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Aliases for LRP12 Gene

Aliases for LRP12 Gene

  • LDL Receptor Related Protein 12 2 3 5
  • Suppressor Of Tumorigenicity 7 Protein 3 4
  • ST7 3 4
  • Low Density Lipoprotein Receptor-Related Protein 12 2
  • Low-Density Lipoprotein Receptor-Related Protein 12 3
  • LRP-12 4

External Ids for LRP12 Gene

Previous GeneCards Identifiers for LRP12 Gene

  • GC00U916985
  • GC08M105570
  • GC08M100702
  • GC08M105501

Summaries for LRP12 Gene

Entrez Gene Summary for LRP12 Gene

  • This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for LRP12 Gene

LRP12 (LDL Receptor Related Protein 12) is a Protein Coding gene. Among its related pathways are Metabolism of fat-soluble vitamins and Metabolism. GO annotations related to this gene include low-density lipoprotein receptor activity. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot for LRP12 Gene

  • Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP12 Gene

Genomics for LRP12 Gene

Regulatory Elements for LRP12 Gene

Enhancers for LRP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F104621 1.3 Ensembl ENCODE 21.8 -33.7 -33746 2.2 PKNOX1 ATF1 ARNT ELK1 GATA2 CBX5 JUNB NCOA1 REST TBX21 LRP12 GC08P104611 ENSG00000283157
GH08F104664 1.7 FANTOM5 Ensembl ENCODE 14 -76.7 -76677 2.6 PKNOX1 ATF1 ARNT GATA2 CBX5 FOS JUNB NCOA1 TBX21 MEF2D DCSTAMP LRP12 ENSG00000283157 GC08P104611
GH08F104616 1.3 FANTOM5 ENCODE 14.1 -28.6 -28599 2.3 PKNOX1 ATF1 ARNT GATA2 FOS JUNB NCOA1 MBD2 MEF2D SMARCA4 LRP12 DCSTAMP GC08P104611 ENSG00000283157
GH08F104642 1.3 FANTOM5 Ensembl ENCODE 13.2 -54.4 -54398 2.0 CBX3 JUN NR2F2 ARID1B JUND ATF3 SMARCA4 FOS ZBTB33 SPI1 LRP12 DCSTAMP GC08P104611 ENSG00000283157
GH08F104669 0.8 FANTOM5 13.4 -80.3 -80276 0.5 PKNOX1 ESRRA L3MBTL2 NR2F1 JUNB JUND ATF3 PBX2 IKZF1 HMBOX1 DCSTAMP LRP12 ENSG00000283157 GC08P104611
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRP12 on UCSC Golden Path with GeneCards custom track

Promoters for LRP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001398414 224 2801 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF48 GLIS2 CBX5 ZNF143
ENSR00001904012 1924 201 PRDM10

Genomic Location for LRP12 Gene

104,489,231 bp from pter
104,589,024 bp from pter
99,794 bases
Minus strand

Genomic View for LRP12 Gene

Genes around LRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP12 Gene

Proteins for LRP12 Gene

  • Protein details for LRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 12
    Protein Accession:
    Secondary Accessions:
    • A8K137
    • B4DRQ2

    Protein attributes for LRP12 Gene

    859 amino acids
    Molecular mass:
    94984 Da
    Quaternary structure:
    • May interact with RACK1, ZFYVE9 and NMRK2.

    Alternative splice isoforms for LRP12 Gene


neXtProt entry for LRP12 Gene

Post-translational modifications for LRP12 Gene

  • Ubiquitination at Lys 160 and Lys 678
  • Glycosylation at Asn 75, Asn 146, Asn 284, Asn 366, Asn 409, and Asn 441
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP12 Gene

No data available for DME Specific Peptides for LRP12 Gene

Domains & Families for LRP12 Gene

Gene Families for LRP12 Gene

Suggested Antigen Peptide Sequences for LRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 CUB domains.
  • Belongs to the LDLR family.
  • Contains 2 CUB domains.
  • Contains 5 LDL-receptor class A domains.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP12: view

Function for LRP12 Gene

Molecular function for LRP12 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for LRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity NAS 12809483
GO:0005515 protein binding IPI 12809483
genes like me logo Genes that share ontologies with LRP12: view
genes like me logo Genes that share phenotypes with LRP12: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP12 Gene

Localization for LRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP12 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP12 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for LRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 12809483
GO:0005905 clathrin-coated pit IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,NAS 9927190
genes like me logo Genes that share ontologies with LRP12: view

Pathways & Interactions for LRP12 Gene

genes like me logo Genes that share pathways with LRP12: view

Gene Ontology (GO) - Biological Process for LRP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis NAS 12809483
GO:0006898 receptor-mediated endocytosis IEA --
GO:0007165 signal transduction NAS 12809483
GO:0040008 regulation of growth NAS 9927190
genes like me logo Genes that share ontologies with LRP12: view

No data available for SIGNOR curated interactions for LRP12 Gene

Transcripts for LRP12 Gene

Unigene Clusters for LRP12 Gene

Low density lipoprotein receptor-related protein 12:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - -

Relevant External Links for LRP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP12 Gene

Protein differential expression in normal tissues from HIPED for LRP12 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRP12 Gene

Protein tissue co-expression partners for LRP12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP12 Gene:


SOURCE GeneReport for Unigene cluster for LRP12 Gene:


mRNA Expression by UniProt/SwissProt for LRP12 Gene:

Tissue specificity: Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
genes like me logo Genes that share expression patterns with LRP12: view

No data available for mRNA differential expression in normal tissues for LRP12 Gene

Orthologs for LRP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP12 34 35
  • 99.69 (n)
(Monodelphis domestica)
Mammalia LRP12 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia LRP12 35
  • 92 (a)
(Canis familiaris)
Mammalia LRP12 34 35
  • 91.09 (n)
(Bos Taurus)
Mammalia LRP12 34 35
  • 90.22 (n)
(Mus musculus)
Mammalia Lrp12 34 16 35
  • 86.32 (n)
(Rattus norvegicus)
Mammalia Lrp12 34
  • 85.31 (n)
(Gallus gallus)
Aves LRP12 34 35
  • 82.77 (n)
(Anolis carolinensis)
Reptilia LRP12 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp12 34
  • 72.49 (n)
(Danio rerio)
Actinopterygii lrp12 34 35
  • 68.43 (n)
wufc44e04 34
fruit fly
(Drosophila melanogaster)
Insecta CG6553 35
  • 27 (a)
(Caenorhabditis elegans)
Secernentea M03E7.4 35
  • 17 (a)
Species where no ortholog for LRP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP12 Gene

Gene Tree for LRP12 (if available)
Gene Tree for LRP12 (if available)

Paralogs for LRP12 Gene

Paralogs for LRP12 Gene

(3) SIMAP similar genes for LRP12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP12: view

Variants for LRP12 Gene

Sequence variations from dbSNP and Humsavar for LRP12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10101563 -- 104,495,197(+) AACTG(G/T)GTTTC reference, synonymous-codon
rs10429349 -- 104,550,948(+) AGGTA(C/T)ATCTG intron-variant
rs10429351 -- 104,551,054(+) CCATC(C/G)CTTAA intron-variant
rs10505059 -- 104,535,748(+) TTAAA(A/C)AGTCT intron-variant
rs10505060 -- 104,535,928(+) ATTTG(A/T)AAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP12 Gene

Variant ID Type Subtype PubMed ID
nsv831417 CNV loss 17160897
nsv508522 CNV deletion 20534489
nsv1132162 CNV deletion 24896259
nsv1115119 CNV deletion 24896259
esv2445240 CNV deletion 19546169
esv2422460 CNV duplication 17116639

Variation tolerance for LRP12 Gene

Residual Variation Intolerance Score: 7.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP12 Gene

Disorders for LRP12 Gene

Relevant External Links for LRP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP12 Gene

Publications for LRP12 Gene

  1. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PMID: 12809483) Battle M.A. … McCormick J.J. (Biochemistry 2003) 2 3 4 64
  2. Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines. (PMID: 9927190) Qing J. … McCormick J.J. (Oncogene 1999) 3 4 22 64
  3. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. (PMID: 22570617) Wiggs J.L. … Haines J.L. (PLoS Genet. 2012) 3 46 64
  4. Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas. (PMID: 14676824) Garnis C. … Lam W.L. (Oncogene 2004) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for LRP12 Gene

Sources for LRP12 Gene

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