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Aliases for LRP10 Gene

Aliases for LRP10 Gene

  • LDL Receptor Related Protein 10 2 3 5
  • LRP-10 3 4
  • Low Density Lipoprotein Receptor-Related Protein 10 2
  • Low-Density Lipoprotein Receptor-Related Protein 10 3
  • MSTP087 3
  • MST087 3
  • LRP9 3

External Ids for LRP10 Gene

Previous GeneCards Identifiers for LRP10 Gene

  • GC14P020717
  • GC14P017128
  • GC14P021331
  • GC14P022410
  • GC14P023340
  • GC14P003458

Summaries for LRP10 Gene

Entrez Gene Summary for LRP10 Gene

  • This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]

GeneCards Summary for LRP10 Gene

LRP10 (LDL Receptor Related Protein 10) is a Protein Coding gene. Among its related pathways are Metabolism of fat-soluble vitamins and Signaling by GPCR. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot for LRP10 Gene

  • Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Wiki entry for LRP10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP10 Gene

Genomics for LRP10 Gene

Regulatory Elements for LRP10 Gene

Enhancers for LRP10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022844 1.9 FANTOM5 ENCODE dbSUPER 21.8 -22.3 -22332 9.9 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 OXA1L LRP10 REM2 PPP1R3E RBM23 THTPA DAD1 HOMEZ PABPN1 HAUS4
GH14G022504 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.7 -333.4 -333426 66.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 MMP14 ABHD4 OXA1L EFS BCL2L2-PABPN1 DAD1 LOC105370399 TRAC C14orf119 OR6J1
GH14G022795 1.5 Ensembl ENCODE dbSUPER 11.4 -74.1 -74063 3.8 PKNOX1 FOXA2 ATF1 ARID4B YBX1 TCF12 MXD4 JUNB REST TBX21 OXA1L MRPL52 SLC7A7 MMP14 ENSG00000199716 LRP10 REM2 CDH24 ENSG00000258458
GH14G022587 1.7 FANTOM5 ENCODE dbSUPER 9.7 -282.5 -282540 3.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 MMP14 PABPN1 OXA1L DAD1 ABHD4 OR6J1 BCL2L2 LRP10 REM2 LINC02332
GH14G022689 1.6 FANTOM5 Ensembl ENCODE 10.3 -181.0 -181013 3.0 HDGF PKNOX1 ARNT GATA2 FOS NCOA1 REST ZNF518A ZNF592 CREB3 OXA1L SLC7A7 OR6J1 MRPL52 MMP14 ENSG00000199716 LRP10 REM2 GC14M022699
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRP10 on UCSC Golden Path with GeneCards custom track

Promoters for LRP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066654 387 2001 PKNOX1 FOXA2 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1

Genomic Location for LRP10 Gene

Chromosome:
14
Start:
22,871,613 bp from pter
End:
22,881,580 bp from pter
Size:
9,968 bases
Orientation:
Plus strand

Genomic View for LRP10 Gene

Genes around LRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP10 Gene

Proteins for LRP10 Gene

  • Protein details for LRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4F1-LRP10_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 10
    Protein Accession:
    Q7Z4F1
    Secondary Accessions:
    • A8K4R5
    • D3DS31
    • O95882
    • Q14CK7
    • Q86T02
    • Q8NCZ4
    • Q9HC42
    • Q9UG33

    Protein attributes for LRP10 Gene

    Size:
    713 amino acids
    Molecular mass:
    76193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Evidence={ECO:0000305}; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Evidence={ECO:0000305}; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP10 Gene

Post-translational modifications for LRP10 Gene

  • Glycosylation at Asn56, posLast=111111, posLast=193193, and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP10 Gene

No data available for DME Specific Peptides for LRP10 Gene

Domains & Families for LRP10 Gene

Gene Families for LRP10 Gene

Suggested Antigen Peptide Sequences for LRP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4F1

UniProtKB/Swiss-Prot:

LRP10_HUMAN :
  • Belongs to the LDLR family.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP10: view

Function for LRP10 Gene

Molecular function for LRP10 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Ontology (GO) - Molecular Function for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005041 low-density lipoprotein receptor activity IEA --
genes like me logo Genes that share ontologies with LRP10: view
genes like me logo Genes that share phenotypes with LRP10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP10

CRISPR Products

miRNA for LRP10 Gene

miRTarBase miRNAs that target LRP10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP10 Gene

Localization for LRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP10 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRP10 gene
Compartment Confidence
plasma membrane 3
extracellular 2

Gene Ontology (GO) - Cellular Components for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 clathrin-coated pit IEA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with LRP10: view

Pathways & Interactions for LRP10 Gene

genes like me logo Genes that share pathways with LRP10: view

Interacting Proteins for LRP10 Gene

Gene Ontology (GO) - Biological Process for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006869 lipid transport IEA --
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with LRP10: view

No data available for SIGNOR curated interactions for LRP10 Gene

Transcripts for LRP10 Gene

Unigene Clusters for LRP10 Gene

Low density lipoprotein receptor-related protein 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for LRP10 Gene

GeneLoc Exon Structure for
LRP10
ECgene alternative splicing isoforms for
LRP10

Expression for LRP10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRP10 Gene

mRNA differential expression in normal tissues according to GTEx for LRP10 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for LRP10 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRP10 Gene



Protein tissue co-expression partners for LRP10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of LRP10 Gene:

LRP10

SOURCE GeneReport for Unigene cluster for LRP10 Gene:

Hs.525232

mRNA Expression by UniProt/SwissProt for LRP10 Gene:

Q7Z4F1-LRP10_HUMAN
Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for LRP10 Gene

  • Lung(4.8)
  • Nervous system(4.7)
  • Intestine(3.7)
  • Pancreas(3.4)
  • Eye(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with LRP10: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRP10 Gene

Orthologs for LRP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP10 34 35
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia LRP10 34 35
  • 87.5 (n)
cow
(Bos Taurus)
Mammalia LRP10 34 35
  • 87.11 (n)
mouse
(Mus musculus)
Mammalia Lrp10 34 16 35
  • 85.95 (n)
rat
(Rattus norvegicus)
Mammalia Lrp10 34
  • 85.33 (n)
oppossum
(Monodelphis domestica)
Mammalia LRP10 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP10 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP10 35
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp10 34
  • 53.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5830 34
zebrafish
(Danio rerio)
Actinopterygii LOC560361 34
  • 49.9 (n)
LRP10 35
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ImpE1 35
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 35
  • 19 (a)
OneToMany
Species where no ortholog for LRP10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP10 Gene

ENSEMBL:
Gene Tree for LRP10 (if available)
TreeFam:
Gene Tree for LRP10 (if available)

Paralogs for LRP10 Gene

Paralogs for LRP10 Gene

(3) SIMAP similar genes for LRP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LRP10: view

Variants for LRP10 Gene

Sequence variations from dbSNP and Humsavar for LRP10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs568022752 Uncertain significance 22,875,702(+) ATGAC(A/G)GCCCT reference, missense
rs1000268552 -- 22,875,064(+) CAGAA(C/G)CTACA reference, missense
rs1000587796 -- 22,876,543(+) AGGGA(C/G)GAGGG intron-variant
rs1000942014 -- 22,879,681(+) AGGCT(C/T)GTGCT utr-variant-3-prime
rs1001287870 -- 22,870,323(+) CCGAG(A/G)CGGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRP10 Gene

Variant ID Type Subtype PubMed ID
nsv1214 CNV deletion 18451855
nsv563998 CNV gain 21841781

Variation tolerance for LRP10 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRP10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRP10 Gene

Disorders for LRP10 Gene

Relevant External Links for LRP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRP10

No disorders were found for LRP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP10 Gene

Publications for LRP10 Gene

  1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PMID: 11123907) Sugiyama T. … Kitamura T. (Biochemistry 2000) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 3 4 64

Products for LRP10 Gene

Sources for LRP10 Gene

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