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LRP1 Gene

protein-coding   GIFtS: 70
GCID: GC12P057497

Low Density Lipoprotein Receptor-Related Protein 1

(Previous name: alpha-2-macroglobulin receptor)
(Previous symbols: APR, A2MR)
  See LRP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Low Density Lipoprotein Receptor-Related Protein 11 2     LRP2
A2MR1 2 3 5     LRP1A2
Alpha-2-Macroglobulin Receptor1 2 3     TGFBR52
APR1 2 3     Prolow-Density Lipoprotein Receptor-Related Protein 12
Apolipoprotein E Receptor2 3     TbetaR-V/LRP-1/IGFBP-3 Receptor2
APOER2 3     Type V Tgf-Beta Receptor2
LRP-12 3     CD91 Antigen3
CD912     EC 1.1.1.948
IGFBP3R2     EC 3.4.21.98

External Ids:    HGNC: 66921   Entrez Gene: 40352   Ensembl: ENSG000001233847   OMIM: 1077705   UniProtKB: Q079543   

Export aliases for LRP1 gene to outside databases

Previous GC identifers: GC12P057746 GC12P057239 GC12P055808 GC12P054560


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LRP1 Gene:
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including
intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is
necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main
component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been
found to be lower than controls in brain tissue from Alzheimer patients. (provided by RefSeq, Jan 2010)

GeneCards Summary for LRP1 Gene:
LRP1 (low density lipoprotein receptor-related protein 1) is a protein-coding gene. Diseases associated with LRP1 include compartment syndrome, and liposarcoma. GO annotations related to this gene include protein complex binding and calcium ion binding. An important paralog of this gene is LRP6.

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954
Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early
embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron
remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between
plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism,
kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission
Function: Functions as a receptor for Pseudomonas aeruginosa exotoxin A

Gene Wiki entry for LRP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRP1 gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 2   NF-kappaB   STAT3   AP-2alpha isoform 4   NF-kappaB1   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): LRP1 promoter sequence
   Search Chromatin IP Primers for LRP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

LRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRP1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P057497:  view genomic region     (about GC identifiers)

Start:
57,522,276 bp from pter      End:
57,607,142 bp from pter
Size:
84,867 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954 (See protein sequence)
Recommended Name: Prolow-density lipoprotein receptor-related protein 1 precursor  
Size: 4544 amino acids; 504606 Da
Subunit: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal
subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and
CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and
DAB1. Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is
enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins
Selected PDB 3D structures from and Proteopedia for LRP1 (see all 7):
1CR8 (3D)        1D2L (3D)        1J8E (3D)        2FYJ (3D)        2FYL (3D)        2KNX (3D)    
Secondary accessions: Q2PP12 Q8IVG8

Explore the universe of human proteins at neXtProt for LRP1: NX_Q07954

Explore proteomics data for LRP1 at MOPED

Post-translational modifications: 

  • Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that
    remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain
    from the membrane1
  • The N-terminus is blocked1
  • Phosphorylated on serine and threonine residues1
  • Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with
    SHC11
  • Glycosylation2 at Asn114, Asn136, Asn185, Asn239, Asn274, Asn357, Asn446, Asn729, Thr894, Ser897,
                                 Asn928, Asn1050, Thr1101, Asn1154, Asn1155, Asn1195, Asn1218, Asn1511, Asn1558, Asn1575 (see all 59)
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for LRP1 (Q07954)
     KNVIALA  CPDGSDE 


    See LRP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002323.2  
    ENSEMBL proteins: 
     ENSP00000451449   ENSP00000243077   ENSP00000341264   ENSP00000451737   ENSP00000451622  
     ENSP00000451012  
    Reactome Protein details: Q07954

    LRP1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for LRP1 (LRP-1 Cluster III, LRP-1 Cluster IV, LRP-1 Cluster II)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for LRP1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRP1
    GenScript Custom Purified and Recombinant Proteins Services for LRP1
    Novus Biologicals LRP1 Proteins
    Novus Biologicals LRP1 Lysates
    Sino Biological Recombinant Protein for LRP1
    Sino Biological Cell Lysate for LRP1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRP1

     
    Search eBioscience for Proteins for LRP1 

    LRP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of LRP1
    R&D Systems Antibodies for LRP1 (LRP-1, LRP-1 Cluster III, LRP-1 Cluster II)
    OriGene Antibodies for LRP1
    OriGene Custom Antibody Services for LRP1
    Novus Biologicals LRP1 Antibodies
    Abcam antibodies for LRP1
    Cloud-Clone Corp. Antibodies for LRP1
    ThermoFisher Antibodies for LRP1
    LSBio Antibodies in human, mouse, rat for LRP1

    LRP1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for LRP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for LRP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRP1
    Cloud-Clone Corp. CLIAs for LRP1
    Search eBioscience for ELISAs for LRP1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    LDLR: Low density lipoprotein receptors

    Selected InterPro protein domains (see all 11):
     IPR002172 LDrepeatLR_classA_rpt
     IPR000033 LDLR_classB_rpt
     IPR001881 EGF-like_Ca-bd_dom
     IPR023415 LDLR_class-A_CS
     IPR000742 EG-like_dom

    Graphical View of Domain Structure for InterPro Entry Q07954

    ProtoNet protein and cluster: Q07954

    4 Blocks protein domains:
    IPB000033 Low-density lipoprotein receptor
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB001881 EGF-like calcium-binding
    IPB002172 Low density lipoprotein-receptor


    UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954
    Similarity: Belongs to the LDLR family
    Similarity: Contains 22 EGF-like domains
    Similarity: Contains 31 LDL-receptor class A domains
    Similarity: Contains 34 LDL-receptor class B repeats


    Find genes that share domains with LRP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRP1_HUMAN, Q07954
    Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early
    embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron
    remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between
    plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism,
    kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission
    Function: Functions as a receptor for Pseudomonas aeruginosa exotoxin A

         Genatlas biochemistry entry for LRP1:
    low-density lipoprotein receptor related protein 1,600kDa,LDLR superfamily,putative susceptibility factor for
    Alzheimer disease

         Enzyme Numbers (IUBMB): EC 3.4.21.92 EC 1.1.1.942

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IEA--
    GO:0004872receptor activity TAS10880251
    GO:0005509calcium ion binding ISS--
    GO:0005515protein binding IPI17326667
    GO:0032403protein complex binding IDA8626514
         
    Find genes that share ontologies with LRP1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for LRP1:
     Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 8 alleles(MGI details for Lrp1) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  embryogenesis  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  nervous system  normal  other  reproductive system 

    Find genes that share phenotypes with LRP1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Lrp1tm1Her for LRP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRP1:
    hsa-mir-335-5p (MIRT017720), hsa-mir-1 (MIRT001359), hsa-mir-338-5p (MIRT001161), hsa-mir-205-5p (MIRT001163), hsa-mir-9-5p (MIRT021326), hsa-mir-545-3p (MIRT001162)

    Block miRNA regulation of human, mouse, rat LRP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRP1 (see all 26):
    hsa-miR-4291 hsa-miR-579 hsa-miR-3152-3p hsa-miR-185* hsa-miR-429 hsa-miR-4318 hsa-miR-944 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidLRP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRP1
    Predesigned siRNA for gene silencing in human, mouse, rat LRP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRP1

    Clone
    Products:
         
    OriGene clones in human, mouse for LRP1 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP1 (NM_002332)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRP1_HUMAN, Q07954: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane;
    Single-pass type I membrane protein. Membrane, coated pit
    LRP1_HUMAN, Q07954: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane;
    Peripheral membrane protein; Extracellular side. Membrane, coated pit
    LRP1_HUMAN, Q07954: Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus.
    Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005765lysosomal membrane IDA17897319
    GO:0005768endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane ISS--

    Find genes that share ontologies with LRP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LRP1 About   (see all 14)  
    See pathways by source

    SuperPathContained pathways About
    1Statin Pathway
    Statin Pathway0.73
    Statin Pathway, Pharmacodynamics0.73
    2Alzheimer's disease
    Alzheimers Disease0.44
    Alzheimer's disease0.44
    3Diseases associated with visual transduction
    Visual phototransduction0.44
    Diseases associated with visual transduction0.43
    Retinoid metabolism and transport0.44
    4Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.53
    Scavenging of Heme from Plasma0.53
    5Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    Canonical Wnt Pathway0.53


    Find genes that share SuperPaths with LRP1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for LRP1
        A-beta Uptake & Degradation

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for LRP1
        Alzheimers Disease Pathway

    5 BioSystems Pathways for LRP1
        Statin Pathway
    Wnt Signaling Pathway NetPath
    Alzheimers Disease
    amb2 Integrin signaling
    PDGFR-beta signaling pathway

    2 Sino Biological Pathways for LRP1
        Canonical Wnt Pathway
    Non-Canonical Wnt Pathway

    2 Reactome Pathways for LRP1
        Retinoid metabolism and transport
    Scavenging of heme from plasma

    1 PharmGKB Pathway for LRP1
        Statin Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for LRP1):
        Alzheimer's disease
    Malaria

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP1: 
              Antigen Presenting Cells in human mouse rat
              WNT Signaling Targets in human mouse rat
              Alzheimer's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for LRP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for LRP1 (Q079541, 2, 3 ENSP000002430774) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APBB1O002131, 2, 3, ENSP000002994024EBI-1046087,EBI-81694 MINT-8206789 MINT-8206758 MINT-8206722 I2D: score=4 STRING: ENSP00000299402
    APPP050672, 3, ENSP000002849814MINT-8206789 I2D: score=2 STRING: ENSP00000284981
    SKILP127572, 3MINT-61637 I2D: score=3 
    MBL2P112261, 2, 3, ENSP000003630794EBI-1046087,EBI-5325353 MINT-8040928 MINT-8040706 MINT-8040679 MINT-8040869 MINT-8040821 I2D: score=1 STRING: ENSP00000363079
    FCN2Q154851, 2, 3, ENSP000002917444EBI-1046087,EBI-7468784 MINT-8040880 MINT-8040690 I2D: score=1 STRING: ENSP00000291744
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001523retinoid metabolic process TAS--
    GO:0006898receptor-mediated endocytosis IEA--
    GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0007568aging IEA--
    GO:0007603phototransduction, visible light TAS--

    Find genes that share ontologies with LRP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRP1

    1 HMDB Compound for LRP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 DrugBank Compounds for LRP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Antihemophilic FactorAHF (see all 3)--targetmodulator21391865 17139284 17016423
    Coagulation Factor IXChristmas factor (see all 4)9001-28-9target--17139284 12522212 17016423
    Tenecteplaset- PA (see all 4)191588-94-0target--8344937 1378833 16303771

    Selected Novoseek inferred chemical compound relationships for LRP1 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha 2 macroglobulin 72.4 4 10072300 (1), 16945147 (1)
    exotoxin-a 58 12 11716468 (2), 16262727 (2), 7686151 (1), 9840615 (1) (see all 7)
    methylamine 47.9 4 15161872 (1), 7589486 (1)
    saporin 47.4 3 10877826 (1), 8226837 (1), 8562904 (1)
    cholesterol 46.4 43 9930403 (4), 19718435 (3), 11839845 (2), 16973241 (2) (see all 26)
    n-acetylleucylleucylnorleucinal 43.2 4 17376415 (2)
    heparin 42.9 32 7717977 (3), 11382778 (3), 9253767 (1), 7989348 (1) (see all 17)
    lipid 36.4 51 9568751 (5), 19823686 (4), 19718435 (2), 12417024 (2) (see all 30)
    mannose 22.6 8 11560994 (2), 10438721 (2), 7579446 (2), 11339811 (1) (see all 5)
    chlorate 22.1 1 7592957 (1)



    Find genes that share compounds with LRP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRP1 gene: 
    NM_002332.2  

    Unigene Cluster for LRP1:

    Low density lipoprotein receptor-related protein 1
    Hs.162757  [show with all ESTs]
    Unigene Representative Sequence: NM_002332
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000553277(uc001snb.3) ENST00000243077(uc001snd.3) ENST00000338962(uc010sre.2)
    ENST00000554174(uc001snc.1) ENST00000556830 ENST00000553446(uc009zph.1 uc009zpi.1)
    ENST00000554118 ENST00000555941 ENST00000555124 ENST00000556247 ENST00000451724
    ENST00000556356
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate LRP1 (see all 26):
    hsa-miR-4291 hsa-miR-579 hsa-miR-3152-3p hsa-miR-185* hsa-miR-429 hsa-miR-4318 hsa-miR-944 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidLRP1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for LRP1
    Predesigned siRNA for gene silencing in human, mouse, rat LRP1
    Clone
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    OriGene clones in human, mouse for LRP1 (see all 4)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRP1 (NM_002332)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRP1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for LRP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRP1
      QuantiTect SYBR Green Assays in human, mouse, rat LRP1
      QuantiFast Probe-based Assays in human, mouse, rat LRP1

    Additional mRNA sequence: 

    AB209498.1 BC021204.2 BC045107.1 BC052593.1 BC072015.1 EF491795.1 EF491814.1 X13916.1 
    X55077.1 

    Selected DOTS entries (see all 27):

    DT.99957844  DT.92412213  DT.95365460  DT.119074  DT.102838207  DT.92358788  DT.97801601  DT.101958636 
    DT.75169204  DT.95365458  DT.121182481  DT.95296546  DT.40284724  DT.95365444  DT.95365447  DT.100797814 
    DT.91848558  DT.91900077  DT.92005792  DT.92421325  DT.92448543  DT.92448546  DT.95361161  DT.455293 

    Selected AceView cDNA sequences (see all 666):

    AI151082 R29349 AI360272 CN482517 AW179035 AA494117 AW469008 BQ706295 
    BM129066 AA968513 AL537758 AA970647 BQ181851 BM547585 CD614577 BI770138 
    BF724229 CD614567 X13916 BG056247 CF780663 CA405672 BQ718887 AI191719 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for LRP1 (see all 28)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                                                  -     -                                                                                                   
    SP2:                                                  -                                                                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47a · 47b ^ 48 ^ 49 ^ 50a · 50b · 50c ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b · 53c · 53d ^ 54a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 54b ^ 55 ^ 56 ^ 57a · 57b · 57c ^ 58 ^ 59 ^ 60a · 60b ^ 61a · 61b ^ 62a · 62b · 62c ^ 63 ^ 64a · 64b ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
    SP1:                                                                                                                                          
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for LRP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    LRP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCAACCCCC
    LRP1 Expression
    About this image


    LRP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             Mature brain microvascular endothelial cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Leydig Cells Testis Interstitium
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Ovary (Reproductive System)
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
    LRP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162757

    UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954
    Tissue specificity: Most abundant in liver, brain and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including LRP1: 
              Antigen Presenting Cells in human mouse rat
              WNT Signaling Targets in human mouse rat
              Alzheimer's Disease in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for LRP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrp11 , 5 low density lipoprotein receptor-related protein 11, 5 89.59(n)1
    98.03(a)1
      10 (74.52 cM)5
    169711  NM_008512.21  NP_032538.21 
     1275381615 
    chicken
    (Gallus gallus)
    Aves LRP11 low density lipoprotein receptor-related protein 1 81.14(n)
    87.09(a)
      396170  NM_205242.1  NP_990573.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRP16
    low density lipoprotein receptor-related protein 1...
    84(a)
    1 ↔ 1
    GL343212.1(2025804-2353959)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.182512 Xenopus laevis transcribed sequence with moderate similarity more 75.63(n)    CB198235.2 
    zebrafish
    (Danio rerio)
    Actinopterygii 570925322   -- 84.92(n)    57092532 
    fruit fly
    (Drosophila melanogaster)
    Insecta yl3
    LRP11
    oogenesis vitellogenin receptor3
    LDL receptor protein 11
    27(a)3
    49.79(n)1
    40.19(a)1
      357991  NM_176104.21  NP_788284.21 
    worm
    (Caenorhabditis elegans)
    Secernentea R01H2.33   -- 32(a)
    (best of 6)
      III(7130392-7132330)   --


    ENSEMBL Gene Tree for LRP1 (if available)
    TreeFam Gene Tree for LRP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRP1 gene
    LRP62  LRP52  LRP22  LRP1B2  EGF2  LDLR2  LRP5L2  LRP42  
    VLDLR2  NID22  NID12  LRP82  
    13 SIMAP similar genes for LRP1 using alignment to 7 protein entries:     LRP1_HUMAN (see all proteins):
    LRP    LRP1B    PRSS7    LRP6    LRP5    LRP5L
    NID2    VLDLR    LRP4    LRP2    LRP8    LDLR
    NOTCH2NL

    Find genes that share paralogs with LRP1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for LRP1
    PGOHUM00000258301


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRP1 (see all 2219)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359954
    A colorectal cancer sample4--see VAR_0359952 R H mis40--------
    VAR_0359944
    A colorectal cancer sample4--see VAR_0359942 E K mis40--------
    rs1379095021,2
    Cuntested157394729(+) TGCTTC/TGTGTG 2 S L mis11Minor allele frequency- T:0.00NA 4552
    rs1899925881,2
    --57354086(+) ACACAC/TTCACA 1 -- us2k10--------
    rs1381225131,2
    --57354127(+) AAGTGA/GGAAGT 1 -- us2k10--------
    rs616263211,2
    C--57354227(+) AGCAAG/AGAAGA 1 -- us2k12Minor allele frequency- A:0.04WA 120
    rs111721121,2
    C,F,A,H--57354280(+) GGTAGG/CGGGAG 1 -- us2k1 tfbs3 trp37Minor allele frequency- C:0.09NA NS WA 334
    rs353142421,2
    C,F--57354326(+) GGTTGC/TTCCAG 1 -- us2k13Minor allele frequency- T:0.02NS WA 206
    rs350888351,2
    C,F--57354448(+) GAGTCC/TGCATA 1 -- us2k13Minor allele frequency- T:0.09NS WA 208
    rs73067421,2
    C,F,A,H--57354479(+) GGCCAT/CGGGAG 1 -- us2k113Minor allele frequency- C:0.06NS EA NA WA 754

    HapMap Linkage Disequilibrium report for LRP1 (57522276 - 57607142 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for LRP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2571611CNV Insertion19546169
    nsv899116CNV Loss21882294
    nsv899114CNV Loss21882294
    dgv96n21CNV Loss19592680
    dgv1428n71CNV Loss21882294
    nsv819001CNV Loss19587683
    nsv519293CNV Loss19592680
    nsv832428CNV Gain17160897
    nsv899115CNV Gain+Loss21882294

    Human Gene Mutation Database (HGMD): LRP1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRP1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 107770    OMIM disorders: --

    3 diseases for LRP1:    
    About MalaCards
    compartment syndrome    liposarcoma    alzheimer's disease


    Find genes that share disorders with LRP1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LRP1 gene (see all 53)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 74 89 18673201 (2), 11252768 (2), 10394937 (2), 11436129 (2) (see all 71)
    senile plaques 57.4 14 7531418 (2), 20477378 (1), 10072300 (1), 10936878 (1) (see all 9)
    cerebral amyloid angiopathy 39.6 4 15634227 (1), 18055545 (1)
    glioblastoma 34.6 30 9879460 (6), 9205092 (5), 19176371 (2), 7961982 (1) (see all 9)
    atherosclerosis 34.2 10 15030790 (2), 11357934 (2), 8199172 (1), 9610960 (1) (see all 8)
    neurofibrillary tangles 31.1 3 9341576 (2), 18855584 (1)
    amyloid deposition 28.3 10 11067868 (2), 15634227 (1), 11193147 (1)
    dementia 25.4 3 16470248 (1), 14575236 (1)
    choriocarcinoma 22 1 10471328 (1)
    neurodegenerative diseases 20.5 3 18559293 (1), 11498265 (1), 17314289 (1)

    Genetic Association Database (GAD): LRP1
    Human Genome Epidemiology (HuGE) Navigator: LRP1 (52 documents)

    Export disorders for LRP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRP1 gene, integrated from 10 sources (see all 758):
    (articles sorted by number of sources associating them with LRP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function between LRP and the PDGF. (PubMed id 11854294)1, 2, 9 Loukinova E.... Strickland D.K. (J. Biol. Chem. 2002)
    2. Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. (PubMed id 15272003)1, 2, 9 Ranganathan S.... Strickland D.K. (J. Biol. Chem. 2004)
    3. Association of the LRP1 gene and cognitive performance with amnestic mild cognitive impairment in elderly Chinese. (PubMed id 19664312)1, 4, 9 Shi Y.M....Jia J.P. (Int Psychogeriatr 2009)
    4. Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy. (PubMed id 15634227)1, 4, 9 Christoforidis M....Krohn K. (Neuropathol. Appl. Neurobiol. 2005)
    5. Polymorphisms of APOE and LRP genes in Brazilian individuals with Alzheimer disease. (PubMed id 18317248)1, 4, 9 Bahia V.S....Nitrini R. (Alzheimer Dis Assoc Disord 2008)
    6. C766T low-density lipoprotein receptor-related protein 1 (LRP1) gene polymorphism and susceptibility to breast cancer. (PubMed id 12793904)1, 4, 9 Benes P....VA!cha J. (Breast Cancer Res. 2003)
    7. Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)1, 4, 9 Cunningham N....O'Donnell J.S. (amp 2005)
    8. Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. (PubMed id 15048651)1, 4, 9 Panza F....Solfrizzi V. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004)
    9. Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease. (PubMed id 12732394)1, 4, 9 Pocathikorn A....Mamotte C. (Atherosclerosis 2003)
    10. The intracellular domain of the low density lipoprotein receptor- related protein modulates transactivation mediated by amyloid precursor protein and Fe65. (PubMed id 12888553)1, 2, 9 Kinoshita A.... Hyman B.T. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 4035 HGNC: 6692 AceView: LRP1 Ensembl:ENSG00000123384 euGenes: HUgn4035
    ECgene: LRP1 Kegg: 4035 H-InvDB: LRP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for LRP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for LRP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRP1 gene:
    Search GeneIP for patents involving LRP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRP1
     SwitchGear 3'UTR luciferase reporter plasmids for LRP1
     SwitchGear Promoter luciferase reporter plasmids for LRP1
     ThermoFisher Antibodies for LRP1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat LRP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRP1
     LSBio Antibodies in human, mouse, rat for LRP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for LRP1
      Search eBioscience for proteins for LRP1
      Search eBioscience for elisas for LRP1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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