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Aliases for LRP10 Gene

Aliases for LRP10 Gene

  • LDL Receptor Related Protein 10 2 3 5
  • Low Density Lipoprotein Receptor-Related Protein 10 2 3
  • LRP-10 3 4
  • MSTP087 3
  • MST087 3
  • LRP9 3

External Ids for LRP10 Gene

Previous GeneCards Identifiers for LRP10 Gene

  • GC14P020717
  • GC14P017128
  • GC14P021331
  • GC14P022410
  • GC14P023340
  • GC14P003458

Summaries for LRP10 Gene

GeneCards Summary for LRP10 Gene

LRP10 (LDL Receptor Related Protein 10) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Metabolism of fat-soluble vitamins. An important paralog of this gene is LRP3.

UniProtKB/Swiss-Prot for LRP10 Gene

  • Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).

Gene Wiki entry for LRP10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP10 Gene

Genomics for LRP10 Gene

Regulatory Elements for LRP10 Gene

Enhancers for LRP10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LRP10 on UCSC Golden Path with GeneCards custom track

Promoters for LRP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LRP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for LRP10 Gene

Chromosome:
14
Start:
22,871,613 bp from pter
End:
22,881,580 bp from pter
Size:
9,968 bases
Orientation:
Plus strand

Genomic View for LRP10 Gene

Genes around LRP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP10 Gene

Proteins for LRP10 Gene

  • Protein details for LRP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4F1-LRP10_HUMAN
    Recommended name:
    Low-density lipoprotein receptor-related protein 10
    Protein Accession:
    Q7Z4F1
    Secondary Accessions:
    • A8K4R5
    • D3DS31
    • O95882
    • Q14CK7
    • Q86T02
    • Q8NCZ4
    • Q9HC42
    • Q9UG33

    Protein attributes for LRP10 Gene

    Size:
    713 amino acids
    Molecular mass:
    76193 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD20037.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG17980.1; Type=Frameshift; Positions=370, 700; Evidence={ECO:0000305}; Sequence=AAQ13610.1; Type=Frameshift; Positions=312, 337, 496, 502, 512; Evidence={ECO:0000305}; Sequence=CAD39174.2; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP10 Gene

Proteomics data for LRP10 Gene at MOPED

Post-translational modifications for LRP10 Gene

  • Glycosylation at Asn 56, Asn 111, Asn 193, and Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for LRP10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRP10 Gene

Domains & Families for LRP10 Gene

Gene Families for LRP10 Gene

Suggested Antigen Peptide Sequences for LRP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4F1

UniProtKB/Swiss-Prot:

LRP10_HUMAN :
  • Contains 2 CUB domains.
  • Belongs to the LDLR family.
Domain:
  • Contains 2 CUB domains.
  • Contains 4 LDL-receptor class A domains.
Family:
  • Belongs to the LDLR family.
genes like me logo Genes that share domains with LRP10: view

Function for LRP10 Gene

Molecular function for LRP10 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity).
genes like me logo Genes that share phenotypes with LRP10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for LRP10

miRNA for LRP10 Gene

miRTarBase miRNAs that target LRP10

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LRP10 Gene

Localization for LRP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP10 Gene

Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LRP10 Gene COMPARTMENTS Subcellular localization image for LRP10 gene
Compartment Confidence
plasma membrane 3
extracellular 2
golgi apparatus 2
endosome 1

Gene Ontology (GO) - Cellular Components for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with LRP10: view

Pathways & Interactions for LRP10 Gene

genes like me logo Genes that share pathways with LRP10: view

Interacting Proteins for LRP10 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000352601%0d%0a9606.ENSP00000357980%0d%0a9606.ENSP00000354623%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000352601 Q7Z4F1-LRP10_HUMAN for LRP10 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for LRP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with LRP10: view

No data available for SIGNOR curated interactions for LRP10 Gene

Drugs & Compounds for LRP10 Gene

No Compound Related Data Available

Transcripts for LRP10 Gene

Unigene Clusters for LRP10 Gene

Low density lipoprotein receptor-related protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9
SP1: - -
SP2: -
SP3: - - -
SP4: - -
SP5: -

Relevant External Links for LRP10 Gene

GeneLoc Exon Structure for
LRP10
ECgene alternative splicing isoforms for
LRP10

Expression for LRP10 Gene

mRNA expression in normal human tissues for LRP10 Gene

mRNA differential expression in normal tissues according to GTEx for LRP10 Gene

This gene is overexpressed in Whole Blood (x7.5).

Protein differential expression in normal tissues from HIPED for LRP10 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRP10 Gene



SOURCE GeneReport for Unigene cluster for LRP10 Gene Hs.525232

mRNA Expression by UniProt/SwissProt for LRP10 Gene

Q7Z4F1-LRP10_HUMAN
Tissue specificity: Expressed in blood leukocyte, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle and heart.
genes like me logo Genes that share expression patterns with LRP10: view

Protein tissue co-expression partners for LRP10 Gene

- Elite partner

Primer Products

Orthologs for LRP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LRP10 35
  • 87.11 (n)
  • 88.61 (a)
LRP10 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP10 35
  • 87.5 (n)
  • 89.51 (a)
LRP10 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp10 35
  • 85.95 (n)
  • 88.06 (a)
Lrp10 16
Lrp10 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LRP10 35
  • 99.67 (n)
  • 99.71 (a)
LRP10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp10 35
  • 85.33 (n)
  • 88.46 (a)
oppossum
(Monodelphis domestica)
Mammalia LRP10 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP10 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP10 36
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lrp10 35
  • 53.17 (n)
  • 52.05 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5830 35
zebrafish
(Danio rerio)
Actinopterygii LOC560361 35
  • 49.9 (n)
  • 42.39 (a)
LRP10 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ImpE1 36
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea M03E7.4 36
  • 19 (a)
OneToMany
Species with no ortholog for LRP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP10 Gene

ENSEMBL:
Gene Tree for LRP10 (if available)
TreeFam:
Gene Tree for LRP10 (if available)

Paralogs for LRP10 Gene

Paralogs for LRP10 Gene

(3) SIMAP similar genes for LRP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with LRP10: view

Variants for LRP10 Gene

Sequence variations from dbSNP and Humsavar for LRP10 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2273837 - 22,873,373(-) GTCCC(A/G)GACCA reference, missense
rs28534929 - 22,875,363(+) GGCTG(A/G/T)TGTGC reference, missense
rs7149064 -- 22,871,256(+) ATTTA(C/T)TGAGT upstream-variant-2KB
rs8011536 -- 22,872,457(+) CGCCA(C/G)CCCCA intron-variant
rs10147709 -- 22,879,737(+) GTGCT(A/G)TACGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for LRP10 Gene

Variant ID Type Subtype PubMed ID
nsv901490 CNV Loss 21882294
nsv1214 CNV Loss 18451855

Variation tolerance for LRP10 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.95% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LRP10 Gene

Disorders for LRP10 Gene

Relevant External Links for LRP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRP10

No disorders were found for LRP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LRP10 Gene

Publications for LRP10 Gene

  1. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. (PMID: 11123907) Sugiyama T. … Kitamura T. (Biochemistry 2000) 2 3 4 67
  2. Mayer-Rokitansky-KA1ster-Hauser syndrome discordance in monozygotic twins: matrix metalloproteinase 14, low-density lipoprotein receptor-related protein 10, extracellular matrix, and neoangiogenesis genes identified as candidate genes in a tissue-specific mosaicism. (PMID: 25492683) Rall K. … Brucker S. (Fertil. Steril. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease. (PMID: 22734645) Brodeur J. … Lavoie C. (Mol Neurodegener 2012) 3

Products for LRP10 Gene

Sources for LRP10 Gene

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