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Aliases for LRP10 Gene

Aliases for LRP10 Gene

  • Low Density Lipoprotein Receptor-Related Protein 10 2 3
  • LRP-10 3 4
  • LRP9 3 6
  • Low-Density Lipoprotein Receptor-Related Protein 10 3
  • MSTP087 3
  • MST087 3

External Ids for LRP10 Gene

Summaries for LRP10 Gene

GeneCards Summary for LRP10 Gene

LRP10 (Low Density Lipoprotein Receptor-Related Protein 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot for LRP10 Gene

  • Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Wiki entry for LRP10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP10 Gene

Genomics for LRP10 Gene

Genomic Location for LRP10 Gene

Start:
22,871,613 bp from pter
End:
22,881,580 bp from pter
Size:
9,968 bases
Orientation:
Plus strand

Genomic View for LRP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP10 Gene

Regulatory Elements for LRP10 Gene

Proteins for LRP10 Gene

  • Protein details for LRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4F1-LRP10_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 10
    Protein Accession:
    Q7Z4F1
    Secondary Accessions:
    • A8K4R5
    • D3DS31
    • O95882
    • Q14CK7
    • Q86T02
    • Q8NCZ4
    • Q9HC42
    • Q9UG33

    Protein attributes for LRP10 Gene

    Size:
    713 amino acids
    Molecular mass:
    76193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Evidence={ECO:0000305}; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Evidence={ECO:0000305}; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP10 Gene

Proteomics data for LRP10 Gene at MOPED

Post-translational modifications for LRP10 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn56, Asn111, Asn193, and Asn299

Other Protein References for LRP10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for LRP10 Gene

Domains for LRP10 Gene

Gene Families for LRP10 Gene

HGNC:
  • LDLR :Low density lipoprotein receptors

Suggested Antigen Peptide Sequences for LRP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4F1

UniProtKB/Swiss-Prot:

LRP10_HUMAN
Domain:
  • Contains 2 CUB domains.:
    • Q7Z4F1
  • Contains 4 LDL-receptor class A domains.:
    • Q7Z4F1
Family:
  • Belongs to the LDLR family.:
    • Q7Z4F1
genes like me logo Genes that share domains with LRP10: view

Function for LRP10 Gene

Molecular function for LRP10 Gene

UniProtKB/Swiss-Prot Function: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Ontology (GO) - Molecular Function for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRP10: view

Phenotypes for LRP10 Gene

genes like me logo Genes that share phenotypes with LRP10: view

miRNA for LRP10 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRP10 Gene

Localization for LRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP10 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP10 Gene COMPARTMENTS Subcellular localization image for LRP10 gene
Compartment Confidence
plasma membrane 3
endosome 2
extracellular 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 coated pit IEA --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP10: view

Pathways for LRP10 Gene

genes like me logo Genes that share pathways with LRP10: view

Interacting Proteins for LRP10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352601%0d%0a9606.ENSP00000357980%0d%0a9606.ENSP00000354623%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q7Z4F1-LRP10_HUMAN ENSP00000352601 for LRP10 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
genes like me logo Genes that share ontologies with LRP10: view

Transcripts for LRP10 Gene

Unigene Clusters for LRP10 Gene

Low density lipoprotein receptor-related protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for LRP10 Gene

GeneLoc Exon Structure for
LRP10
ECgene alternative splicing isoforms for
LRP10

Expression for LRP10 Gene

mRNA expression in normal human tissues for LRP10 Gene

mRNA differential expression in normal tissues according to GTEx for LRP10 Gene

This gene is overexpressed in Whole Blood (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRP10 Gene

SOURCE GeneReport for Unigene cluster for LRP10 Gene Hs.525232

mRNA Expression by UniProt/SwissProt for LRP10 Gene

Q7Z4F1-LRP10_HUMAN
Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.
genes like me logo Genes that share expressions with LRP10: view

Orthologs for LRP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP10 35
  • 99.67 (n)
  • 99.71 (a)
LRP10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP10 35
  • 87.11 (n)
  • 88.61 (a)
LRP10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP10 35
  • 87.5 (n)
  • 89.51 (a)
LRP10 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp10 35
  • 85.95 (n)
  • 88.06 (a)
Lrp10 16
Lrp10 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP10 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP10 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp10 35
  • 85.33 (n)
  • 88.46 (a)
lizard
(Anolis carolinensis)
Reptilia LRP10 36
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5830 35
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp10 35
  • 53.17 (n)
  • 52.05 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560361 35
  • 49.9 (n)
  • 42.39 (a)
LRP10 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ImpE1 36
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 19 (a)
OneToMany
Species with no ortholog for LRP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP10 Gene

ENSEMBL:
Gene Tree for LRP10 (if available)
TreeFam:
Gene Tree for LRP10 (if available)

Paralogs for LRP10 Gene

Paralogs for LRP10 Gene

Selected SIMAP similar genes for LRP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LRP10: view

Variants for LRP10 Gene

Sequence variations from dbSNP and Humsavar for LRP10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1062653 -- 22,877,759(+) ACCCC(A/G)GTCCC utr-variant-3-prime
rs1062656 -- 22,876,078(+) CCTGC(C/G)TGCTG reference, missense
rs1142013 -- 22,880,819(+) GCCAA(C/G)ATGGT utr-variant-3-prime
rs2273837 - 22,873,373(-) GTCCC(A/G)GACCA reference, missense
rs2295905 -- 22,879,743(-) TACAC(C/T)TCGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRP10 Gene

Variant ID Type Subtype PubMed ID
nsv901490 CNV Loss 21882294
nsv1214 CNV Loss 18451855

Relevant External Links for LRP10 Gene

HapMap Linkage Disequilibrium report
LRP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP10 Gene

Disorders for LRP10 Gene

No disorders were found for LRP10 Gene.

No data available for UniProtKB/Swiss-Prot for LRP10 Gene

Publications for LRP10 Gene

  1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PMID: 11123907) Sugiyama T. … Kitamura T. (Biochemistry 2000) 2 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4

Products for LRP10 Gene

Sources for LRP10 Gene

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