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Aliases for LRP1B Gene

Aliases for LRP1B Gene

  • Low Density Lipoprotein Receptor-Related Protein 1B 2 3
  • Low-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor 3 4
  • LRP-Deleted In Tumors 2 3
  • LRP-DIT 3 4
  • LRP-1B 3 4
  • LRPDIT 3 4
  • Low Density Lipoprotein Receptor Related Protein-Deleted In Tumor 3
  • Low Density Lipoprotein-Related Protein 1B (Deleted In Tumors) 3
  • Low-Density Lipoprotein Receptor-Related Protein 1B 3
  • EC 3.4.21.9 63
  • EC 1.1.1.94 63

External Ids for LRP1B Gene

Previous GeneCards Identifiers for LRP1B Gene

  • GC02M138677
  • GC02M139296
  • GC02M141011
  • GC02M141199
  • GC02M140822
  • GC02M140705
  • GC02M132979
  • GC02M141012
  • GC02M141017
  • GC02M141020
  • GC02M141023

Summaries for LRP1B Gene

Entrez Gene Summary for LRP1B Gene

  • LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001 [PubMed 11384978]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRP1B Gene

LRP1B (Low Density Lipoprotein Receptor-Related Protein 1B) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and low-density lipoprotein receptor activity. An important paralog of this gene is LDLR.

UniProtKB/Swiss-Prot for LRP1B Gene

  • Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis

Gene Wiki entry for LRP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP1B Gene

Genomics for LRP1B Gene

Genomic Location for LRP1B Gene

Start:
140,231,423 bp from pter
End:
142,131,701 bp from pter
Size:
1,900,279 bases
Orientation:
Minus strand

Genomic View for LRP1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP1B Gene

Proteins for LRP1B Gene

  • Protein details for LRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZR2-LRP1B_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 1B
    Protein Accession:
    Q9NZR2
    Secondary Accessions:
    • Q8WY29
    • Q8WY30
    • Q8WY31

    Protein attributes for LRP1B Gene

    Size:
    4599 amino acids
    Molecular mass:
    515498 Da
    Quaternary structure:
    • Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands
    Miscellaneous:
    • The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs

neXtProt entry for LRP1B Gene

Proteomics data for LRP1B Gene at MOPED

Selected DME Specific Peptides for LRP1B Gene

Post-translational modifications for LRP1B Gene

  • Glycosylation at Asn134, Asn190, Asn220, Asn313, Asn360, Asn443, Asn725, Asn758, Asn829, Asn883, Asn919, Asn1041, Asn1089, Asn1145, Asn1209, Asn1298, Asn1502, Asn1549, Asn1636, Asn1754, Asn1816, Asn1921, Asn1983, Asn2105, Asn2458, Asn2488, Asn2507, Asn2549, Asn2626, Asn2647, Asn2802, Asn2892, Asn3034, Asn3066, Asn3076, Asn3164, Asn3310, Asn3316, Asn3682, Asn3877, Asn3894, Asn3906, Asn4017, Asn4204, Asn4381, and Asn4420
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP1B Gene

Domains for LRP1B Gene

Gene Families for LRP1B Gene

HGNC:
  • LDLR :Low density lipoprotein receptors

Graphical View of Domain Structure for InterPro Entry

Q9NZR2

UniProtKB/Swiss-Prot:

LRP1B_HUMAN :
  • Q9NZR2
Domain:
  • Contains 22 EGF-like domains.
  • Contains 32 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
Similarity:
  • Contains 34 LDL-receptor class B repeats.
genes like me logo Genes that share domains with LRP1B: view

Function for LRP1B Gene

Molecular function for LRP1B Gene

UniProtKB/Swiss-Prot Function: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis

Enzyme Numbers (IUBMB) for LRP1B Gene

Gene Ontology (GO) - Molecular Function for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRP1B: view

Phenotypes for LRP1B Gene

genes like me logo Genes that share phenotypes with LRP1B: view

Animal Models for LRP1B Gene

MGI Knock Outs for LRP1B:

miRNA for LRP1B Gene

miRTarBase miRNAs that target LRP1B

No data available for Transcription Factor Targeting and HOMER Transcription for LRP1B Gene

Localization for LRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP1B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP1B Gene COMPARTMENTS Subcellular localization image for LRP1B gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0043235 receptor complex IDA 23382219
genes like me logo Genes that share ontologies with LRP1B: view

Pathways for LRP1B Gene

SuperPathways for LRP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006898 receptor-mediated endocytosis IEA --
GO:0015031 protein transport TAS 10766186
genes like me logo Genes that share ontologies with LRP1B: view

No data available for Pathways by source for LRP1B Gene

Transcripts for LRP1B Gene

mRNA/cDNA for LRP1B Gene

Unigene Clusters for LRP1B Gene

Low density lipoprotein receptor-related protein 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP1B Gene

No ASD Table

Relevant External Links for LRP1B Gene

GeneLoc Exon Structure for
LRP1B
ECgene alternative splicing isoforms for
LRP1B

Expression for LRP1B Gene

mRNA expression in normal human tissues for LRP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRP1B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRP1B Gene

SOURCE GeneReport for Unigene cluster for LRP1B Gene Hs.656461

mRNA Expression by UniProt/SwissProt for LRP1B Gene

Q9NZR2-LRP1B_HUMAN
Tissue specificity: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.
genes like me logo Genes that share expressions with LRP1B: view

Orthologs for LRP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP1B 35
  • 99.38 (n)
  • 99.43 (a)
LRP1B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP1B 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP1B 35
  • 93.55 (n)
  • 96.87 (a)
LRP1B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp1b 35
  • 87.88 (n)
  • 91.65 (a)
Lrp1b 16
Lrp1b 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP1B 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves LRP1B 35
  • 81.53 (n)
  • 86.21 (a)
LRP1B 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP1B 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp1b 35
  • 76.06 (n)
  • 80.15 (a)
zebrafish
(Danio rerio)
Actinopterygii lrp1ba 36
  • 65 (a)
OneToMany
lrp1ba 36
  • 67 (a)
OneToMany
lrp1bb 35
  • 68.54 (n)
  • 71.03 (a)
lrp1bb 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta yl 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F14B4.1 36
  • 27 (a)
OneToMany
B0244.8 37
  • 34 (a)
R01H2.3 37
  • 34 (a)
F47B3.8 37
  • 28 (a)
T21E3.3 37
  • 29 (a)
rme-2 37
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToMany
Species with no ortholog for LRP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP1B Gene

ENSEMBL:
Gene Tree for LRP1B (if available)
TreeFam:
Gene Tree for LRP1B (if available)

Paralogs for LRP1B Gene

Paralogs for LRP1B Gene

genes like me logo Genes that share paralogs with LRP1B: view

Variants for LRP1B Gene

Sequence variations from dbSNP and Humsavar for LRP1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs164975 -- 141,677,344(+) AAACC(A/C)TATTG intron-variant
rs164976 -- 141,677,646(+) cacca(C/T)gcccc intron-variant
rs164977 -- 141,677,722(+) gacct(C/T)gggtg intron-variant
rs164978 -- 141,678,554(+) caatg(C/T)ggata intron-variant
rs164979 -- 141,678,890(+) aaact(C/T)cagcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP1B Gene

Variant ID Type Subtype PubMed ID
nsv875180 CNV Gain 21882294
nsv834392 CNV Gain 17160897
esv270708 CNV Insertion 20981092
nsv2948 CNV Insertion 18451855
nsv875185 CNV Loss 21882294
esv2658234 CNV Deletion 23128226
nsv459496 CNV Loss 19166990
nsv875186 CNV Loss 21882294
nsv459507 CNV Loss 19166990
nsv470488 CNV Loss 18288195
nsv875187 CNV Loss 21882294
dgv4323n71 CNV Loss 21882294
dgv4324n71 CNV Loss 21882294
nsv459518 CNV Loss 19166990
nsv433205 CNV Loss 18776910
esv988978 CNV Insertion 20482838
esv2720896 CNV Deletion 23290073
esv2720897 CNV Deletion 23290073
esv2740831 CNV Deletion 23290073
dgv667e201 CNV Deletion 23290073
esv2720899 CNV Deletion 23290073
nsv459529 CNV Gain 19166990
nsv875193 CNV Loss 21882294
dgv229n21 CNV Gain 19592680
nsv528276 CNV Gain 19592680
dgv4325n71 CNV Loss 21882294
dgv4326n71 CNV Loss 21882294
dgv4327n71 CNV Loss 21882294
dgv477n27 CNV Loss 19166990
nsv875200 CNV Loss 21882294
dgv4328n71 CNV Loss 21882294
dgv4329n71 CNV Loss 21882294
nsv875206 CNV Loss 21882294
nsv821736 CNV Loss 20364138
esv272096 CNV Insertion 20981092
esv272817 CNV Insertion 20981092
esv2484504 CNV Deletion 19546169
esv2066444 CNV Deletion 18987734
nsv507037 CNV Insertion 20534489
nsv875208 CNV Loss 21882294
nsv470490 CNV Loss 18288195
nsv470489 CNV Gain 18288195
nsv875209 CNV Loss 21882294
esv2720901 CNV Deletion 23290073
nsv875210 CNV Loss 21882294
nsv875211 CNV Loss 21882294
esv2480394 CNV Deletion 19546169
esv2660530 CNV Deletion 23128226
dgv4330n71 CNV Loss 21882294
nsv875213 CNV Loss 21882294
dgv4331n71 CNV Loss 21882294
dgv4332n71 CNV Loss 21882294
dgv4333n71 CNV Loss 21882294
nsv459574 CNV Loss 19166990
esv271498 CNV Insertion 20981092
nsv875224 CNV Loss 21882294
nsv875228 CNV Loss 21882294
nsv459585 CNV Loss 19166990
nsv818086 CNV Loss 17921354
nsv875229 CNV Loss 21882294
nsv821737 CNV Gain 20364138
nsv819672 CNV Gain 19587683
esv1002626 CNV Loss 20482838
esv1010724 CNV Deletion 20482838
nsv875230 CNV Loss 21882294
esv2720902 CNV Deletion 23290073
esv2720903 CNV Deletion 23290073
dgv1266e1 CNV Complex 17122850
esv2675340 CNV Deletion 23128226
nsv517341 CNV Loss 19592680
dgv4334n71 CNV Loss 21882294
esv269631 CNV Insertion 20981092
esv273483 CNV Insertion 20981092
nsv522203 CNV Loss 19592680
nsv215437 CNV Loss 16902084
nsv875233 CNV Loss 21882294
nsv875234 CNV Loss 21882294
nsv875235 CNV Loss 21882294
dgv4335n71 CNV Loss 21882294
nsv522093 CNV Gain 19592680
nsv459596 CNV Loss 19166990
dgv161e55 CNV Gain 17911159
nsv523571 CNV Loss 19592680
nsv875239 CNV Gain 21882294
essv9580 CNV CNV 17122850
nsv821738 CNV Gain 20364138
nsv875240 CNV Loss 21882294
nsv526332 CNV Loss 19592680
nsv875241 CNV Gain 21882294
esv1011284 CNV Insertion 20482838
esv1511272 CNV Insertion 17803354
nsv214199 CNV Insertion 16902084
nsv875242 CNV Loss 21882294
nsv875243 CNV Loss 21882294
nsv516298 CNV Gain 19592680
nsv214554 CNV Insertion 16902084
nsv10196 CNV Gain 18304495
esv27616 CNV Loss 19812545
nsv821739 CNV Loss 20364138
nsv459618 CNV Loss 19166990
nsv470491 CNV Loss 18288195
dgv735e199 CNV Deletion 23128226
nsv821740 CNV Loss 20364138
esv2720904 CNV Deletion 23290073
nsv441788 CNV CNV 18776908
nsv834393 CNV Gain 17160897
nsv459629 CNV Loss 19166990
nsv459640 CNV Loss 19166990
nsv518726 CNV Loss 19592680
dgv736e199 CNV Deletion 23128226
esv24931 CNV Loss 19812545
esv2667057 CNV Deletion 23128226
esv274263 CNV Insertion 20981092
esv271763 CNV Insertion 20981092
dgv4336n71 CNV Loss 21882294
esv2425365 CNV Deletion 19546169
esv1935046 CNV Deletion 18987734
esv3645 CNV Deletion 18987735
esv2720905 CNV Deletion 23290073
esv9456 CNV Loss 19470904
esv995362 CNV Deletion 20482838
esv1788294 CNV Deletion 17803354
nsv214324 CNV Loss 16902084
nsv511815 CNV Loss 21212237
esv2511578 CNV Deletion 19546169
esv2151280 CNV Deletion 18987734
esv2677390 CNV Deletion 23128226
esv2720907 CNV Deletion 23290073
nsv834394 CNV Gain 17160897
nsv433206 CNV Loss 18776910
nsv459651 CNV Loss 19166990
nsv470492 CNV Loss 18288195
dgv4337n71 CNV Loss 21882294
dgv4338n71 CNV Loss 21882294
nsv508111 CNV Loss 20534489
nsv459674 CNV Loss 19166990
esv1462127 CNV Insertion 17803354
nsv875251 CNV Loss 21882294
nsv875252 CNV Gain 21882294
esv268365 CNV Insertion 20981092
nsv526107 CNV Gain 19592680
esv269123 CNV Insertion 20981092
esv5978 CNV Loss 19470904
esv2720908 CNV Deletion 23290073
nsv875253 CNV Loss 21882294
nsv875254 CNV Loss 21882294

Relevant External Links for LRP1B Gene

HapMap Linkage Disequilibrium report
LRP1B
Human Gene Mutation Database (HGMD)
LRP1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP1B Gene

Disorders for LRP1B Gene

(3) Novoseek inferred disease relationships for LRP1B Gene

Disease -log(P) Hits PubMed IDs
cancer lung 28.6 2
carcinoma squamous cell 17.4 3
tumors 15.8 8

Relevant External Links for LRP1B

Genetic Association Database (GAD)
LRP1B
Human Genome Epidemiology (HuGE) Navigator
LRP1B
genes like me logo Genes that share disorders with LRP1B: view

No data available for UniProtKB/Swiss-Prot for LRP1B Gene

Publications for LRP1B Gene

  1. Genomic organization of a new candidate tumor suppressor gene, LRP1B. (PMID: 11031110) Liu C.-X. … Lisitsyn N.A. (Genomics 2000) 3 4 23
  2. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PMID: 11384978) Liu C.-X. … Bu G. (J. Biol. Chem. 2001) 3 4 23
  3. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. (PMID: 10766186) Liu C.-X. … Lisitsyn N.A. (Cancer Res. 2000) 2 3 4
  4. Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. (PMID: 12194987) Li Y. … Bu G. (J. Biol. Chem. 2002) 3 23
  5. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. (PMID: 15126508) Cam J.A. … Bu G. (J. Biol. Chem. 2004) 3 23

Products for LRP1B Gene

Sources for LRP1B Gene

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