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Aliases for LRP12 Gene

Aliases for LRP12 Gene

  • LDL Receptor Related Protein 12 2 3 5
  • Low Density Lipoprotein Receptor-Related Protein 12 2 3
  • Suppressor Of Tumorigenicity 7 Protein 3 4
  • ST7 3 4
  • LRP-12 4

External Ids for LRP12 Gene

Previous GeneCards Identifiers for LRP12 Gene

  • GC00U916985
  • GC08M105570
  • GC08M100702
  • GC08M105501

Summaries for LRP12 Gene

Entrez Gene Summary for LRP12 Gene

  • This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for LRP12 Gene

LRP12 (LDL Receptor Related Protein 12) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include low-density lipoprotein receptor activity. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot for LRP12 Gene

  • Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP12 Gene

Genomics for LRP12 Gene

Regulatory Elements for LRP12 Gene

Promoters for LRP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRP12 Gene

Chromosome:
8
Start:
104,489,231 bp from pter
End:
104,589,024 bp from pter
Size:
99,794 bases
Orientation:
Minus strand

Genomic View for LRP12 Gene

Genes around LRP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP12 Gene

Proteins for LRP12 Gene

  • Protein details for LRP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y561-LRP12_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 12
    Protein Accession:
    Q9Y561
    Secondary Accessions:
    • A8K137
    • B4DRQ2

    Protein attributes for LRP12 Gene

    Size:
    859 amino acids
    Molecular mass:
    94984 Da
    Quaternary structure:
    • May interact with RACK1, ZFYVE9 and NMRK2.

    Alternative splice isoforms for LRP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP12 Gene

Proteomics data for LRP12 Gene at MOPED

Post-translational modifications for LRP12 Gene

  • Ubiquitination at Lys 160 and Lys 678
  • Glycosylation at Asn 75, Asn 146, Asn 284, Asn 366, Asn 409, and Asn 441
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP12 Gene

Antibody Products

No data available for DME Specific Peptides for LRP12 Gene

Domains & Families for LRP12 Gene

Gene Families for LRP12 Gene

Suggested Antigen Peptide Sequences for LRP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y561

UniProtKB/Swiss-Prot:

LRP12_HUMAN :
  • Contains 2 CUB domains.
  • Belongs to the LDLR family.
Domain:
  • Contains 2 CUB domains.
  • Contains 5 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP12: view

Function for LRP12 Gene

Molecular function for LRP12 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.
genes like me logo Genes that share phenotypes with LRP12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP12 Gene

Localization for LRP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP12 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP12 Gene COMPARTMENTS Subcellular localization image for LRP12 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for LRP12 Gene

Pathways & Interactions for LRP12 Gene

genes like me logo Genes that share pathways with LRP12: view

Gene Ontology (GO) - Biological Process for LRP12 Gene

None

No data available for SIGNOR curated interactions for LRP12 Gene

Drugs & Compounds for LRP12 Gene

No Compound Related Data Available

Transcripts for LRP12 Gene

Unigene Clusters for LRP12 Gene

Low density lipoprotein receptor-related protein 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b
SP1: - -
SP2: -
SP3: - -
SP4:

Relevant External Links for LRP12 Gene

GeneLoc Exon Structure for
LRP12
ECgene alternative splicing isoforms for
LRP12

Expression for LRP12 Gene

mRNA expression in normal human tissues for LRP12 Gene

Protein differential expression in normal tissues from HIPED for LRP12 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRP12 Gene



SOURCE GeneReport for Unigene cluster for LRP12 Gene Hs.600630

mRNA Expression by UniProt/SwissProt for LRP12 Gene

Q9Y561-LRP12_HUMAN
Tissue specificity: Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney. Expressed at very low levels in a number of tumor-derived cell lines.
genes like me logo Genes that share expression patterns with LRP12: view

Protein tissue co-expression partners for LRP12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LRP12 Gene

Orthologs for LRP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP12 35
  • 99.69 (n)
  • 99.53 (a)
LRP12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP12 36
  • 96 (a)
OneToOne
LRP12 35
  • 90.22 (n)
  • 95.81 (a)
dog
(Canis familiaris)
Mammalia LRP12 35
  • 91.09 (n)
  • 94.96 (a)
LRP12 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp12 16
Lrp12 35
  • 86.32 (n)
  • 92.77 (a)
Lrp12 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP12 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP12 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp12 35
  • 85.31 (n)
  • 91.84 (a)
chicken
(Gallus gallus)
Aves LRP12 35
  • 82.77 (n)
  • 89.21 (a)
LRP12 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp12 35
  • 72.49 (n)
  • 80.14 (a)
zebrafish
(Danio rerio)
Actinopterygii lrp12 36
  • 72 (a)
OneToOne
lrp12 35
  • 68.43 (n)
  • 74.48 (a)
wufc44e04 35
fruit fly
(Drosophila melanogaster)
Insecta CG6553 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 17 (a)
OneToMany
Species with no ortholog for LRP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP12 Gene

ENSEMBL:
Gene Tree for LRP12 (if available)
TreeFam:
Gene Tree for LRP12 (if available)

Paralogs for LRP12 Gene

Paralogs for LRP12 Gene

(3) SIMAP similar genes for LRP12 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LRP12: view

Variants for LRP12 Gene

Sequence variations from dbSNP and Humsavar for LRP12 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16871494 - 104,491,173(+) GGAAC(C/T)TGCAC reference, missense
rs3018440 -- 104,511,063(+) tgaga(A/T)agagt intron-variant
rs2959031 -- 104,506,752(-) CAAAG(A/G)CCACC intron-variant
rs4537272 -- 104,573,071(+) TCGAT(C/T)GTATT intron-variant
rs4413742 -- 104,511,446(+) ttggg(C/G/T)gcagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP12 Gene

Variant ID Type Subtype PubMed ID
nsv831417 CNV Loss 17160897
nsv508522 CNV Loss 20534489
esv2422460 CNV Duplication 17116639
esv2445240 CNV Deletion 19546169

Variation tolerance for LRP12 Gene

Residual Variation Intolerance Score: 7.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP12 Gene

HapMap Linkage Disequilibrium report
LRP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP12 Gene

Disorders for LRP12 Gene

Relevant External Links for LRP12

Genetic Association Database (GAD)
LRP12
Human Genome Epidemiology (HuGE) Navigator
LRP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRP12

No disorders were found for LRP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP12 Gene

Publications for LRP12 Gene

  1. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. (PMID: 12809483) Battle M.A. … McCormick J.J. (Biochemistry 2003) 2 3 4 67
  2. Overexpression of LRP12, a gene contained within an 8q22 amplicon identified by high-resolution array CGH analysis of oral squamous cell carcinomas. (PMID: 14676824) Garnis C. … Lam W.L. (Oncogene 2004) 2 3
  3. Cloning and characterization of a novel gene encoding a putative transmembrane protein with altered expression in some human transformed and tumor-derived cell lines. (PMID: 9927190) Qing J. … McCormick J.J. (Oncogene 1999) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A. … Kocher T. (J. Clin. Periodontol. 2013) 3

Products for LRP12 Gene

Sources for LRP12 Gene

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