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LRP2 Gene

protein-coding GIFtS: 62

GC02M169693

low density lipoprotein-related protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DBS ^¹, ², ⁵
Megalin ^³
gp330 ^¹, ², ³
megalin ^²

Descriptions
Glycoprotein 330 ^³
Heymann nephritis antigen homolog ^²
calcium sensor protein ^²
low density lipoprotein-related protein 2 ^²

External Ids
HGNC: 6694¹
Entrez Gene: 4036²
UniProtKB: P98164³
Ensembl: ENSG00000081479⁷

Search outside databases for aliases for LRP2 gene

Previous GC identifers: GC02M168036 GC02M168526 GC02M169947 GC02M170187 GC02M169810

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LRP2:

Lipoprotein receptor-related protein-2 (LRP2), also called glycoprotein-330 or megalin (Farquhar,

1995 [PubMed 7657789]), is part of the Heymann nephritis antigenic complex with RAP (LRPAP1; MIM

104225) (Farquhar et al., 1995 [PubMed 7579068]) and is a member of a family of receptors with

structural similarities to the low density lipoprotein receptor (LDLR; MIM 606945).[supplied by

OMIM]

UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164

Function: Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in

regulation of parathyroid-hormone and para-thyroid-hormone-related protein release

Gene Wiki entry for LRP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LRP2 gene

Entrez Gene cytogenetic band: 2q24-q31 Ensembl cytogenetic band: 2q31.1 HGNC cytogenetic band: 2q24-q31

LRP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M169693: (about GC identifiers)

Start:	169,691,865 bp from pter
End:	169,927,368 bp from pter
Size:	235,504 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164 (See protein sequence)

Recommended Name: Low-density lipoprotein receptor-related protein 2 precursor

Size: 4655 amino acids; 521958 Da

Subunit: Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen

activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase,

lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a

receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts

with LRP2BP

Subcellular location: Membrane; Single-pass type I membrane protein. Membrane, coated pit

Secondary accessions: O00711 Q16215

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004516.2

ENSEMBL proteins:

ENSP00000263816

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Lrp2 / Megalin)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/11 Gene Ontology (GO) cellular component terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	IEA	--
GO:0005764	lysosome	TAS	7768901
GO:0005768	endosome	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	IEA	--

About this table

Antibodies for LRP2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for LRP2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Lrp2 / Megalin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LRP2)
	Search Novus for antibodies for LRP2

Assays for LRP2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P98164

ProtoNet protein and cluster: P98164

4 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164

Similarity: Belongs to the LDLR family

Similarity: Contains 17 EGF-like domains

Similarity: Contains 36 LDL-receptor class A domains

Similarity: Contains 37 LDL-receptor class B repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LRP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LRP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004525

Applied Biosystems Silencer® siRNAs for LRP2

Sigma-Aldrich siRNA and siRNA Panels for LRP2

Sigma-Aldrich shRNA for LRP2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004525
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004525
untagged cDNA clone in CMV expression vector: NM_004525

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004525

UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164

Function: Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in

regulation of parathyroid-hormone and para-thyroid-hormone-related protein release

Genatlas biochemistry entry for LRP2:

multifunctional clearance receptor,Ca++ binding megalin (glycoprotein 330,gp330),LDLR receptor

superfamily,expressed in the neuroepithelium and in proximal tubular cells of the

kidney,possessing broad ligand specificity and mediating the uptake and lysosomal degradation of

macromolecules including lipoproteins,proteases and protease inhibitors and in vivo the Ca2+

sensing in the parathyroids and renal uptake and activation of CYP25D1A,also expressed on the

apical surfaces of epithelial cells lining specific regions of the male and female reproductive

tracts and in seminal vesicle (rat) where it acts as an endocytic receptor for seminal vesicle

secretory protein 2

14 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lrp2):

cellular	craniofacial	embryogenesis	endocrine/exocrine gland	growth/size
hearing/vestibular/ear	homeostasis/metabolism	lethality-prenatal/perinatal	nervous system	renal/urinary system
reproductive system	respiratory system	skeleton	vision/eye

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	9773776 14528014
GO:0017124	SH3 domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for LRP2

5/53 Interacting proteins for LRP2 (ENSP00000263816³ P98164^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 53 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-947916, EBI-375543
ATN1	P54259²	MINT-2860530
GIPC1	ENSP00000340698³	STRING (score=.999)
GC	ENSP00000273951³	STRING (score=.997)
SHH	ENSP00000297261³	STRING (score=.993)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006486	protein amino acid glycosylation	TAS	2786251
GO:0006629	lipid metabolic process	TAS	7768901
GO:0006766	vitamin metabolic process	IEA	--
GO:0006898	receptor-mediated endocytosis	TAS	7768901
GO:0008283	cell proliferation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LRP2
10/14 Novoseek chemical compound relationships for LRP2 gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	53.53	132	1861632 (4), 1382088 (3), 9872924 (2), 9336177 (2) (see all 68)
aminoglycosides	44.67	8	16679740 (3), 7544804 (1), 11700326 (1), 17909519 (1) (see all 6)
ryanodine	24.82	3	9202848 (1), 12731896 (1), 10341294 (1)
dbc-amp	10.85	1	7768901 (1)
lipid	4.77	8	11132040 (1), 15457546 (1), 18174661 (1), 15891391 (1) (see all 6)
allergens	4.51	2	9935306 (1), 9648704 (1)
nitric oxide	3.54	1	11689164 (1)
cholesterol	3.21	11	18174661 (2), 15469912 (1), 18791690 (1), 15375181 (1)
sodium	0.00	1	12620920 (1)
phospholipid	0.00	1	9727058 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LRP2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LRP2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004525

Sigma-Aldrich siRNA and siRNA Panels for LRP2

Sigma-Aldrich shRNA for LRP2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004525

REFSEQ mRNAs for LRP2 gene:

NM_004525.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004525

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004525
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004525
                                 untagged cDNA clone in CMV expression vector: NM_004525

Additional cDNA sequence:

AK295005.1 AK302843.1 AY265357.1 AY265358.1 S73145.1 U04441.1 U33837.1

4 DOTS entries:

DT.308793 DT.75124593 DT.70101705 DT.120996083

24/85 AceView cDNA sequences (see all 85 ):

BQ025820 AY265358 AW025388 S73145 AL698960 BF772450 AW149108 AI668574

U33837 AL698310 BQ023258 AW296105 BF196079 BU754442 R76808 NM_004525

BM929864 AU117089 BG399256 BG399349 AI470538 CD673312 AL713126 AI821456

highest scoring ESTs for LRP2:

U33837 AY265357 AY265358 AA507421 AI025985 AI307253 AI308239 AI436683 AI613124 AI760092

Unigene Cluster for LRP2:

Low density lipoprotein-related protein 2

Hs.657729 [show with all ESTs]

Unigene Representative Sequence: NM_004525

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000263816

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LRP2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LRP2

¹ / ² / ³

6 probe-sets matching LRP2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
85083_at²^{, 3}	U95-D	1	1.00	1.00	0.81	1.24	AA507421	0.60	1.00	0.82	1
35009_at²^{, 3}	U95-A	1	0.94	1.00	0.92	0.83	U33837	1.00	1.00	1.00	1
205710_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004525	0.60	1.00	0.82	1
230863_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R73030	0.20	1.00	0.72	1
205710_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
230863_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LRP2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.657729
Expression variation in blood from EXPOLDB for LRP2
UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164
Tissue specificity: Absorptive epithelia, including renal proximal tubules

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LRP2 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LRP2¹	--	low density lipoprotein-related protein 2	84.7(n) 79.29(a)	478781 XM_535946.2 XP_535946.2
chimpanzee (Pan troglodytes)	LRP2¹	--	low density lipoprotein-related protein 2	99.47(n) 99.48(a)	459713 XM_515882.2 XP_515882.2
cow (Bos taurus)	LRP2¹	--	low density lipoprotein-related protein 2	79.91(n) 69.61(a)	514768 XM_592673.3 XP_592673.3
rat (Rattus norvegicus)	Lrp2¹	--	low density lipoprotein-related protein 2	79.68(n) 76.65(a)	29216 NM_030827.1 NP_110454.1
mouse (Mus musculus)	Lrp2^{1, 5}	2 (40.00 cM)⁵	low density lipoprotein receptor-related protein 2^{1, 5}	80.05(n)¹ 76.95(a)¹	14725¹ NM_001081088.1¹ NP_001074557.1¹ AA560330⁵ AF197160⁵ (see all 23)

About this table Species with no ortholog for LRP2

ENSEMBL Gene Tree for LRP2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LRP2 gene

VLDLR² LDLR² LRP8²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1455 NCBI SNPs in LRP2 are shown (see all 1455 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 447)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2075252^1,2	A,C,F,H,O	169719231(-)	`ATCCCA/GAGGAC`	1	K/E	mis¹		19		EA NA EU WA	2560
	rs3755166^1,2	A,C,F,H	169928127(+)	`TCCTTG/ATTTAG`	1	--	ng3¹		11		EA NA EU WA	2284
	rs4667591^1,2	A,C,F,H	169711678(+)	`CTCGAT/GTTTAG`	1	L/I	mis¹		13		EA NA EU WA	1132
	rs2228168^1,2	C,F,H	169776810(-)	`TTTCAT/CTGTTG`	1	T/I	mis¹		13		MN NA EU EA WA	1106
	rs4667596^1,2	C,F,H	169778418(+)	`TGCGTC/TTGTGA`	1	R/K	mis¹		8		EU EA WA	826
	rs17848149^1,2	C,F	169805953(-)	`CTGTGA/CCAACG`	1	D/A	mis¹ ese³		5		NA EU EA WA	496
	rs17848169^1,2	C,F	169768849(-)	`CCACAA/GATTTG`	1	N/D	mis¹ ese³		5		NA EU EA WA	498
	rs34291900^1,2	C,F	169837793(-)	`TGGGGG/ACTGTG`	1	D/G	mis¹		5		NA EU EA WA	498
--	rs2228171^1,2	C,F	169761751(-)	`AATGCG/ACATCT`	1	T/A	mis¹		17		MN EA NA EU WA	2610
	rs12612683^1,2	A,C	169928840(+)	`TACTTC/TGGAAA`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for LRP2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600073 disorders: 222448

UniProtKB/Swiss-Prot: LRP2_HUMAN, P98164

Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also called

faciooculoacousticorenal (FOAR) syndrome. DBS is a rare autosomal recessive disorder characterized

by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia,

facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The

FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural

hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the

classic distinguishing features between the 2 disorders were presence of proteinuria and absence

of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2

disorders shared many phenotypic features and may be identical. Although there is variability in

the expression of some features (e.g., agenesis of the corpus callosum and proteinuria), DBS and

FOAR are now considered to represent the same entity

10/29 Novoseek disease relationships for LRP2 gene (see all 29 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dent disease	89.34	11	15052463 (4), 11752029 (2), 15338396 (1), 18025833 (1) (see all 7)
nephropathy membranous	80.14	8	9207124 (1), 16189625 (1), 2133428 (1), 1495959 (1) (see all 7)
glomerulonephritis	71.82	43	2133428 (6), 7944157 (2), 1495959 (2), 8238258 (2) (see all 22)
proteinuria	65.55	13	10514418 (3), 11132040 (1), 12187318 (1), 17729440 (1) (see all 11)
membranous nephritis	64.51	2	10886254 (1)
cystinosis	52.56	1	18455850 (1)
lowe syndrome	50.51	2	11752029 (2)
hypercalciuria	49.01	2	15052463 (1), 17708714 (1)
holoprosencephaly	47.36	1	11228189 (1)
nephrocalcinosis	38.14	1	15052463 (1)

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GeneTests: LRP2

Donnai-Barrow Syndrome

Human Gene Mutation Database: LRP2
Human Genome Epidemiology Navigator: LRP2 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/309 PubMed articles for LRP2 gene (see all 309 ):

Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1). (PubMed id 7959795)^{1, 2, 3, 4} Korenberg J.R....Argraves W.S. (1994)
Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. (PubMed id 7768901)^{1, 3, 4} Kounnas M.Z.... Argraves W.S. (1995)
Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties. (PubMed id 8706697)^{1, 3, 4} Hjaelm G.... Morse B. (1996)
Mutations in LRP2, which encodes the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. (PubMed id 17632512)^{3, 4} Kantarci S.... Pober B.R. (2007)
Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. (PubMed id 12508107)^{3, 4} Petersen H.H....Willnow T.E. (2003)
A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily. (PubMed id 8187828)^{3, 4} Lundgren S.... Rask L. (1994)
The Heymann nephritis antigenic complex: megalin (gp330) and RAP. (PubMed id 7579068)^{1, 3} Farquhar M.G....Orlando R.A. (1995)
Autoantibodies to low-density-lipoprotein-receptor-related protein 2 (LRP2) in systemic autoimmune diseases. (PubMed id 12723989)^{1, 3} Ooka S....Kato T. (2003)
Evidence for the role of megalin in renal uptake of transthyretin. (PubMed id 10982792)^{1, 3} Sousa M.M....Saraiva M.J. (2000)
The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes. (PubMed id 11274227)^{1, 3} Patrie K.M....Margolis B. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 4036	HGNC: 6694	AceView: LRP2	Ensembl:ENSG00000081479	euGenes: HUgn4036
ECgene: LRP2	H-InvDB: LRP2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LRP2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LRP2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LRP2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LRP2		Antibodies for LRP2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LRP2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Antibodies (Lrp2 / Megalin)

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LRP2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
LRP2 Gene at Home site.
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LRP2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for LRP2

Summaries
for LRP2

Genomic Location
for LRP2

Proteins
for LRP2

Protein Domains/
Families
for LRP2

Gene Function
for LRP2

Pathways & Interactions
for LRP2

Drugs & Compounds
for LRP2

Transcripts
for LRP2

Expression
for LRP2

Orthologs
for LRP2

Paralogs
for LRP2

SNPs/Variants
for LRP2

Disorders & Mutations
for LRP2

Medical News
for LRP2

Publications
for LRP2

Search for LRP2

Genome Databases showing LRP2

Other Databases showing LRP2

Specialized Databases showing LRP2

Licensable Technologies
for LRP2

Services
for LRP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LRP2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor LRP2

Summariesfor LRP2

Genomic Locationfor LRP2

Proteinsfor LRP2

Protein Domains/Familiesfor LRP2

Gene Functionfor LRP2

Pathways & Interactionsfor LRP2

Drugs & Compoundsfor LRP2

Transcriptsfor LRP2

Expression for LRP2

Orthologsfor LRP2

Paralogsfor LRP2

SNPs/Variantsfor LRP2

Disorders & Mutationsfor LRP2

Medical Newsfor LRP2

Publicationsfor LRP2

Search for LRP2

Genome Databases showing LRP2

Other Databases showing LRP2

Specialized Databases showing LRP2

Licensable Technologiesfor LRP2

Servicesfor LRP2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LRP2

Summaries
for LRP2

Genomic Location
for LRP2

Proteins
for LRP2

Protein Domains/
Families
for LRP2

Gene Function
for LRP2

Pathways & Interactions
for LRP2

Drugs & Compounds
for LRP2

Transcripts
for LRP2

Expression
for LRP2

Orthologs
for LRP2

Paralogs
for LRP2

SNPs/Variants
for LRP2

Disorders & Mutations
for LRP2

Medical News
for LRP2

Publications
for LRP2

Licensable Technologies
for LRP2

Services
for LRP2