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Aliases for LRP2BP Gene

Aliases for LRP2BP Gene

  • LRP2 Binding Protein 2 3 5
  • Megalin-Binding Protein 3 4
  • MegBP 3 4
  • LRP2-Binding Protein 3
  • KIAA1325 4

External Ids for LRP2BP Gene

Previous GeneCards Identifiers for LRP2BP Gene

  • GC04M186661
  • GC04M186522
  • GC04M186285
  • GC04M182038

Summaries for LRP2BP Gene

GeneCards Summary for LRP2BP Gene

LRP2BP (LRP2 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LRP2BP Gene

  • May act as an adapter that regulates LRP2 function.

Additional gene information for LRP2BP Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP2BP Gene

Genomics for LRP2BP Gene

Regulatory Elements for LRP2BP Gene

Enhancers for LRP2BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H185357 1.1 Ensembl ENCODE 29.2 +38.0 38032 3 HDAC1 PKNOX1 ATF1 TCF12 GATA2 FOS ATF7 CREM SMARCB1 ZNF592 LRP2BP ANKRD37 UFSP2 LOC105377591 CFAP97
GH04H185394 1.1 ENCODE 26.2 +0.8 759 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 UFSP2 LRP2BP LOC105377591 C4orf47 SNX25 CFAP97 ANKRD37 GC04M185389
GH04H185303 1.4 Ensembl ENCODE dbSUPER 17.1 +90.5 90513 5 HDGF RB1 BATF RAD21 SCRT2 ZNF143 FOS ETV6 RUNX3 IKZF2 CFAP97 LRP2BP SNX25 LOC105377591
GH04H185318 1.3 ENCODE dbSUPER 17.2 +78.1 78092 1 PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B DMAP1 TCF12 GATA2 ATF7 LRP2BP CFAP97 LOC105377591
GH04H185343 1.2 Ensembl ENCODE dbSUPER 18.2 +52.1 52098 2 SRF ZNF687 TBL1XR1 JUNB ELF1 BATF JUND HDAC2 POLR2A EED LRP2BP PDLIM3 UFSP2 LOC105377591 CFAP97
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRP2BP on UCSC Golden Path with GeneCards custom track

Promoters for LRP2BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for LRP2BP Gene

185,363,878 bp from pter
185,396,935 bp from pter
33,058 bases
Minus strand

Genomic View for LRP2BP Gene

Genes around LRP2BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP2BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP2BP Gene

Proteins for LRP2BP Gene

  • Protein details for LRP2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    LRP2-binding protein
    Protein Accession:
    Secondary Accessions:
    • A6NJR7
    • A7E219
    • B3KX83
    • Q9NSN6

    Protein attributes for LRP2BP Gene

    347 amino acids
    Molecular mass:
    39780 Da
    Quaternary structure:
    • Interacts with LRP2.
    • Sequence=BAA92563.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP2BP Gene


neXtProt entry for LRP2BP Gene

Post-translational modifications for LRP2BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRP2BP Gene

Domains & Families for LRP2BP Gene

Gene Families for LRP2BP Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for LRP2BP Gene

Suggested Antigen Peptide Sequences for LRP2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with LRP2BP: view

No data available for UniProtKB/Swiss-Prot for LRP2BP Gene

Function for LRP2BP Gene

Molecular function for LRP2BP Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter that regulates LRP2 function.

Phenotypes From GWAS Catalog for LRP2BP Gene

Gene Ontology (GO) - Molecular Function for LRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12508107
genes like me logo Genes that share ontologies with LRP2BP: view
genes like me logo Genes that share phenotypes with LRP2BP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRP2BP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP2BP Gene

Localization for LRP2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP2BP Gene

Cytoplasm. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP2BP gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LRP2BP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LRP2BP Gene

Pathways & Interactions for LRP2BP Gene

SuperPathways for LRP2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP2BP Gene


No data available for Pathways by source and SIGNOR curated interactions for LRP2BP Gene

Drugs & Compounds for LRP2BP Gene

No Compound Related Data Available

Transcripts for LRP2BP Gene

Unigene Clusters for LRP2BP Gene

LRP2 binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LRP2BP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LRP2BP Gene

No ASD Table

Relevant External Links for LRP2BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP2BP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRP2BP Gene

Protein differential expression in normal tissues from HIPED for LRP2BP Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP2BP Gene

Protein tissue co-expression partners for LRP2BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP2BP Gene:


SOURCE GeneReport for Unigene cluster for LRP2BP Gene:


Evidence on tissue expression from TISSUES for LRP2BP Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with LRP2BP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP2BP Gene

Orthologs for LRP2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP2BP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP2BP 33 34
  • 99.81 (n)
(Canis familiaris)
Mammalia LRP2BP 33 34
  • 89.43 (n)
(Bos Taurus)
Mammalia LRP2BP 33 34
  • 88.47 (n)
(Rattus norvegicus)
Mammalia Lrp2bp 33
  • 84.06 (n)
(Mus musculus)
Mammalia Lrp2bp 16 34 33
  • 82.71 (n)
(Monodelphis domestica)
Mammalia LRP2BP 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia LRP2BP 34
  • 66 (a)
(Gallus gallus)
Aves LRP2BP 33 34
  • 68.76 (n)
(Anolis carolinensis)
Reptilia LRP2BP 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp2bp 33
  • 61.49 (n)
(Danio rerio)
Actinopterygii lrp2bp 33 34
  • 57.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
Species where no ortholog for LRP2BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP2BP Gene

Gene Tree for LRP2BP (if available)
Gene Tree for LRP2BP (if available)

Paralogs for LRP2BP Gene

No data available for Paralogs for LRP2BP Gene

Variants for LRP2BP Gene

Sequence variations from dbSNP and Humsavar for LRP2BP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000035665 -- 185,381,569(+) GAAGA(A/C)TGCTT intron-variant, upstream-variant-2KB
rs1000157102 -- 185,396,159(+) CCCTG(C/T)GCGGG intron-variant, upstream-variant-2KB
rs1000296286 -- 185,378,317(+) CTCAT(C/T)GCCTA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000377933 -- 185,396,345(+) ACGGG(A/G)AGCTG intron-variant, upstream-variant-2KB
rs1000404904 -- 185,390,085(+) TCTTT(C/T)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP2BP Gene

Variant ID Type Subtype PubMed ID
esv3603492 CNV gain 21293372
esv3603493 CNV gain 21293372
nsv428456 CNV gain+loss 18775914

Variation tolerance for LRP2BP Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP2BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP2BP Gene

Disorders for LRP2BP Gene

Relevant External Links for LRP2BP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP2BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP2BP Gene

Publications for LRP2BP Gene

  1. Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. (PMID: 12508107) Petersen HH … Willnow TE (Journal of cell science 2003) 2 3 4 60
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. A 56-year-old female patient with facio-oculo-acoustico-renal syndrome (FOAR) syndrome. Report on the natural history and of a novel mutation. (PMID: 19577669) Stora S … Mégarbané A (European journal of medical genetics 2009) 3 60
  5. Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin. (PMID: 19366958) Thrailkill KM … Fowlkes JL (Diabetes care 2009) 3 60

Products for LRP2BP Gene

Sources for LRP2BP Gene

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