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LRP1B Gene

protein-coding   GIFtS: 56
GCID: GC02M141023

Low Density Lipoprotein Receptor-Related Protein 1B

  Search for LRP1B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein 1B1 2     Low Density Lipoprotein Receptor Related Protein-Deleted In Tumor2
LRP-Deleted In Tumors1 2     Low Density Lipoprotein-Related Protein 1B (Deleted In Tumors)2
Low-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor2 3     Low-Density Lipoprotein Receptor-Related Protein 1B2
LRP-1B2 3     EC 1.1.1.948
LRP-DIT2 3     EC 3.4.21.98
LRPDIT2 3     

External Ids:    HGNC: 66931   Entrez Gene: 533532   Ensembl: ENSG000001687027   OMIM: 6087665   UniProtKB: Q9NZR23   

Export aliases for LRP1B gene to outside databases

Previous GC identifers: GC02M138677 GC02M139296 GC02M141011 GC02M141199 GC02M140822 GC02M140705 GC02M132979 GC02M141012 GC02M141017 GC02M141020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRP1B Gene:
LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of
roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001
(PubMed 11384978)).(supplied by OMIM, Mar 2008)

GeneCards Summary for LRP1B Gene:
LRP1B (low density lipoprotein receptor-related protein 1B) is a protein-coding gene. GO annotations related to this gene include low-density lipoprotein receptor activity and calcium ion binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: LRP1B_HUMAN, Q9NZR2
Function: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated
endocytosis

Gene Wiki entry for LRP1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRP1B gene promoter:
         Max1   ISGF-3   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   PPAR-gamma1   IRF-7A   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): LRP1B promoter sequence
   Search Chromatin IP Primers for LRP1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.2   Ensembl cytogenetic band:  2q22.2   HGNC cytogenetic band: 2q21.2

LRP1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M141023:  view genomic region     (about GC identifiers)

Start:
140,988,992 bp from pter      End:
142,889,270 bp from pter
Size:
1,900,279 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRP1B_HUMAN, Q9NZR2 (See protein sequence)
Recommended Name: Low-density lipoprotein receptor-related protein 1B precursor  
Size: 4599 amino acids; 515498 Da
Subunit: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the
ligands
Miscellaneous: The gene is preferentially inactivated in one histological type of lung cancer (non-small cell lung
cancer (NSCLC)). May thus play an important role in tumorigenesis of NSCLCs
Secondary accessions: Q8WY29 Q8WY30 Q8WY31

Explore the universe of human proteins at neXtProt for LRP1B: NX_Q9NZR2

Explore proteomics data for LRP1B at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn134, Asn190, Asn220, Asn313, Asn360, Asn443, Asn725, Asn758, Asn829, Asn883,
                                 Asn919, Asn1041, Asn1089, Asn1145, Asn1209, Asn1298, Asn1502, Asn1549, Asn1636, Asn1754 (see all 46)
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for LRP1B (Q9NZR2)
     KNVIALA  CPDGSDE 


    See LRP1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061027.2  
    ENSEMBL proteins: 
     ENSP00000374135   ENSP00000415052   ENSP00000393859   ENSP00000413239  

    LRP1B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for LRP1B

     
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    LSBio Antibodies in human, mouse, rat for LRP1B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LDLR: Low density lipoprotein receptors

    Selected InterPro protein domains (see all 11):
     IPR002172 LDrepeatLR_classA_rpt
     IPR000033 LDLR_classB_rpt
     IPR001881 EGF-like_Ca-bd_dom
     IPR023415 LDLR_class-A_CS
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NZR2

    ProtoNet protein and cluster: Q9NZR2

    3 Blocks protein domains:
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: LRP1B_HUMAN, Q9NZR2
    Similarity: Belongs to the LDLR family
    Similarity: Contains 14 EGF-like domains
    Similarity: Contains 32 LDL-receptor class A domains
    Similarity: Contains 36 LDL-receptor class B repeats


    Find genes that share domains with LRP1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRP1B_HUMAN, Q9NZR2
    Function: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated
    endocytosis

         Enzyme Numbers (IUBMB): EC 3.4.21.92 EC 1.1.1.942

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005041low-density lipoprotein receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRP1B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for LRP1B:
     Decreased influenza A virus in  Decreased influenza A/WSN/33 r 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lrp1b):
     mortality/aging  normal 

    Find genes that share phenotypes with LRP1B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LRP1B: Lrp1btm1Wtsi Lrp1btm2Wtsi Lrp1btm1Her

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRP1B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRP1B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRP1B

    miRNA
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    miRTarBase miRNAs that target LRP1B:
    hsa-mir-335-5p (MIRT016828), hsa-mir-26b-5p (MIRT028914)

    Block miRNA regulation of human, mouse, rat LRP1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRP1B (see all 101):
    hsa-miR-548j hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidLRP1B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRP1B
    Predesigned siRNA for gene silencing in human, mouse, rat LRP1B

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: LRP1B (NM_018557)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRP1B_HUMAN, Q9NZR2: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0043235receptor complex IDA--

    Find genes that share ontologies with LRP1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP1B: 
              Lymphoma in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRP1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRP1B (Q9NZR23 ENSP000003741354) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPP050673, ENSP000002849814I2D: score=1 STRING: ENSP00000284981
    GRB7Q144513, ENSP000003107714I2D: score=1 STRING: ENSP00000310771
    ITGB2P051073, ENSP000003032424I2D: score=1 STRING: ENSP00000303242
    MAPK8IP2Q133873, ENSP000003305724I2D: score=1 STRING: ENSP00000330572
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006898receptor-mediated endocytosis TAS10766186
    GO:0015031protein transport TAS10766186

    Find genes that share ontologies with LRP1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRP1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRP1B gene: 
    NM_018557.2  

    Unigene Cluster for LRP1B:

    Low density lipoprotein receptor-related protein 1B
    Hs.656461  [show with all ESTs]
    Unigene Representative Sequence: NM_018557
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389484(uc002tvj.1 uc010fnl.1) ENST00000437977 ENST00000442974
    ENST00000434794 ENST00000486364
    miRNA
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    Block miRNA regulation of human, mouse, rat LRP1B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRP1B (see all 101):
    hsa-miR-548j hsa-miR-106a hsa-miR-15a hsa-miR-200a hsa-miR-519a hsa-miR-93 hsa-miR-548a-5p hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidLRP1B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRP1B
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP1B (NM_018557)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LRP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP1B
      QuantiTect SYBR Green Assays in human, mouse, rat LRP1B
      QuantiFast Probe-based Assays in human, mouse, rat LRP1B

    Additional mRNA sequence: 

    AB209707.1 AF176832.1 AK054663.1 

    2 DOTS entries:

    DT.311192  DT.304181 

    Selected AceView cDNA sequences (see all 27):

    N98646 N54699 AA298841 BX478265 CD629328 AL534962 CD629326 AA912378 
    CD629330 BF951923 AV724690 N76151 N95698 AL565722 AI918335 N66092 
    N66097 BF513391 AV724816 CD629332 AV723069 N64746 N63407 CD629336 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRP1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACTACCT
    LRP1B Expression
    About this image


    LRP1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     NULL (Uncategorized)
             Vascular endothelial growth factor-induced cells
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Eye (Sensory Organs)
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Brain (Nervous System)
             Oligodendrocyte Precursor Cells Forebrain White Matter
     
     Larynx (Respiratory System)
    LRP1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRP1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656461

    UniProtKB/Swiss-Prot: LRP1B_HUMAN, Q9NZR2
    Tissue specificity: Expressed in thyroid gland and in salivary gland, as well as in adult and fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP1B: 
              Lymphoma in human mouse rat
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRP1B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP1B
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    QuantiFast Probe-based Assays in human, mouse, rat LRP1B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRP1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrp1b1 , 5 low density lipoprotein-related protein 1B (deleted more1, 5 87.88(n)1
    91.65(a)1
      2 (24.51 cM)5
    942171  NM_053011.21  NP_443737.21 
     405952485 
    chicken
    (Gallus gallus)
    Aves LRP1B1 low density lipoprotein receptor-related protein 1B 81.53(n)
    86.21(a)
      424301  XM_422146.4  XP_422146.4 
    lizard
    (Anolis carolinensis)
    Reptilia LRP1B6
    low density lipoprotein receptor-related protein 1...
    83(a)
    1 ↔ 1
    1(99535421-99984276)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrp1b1 low density lipoprotein receptor-related protein 1B 76.06(n)
    80.15(a)
      100485687  XM_002937356.2  XP_002937402.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lrp1bb1 low density lipoprotein receptor-related protein 1Bb 68.54(n)
    71.03(a)
      559293  XM_001920004.4  XP_001920039.4 
    worm
    (Caenorhabditis elegans)
    Secernentea R01H2.33   -- 34(a)
    (best of 5)
      III(7130392-7132330)   --


    ENSEMBL Gene Tree for LRP1B (if available)
    TreeFam Gene Tree for LRP1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRP1B gene
    LRP62  LRP52  LRP22  EGF2  LDLR2  LRP5L2  LRP42  VLDLR2  
    NID12  NID22  LRP82  LRP12  
    14 SIMAP similar genes for LRP1B using alignment to 20 protein entries:     LRP1B_HUMAN (see all proteins):
    LRP    LRP1    F9    LRP4    EGF    VLDLR
    LRP6    LRP5L    LRP2    LDLR    CUBN    LRP5
    NRG4    LRP8

    Find genes that share paralogs with LRP1B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRP1B (see all 42059)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2074624751,2
    Cuntested1141161844(+) GTTCAC/TGCCAT 1 -- int10--------
    rs1916584561,2
    Cuntested1141281439(+) AATACA/G/TGCAAG 1 -- int10--------
    rs1447522891,2
    Cuntested1141526805(+) CCACGA/GCAAAT 2 A V mis10--------
    rs1491239611,2
    Cuntested1142567863(+) AGACTC/TGTCTG 2 K E mis10--------
    rs30613671,2
    C--133355862(+) acaca-/CA/   
      CACACA
    TAGAC
    1 -- int11NA 2
    rs347198371,2
    C--134171678(+) TTTTT-/T/TTTA
            
    AGGGC
    1 -- int10--------
    rs58348761,2
    C--134628277(+) GAGAC-/T/TAC 
            
    ATTTG
    1 -- int11NA 2
    rs566761361,2
    C--140825556(+) AAAAA-/A/AA  
            
    TACAG
    1 -- int11NA 2
    rs729004811,2
    C,F--140988519(+) ACTCAA/GTGTTA 1 -- int11Minor allele frequency- G:0.05NA 120
    rs1392178831,2
    --140988536(+) TCAGAC/TGCACC 1 -- int10--------

    HapMap Linkage Disequilibrium report for LRP1B (140988992 - 141238992 bp, first 250kb of LRP1B)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for LRP1B (see all 146):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658234CNV Deletion23128226
    esv2720899CNV Deletion23290073
    esv2066444CNV Deletion18987734
    dgv736e199CNV Deletion23128226
    esv2720897CNV Deletion23290073
    esv2740831CNV Deletion23290073
    esv2720905CNV Deletion23290073
    esv2480394CNV Deletion19546169
    esv1010724CNV Deletion20482838
    esv2660530CNV Deletion23128226

    Human Gene Mutation Database (HGMD): LRP1B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRP1B
    DNA2.0 Custom Variant and Variant Library Synthesis for LRP1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608766    OMIM disorders: --


    Find genes that share disorders with LRP1B           About GenesLikeMe

    3 Novoseek inferred disease relationships for LRP1B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer lung 28.6 2 11031110 (1), 15126508 (1)
    carcinoma squamous cell 17.4 3 15172977 (2), 16918994 (1)
    tumors 15.8 9 11031110 (2), 11384978 (2), 17658514 (1), 15172977 (1) (see all 6)

    Genetic Association Database (GAD): LRP1B
    Human Genome Epidemiology (HuGE) Navigator: LRP1B (2 documents)

    Export disorders for LRP1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRP1B gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with LRP1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. (PubMed id 10766186)1, 2, 3 Liu C.-X....Lisitsyn N.A. (Cancer Res. 2000)
    2. The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. (PubMed id 11384978)1, 2, 9 Liu C.-X.... Bu G. (J. Biol. Chem. 2001)
    3. Genomic organization of a new candidate tumor suppressor gene, LRP1B. (PubMed id 11031110)1, 2, 9 Liu C.-X.... Lisitsyn N.A. (Genomics 2000)
    4. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010)
    7. Genome-wide association identifies ATOH7 as a major gene determining human optic disc size. (PubMed id 20395239)1, 4 Macgregor S....Mackey D.A. (Hum. Mol. Genet. 2010)
    8. A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis. (PubMed id 19367585)1, 4 Poduslo S.E....Spiro A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    9. Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. (PubMed id 15172977)1, 9 Sonoda I....Inazawa J. (Cancer Res. 2004)
    10. Striking differences of LDL receptor-related protein 1B expression in mouse and human. (PubMed id 15963947)1, 9 Li Y....Bu G. (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53353 HGNC: 6693 AceView: LRP1B Ensembl:ENSG00000168702 euGenes: HUgn53353
    ECgene: LRP1B H-InvDB: LRP1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRP1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LRP1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LRP1B gene:
    Search GeneIP for patents involving LRP1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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