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LRP10 Gene

protein-coding   GIFtS: 57
GCID: GC14P023340

Low Density Lipoprotein Receptor-Related Protein 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein 101 2
LRP-102 3
LRP92 5
MST0872
Low-Density Lipoprotein Receptor-Related Protein 102

External Ids:    HGNC: 145531   Entrez Gene: 260202   Ensembl: ENSG000001973247   OMIM: 6099215   UniProtKB: Q7Z4F13   

Export aliases for LRP10 gene to outside databases

Previous GC identifers: GC14P020717 GC14P017128 GC14P021331 GC14P022410 GC14P003458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRP10 Gene:
LRP10 (low density lipoprotein receptor-related protein 10) is a protein-coding gene. An important paralog of this gene is LRP12.

UniProtKB/Swiss-Prot: LRP10_HUMAN, Q7Z4F1
Function: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal
transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity)

Gene Wiki entry for LRP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRP10 gene promoter:
         NF-1   NF-1/L   AML1a   HTF   Hand1   ZID   Pax-4a   E47   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRP10 promoter sequence
   Search Chromatin IP Primers for LRP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

LRP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP10 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P023340:  view genomic region     (about GC identifiers)

Start:
23,340,822 bp from pter      End:
23,350,789 bp from pter
Size:
9,968 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRP10_HUMAN, Q7Z4F1 (See protein sequence)
Recommended Name: Low-density lipoprotein receptor-related protein 10 precursor  
Size: 713 amino acids; 76193 Da
Sequence caution: Sequence=AAD20037.1; Type=Erroneous initiation; Sequence=AAG17980.1; Type=Frameshift;
Positions=370, 700; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Sequence=CAD39174.2;
Type=Miscellaneous discrepancy; Note=Chimera;
Secondary accessions: A8K4R5 D3DS31 O95882 Q14CK7 Q86T02 Q8NCZ4 Q9HC42 Q9UG33
Alternative splicing: 2 isoforms:  Q7Z4F1-1   Q7Z4F1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for LRP10: NX_Q7Z4F1

Explore proteomics data for LRP10 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn56, Asn111, Asn193, Asn299
  • Modification sites at PhosphoSitePlus

  • See LRP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054764.2  
    ENSEMBL proteins: 
     ENSP00000352601   ENSP00000447559   ENSP00000447977  
    Reactome Protein details: Q7Z4F1

    LRP10 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for LRP10
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    Novus Biologicals LRP10 Protein
    Novus Biologicals LRP10 Lysate
    Sino Biological Recombinant Protein for LRP10
    Sino Biological Cell Lysate for LRP10
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRP10

     
    Search eBioscience for Proteins for LRP10 

     
    antibodies-online proteins for LRP10 (3 products) 

     
    antibodies-online peptides for LRP10

    LRP10 Antibody Products:

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    antibodies-online antibodies for LRP10 (17 products) 

    LRP10 Assay Products:

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    Cloud-Clone Corp. ELISAs for LRP10
    Cloud-Clone Corp. CLIAs for LRP10
    Search eBioscience for ELISAs for LRP10 
    antibodies-online kits for LRP10 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LDLR: Low density lipoprotein receptors

    3 InterPro protein domains:
     IPR000859 CUB_dom
     IPR002172 LDrepeatLR_classA_rpt
     IPR023415 LDLR_class-A_CS

    Graphical View of Domain Structure for InterPro Entry Q7Z4F1

    ProtoNet protein and cluster: Q7Z4F1

    2 Blocks protein domains:
    IPB000859 CUB domain
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: LRP10_HUMAN, Q7Z4F1
    Similarity: Belongs to the LDLR family
    Similarity: Contains 2 CUB domains
    Similarity: Contains 4 LDL-receptor class A domains


    Find genes that share domains with LRP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRP10_HUMAN, Q7Z4F1
    Function: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal
    transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRP10           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRP10:
     Decreased viability of wild-ty 

         1 MGI phenotypic allele for Lrp10 (no phenotypes)

    Find genes that share phenotypes with LRP10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrp10tm1Lex for LRP10

       genOway: Develop your customized and physiologically relevant rodent model for LRP10

    miRNA
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    miRTarBase miRNAs that target LRP10:
    hsa-mir-124-3p (MIRT023152), hsa-mir-29b-3p (MIRT048363), hsa-mir-222-3p (MIRT046674), hsa-mir-335-5p (MIRT019186)

    Block miRNA regulation of human, mouse, rat LRP10 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate LRP10:
    hsa-miR-31 hsa-miR-145* hsa-miR-182 hsa-miR-122 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidLRP10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat LRP10

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for LRP10

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    OriGene ORF clones in mouse, rat for LRP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP10 (NM_014045)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRP10

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRP10_HUMAN, Q7Z4F1: Membrane; Single-pass type I membrane protein (Potential). Membrane, coated pit (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endosome2
    extracellular2
    chloroplast1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005905coated pit IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with LRP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LRP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    2Signaling by GPCR
    Signal Transduction0.58
    3Disease
    Disease


    Find genes that share SuperPaths with LRP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for LRP10
        Retinoid metabolism and transport


        Pathway & Disease-focused RT2 Profiler PCR Array including LRP10: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRP10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LRP10 (Q7Z4F13 ENSP000003526014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTRA1Q927433, ENSP000003579804I2D: score=1 STRING: ENSP00000357980
    DFNB31ENSP000003546234STRING: ENSP00000354623
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--

    Find genes that share ontologies with LRP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRP10



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRP10 gene: 
    NM_014045.3  

    Unigene Cluster for LRP10:

    Low density lipoprotein receptor-related protein 10
    Hs.525232  [show with all ESTs]
    Unigene Representative Sequence: NM_014045
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000359591(uc001whd.3 uc001whe.3) ENST00000546834 ENST00000553002
    ENST00000551466 ENST00000470660
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRP10 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate LRP10:
    hsa-miR-31 hsa-miR-145* hsa-miR-182 hsa-miR-122 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidLRP10 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRP10
    Predesigned siRNA for gene silencing in human, mouse, rat LRP10
    Clone
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    OriGene clones in human, mouse for LRP10 (see all 6)
    OriGene ORF clones in mouse, rat for LRP10
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP10 (NM_014045)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP10
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRP10
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP10
      QuantiTect SYBR Green Assays in human, mouse, rat LRP10
      QuantiFast Probe-based Assays in human, mouse, rat LRP10

    Additional mRNA sequence: 

    AF131760.1 AF172816.1 AF177336.1 AK025898.1 AK291030.1 AL080164.1 AL110149.1 AL834518.1 
    AY358399.1 BC000424.2 BC018816.2 BC064901.1 BC080648.1 BC088378.1 BC113714.1 BC113716.1 
    BX161500.1 CR457151.1 

    Selected DOTS entries (see all 29):

    DT.75182728  DT.91896023  DT.434472  DT.95293751  DT.120760280  DT.102836151  DT.100886211  DT.102836146 
    DT.102836150  DT.102836153  DT.120760336  DT.100693988  DT.102836147  DT.102836154  DT.92463603  DT.95254061 
    DT.100647646  DT.100675732  DT.100677074  DT.100768719  DT.100886209  DT.100886218  DT.102836157  DT.120760334 

    Selected AceView cDNA sequences (see all 668):

    BM829834 BQ723477 AA627054 BU150302 CA426707 AI393983 CF125003 CK822739 
    BQ691357 BF984681 BU860521 BQ686475 CF265082 AI084574 CF125295 BF968513 
    AL080164 BX161500 NM_014045 BM997452 CA488311 CD677124 BQ025860 AI912329 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for LRP10    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
    SP1:                    -                       -                                                         
    SP2:                    -                                                                                 
    SP3:                                            -                 -     -                                 
    SP4:                                                                                      -     -         
    SP5:                                            -                                                         


    ECgene alternative splicing isoforms for LRP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAGACACC
    LRP10 Expression
    About this image


    LRP10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 15 entries
             Cerebral Cortex
             Olfactory Bulb   
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Neural Tube (Nervous System)
             Metencephalon
     
     Spinal Cord (Nervous System)
    LRP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525232

    UniProtKB/Swiss-Prot: LRP10_HUMAN, Q7Z4F1
    Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus,
    colon, skeletal muscle and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including LRP10: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRP10
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP10
    QuantiTect SYBR Green Assays in human, mouse, rat LRP10
    QuantiFast Probe-based Assays in human, mouse, rat LRP10
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LRP10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrp101 , 5 low-density lipoprotein receptor-related protein 1 more1, 5 85.95(n)1
    88.06(a)1
      14 (27.80 cM)5
    651071  NM_022993.31  NP_075369.21 
     544641475 
    lizard
    (Anolis carolinensis)
    Reptilia LRP106
    low density lipoprotein receptor-related protein 1...
    53(a)
    1 ↔ 1
    GL343879.1(1612-11940)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58302 Xenopus laevis transcribed sequence with weak similarity more 73.64(n)    BJ069090.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5603611 low-density lipoprotein receptor-related protein 1 more 49.9(n)
    42.39(a)
      560361  XM_683767.6  XP_688859.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta ImpE16
    Ecdysone-inducible gene E1
    8(a)
    many ↔ many
    3L(8365505-8384271)
    worm
    (Caenorhabditis elegans)
    Secernentea M03E7.46
    Protein M03E7.4 (M03E7.4) mRNA, complete cds
    19(a)
    1 → many
    V(5609414-5613219) WBGene00019756


    ENSEMBL Gene Tree for LRP10 (if available)
    TreeFam Gene Tree for LRP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRP10 gene
    LRP122  LRP32  LDLRAD32  
    3 SIMAP similar genes for LRP10 using alignment to 5 protein entries:     LRP10_HUMAN (see all proteins):
    LRP12    VLDLR    LRP3

    Find genes that share paralogs with LRP10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRP10 (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999589191,2
    --23338995(+) AAAAC-/AAAAAC 1 -- us2k10--------
    rs116221841,2
    C,F,H--23339000(+) caaaaC/AaaaaA 1 -- us2k16Minor allele frequency- A:0.17WA NA CSA EA 368
    rs2013396621,2
    --23339000(+) CAAAA-/CAAAAA 1 -- us2k10--------
    rs1897156851,2
    --23339124(+) TCACAC/TTTGTT 1 -- us2k10--------
    rs1140777141,2
    F--23339256(+) CGGCGC/TGCACC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1824214731,2
    --23339279(+) TACTTC/GGGGGG 1 -- us2k10--------
    rs1878121671,2
    --23339326(+) AACCCG/TGGAGG 1 -- us2k10--------
    rs1926955131,2
    --23339501(+) CTCACA/GCCTGT 1 -- us2k10--------
    rs1402398211,2
    --23339634(+) GCAGCA/GGGCGC 1 -- us2k10--------
    rs1851383631,2
    --23339638(+) CGGGCA/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for LRP10 (23340822 - 23350789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for LRP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901490CNV Loss21882294
    nsv1214CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609921    OMIM disorders: --


    Find genes that share disorders with LRP10           About GenesLikeMe


    Export disorders for LRP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRP10 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with LRP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PubMed id 11123907)1, 2, 3 Sugiyama T.... Kitamura T. (Biochemistry 2000)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    5. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 2 Yu W.... Gibbs R.A. (Genome Res. 1997)
    6. LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease. (PubMed id 22734645)1 Brodeur J....Lavoie C. (Mol Neurodegener 2012)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway. (PubMed id 20093106)1 Jeong Y.H....Saeki S. (Biochem. Biophys. Res. Commun. 2010)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26020 HGNC: 14553 AceView: LRP10 Ensembl:ENSG00000197324 euGenes: HUgn26020
    ECgene: LRP10 H-InvDB: LRP10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRP10 gene:
    Search GeneIP for patents involving LRP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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