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Aliases for LRP11 Gene

Aliases for LRP11 Gene

  • Low Density Lipoprotein Receptor-Related Protein 11 2 3
  • LRP-11 3 4
  • BA350J20.3 3
  • MANSC3 3

External Ids for LRP11 Gene

Previous GeneCards Identifiers for LRP11 Gene

  • GC06M150095
  • GC06M150170
  • GC06M150232
  • GC06M150139
  • GC06M147705

Summaries for LRP11 Gene

GeneCards Summary for LRP11 Gene

LRP11 (Low Density Lipoprotein Receptor-Related Protein 11) is a Protein Coding gene. An important paralog of this gene is SPINT2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP11 Gene

Genomics for LRP11 Gene

Regulatory Elements for LRP11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for LRP11 Gene

Chromosome:
6
Start:
149,795,188 bp from pter
End:
149,864,348 bp from pter
Size:
69,161 bases
Orientation:
Minus strand

Genomic View for LRP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP11 Gene

Proteins for LRP11 Gene

  • Protein details for LRP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ4-LRP11_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 11
    Protein Accession:
    Q86VZ4
    Secondary Accessions:
    • Q5VYC0
    • Q96SN6

    Protein attributes for LRP11 Gene

    Size:
    500 amino acids
    Molecular mass:
    53311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP11 Gene

Proteomics data for LRP11 Gene at MOPED

Post-translational modifications for LRP11 Gene

  • Glycosylation at Asn 164, Thr 197, Asn 291, Ser 293, Thr 303, Ser 360, Thr 367, Thr 386, and Asn 401
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LRP11 Gene

Domains & Families for LRP11 Gene

Gene Families for LRP11 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VZ4

UniProtKB/Swiss-Prot:

LRP11_HUMAN :
  • Contains 1 LDL-receptor class A domain.
  • Belongs to the LDLR family.
Domain:
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 MANSC domain.
  • Contains 1 PKD domain.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP11: view

Function for LRP11 Gene

Gene Ontology (GO) - Molecular Function for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051219 phosphoprotein binding IMP 17620599
genes like me logo Genes that share ontologies with LRP11: view
genes like me logo Genes that share phenotypes with LRP11: view

Animal Model Products

miRNA for LRP11 Gene

miRTarBase miRNAs that target LRP11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP11 Gene

Localization for LRP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP11 Gene COMPARTMENTS Subcellular localization image for LRP11 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IC 17620599
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP11: view

Pathways & Interactions for LRP11 Gene

SuperPathways for LRP11 Gene

No Data Available

Interacting Proteins for LRP11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000239367%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000239367 Q86VZ4-LRP11_HUMAN for LRP11 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat IEA --
GO:0009409 response to cold IEA --
GO:0009414 response to water deprivation IEA --
GO:0009612 response to mechanical stimulus IEA --
GO:0033555 multicellular organismal response to stress IEA --
genes like me logo Genes that share ontologies with LRP11: view

No data available for Pathways by source and SIGNOR curated interactions for LRP11 Gene

Drugs & Compounds for LRP11 Gene

No Compound Related Data Available

Transcripts for LRP11 Gene

Unigene Clusters for LRP11 Gene

Low density lipoprotein receptor-related protein 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP11 Gene

No ASD Table

Relevant External Links for LRP11 Gene

GeneLoc Exon Structure for
LRP11
ECgene alternative splicing isoforms for
LRP11

Expression for LRP11 Gene

mRNA expression in normal human tissues for LRP11 Gene

Protein differential expression in normal tissues from HIPED for LRP11 Gene

This gene is overexpressed in Cerebrospinal fluid (25.7), Saliva (24.4), and Plasma (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRP11 Gene



SOURCE GeneReport for Unigene cluster for LRP11 Gene Hs.408355

genes like me logo Genes that share expression patterns with LRP11: view

Protein tissue co-expression partners for LRP11 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP11 Gene

Orthologs for LRP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRP11 35
  • 84.74 (n)
  • 82.33 (a)
LRP11 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP11 35
  • 87.25 (n)
  • 87.25 (a)
LRP11 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp11 35
  • 78.11 (n)
  • 73.18 (a)
Lrp11 16
Lrp11 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRP11 35
  • 99.6 (n)
  • 99.6 (a)
LRP11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp11 35
  • 78.59 (n)
  • 75.43 (a)
oppossum
(Monodelphis domestica)
Mammalia LRP11 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP11 36
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRP11 35
  • 69.58 (n)
  • 65.66 (a)
LRP11 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP11 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp11 35
  • 61.79 (n)
  • 58.33 (a)
Str.12474 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25624 35
zebrafish
(Danio rerio)
Actinopterygii lrp11 35
  • 59.34 (n)
  • 55.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3864 36
  • 30 (a)
OneToMany
Species with no ortholog for LRP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP11 Gene

ENSEMBL:
Gene Tree for LRP11 (if available)
TreeFam:
Gene Tree for LRP11 (if available)

Paralogs for LRP11 Gene

Paralogs for LRP11 Gene

genes like me logo Genes that share paralogs with LRP11: view

Variants for LRP11 Gene

Sequence variations from dbSNP and Humsavar for LRP11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11278 -- 149,853,077(-) GCCGC(A/C/G)AGAGC missense, reference, nc-transcript-variant
rs14314 -- 149,820,395(-) AAAAG(G/T)TTCCT utr-variant-3-prime, intron-variant
rs868375 -- 149,844,905(-) TCCAT(A/T)CCTTA intron-variant
rs880245 -- 149,846,262(-) GTTCC(A/G)AGCTA intron-variant
rs880246 -- 149,845,972(-) GTACC(C/T)GCGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP11 Gene

Variant ID Type Subtype PubMed ID
nsv886762 CNV Loss 21882294
nsv886763 CNV Loss 21882294
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv823860 CNV Gain 20364138

Variation tolerance for LRP11 Gene

Residual Variation Intolerance Score: 55.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP11 Gene

HapMap Linkage Disequilibrium report
LRP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP11 Gene

Disorders for LRP11 Gene

Relevant External Links for LRP11

Genetic Association Database (GAD)
LRP11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRP11
genes like me logo Genes that share disorders with LRP11: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP11 Gene

Publications for LRP11 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67
  3. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 67
  4. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 67
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67

Products for LRP11 Gene

Sources for LRP11 Gene

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