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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LRP1 Gene

protein-coding GIFtS: 71
GCID: GC12P057497

low density lipoprotein receptor-related protein 1

(Previous name: alpha-2-macroglobulin receptor )
(Previous symbols: APR, A2MR)

Explore 76 diseases affiliated with
LRP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Low Density Lipoprotein Receptor-Related Protein 1¹ ²		IGFBP3R²
A2MR¹ ² ³ ⁵		TGFBR5²
Alpha-2-Macroglobulin Receptor¹ ² ³		Prolow-Density Lipoprotein Receptor-Related Protein 1²
APR¹ ² ³		TbetaR-V/LRP-1/IGFBP-3 Receptor²
CD91¹ ²		Type V Tgf-Beta Receptor²
LRP¹ ²		CD91 Antigen³
Apolipoprotein E Receptor² ³		EC 1.1.1.94⁸
APOER² ³		EC 3.4.21.9⁸
LRP-1² ³

External Ids:	HGNC: 6692¹	Entrez Gene: 4035²	Ensembl: ENSG00000123384⁷	OMIM: 107770⁵	UniProtKB: Q07954³

Export aliases for LRP1 gene to outside databases

Previous GC identifers: GC12P057746 GC12P057239 GC12P055808 GC12P054560

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LRP1:

The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including

intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is

necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of

amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower

than controls in brain tissue from Alzheimer patients. (provided by RefSeq, Jan 2010)

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early

embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron

remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between

plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism,

kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission

Function: Functions as a receptor for Pseudomonas aeruginosa exotoxin A

Gene Wiki entry for LRP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LRP1 gene promoter:
AP-2alpha isoform 3 AP-1 AP-2alpha isoform 2 NF-kappaB STAT3 AP-2alpha isoform 4 NF-kappaB1 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): LRP1 promoter sequence

Search SABiosciences Chromatin IP Primers for LRP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LRP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13-q14 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13-q14

LRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP1 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P057497: view genomic region (about GC identifiers)

Start:	57,522,276 bp from pter	End:	57,607,142 bp from pter
Size:	84,867 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954 (See protein sequence)

Recommended Name: Prolow-density lipoprotein receptor-related protein 1 precursor

Size: 4544 amino acids; 504606 Da

Subunit: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal

subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI.

Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1.

Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by

tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins

Subcellular location: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass

type I membrane protein. Membrane, coated pit

Subcellular location: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral

membrane protein; Extracellular side. Membrane, coated pit

Subcellular location: Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus.

Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus

6/7 PDB 3D structures from and Proteopedia for LRP1 (see all 7):

1CR8 (3D)

1D2L (3D)

1J8E (3D)

2FYJ (3D)

2FYL (3D)

2KNX (3D)

Secondary accessions: Q2PP12 Q8IVG8

Explore the universe of human proteins at neXtProt for LRP1: NX_Q07954

Post-translational modifications:

Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that

remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from

the membrane¹

The N-terminus is blocked¹

Phosphorylated on serine and threonine residues¹

Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q07954

2 DME Specific Peptides for LRP1 (Q07954)

KNVIALA

CPDGSDE

LRP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002323.2

ENSEMBL proteins:

ENSP00000451449 ENSP00000243077 ENSP00000341264 ENSP00000451737 ENSP00000451622

ENSP00000451012

Reactome Protein details: Q07954
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for LRP1 (LRP-1 Cluster III, LRP-1 Cluster IV, LRP-1 Cluster II)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: LRP1 OriGene Custom Protein Services for LRP1
	GenScript Custom Purified and Recombinant Proteins Services for LRP1
	Novus Biologicals LRP1 Proteins Novus Biologicals LRP1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LRP1

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005768	endosome	--	--
GO:0005887	integral to plasma membrane	ISS	--

LRP1 for ontologies About GeneDecksing

LRP1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LRP1
	R&D Systems Antibodies for LRP1 (LRP-1, LRP-1 Cluster III, LRP-1 Cluster II)
	OriGene Antibodies: LRP1 OriGene Custom Antibody Services for LRP1
	GenScript Superior Antibodies for LRP1
	Novus Biologicals LRP1 Antibodies
	Abcam antibodies for LRP1
	Uscn Antibodies for LRP1
	ThermoFisher Antibodies for LRP1

Assay Products for LRP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LRP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LRP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LRP1 for domains About GeneDecksing

5/11 InterPro domains/families (see all 11):

IPR000033 LDLR_classB_rpt

IPR023415 LDLR_class-A_CS

IPR000742 EG-like_dom

IPR026823 cEGF

IPR000152 EGF-type_Asp/Asn_hydroxyl_site

Graphical View of Domain Structure for InterPro Entry Q07954

ProtoNet protein and cluster: Q07954

4 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Similarity: Belongs to the LDLR family

Similarity: Contains 22 EGF-like domains

Similarity: Contains 31 LDL-receptor class A domains

Similarity: Contains 34 LDL-receptor class B repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early

embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron

remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between

plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism,

kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission

Function: Functions as a receptor for Pseudomonas aeruginosa exotoxin A

Genatlas biochemistry entry for LRP1:

low-density lipoprotein receptor related protein 1,600kDa,LDLR superfamily,putative susceptibility factor for Alzheimer

disease

Enzyme Numbers (IUBMB): EC 3.4.21.9² EC 1.1.1.94²

miRNA Products:		miRTarBase miRNAs that target LRP1: hsa-mir-1 (MIRT001359), hsa-mir-338-5p (MIRT001161), hsa-mir-205 (MIRT001163), hsa-mir-545 (MIRT001162)

		OriGene 3'-UTR Clone: LRP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRP1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate LRP1 (see all 26):
		hsa-miR-4291 hsa-miR-579 hsa-miR-3152-3p hsa-miR-185* hsa-miR-429 hsa-miR-4318 hsa-miR-944 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: LRP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRP1 (see all 4) OriGene shRNA RFP: LRP1 OriGene siRNA: LRP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LRP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRP1 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LRP1 (NM_002332)
		Sino Biological Human cDNA Clone for LRP1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LRP1
		Search LifeMap BioReagents cell lines for LRP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	--	--
GO:0004872	receptor activity	TAS	10880251
GO:0005509	calcium ion binding	ISS	--
GO:0005515	protein binding	IPI	8626514
GO:0032403	protein complex binding	IDA	8626514

LRP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for LRP1:

Increased HPV18 LCR reporter a

Animal Models:
Mouse knock-out Lrp1^tm1Her for LRP1
14 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Lrp1):

adipose tissue	behavior/neurological	cardiovascular system	embryogenesis	growth/size
homeostasis/metabolism	immune system	liver/biliary system	mortality/aging	muscle
nervous system	normal	reproductive system	skeleton

LRP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Retinoid metabolism and transport

	Retinoid metabolism and transport	1.00			Diseases associated with visual transduction	0.73
	Visual phototransduction	0.74

Statin Pathway, Pharmacodynamics

Statin Pathway, Pharmacodynamics

1.00

Statin Pathway

0.80

Cleavage of Alpha-1-Microglobulin

Binding and Uptake of Ligands by Scavenger Receptors

0.79

Scavenging of Heme from Plasma

0.79

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

Alzheimer's disease

0.43

Alzheimers Disease

0.00

Endocytosis of LRP1:Hemopexin:heme

Endocytosis of LRP1:Hemopexin:heme

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for LRP1

Metalloproteases in connective tissue degradation

1 R&D Systems Pathway for LRP1

A-beta Uptake & Degradation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for LRP1

Alzheimers Disease Pathway

5 BioSystems Pathways for LRP1

	Statin Pathway
	Wnt Signaling Pathway NetPath
	Alzheimers Disease
	amb2 Integrin signaling
	PDGFR-beta signaling pathway

5/8 Reactome Pathways for LRP1 (see all 8)

	Diseases associated with visual transduction
	Scavenging of Heme from Plasma
	Visual phototransduction
	Disease
	Retinoid metabolism and transport

1 PharmGKB Pathway for LRP1

Statin Pathway, Pharmacodynamics

2 Kegg Pathways (Kegg details for LRP1):

	Alzheimer's disease
	Malaria

LRP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LRP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/84 Interacting proteins for LRP1 (Q07954^{1, 2, 3} ENSP00000243077⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 84)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APBB1	O00213²^,³, ENSP00000299402⁴	MINT-8206789 MINT-8206758 MINT-8206722 I2D: score=4 STRING: ENSP00000299402
APP	P05067²^,³, ENSP00000284981⁴	MINT-8206789 I2D: score=2 STRING: ENSP00000284981
SKIL	P12757²^,³	MINT-61637 I2D: score=3
MBL2	P11226²^,³, ENSP00000363079⁴	MINT-8040928 MINT-8040706 MINT-8040679 MINT-8040869 MINT-8040821 I2D: score=1 STRING: ENSP00000363079
FCN2	Q15485²^,³, ENSP00000291744⁴	MINT-8040880 MINT-8040690 I2D: score=1 STRING: ENSP00000291744

About this table

Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006898	receptor-mediated endocytosis	IEA	--
GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway	--	--
GO:0007568	aging	--	--
GO:0008203	cholesterol metabolic process	IEA	--
GO:0008283	cell proliferation	--	--

LRP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LRP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LRP1

1 HMDB Compound for LRP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

3 DrugBank Compounds for LRP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Antihemophilic Factor	AHF (see all 3)	--	target	modulator	21391865 17139284 17016423
Coagulation Factor IX	Christmas factor (see all 4)	9001-28-9	target	--	17139284 12522212 17016423
Tenecteplase	t- PA (see all 4)	191588-94-0	target	--	8344937 1378833 16303771

10/53 Novoseek chemical compound relationships for LRP1 gene (see all 53) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha 2 macroglobulin	72.4	4	10072300 (1), 16945147 (1)
exotoxin-a	58	12	11716468 (2), 16262727 (2), 7686151 (1), 9840615 (1) (see all 7)
methylamine	47.9	4	15161872 (1), 7589486 (1)
saporin	47.4	3	10877826 (1), 8226837 (1), 8562904 (1)
cholesterol	46.4	43	9930403 (4), 19718435 (3), 11839845 (2), 16973241 (2) (see all 26)
n-acetylleucylleucylnorleucinal	43.2	4	17376415 (2)
heparin	42.9	32	7717977 (3), 11382778 (3), 9253767 (1), 7989348 (1) (see all 17)
lipid	36.4	51	9568751 (5), 19823686 (4), 19718435 (2), 12417024 (2) (see all 30)
mannose	22.6	8	11560994 (2), 10438721 (2), 7579446 (2), 11339811 (1) (see all 5)
chlorate	22.1	1	7592957 (1)

Search CenterWatch for drugs/clinical trials and news about LRP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LRP1 gene:

NM_002332.2

Unigene Cluster for LRP1:

Low density lipoprotein receptor-related protein 1

Hs.162757 [show with all ESTs]

Unigene Representative Sequence: NM_002332

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000553277(uc001snb.3) ENST00000243077(uc001snd.3) ENST00000338962(uc010sre.2)

ENST00000554174(uc001snc.1) ENST00000556830 ENST00000553446(uc009zph.1 uc009zpi.1)

ENST00000554118 ENST00000555941 ENST00000555124 ENST00000556247 ENST00000451724

ENST00000556356

miRNA Products:		OriGene 3'-UTR Clone: LRP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LRP1
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate LRP1 (see all 26):
		hsa-miR-4291 hsa-miR-579 hsa-miR-3152-3p hsa-miR-185* hsa-miR-429 hsa-miR-4318 hsa-miR-944 hsa-miR-103a

		SwitchGear 3'UTR luciferase reporter plasmid: LRP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LRP1 (see all 4) OriGene shRNA RFP: LRP1 OriGene siRNA: LRP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LRP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LRP1 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LRP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LRP1 (NM_002332)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP1
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LRP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LRP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LRP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LRP1

Additional cDNA sequence:

AB209498.1 BC021204.2 BC045107.1 BC052593.1 BC072015.1 EF491795.1 EF491814.1 X13916.1

X55077.1

24/27 DOTS entries (see all 27):

DT.99957844 DT.92412213 DT.95365460 DT.119074 DT.102838207 DT.92358788 DT.97801601 DT.101958636

DT.75169204 DT.95365458 DT.121182481 DT.95296546 DT.40284724 DT.95365444 DT.95365447 DT.100797814

DT.91848558 DT.91900077 DT.92005792 DT.92421325 DT.92448543 DT.92448546 DT.95361161 DT.455293

24/666 AceView cDNA sequences (see all 666):

CA413981 X13916 CA414447 AI273102 BM677141 AI573126 BM987286 CD559102

AA938449 AA883896 AI141705 CD514501 AI151082 AW469008 AI360902 CA388862

BM547585 AI360272 AI678386 AI004371 AK122840 CA426977 BU146193 BU627214

GeneLoc Exon Structure

5/28 Alternative Splicing Database (ASD) splice patterns (SP) for LRP1 (see all 28) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^
SP1:																	-		-
SP2:																	-
SP3:
SP4:
SP5:

ExUns:	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	·	31c	^	32	^	33	^	34	^	35a	·	35b	^	36	^	37	^	38	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	39	^	40	^	41	^	42	^	43a	·	43b	^	44	^	45	^	46a	·	46b	^	47a	·	47b	^	48	^	49	^	50a	·	50b	·	50c	^	51a	·	51b	^	52a	·	52b	^	53a	·	53b	·	53c	·	53d	^	54a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	54b	^	55	^	56	^	57a	·	57b	·	57c	^	58	^	59	^	60a	·	60b	^	61a	·	61b	^	62a	·	62b	·	62c	^	63	^	64a	·	64b	^	65	^	66	^	67	^	68	^	69	^
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LRP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LRP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCAACCCCC

About this image

LRP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

6 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Mature Choroid Plexus Cells

Choroid Plexus

Testis

Brain

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Spinal Cord

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature brain microvascular endothelial cells (Derivation of blood-...)

See LRP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LRP1

SOURCE GeneReport for Unigene cluster: Hs.162757

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Tissue specificity: Most abundant in liver, brain and lung

SABiosciences Expression via Pathway-Focused PCR Arrays including LRP1:

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Alzheimer's Disease in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LRP1 gene from 4/19 species (see all 19) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	LRP1⁶	--	84(a)	1 ↔ 1	GL343212.1(2025804-2353959)
African clawed frog (Xenopus laevis)	Amphibia	Xl.18251²	Xenopus laevis transcribed sequence with moderate similarity more	75.63(n)		CB198235.2
zebrafish (Danio rerio)	Actinopterygii	57092532²	--	84.92(n)		57092532
fruit fly (Drosophila melanogaster)	Insecta	yl³ LRP1¹	oogenesis vitellogenin receptor³ LDL receptor protein 1¹	27(a)³ 50.15(n)¹ 40.67(a)¹		35799¹ NM_176104.1¹ NP_788284.1¹

ENSEMBL Gene Tree for LRP1 (if available)
TreeFam Gene Tree for LRP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LRP1 gene

LRP5² LRP6² LRP2² SORL1² LRP1B² EGF² LDLR² LRP5L²

LRP4² VLDLR² NID2² NID1² LRP8²

13 SIMAP similar genes for LRP1 using alignment to 7 protein entries: LRP1_HUMAN (see all proteins):

LRP LRP1B PRSS7 LRP6 LRP5 LRP5L

NID2 VLDLR LRP4 LRP2 LRP8 LDLR

NOTCH2NL

LRP1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for LRP1
PGOHUM00000258301

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs137909502^1,2	C	other	57560824(+)	`TGCTTC/TGTGTG`	2	S L	mis¹		1		NA	4552
rs189992588^1,2		--	57520294(+)	`ACACAC/TTCACA`	1	--	us2k¹		0	--	--	--	--
rs138122513^1,2		--	57520335(+)	`AAGTGA/GGAAGT`	1	--	us2k¹		0	--	--	--	--
rs61626321^1,2	C,	--	57520435(+)	`AGCAAG/AGAAGA`	1	--	us2k¹		2		WA	120
rs11172112^1,2	C,F,A,H,	--	57520488(+)	`GGTAGG/CGGGAG`	1	--	us2k¹ tfbs³ trp³		7		NA NS WA	334
rs35314242^1,2	C,F,	--	57520534(+)	`GGTTGC/TTCCAG`	1	--	us2k¹		3		NS WA	206
rs35088835^1,2	C,F,	--	57520656(+)	`GAGTCC/TGCATA`	1	--	us2k¹		3		NS WA	208
rs7306742^1,2	C,F,A,H,	--	57520687(+)	`GGCCAT/CGGGAG`	1	--	us2k¹		13		NS EA NA WA	754
rs35603030^1,2	C,	--	57520729(+)	`TGCCTG/AGAGCA`	1	--	us2k¹		2		NS	90
rs35408366^1,2	C,F,	--	57520767(+)	`NNNNAG/TATATA`	1	--	us2k¹		3		NS NA	210

HapMap Linkage Disequilibrium report for LRP1 (57522276 - 57607142 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LRP1
2 Indels: 101522 58583
Human Gene Mutation Database (HGMD): LRP1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LRP1

DNA2.0 Custom Variant and Variant Library Synthesis for LRP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LRP1 for disorders           About GeneDecksing

OMIM gene information: 107770    OMIM disorders: --

20/76 diseases for LRP1 (see all 76):    About MalaCards

cerebral amyloid angiopathy inclusion body myositis von willebrand's disease myxoid liposarcoma

coronary heart disease venous thrombosis liposarcoma myocardial infarction

marfan syndrome hypercholesterolemia familial hypercholesterolemia alzheimer's disease

macular degeneration multiple sclerosis neurodegenerative disease myositis

aortic atherosclerosis thrombosis amyloidosis thromboembolism

10/53 Novoseek disease relationships for LRP1 gene (see all 53) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	74	89	18673201 (2), 11252768 (2), 10394937 (2), 11436129 (2) (see all 71)
senile plaques	57.4	14	7531418 (2), 20477378 (1), 10072300 (1), 10936878 (1) (see all 9)
cerebral amyloid angiopathy	39.6	4	15634227 (1), 18055545 (1)
glioblastoma	34.6	30	9879460 (6), 9205092 (5), 19176371 (2), 7961982 (1) (see all 9)
atherosclerosis	34.2	10	15030790 (2), 11357934 (2), 8199172 (1), 9610960 (1) (see all 8)
neurofibrillary tangles	31.1	3	9341576 (2), 18855584 (1)
amyloid deposition	28.3	10	11067868 (2), 15634227 (1), 11193147 (1)
dementia	25.4	3	16470248 (1), 14575236 (1)
choriocarcinoma	22	1	10471328 (1)
neurodegenerative diseases	20.5	3	18559293 (1), 11498265 (1), 17314289 (1)

Genetic Association Database (GAD): LRP1
Human Genome Epidemiology (HuGE) Navigator: LRP1 (52 documents)

Export disorders for LRP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LRP1 gene, integrated from 9 sources (see all 723):
(articles sorted by number of sources associating them with LRP1)

Utopia: connect your pdf to the dynamic
world of online information

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. (PubMed id 11854294)^{1, 2, 9} Loukinova E.... Strickland D.K. (2002)
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. (PubMed id 15272003)^{1, 2, 9} Ranganathan S.... Strickland D.K. (2004)
Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy. (PubMed id 15634227)^{1, 4, 9} Christoforidis M....Krohn K. (2005)
C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer. (PubMed id 12793904)^{1, 4, 9} Benes P....Vacha J. (2003)
Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)^{1, 4, 9} Cunningham N....O'Donnell J.S. (2005)
Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. (PubMed id 15048651)^{1, 4, 9} Panza F....Solfrizzi V. (2004)
Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease. (PubMed id 12732394)^{1, 4, 9} Pocathikorn A....Mamotte C. (2003)
The intracellular domain of the low density lipoprotein receptor- related protein modulates transactivation mediated by amyloid precursor protein and Fe65. (PubMed id 12888553)^{1, 2, 9} Kinoshita A.... Hyman B.T. (2003)
The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. (PubMed id 11931574)^{1, 4, 9} Benes P....Vacha J. (2002)
Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. (PubMed id 11076057)^{1, 4, 9} Hatanaka Y....Ogihara T. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4035	HGNC: 6692	AceView: LRP1	Ensembl:ENSG00000123384	euGenes: HUgn4035
ECgene: LRP1	Kegg: 4035	H-InvDB: LRP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LRP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for LRP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for LRP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for LRP1 gene:
Search GeneIP for patents involving LRP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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LRP1 Gene

low density lipoprotein receptor-related protein 1

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Cerebral Amyloid Angiopathy
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LRP1 Gene

low density lipoprotein receptor-related protein 1

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