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Aliases for LRP1B Gene

Aliases for LRP1B Gene

  • LDL Receptor Related Protein 1B 2 3 5
  • Low-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor 3 4
  • Low Density Lipoprotein Receptor-Related Protein 1B 2 3
  • LRP-Deleted In Tumors 2 3
  • LRP-DIT 3 4
  • LRP-1B 3 4
  • LRPDIT 3 4
  • Low Density Lipoprotein Receptor Related Protein-Deleted In Tumor 3
  • Low Density Lipoprotein-Related Protein 1B (Deleted In Tumors) 3
  • Candidate Tumor Suppressor Protein 3
  • EC 63
  • EC 63

External Ids for LRP1B Gene

Previous GeneCards Identifiers for LRP1B Gene

  • GC02M138677
  • GC02M139296
  • GC02M141011
  • GC02M141199
  • GC02M140822
  • GC02M140705
  • GC02M132979
  • GC02M141012
  • GC02M141017
  • GC02M141020
  • GC02M141023

Summaries for LRP1B Gene

Entrez Gene Summary for LRP1B Gene

  • LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001 [PubMed 11384978]).[supplied by OMIM, Mar 2008]

GeneCards Summary for LRP1B Gene

LRP1B (LDL Receptor Related Protein 1B) is a Protein Coding gene. Diseases associated with LRP1B include Endocervical Carcinoma. GO annotations related to this gene include calcium ion binding and low-density lipoprotein receptor activity. An important paralog of this gene is LRP1.

UniProtKB/Swiss-Prot for LRP1B Gene

  • Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Gene Wiki entry for LRP1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP1B Gene

Genomics for LRP1B Gene

Regulatory Elements for LRP1B Gene

Enhancers for LRP1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRP1B on UCSC Golden Path with GeneCards custom track

Promoters for LRP1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRP1B on UCSC Golden Path with GeneCards custom track

Genomic Location for LRP1B Gene

140,231,423 bp from pter
142,132,474 bp from pter
1,901,052 bases
Minus strand

Genomic View for LRP1B Gene

Genes around LRP1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP1B Gene

Proteins for LRP1B Gene

  • Protein details for LRP1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 1B
    Protein Accession:
    Secondary Accessions:
    • Q8WY29
    • Q8WY30
    • Q8WY31

    Protein attributes for LRP1B Gene

    4599 amino acids
    Molecular mass:
    515498 Da
    Quaternary structure:
    • Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands.
    • The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs.

neXtProt entry for LRP1B Gene

Proteomics data for LRP1B Gene at MOPED

Selected DME Specific Peptides for LRP1B Gene

Post-translational modifications for LRP1B Gene

  • Glycosylation at Asn 134, Asn 190, Asn 220, Asn 313, Asn 360, Asn 443, Asn 725, Asn 758, Asn 829, Asn 883, Asn 919, Asn 1041, Asn 1089, Asn 1145, Asn 1209, Asn 1298, Asn 1502, Asn 1549, Asn 1636, Asn 1754, Asn 1816, Asn 1921, Asn 1983, Asn 2105, Asn 2458, Asn 2488, Asn 2507, Asn 2549, Asn 2626, Asn 2647, Asn 2802, Asn 2892, Asn 3034, Asn 3066, Asn 3076, Asn 3164, Asn 3310, Asn 3316, Asn 3682, Asn 3877, Asn 3894, Asn 3906, Asn 4017, Asn 4204, Asn 4381, and Asn 4420
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP1B Gene

Domains & Families for LRP1B Gene

Gene Families for LRP1B Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 22 EGF-like domains.
  • Belongs to the LDLR family.
  • Contains 34 LDL-receptor class B repeats.
  • Contains 22 EGF-like domains.
  • Contains 32 LDL-receptor class A domains.
  • Belongs to the LDLR family.
  • Contains 34 LDL-receptor class B repeats.
genes like me logo Genes that share domains with LRP1B: view

Function for LRP1B Gene

Molecular function for LRP1B Gene

UniProtKB/Swiss-Prot Function:
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

Enzyme Numbers (IUBMB) for LRP1B Gene

Gene Ontology (GO) - Molecular Function for LRP1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with LRP1B: view
genes like me logo Genes that share phenotypes with LRP1B: view

Animal Models for LRP1B Gene

MGI Knock Outs for LRP1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP1B

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for LRP1B Gene

Localization for LRP1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP1B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRP1B Gene COMPARTMENTS Subcellular localization image for LRP1B gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for LRP1B Gene

Pathways & Interactions for LRP1B Gene

SuperPathways for LRP1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for LRP1B Gene


No data available for Pathways by source and SIGNOR curated interactions for LRP1B Gene

Drugs & Compounds for LRP1B Gene

(1) Drugs for LRP1B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
COG 133 Pharma ApoE mimetic peptide, ApoE peptide fragment 0

(1) ApexBio Compounds for LRP1B Gene

Compound Action Cas Number
COG 133 ApoE mimetic peptide 514200-66-9
genes like me logo Genes that share compounds with LRP1B: view

Transcripts for LRP1B Gene

Unigene Clusters for LRP1B Gene

Low density lipoprotein receptor-related protein 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP1B Gene

No ASD Table

Relevant External Links for LRP1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP1B Gene

mRNA expression in normal human tissues for LRP1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRP1B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for LRP1B Gene

This gene is overexpressed in Prostate (21.5), Breast (18.4), Neutrophil (13.6), and Ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LRP1B Gene

SOURCE GeneReport for Unigene cluster for LRP1B Gene Hs.656461

mRNA Expression by UniProt/SwissProt for LRP1B Gene

Tissue specificity: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain.
genes like me logo Genes that share expression patterns with LRP1B: view

Primer Products

No data available for Protein tissue co-expression partners for LRP1B Gene

Orthologs for LRP1B Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP1B Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LRP1B 35
  • 93.55 (n)
  • 96.87 (a)
LRP1B 36
  • 97 (a)
(Mus musculus)
Mammalia Lrp1b 35
  • 87.88 (n)
  • 91.65 (a)
Lrp1b 16
Lrp1b 36
  • 91 (a)
(Pan troglodytes)
Mammalia LRP1B 35
  • 99.38 (n)
  • 99.43 (a)
LRP1B 36
  • 99 (a)
(Bos Taurus)
Mammalia LRP1B 36
  • 95 (a)
(Monodelphis domestica)
Mammalia LRP1B 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
-- 36
  • 81 (a)
-- 36
  • 86 (a)
(Gallus gallus)
Aves LRP1B 35
  • 81.53 (n)
  • 86.21 (a)
LRP1B 36
  • 84 (a)
(Anolis carolinensis)
Reptilia LRP1B 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp1b 35
  • 76.06 (n)
  • 80.15 (a)
(Danio rerio)
Actinopterygii lrp1bb 35
  • 68.54 (n)
  • 71.03 (a)
lrp1ba 36
  • 65 (a)
lrp1ba 36
  • 67 (a)
lrp1bb 36
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta yl 37
  • 27 (a)
(Caenorhabditis elegans)
Secernentea B0244.8 37
  • 34 (a)
F47B3.8 37
  • 28 (a)
R01H2.3 37
  • 34 (a)
rme-2 37
  • 25 (a)
T21E3.3 37
  • 29 (a)
F14B4.1 36
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for LRP1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP1B Gene

Gene Tree for LRP1B (if available)
Gene Tree for LRP1B (if available)

Paralogs for LRP1B Gene

Paralogs for LRP1B Gene

genes like me logo Genes that share paralogs with LRP1B: view

Variants for LRP1B Gene

Sequence variations from dbSNP and Humsavar for LRP1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs371536401 - 140,475,294(+) AACAC(A/G)GCCAA reference, missense
rs12990449 - 141,810,341(+) AGCTC(C/T)GGGAG reference, missense
rs34488772 - 140,485,349(-) TCCTC(A/G)AGCTG reference, missense
rs1878740 - 140,442,546(-) GTGAC(A/G)AGGAT reference, missense
rs35546150 - 140,358,878(-) CGGAG(A/C)AAATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LRP1B Gene

Variant ID Type Subtype PubMed ID
nsv875180 CNV Gain 21882294
nsv834392 CNV Gain 17160897
esv270708 CNV Insertion 20981092
nsv2948 CNV Insertion 18451855
nsv875185 CNV Loss 21882294
esv2658234 CNV Deletion 23128226
nsv459496 CNV Loss 19166990
nsv875186 CNV Loss 21882294
nsv459507 CNV Loss 19166990
nsv470488 CNV Loss 18288195
nsv875187 CNV Loss 21882294
dgv4323n71 CNV Loss 21882294
dgv4324n71 CNV Loss 21882294
nsv459518 CNV Loss 19166990
nsv433205 CNV Loss 18776910
esv988978 CNV Insertion 20482838
esv2720896 CNV Deletion 23290073
esv2720897 CNV Deletion 23290073
esv2740831 CNV Deletion 23290073
dgv667e201 CNV Deletion 23290073
esv2720899 CNV Deletion 23290073
nsv459529 CNV Gain 19166990
nsv875193 CNV Loss 21882294
dgv229n21 CNV Gain 19592680
nsv528276 CNV Gain 19592680
dgv4325n71 CNV Loss 21882294
dgv4326n71 CNV Loss 21882294
dgv4327n71 CNV Loss 21882294
dgv477n27 CNV Loss 19166990
nsv875200 CNV Loss 21882294
dgv4328n71 CNV Loss 21882294
dgv4329n71 CNV Loss 21882294
nsv875206 CNV Loss 21882294
nsv821736 CNV Loss 20364138
esv272096 CNV Insertion 20981092
esv272817 CNV Insertion 20981092
esv2484504 CNV Deletion 19546169
esv2066444 CNV Deletion 18987734
nsv507037 CNV Insertion 20534489
nsv875208 CNV Loss 21882294
nsv470490 CNV Loss 18288195
nsv470489 CNV Gain 18288195
nsv875209 CNV Loss 21882294
esv2720901 CNV Deletion 23290073
nsv875210 CNV Loss 21882294
nsv875211 CNV Loss 21882294
esv2480394 CNV Deletion 19546169
esv2660530 CNV Deletion 23128226
dgv4330n71 CNV Loss 21882294
nsv875213 CNV Loss 21882294
dgv4331n71 CNV Loss 21882294
dgv4332n71 CNV Loss 21882294
dgv4333n71 CNV Loss 21882294
nsv459574 CNV Loss 19166990
esv271498 CNV Insertion 20981092
nsv875224 CNV Loss 21882294
nsv875228 CNV Loss 21882294
nsv459585 CNV Loss 19166990
nsv818086 CNV Loss 17921354
nsv875229 CNV Loss 21882294
nsv821737 CNV Gain 20364138
nsv819672 CNV Gain 19587683
esv1002626 CNV Loss 20482838
esv1010724 CNV Deletion 20482838
nsv875230 CNV Loss 21882294
esv2720902 CNV Deletion 23290073
esv2720903 CNV Deletion 23290073
dgv1266e1 CNV Complex 17122850
esv2675340 CNV Deletion 23128226
nsv517341 CNV Loss 19592680
dgv4334n71 CNV Loss 21882294
esv269631 CNV Insertion 20981092
esv273483 CNV Insertion 20981092
nsv522203 CNV Loss 19592680
nsv215437 CNV Loss 16902084
nsv875233 CNV Loss 21882294
nsv875234 CNV Loss 21882294
nsv875235 CNV Loss 21882294
dgv4335n71 CNV Loss 21882294
nsv522093 CNV Gain 19592680
nsv459596 CNV Loss 19166990
dgv161e55 CNV Gain 17911159
nsv523571 CNV Loss 19592680
nsv875239 CNV Gain 21882294
essv9580 CNV CNV 17122850
nsv821738 CNV Gain 20364138
nsv875240 CNV Loss 21882294
nsv526332 CNV Loss 19592680
nsv875241 CNV Gain 21882294
esv1011284 CNV Insertion 20482838
esv1511272 CNV Insertion 17803354
nsv214199 CNV Insertion 16902084
nsv875242 CNV Loss 21882294
nsv875243 CNV Loss 21882294
nsv516298 CNV Gain 19592680
nsv214554 CNV Insertion 16902084
nsv10196 CNV Gain 18304495
esv27616 CNV Loss 19812545
nsv821739 CNV Loss 20364138
nsv459618 CNV Loss 19166990
nsv470491 CNV Loss 18288195
dgv735e199 CNV Deletion 23128226
nsv821740 CNV Loss 20364138
esv2720904 CNV Deletion 23290073
nsv441788 CNV CNV 18776908
nsv834393 CNV Gain 17160897
nsv459629 CNV Loss 19166990
nsv459640 CNV Loss 19166990
nsv518726 CNV Loss 19592680
dgv736e199 CNV Deletion 23128226
esv24931 CNV Loss 19812545
esv2667057 CNV Deletion 23128226
esv274263 CNV Insertion 20981092
esv271763 CNV Insertion 20981092
dgv4336n71 CNV Loss 21882294
esv2425365 CNV Deletion 19546169
esv1935046 CNV Deletion 18987734
esv3645 CNV Deletion 18987735
esv2720905 CNV Deletion 23290073
esv9456 CNV Loss 19470904
esv995362 CNV Deletion 20482838
esv1788294 CNV Deletion 17803354
nsv214324 CNV Loss 16902084
nsv511815 CNV Loss 21212237
esv2511578 CNV Deletion 19546169
esv2151280 CNV Deletion 18987734
esv2677390 CNV Deletion 23128226
esv2720907 CNV Deletion 23290073
nsv834394 CNV Gain 17160897
nsv433206 CNV Loss 18776910
nsv459651 CNV Loss 19166990
nsv470492 CNV Loss 18288195
dgv4337n71 CNV Loss 21882294
dgv4338n71 CNV Loss 21882294
nsv508111 CNV Loss 20534489
nsv459674 CNV Loss 19166990
esv1462127 CNV Insertion 17803354
nsv875251 CNV Loss 21882294
nsv875252 CNV Gain 21882294
esv268365 CNV Insertion 20981092
nsv526107 CNV Gain 19592680
esv269123 CNV Insertion 20981092
esv5978 CNV Loss 19470904
esv2720908 CNV Deletion 23290073
nsv875253 CNV Loss 21882294
nsv875254 CNV Loss 21882294

Variation tolerance for LRP1B Gene

Residual Variation Intolerance Score: 0.446% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.88; 91.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP1B Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP1B Gene

Disorders for LRP1B Gene

MalaCards: The human disease database

(1) MalaCards diseases for LRP1B Gene - From: DISEASES

Disorder Aliases PubMed IDs
endocervical carcinoma
  • carcinoma of endocervix
- elite association - COSMIC cancer census association via MalaCards
Search LRP1B in MalaCards View complete list of genes associated with diseases

Relevant External Links for LRP1B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LRP1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRP1B Gene

Publications for LRP1B Gene

  1. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. (PMID: 10766186) Liu C.-X. … Lisitsyn N.A. (Cancer Res. 2000) 2 3 4 67
  2. Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma. (PMID: 16918994) Nakagawa T. … Imoto I. (Cancer Sci. 2006) 3 23
  3. Striking differences of LDL receptor-related protein 1B expression in mouse and human. (PMID: 15963947) Li Y. … Bu G. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. (PMID: 15126508) Cam J.A. … Bu G. (J. Biol. Chem. 2004) 3 23
  5. LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors. (PMID: 15166012) Tanaga K. … Saito Y. (Arterioscler. Thromb. Vasc. Biol. 2004) 3 23

Products for LRP1B Gene

Sources for LRP1B Gene