da
    Quaternary structure:
    • Interacts with LRP2.
    • Sequence=BAA92563.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP2BP Gene


neXtProt entry for LRP2BP Gene

Proteomics data for LRP2BP Gene at MOPED

Post-translational modifications for LRP2BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LRP2BP Gene

No data available for DME Specific Peptides for LRP2BP Gene

Domains & Families for LRP2BP Gene

Protein Domains for LRP2BP Gene

Suggested Antigen Peptide Sequences for LRP2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 Sel1-like repeats.
  • Contains 6 Sel1-like repeats.
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with LRP2BP: view

No data available for Gene Families for LRP2BP Gene

Function for LRP2BP Gene

Molecular function for LRP2BP Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter that regulates LRP2 function.
genes like me logo Genes that share phenotypes with LRP2BP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP2BP Gene

Localization for LRP2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP2BP Gene

Cytoplasm. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.

Subcellular locations from

Jensen Localization Image for LRP2BP Gene COMPARTMENTS Subcellular localization image for LRP2BP gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LRP2BP Gene

Pathways & Interactions for LRP2BP Gene

SuperPathways for LRP2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP2BP Gene


No data available for Pathways by source and SIGNOR curated interactions for LRP2BP Gene

Drugs & Compounds for LRP2BP Gene

No Compound Related Data Available

Transcripts for LRP2BP Gene

Unigene Clusters for LRP2BP Gene

LRP2 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP2BP Gene

No ASD Table

Relevant External Links for LRP2BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP2BP Gene

mRNA expression in normal human tissues for LRP2BP Gene

Protein differential expression in normal tissues from HIPED for LRP2BP Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP2BP Gene

SOURCE GeneReport for Unigene cluster for LRP2BP Gene Hs.558513

genes like me logo Genes that share expression patterns with LRP2BP: view

Protein tissue co-expression partners for LRP2BP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP2BP Gene

Orthologs for LRP2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP2BP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRP2BP 35
  • 88.47 (n)
  • 91.35 (a)
  • 90 (a)
(Canis familiaris)
Mammalia LRP2BP 35
  • 89.43 (n)
  • 91.35 (a)
  • 91 (a)
(Mus musculus)
Mammalia Lrp2bp 35
  • 82.71 (n)
  • 86.38 (a)
Lrp2bp 16
Lrp2bp 36
  • 86 (a)
(Pan troglodytes)
Mammalia LRP2BP 35
  • 99.81 (n)
  • 99.71 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Lrp2bp 35
  • 84.06 (n)
  • 88.12 (a)
(Monodelphis domestica)
Mammalia LRP2BP 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LRP2BP 36
  • 66 (a)
(Gallus gallus)
Aves LRP2BP 35
  • 68.76 (n)
  • 67.13 (a)
  • 59 (a)
(Anolis carolinensis)
Reptilia LRP2BP 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp2bp 35
  • 61.49 (n)
  • 57.77 (a)
(Danio rerio)
Actinopterygii lrp2bp 35
  • 57.57 (n)
  • 52.06 (a)
lrp2bp 36
  • 48 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
Species with no ortholog for LRP2BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP2BP Gene

Gene Tree for LRP2BP (if available)
Gene Tree for LRP2BP (if available)

Paralogs for LRP2BP Gene

No data available for Paralogs for LRP2BP Gene

Variants for LRP2BP Gene

Sequence variations from dbSNP and Humsavar for LRP2BP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1288551 -- 185,365,645(-) ccggc(A/G)cagtg utr-variant-3-prime
rs1288552 -- 185,364,903(-) TCGCA(A/G)TGTAA downstream-variant-500B, utr-variant-3-prime
rs3841656 -- 185,365,019(-) ACACA(-/CA)TACAC utr-variant-3-prime
rs7664573 -- 185,367,692(+) AACAA(G/T)TTGGG intron-variant
rs10673106 -- 185,394,316(+) AATCT(-/TAG)TAGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP2BP Gene

Variant ID Type Subtype PubMed ID
nsv428456 CNV Gain+Loss 18775914

Variation tolerance for LRP2BP Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP2BP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP2BP Gene

Disorders for LRP2BP Gene

Relevant External Links for LRP2BP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP2BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP2BP Gene

Publications for LRP2BP Gene

  1. Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. (PMID: 12508107) Petersen H.H. … Willnow T.E. (J. Cell Sci. 2003) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. A 56-year-old female patient with facio-oculo-acoustico-renal syndrome (FOAR) syndrome. Report on the natural history and of a novel mutation. (PMID: 19577669) Stora S. … MAcgarbanAc A. (Eur J Med Genet 2009) 3
  4. Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin. (PMID: 19366958) Thrailkill K.M. … Fowlkes J.L. (Diabetes Care 2009) 3
  5. Renal tubule albumin transport. (PMID: 15709971) Gekle M. (Annu. Rev. Physiol. 2005) 23

Products for LRP2BP Gene

Sources for LRP2BP Gene

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