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Aliases for LRP11 Gene

Aliases for LRP11 Gene

  • LDL Receptor Related Protein 11 2 3 5
  • LRP-11 3 4
  • Low Density Lipoprotein Receptor-Related Protein 11 2
  • Low-Density Lipoprotein Receptor-Related Protein 11 3
  • BA350J20.3 3
  • MANSC3 3

External Ids for LRP11 Gene

Previous GeneCards Identifiers for LRP11 Gene

  • GC06M150095
  • GC06M150170
  • GC06M150232
  • GC06M150139
  • GC06M147705

Summaries for LRP11 Gene

GeneCards Summary for LRP11 Gene

LRP11 (LDL Receptor Related Protein 11) is a Protein Coding gene. An important paralog of this gene is SPINT1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP11 Gene

Genomics for LRP11 Gene

Regulatory Elements for LRP11 Gene

Enhancers for LRP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F149745 1.1 ENCODE 14.2 +117.9 117938 2.0 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 CBX5 ZNF143 ZNF207 FOS ENSG00000231760 PPIL4 LATS1 LRP11 NUP43 GINM1 ENSG00000233330 ENSG00000216906 PCMT1
GH06F149840 1.1 Ensembl ENCODE 12.9 +23.5 23497 1.5 ELF3 ARID4B SIN3A ZNF48 RAD21 SLC30A9 SCRT2 ZNF143 FOS THAP11 ENSG00000231760 LRP11 RAET1E GINM1 ENSG00000202343 ENSG00000233330 RPS18P9 ENSG00000273132
GH06F149886 1.2 Ensembl ENCODE 11.7 -24.9 -24858 5.2 TBP INSM2 NFXL1 RFX5 ZEB1 ZNF366 RCOR1 FOS EGR2 ZNF362 ENSG00000216906 RAET1E ENSG00000231760 NUP43 KATNA1 LRP11 LATS1 LOC105378051
GH06F150766 1.3 Ensembl ENCODE 10.2 -903.0 -902985 2.2 ATF1 PKNOX1 ARNT ZNF493 ZFP64 FEZF1 ZNF766 ZNF202 NCOA1 REST HSPA8P15 ENSG00000231760 ZBTB2 LRP11 ENSG00000216906 PDCL3P5 ENSG00000226599
GH06F149934 0.9 ENCODE 14.2 -70.0 -70022 0.2 ATF1 TBL1XR1 INSM2 BRCA1 ZNF2 RAD21 ZNF143 ZNF391 CREM ZNF654 LRP11 ENSG00000216906 LOC105378052 RAET1G
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRP11 on UCSC Golden Path with GeneCards custom track

Promoters for LRP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001230525 348 2800 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ZNF766 GLIS2 ZNF143 SP3 JUNB

Genomic Location for LRP11 Gene

149,795,188 bp from pter
149,864,348 bp from pter
69,161 bases
Minus strand

Genomic View for LRP11 Gene

Genes around LRP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP11 Gene

Proteins for LRP11 Gene

  • Protein details for LRP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Low-density lipoprotein receptor-related protein 11
    Protein Accession:
    Secondary Accessions:
    • Q5VYC0
    • Q96SN6

    Protein attributes for LRP11 Gene

    500 amino acids
    Molecular mass:
    53311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LRP11 Gene


neXtProt entry for LRP11 Gene

Post-translational modifications for LRP11 Gene

  • Glycosylation at Asn 164, Thr 197, Asn 291, Ser 293, Thr 303, Ser 360, Thr 367, Thr 386, and Asn 401
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP11 Gene

No data available for DME Specific Peptides for LRP11 Gene

Domains & Families for LRP11 Gene

Gene Families for LRP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 LDL-receptor class A domain.
  • Belongs to the LDLR family.
  • Contains 1 LDL-receptor class A domain.
  • Contains 1 MANSC domain.
  • Contains 1 PKD domain.
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP11: view

Function for LRP11 Gene

Gene Ontology (GO) - Molecular Function for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051219 phosphoprotein binding IMP 17620599
genes like me logo Genes that share ontologies with LRP11: view
genes like me logo Genes that share phenotypes with LRP11: view

Animal Model Products

miRNA for LRP11 Gene

miRTarBase miRNAs that target LRP11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP11 Gene

Localization for LRP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP11 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP11 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IC 17620599
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP11: view

Pathways & Interactions for LRP11 Gene

SuperPathways for LRP11 Gene

No Data Available

Interacting Proteins for LRP11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000239367 Q86VZ4-LRP11_HUMAN for LRP11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for LRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009408 response to heat IEA --
GO:0009409 response to cold IEA --
GO:0009414 response to water deprivation IEA --
GO:0009612 response to mechanical stimulus IEA --
GO:0033555 multicellular organismal response to stress IEA --
genes like me logo Genes that share ontologies with LRP11: view

No data available for Pathways by source and SIGNOR curated interactions for LRP11 Gene

Transcripts for LRP11 Gene

Unigene Clusters for LRP11 Gene

Low density lipoprotein receptor-related protein 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP11 Gene

No ASD Table

Relevant External Links for LRP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for LRP11 Gene

Protein differential expression in normal tissues from HIPED for LRP11 Gene

This gene is overexpressed in Cerebrospinal fluid (25.7), Saliva (24.4), and Plasma (18.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for LRP11 Gene

Protein tissue co-expression partners for LRP11 Gene

NURSA nuclear receptor signaling pathways regulating expression of LRP11 Gene:


SOURCE GeneReport for Unigene cluster for LRP11 Gene:

genes like me logo Genes that share expression patterns with LRP11: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for LRP11 Gene

Orthologs for LRP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRP11 34 35
  • 99.6 (n)
(Canis familiaris)
Mammalia LRP11 34 35
  • 87.25 (n)
(Bos Taurus)
Mammalia LRP11 34 35
  • 84.74 (n)
(Rattus norvegicus)
Mammalia Lrp11 34
  • 78.59 (n)
(Mus musculus)
Mammalia Lrp11 34 16 35
  • 78.11 (n)
(Monodelphis domestica)
Mammalia LRP11 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia LRP11 35
  • 54 (a)
(Gallus gallus)
Aves LRP11 34 35
  • 69.58 (n)
(Anolis carolinensis)
Reptilia LRP11 35
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp11 34
  • 61.79 (n)
Str.12474 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25624 34
(Danio rerio)
Actinopterygii lrp11 34
  • 59.34 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3864 35
  • 30 (a)
Species where no ortholog for LRP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRP11 Gene

Gene Tree for LRP11 (if available)
Gene Tree for LRP11 (if available)

Paralogs for LRP11 Gene

Paralogs for LRP11 Gene

genes like me logo Genes that share paralogs with LRP11: view

Variants for LRP11 Gene

Sequence variations from dbSNP and Humsavar for LRP11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10080756 -- 149,861,696(+) tattt(C/T)ttttt intron-variant, upstream-variant-2KB
rs1055274 -- 149,865,214(+) GCTTC(A/C)CCTTG intron-variant, upstream-variant-2KB, utr-variant-3-prime, splice-donor-variant
rs10553273 -- 149,862,596(+) TTTTT(-/T)AAGAT intron-variant, upstream-variant-2KB
rs10625131 -- 149,836,834(+) AAAGA(-/AAAA)AAAAA intron-variant
rs10712132 -- 149,832,638(+) TGTAC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP11 Gene

Variant ID Type Subtype PubMed ID
nsv823860 CNV gain 20364138
nsv517022 CNV gain+loss 19592680
esv3356372 CNV insertion 20981092

Variation tolerance for LRP11 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.75; 91.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP11 Gene

Disorders for LRP11 Gene

Relevant External Links for LRP11

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LRP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP11 Gene

Publications for LRP11 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 64

Products for LRP11 Gene

Sources for LRP11 Gene

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