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Aliases for LRP2BP Gene

Aliases for LRP2BP Gene

  • LRP2 Binding Protein 2 3 5
  • Megalin-Binding Protein 3 4
  • MegBP 3 4
  • LRP2-Binding Protein 3
  • KIAA1325 4

External Ids for LRP2BP Gene

Previous GeneCards Identifiers for LRP2BP Gene

  • GC04M186661
  • GC04M186522
  • GC04M186285
  • GC04M182038

Summaries for LRP2BP Gene

GeneCards Summary for LRP2BP Gene

LRP2BP (LRP2 Binding Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for LRP2BP Gene

  • May act as an adapter that regulates LRP2 function.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP2BP Gene

Genomics for LRP2BP Gene

Regulatory Elements for LRP2BP Gene

Enhancers for LRP2BP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F185357 0.5 Ensembl ENCODE 29.2 +38.0 38032 3.1 HDAC1 RAD21 GATA2 FOS CREM CEBPB SMARCB1 SMARCA4 PBX2 CEBPA LRP2BP ANKRD37 UFSP2 LOC105377591 CFAP97
GH04F185086 1.1 FANTOM5 Ensembl 29.1 +310.5 310543 0.4 L3MBTL2 ZBTB33 REST MGA LRP2BP CCDC110 HELT CASP3 PRIMPOL LOC105377588 SLC25A4
GH04F185383 0.2 ENCODE 22 +13.2 13196 1.1 CTBP1 SAP130 POLR2A HLF DPF2 CREM ATF2 ZBTB40 RXRB LRP2BP ANKRD37 LOC105377591
GH04F185343 0.9 Ensembl ENCODE 18.2 +52.1 52098 2.4 ATF1 MLX ARID4B SIN3A YY1 ELK1 SP5 MXD4 ZHX2 JUNB LRP2BP PRIMPOL UFSP2 LOC105377591 CFAP97
GH04F185318 1 ENCODE 17.2 +78.1 78092 1.3 PKNOX1 ATF1 ARNT MLX ARID4B DMAP1 GATA2 NCOA1 MIER2 PPARG LRP2BP CFAP97 LOC105377591
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around LRP2BP on UCSC Golden Path with GeneCards custom track

Promoters for LRP2BP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001255931 635 3401 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for LRP2BP Gene

Chromosome:
4
Start:
185,363,878 bp from pter
End:
185,396,935 bp from pter
Size:
33,058 bases
Orientation:
Minus strand

Genomic View for LRP2BP Gene

Genes around LRP2BP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP2BP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP2BP Gene

Proteins for LRP2BP Gene

  • Protein details for LRP2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2M1-LR2BP_HUMAN
    Recommended name:
    LRP2-binding protein
    Protein Accession:
    Q9P2M1
    Secondary Accessions:
    • A6NJR7
    • A7E219
    • B3KX83
    • Q9NSN6

    Protein attributes for LRP2BP Gene

    Size:
    347 amino acids
    Molecular mass:
    39780 Da
    Quaternary structure:
    • Interacts with LRP2.
    SequenceCaution:
    • Sequence=BAA92563.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP2BP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP2BP Gene

Post-translational modifications for LRP2BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRP2BP Gene

Domains & Families for LRP2BP Gene

Protein Domains for LRP2BP Gene

Suggested Antigen Peptide Sequences for LRP2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2M1

UniProtKB/Swiss-Prot:

LR2BP_HUMAN :
  • Contains 6 Sel1-like repeats.
Similarity:
  • Contains 6 Sel1-like repeats.
  • Contains 1 TPR repeat.
genes like me logo Genes that share domains with LRP2BP: view

No data available for Gene Families for LRP2BP Gene

Function for LRP2BP Gene

Molecular function for LRP2BP Gene

UniProtKB/Swiss-Prot Function:
May act as an adapter that regulates LRP2 function.

Gene Ontology (GO) - Molecular Function for LRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12508107
genes like me logo Genes that share ontologies with LRP2BP: view
genes like me logo Genes that share phenotypes with LRP2BP: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP2BP Gene

Localization for LRP2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP2BP Gene

Cytoplasm. Note=Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP2BP Gene COMPARTMENTS Subcellular localization image for LRP2BP gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRP2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LRP2BP: view

Pathways & Interactions for LRP2BP Gene

SuperPathways for LRP2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP2BP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LRP2BP Gene

Transcripts for LRP2BP Gene

Unigene Clusters for LRP2BP Gene

LRP2 binding protein:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP2BP Gene

No ASD Table

Relevant External Links for LRP2BP Gene

GeneLoc Exon Structure for
LRP2BP
ECgene alternative splicing isoforms for
LRP2BP

Expression for LRP2BP Gene

mRNA expression in normal human tissues for LRP2BP Gene

Protein differential expression in normal tissues from HIPED for LRP2BP Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP2BP Gene



Protein tissue co-expression partners for LRP2BP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP2BP Gene:

LRP2BP

SOURCE GeneReport for Unigene cluster for LRP2BP Gene:

Hs.558513
genes like me logo Genes that share expression patterns with LRP2BP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP2BP Gene

Orthologs for LRP2BP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP2BP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP2BP 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia LRP2BP 34 35
  • 89.43 (n)
cow
(Bos Taurus)
Mammalia LRP2BP 34 35
  • 88.47 (n)
rat
(Rattus norvegicus)
Mammalia Lrp2bp 34
  • 84.06 (n)
mouse
(Mus musculus)
Mammalia Lrp2bp 34 16 35
  • 82.71 (n)
oppossum
(Monodelphis domestica)
Mammalia LRP2BP 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP2BP 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRP2BP 34 35
  • 68.76 (n)
lizard
(Anolis carolinensis)
Reptilia LRP2BP 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp2bp 34
  • 61.49 (n)
zebrafish
(Danio rerio)
Actinopterygii lrp2bp 34 35
  • 57.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 49 (a)
OneToOne
Species where no ortholog for LRP2BP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP2BP Gene

ENSEMBL:
Gene Tree for LRP2BP (if available)
TreeFam:
Gene Tree for LRP2BP (if available)

Paralogs for LRP2BP Gene

No data available for Paralogs for LRP2BP Gene

Variants for LRP2BP Gene

Sequence variations from dbSNP and Humsavar for LRP2BP Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10007747 -- 185,377,439(+) CTTGA(A/C)CCCAG intron-variant
rs10015887 -- 185,375,299(+) TAAAA(A/C)TACAA intron-variant
rs10017920 -- 185,372,003(+) TACAC(C/T)GTGGG intron-variant
rs10018215 -- 185,381,252(+) GTTGT(G/T)TTAGT intron-variant, upstream-variant-2KB
rs10028515 -- 185,396,363(+) CTCCC(A/G)GTTTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRP2BP Gene

Variant ID Type Subtype PubMed ID
esv3603492 CNV gain 21293372
esv3603493 CNV gain 21293372
nsv428456 CNV gain+loss 18775914

Variation tolerance for LRP2BP Gene

Residual Variation Intolerance Score: 56.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP2BP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRP2BP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP2BP Gene

Disorders for LRP2BP Gene

Relevant External Links for LRP2BP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRP2BP

No disorders were found for LRP2BP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP2BP Gene

Publications for LRP2BP Gene

  1. Functional interaction of megalin with the megalin-binding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. (PMID: 12508107) Petersen H.H. … Willnow T.E. (J. Cell Sci. 2003) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Microalbuminuria in type 1 diabetes is associated with enhanced excretion of the endocytic multiligand receptors megalin and cubilin. (PMID: 19366958) Thrailkill K.M. … Fowlkes J.L. (Diabetes Care 2009) 3 64
  4. A 56-year-old female patient with facio-oculo-acoustico-renal syndrome (FOAR) syndrome. Report on the natural history and of a novel mutation. (PMID: 19577669) Stora S. … MAcgarbanAc A. (Eur J Med Genet 2009) 3 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for LRP2BP Gene

Sources for LRP2BP Gene

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