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LRP1 Gene

protein-coding GIFtS: 72

GC12P055808

low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: APR, A2MR)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
A2MR ^², ³, ⁵
APOER ^², ³
APR ^², ³
CD91 ^¹, ²
FLJ16451 ^²
IGFBP3R ^²
LRP ^¹, ², ³
MGC88725 ^²
TGFBR5 ^²

Descriptions
Alpha-2-macroglobulin receptor ^², ³
Apolipoprotein E receptor ^³
CD91 antigen ^³
TbetaR-V/LRP-1/IGFBP-3 receptor ^²
low density lipoprotein-related protein 1 ^²
low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) ^²
type V tgf-beta receptor ^²

External Ids
HGNC: 6692¹
Entrez Gene: 4035²
UniProtKB: Q07954³
Ensembl: ENSG00000123384⁷

Search outside databases for aliases for LRP1 gene

Previous GC identifers: GC12P057497 GC12P057746 GC12P057239

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells.

Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the

plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as

the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.

May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling,

neuronal calcium signaling as well as neurotransmission

Gene Wiki entry for LRP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LRP1 gene

Entrez Gene cytogenetic band: 12q13-q14 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13-q14

LRP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P055808: (about GC identifiers)

Start:	55,808,543 bp from pter
End:	55,893,409 bp from pter
Size:	84,867 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954 (See protein sequence)

Recommended Name: Prolow-density lipoprotein receptor-related protein 1 precursor

Size: 4544 amino acids; 504575 Da

Subunit: Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached

515-kDa amino-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in

a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The

intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1

Subcellular location: Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell

membrane; Single-pass type I membrane protein. Membrane, coated pit

Subcellular location: Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell

membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit

Subcellular location: Low-density lipoprotein receptor-related protein 1 intracellular domain:

Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the

cytoplasm and in the nucleus

PDB structures from and Proteopedia :

1CR8 (3D)

1D2L (3D)

1J8E (3D)

2FYJ (3D)

2FYL (3D)

Secondary accessions: Q2PP12 Q8IVG8

Post-translational modifications:

Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain

(LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85

releases the intracellular domain from the membrane¹

The N-terminus is blocked¹

Phosphorylated on serine and threonine residues¹

Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes

interaction with SHC1¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002323.2

ENSEMBL proteins:

ENSP00000341264 ENSP00000243077 ENSP00000377419

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for LRP1
	R&D Systems Recombinant & Natural Proteins for LRP1 (LRP-1 Cluster II)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Low Density LRP, MDR Related Antigen)
	Human Recombinant Proteins from Abnova (LRP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	2779654
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	3266596

About this table

Antibodies for LRP1:

	Invitrogen Antibodies for LRP1
	Millipore Mono- and Polyclonal Antibodies for the study of LRP1
	Sigma-Aldrich Antibodies for LRP1
	R&D Systems Antibodies for LRP1 (LRP-1 Cluster II)
	Antibodies from Abcam (Low Density LRP, MDR Related Antigen), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (LRP1)
	Novus Biologicals Antibodies for LRP1

Assays for LRP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q07954

ProtoNet protein and cluster: Q07954

4 Blocks protein families:

IPB000033 Low-density lipoprotein receptor

IPB000152 Aspartic acid and asparagine hydroxylation site

IPB001881 EGF-like calcium-binding

IPB002172 Low density lipoprotein-receptor

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Similarity: Belongs to the LDLR family

Similarity: Contains 22 EGF-like domains

Similarity: Contains 31 LDL-receptor class A domains

Similarity: Contains 34 LDL-receptor class B repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LRP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LRP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002332

Applied Biosystems Silencer® siRNAs for LRP1

Sigma-Aldrich siRNA and siRNA Panels for LRP1

Sigma-Aldrich shRNA for LRP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LRP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002332
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002332
untagged cDNA clone in CMV expression vector: NM_002332

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002332

UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954

Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells.

Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the

plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as

the local metabolism of complexes between plasminogen activators and their endogenous inhibitors.

May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling,

neuronal calcium signaling as well as neurotransmission

Genatlas biochemistry entry for LRP1:

low-density lipoprotein receptor related protein 1,600kDa,LDLR superfamily,putative susceptibility

factor for Alzheimer disease

7 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Lrp1):

	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
liver/biliary system	normal

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	10880251
GO:0005319	lipid transporter activity	TAS	3266596
GO:0005509	calcium ion binding	TAS	3266596
GO:0008034	lipoprotein binding	TAS	2779654
GO:0034185	apolipoprotein binding	IPI	18635818

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for LRP1 (Your Favorite Gene powered by Ingenuity)

Wnt/&beta
Molecular Mechanisms of Cancer
Factors Promoting Cardiogenesis in Vertebrates

GeneDecks LRP1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for LRP1

5/65 Interacting proteins for LRP1 (ENSP00000243077³ Q07954²) via UniProtKB, MINT, and/or STRING (see all 65 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SKIL	P12757²	MINT-61637
LPL	ENSP00000309757³	STRING (score=.999)
PLAT	ENSP00000220809³	STRING (score=.999)
A2M	ENSP00000323929³	STRING (score=.998)
APOE	ENSP00000252486³	STRING (score=.997)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	3266596
GO:0006897	endocytosis	IEA	--
GO:0007275	multicellular organismal development	IEA	--
GO:0008283	cell proliferation	TAS	3266596

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LRP1
10/34 Novoseek chemical compound relationships for LRP1 gene (see all 34 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alpha 2 macroglobulin	73.08	4	10072300 (1), 16945147 (1)
exotoxin-a	59.25	12	11716468 (2), 16262727 (2), 7686151 (1), 9840615 (1) (see all 7)
methylamine	49.41	4	15161872 (1), 7589486 (1)
saporin	49.12	3	10877826 (1), 8226837 (1), 8562904 (1)
cholesterol	44.89	37	9930403 (4), 11839845 (2), 12946703 (2), 16973241 (2) (see all 22)
lipid	36.76	43	9568751 (5), 12417024 (2), 9051197 (2), 11257257 (2) (see all 28)
mannose	24.74	8	11560994 (2), 10438721 (2), 7579446 (2), 11339811 (1) (see all 5)
chlorate	24.12	1	7592957 (1)
cholesterol ester	23.18	3	12566436 (2), 8645351 (1)
heparan sulfate	21.23	4	12426223 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LRP1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (LRP1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002332

Sigma-Aldrich siRNA and siRNA Panels for LRP1

Sigma-Aldrich shRNA for LRP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002332

REFSEQ mRNAs for LRP1 gene:

NM_002332.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002332

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002332
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002332
                                 untagged cDNA clone in CMV expression vector: NM_002332

Additional cDNA sequence:

AB209498.1 BC021204.2 BC045107.1 BC052593.1 BC072015.1 EF491795.1 EF491814.1 X13916.1

X55077.1

24/25 DOTS entries (see all 25 ):

DT.99957844 DT.92412213 DT.95365460 DT.119074 DT.102838207 DT.92358788 DT.97801601 DT.101958636

DT.75169204 DT.95296546 DT.95365458 DT.91848558 DT.100797814 DT.40284724 DT.92448546 DT.95365444

DT.95365447 DT.91900077 DT.92005792 DT.92421325 DT.92448543 DT.95251261 DT.95361161 DT.91958348

24/666 AceView cDNA sequences (see all 666 ):

BM701496 CN482517 CA395263 BU627214 BI770138 CA420488 CD515029 BQ181851

AI360272 CA395140 BU624405 BF724229 AW469008 BQ030027 X13916 CA405672

AA309054 CK000847 BG222378 BU849652 AI921389 AA970647 AA938449 BM678680

highest scoring ESTs for LRP1:

AI969879 X13916 AA034304 AA043572 AA045343 AA045445 AA147753 AA148688 AA161239 AA309054

Unigene Cluster for LRP1:

Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

Hs.162757 [show with all ESTs]

Unigene Representative Sequence: NM_002332

GeneLoc Exon Structure

5/28 Alternative Splicing Database (ASD) splice patterns (SP) for LRP1 (see all 28 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9a	·	9b	·	9c	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^
SP1:																	-		-
SP2:																	-
SP3:
SP4:
SP5:

ExUns:	18	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31a	·	31b	·	31c	^	32	^	33	^	34	^	35a	·	35b	^	36	^	37	^	38	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	39	^	40	^	41	^	42	^	43a	·	43b	^	44	^	45	^	46a	·	46b	^	47a	·	47b	^	48	^	49	^	50a	·	50b	·	50c	^	51a	·	51b	^	52a	·	52b	^	53a	·	53b	·	53c	·	53d	^	54a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	54b	^	55	^	56	^	57a	·	57b	·	57c	^	58	^	59	^	60a	·	60b	^	61a	·	61b	^	62a	·	62b	·	62c	^	63	^	64a	·	64b	^	65	^	66	^	67	^	68	^	69	^
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for LRP1

3 Ensembl transcripts including schematic representations:

ENST00000338962 ENST00000243077 ENST00000393833

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LRP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LRP1

¹ / ² / ³

8 probe-sets matching LRP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
74541_at²^{, 3}	U95-D	1	1.00	1.00	0.97	1.15	AI969879	1.00	1.00	1.00	1
38775_at²^{, 3}	U95-A	1	1.00	1.00	0.94	0.85	X13916	1.00	1.00	1.00	1
200785_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002332	0.60	1.00	0.82	1
200784_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF304759	0.80	1.00	0.91	1
200785_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555353_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200784_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1569042_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LRP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCAACCCCC

SOURCE GeneReport for Unigene cluster: Hs.162757
Expression variation in blood from EXPOLDB for LRP1
UniProtKB/Swiss-Prot: LRP1_HUMAN, Q07954
Tissue specificity: Most abundant in liver, brain and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LRP1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LRP1¹	--	low density lipoprotein-related protein 1 (alpha-2-macroglobulin more	91.33(n) 96.96(a)	481124 XM_538245.2 XP_538245.2
rat (Rattus norvegicus)	Lrp1¹	--	low density lipoprotein-related protein 1 (alpha-2-macroglobulin more	89.61(n) 97.95(a)	299858 XM_243524.4 XP_243524.3
mouse (Mus musculus)	Lrp1^{1, 5}	10⁵	low density lipoprotein receptor-related protein 1^{1, 5}	89.58(n)¹ 98(a)¹	16971¹ NM_008512.2¹ NP_032538.2¹ AF367720⁵ AF369389⁵ (see all 112)
zebrafish (Danio rerio)	57092532²	--	--	84.92(n)	57092532
fruit fly (Drosophila melanogaster)	yl³ CG33087¹	1 12E3--4³	oogenesis vitellogenin receptor³ CG33087¹	27(a)³ 50.15(n)¹ 40.67(a)¹	35799¹ NM_176104.1¹ NP_788284.1¹

About this table Species with no ortholog for LRP1

ENSEMBL Gene Tree for LRP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LRP1 gene

LRP1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/495 NCBI SNPs in LRP1 are shown (see all 495 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 296)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7304504^1,2	A,C,F,H	55892653(+)	`CTGCCG/AGTGAA`	1	--	ut3¹ ese³		4		EU WA NS	330
	rs7306742^1,2	A,C,F,H	55806954(+)	`GGCCAT/CGGGAG`	1	--	ng5¹		6		EU EA WA NS	494
	rs2306691^1,2	C,F,H	55825069(+)	`GCACCA/GACACA`	1	N/D	mis¹		9		EA EU WA	2306
	rs11172112^1,2	A,C,F	55806755(+)	`GGTAGG/CGGGAG`	1	--	ng5¹ tfbs³ trp³		2		NS	88
	rs34577247^1,2	C,F	55864940(+)	`GGATCG/AACCTG`	1	N/D	mis¹		7		NA NS EU EA WA	588
	rs7397167^1,2	C,F	55876051(+)	`CAGCCC/AAGGTG`	1	P/Q	mis¹ ese³		3		NA NS	162
	rs11172123^1,2	C,H	55865132(+)	`TCAGGA/GCTCAT`	1	T/A	mis¹ ese³		8		EU EA WA	826
	rs35314242^1,2	F	55806801(+)	`GGTTGC/TTCCAG`	1	--	ng5¹		2		NS	88
--	rs12425887^1,2	C	55808661(+)	`CACCCA/CCCCTC`	1	--	ut5¹ ese³ trp³		0	--	--	--	--
	rs12369946^1,2	H	55871478(+)	`AGCACG/ATGGGC`	1	M/V	mis¹ ese³		4		EU EA WA	400

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HapMap Linkage Disequilibrium images for LRP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 107770

10/49 Novoseek disease relationships for LRP1 gene (see all 49 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	74.14	83	18673201 (2), 11252768 (2), 10394937 (2), 11436129 (2) (see all 65)
senile plaques	54.83	12	7531418 (2), 10072300 (1), 10936878 (1), 11193147 (1) (see all 7)
cerebral amyloid angiopathy	35.18	4	15634227 (1), 18055545 (1)
atherosclerosis	33.59	10	15030790 (2), 11357934 (2), 8199172 (1), 9610960 (1) (see all 8)
glioblastoma	32.30	30	9879460 (6), 9205092 (5), 19176371 (2), 7961982 (1) (see all 9)
amyloid deposition	23.65	10	11067868 (2), 15634227 (1), 11193147 (1)
neurodegenerative diseases	21.38	3	18559293 (1), 11498265 (1), 17314289 (1)
dementia	21.08	3	16470248 (1), 14575236 (1)
neurofibrillary tangles	18.57	3	9341576 (2), 18855584 (1)
choriocarcinoma	16.78	1	10471328 (1)

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1 PharmGKB disease relationship for LRP1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Gene Mutation Database: LRP1
Genetic Association Database: LRP1
Human Genome Epidemiology Navigator: LRP1 (34 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/595 PubMed articles for LRP1 gene (see all 595 ):

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. (PubMed id 11854294)^{1, 3, 4} Loukinova E.... Strickland D.K. (2002)
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules. (PubMed id 15272003)^{1, 3, 4} Ranganathan S.... Strickland D.K. (2004)
Genetic-morphologic association study: association between the low density lipoprotein-receptor related protein (LRP) and cerebral amyloid angiopathy. (PubMed id 15634227)^{1, 3, 6} Christoforidis M....Krohn K. (2005)
Low-density lipoprotein receptor-related protein polymorphisms in patients with elevated factor VIII coagulant activity and venous thrombosis. (PubMed id 16175004)^{1, 3, 6} Cunningham N....O'Donnell J.S. (2005)
Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. (PubMed id 15048651)^{1, 3, 6} Panza F....Solfrizzi V. (2004)
Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease. (PubMed id 12732394)^{1, 3, 6} Pocathikorn A....Mamotte C. (2003)
The intracellular domain of the low density lipoprotein receptor- related protein modulates transactivation mediated by amyloid precursor protein and Fe65. (PubMed id 12888553)^{1, 3, 4} Kinoshita A.... Hyman B.T. (2003)
The relationship among apolipoprotein(a) polymorphisms, the low-density lipoprotein receptor-related protein, and the very low density lipoprotein receptor genes, and plasma lipoprotein(A) concentration in the Czech population. (PubMed id 11931574)^{1, 3, 6} Benes P....Vacha J. (2002)
Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. (PubMed id 11076057)^{1, 3, 6} Hatanaka Y....Ogihara T. (2000)
NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)- macroglobulin. (PubMed id 10652313)^{1, 3, 4} Dolmer K.... Gettins P.G.W. (2000)

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Entrez Gene: 4035	HGNC: 6692	AceView: LRP1	Ensembl:ENSG00000123384	euGenes: HUgn4035
ECgene: LRP1	H-InvDB: LRP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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ATLAS Chromosomes in Cancer entry for LRP1	Genetics and Cytogenetics in Oncology and Haematology

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LRP1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for LRP1

Summaries
for LRP1

Genomic Location
for LRP1

Proteins
for LRP1

Protein Domains/
Families
for LRP1

Gene Function
for LRP1

Pathways & Interactions
for LRP1

Drugs & Compounds
for LRP1

Transcripts
for LRP1

Expression
for LRP1

Orthologs
for LRP1

Paralogs
for LRP1

SNPs/Variants
for LRP1

Disorders & Mutations
for LRP1

Medical News
for LRP1

Publications
for LRP1

Search for LRP1

Genome Databases showing LRP1

Other Databases showing LRP1

Specialized Databases showing LRP1

Licensable Technologies
for LRP1

Services
for LRP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LRP1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor LRP1

Summariesfor LRP1

Genomic Locationfor LRP1

Proteinsfor LRP1

Protein Domains/Familiesfor LRP1

Gene Functionfor LRP1

Pathways & Interactionsfor LRP1

Drugs & Compoundsfor LRP1

Transcriptsfor LRP1

Expression for LRP1

Orthologsfor LRP1

Paralogsfor LRP1

SNPs/Variantsfor LRP1

Disorders & Mutationsfor LRP1

Medical Newsfor LRP1

Publicationsfor LRP1

Search for LRP1

Genome Databases showing LRP1

Other Databases showing LRP1

Specialized Databases showing LRP1

Licensable Technologiesfor LRP1

Servicesfor LRP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LRP1

Summaries
for LRP1

Genomic Location
for LRP1

Proteins
for LRP1

Protein Domains/
Families
for LRP1

Gene Function
for LRP1

Pathways & Interactions
for LRP1

Drugs & Compounds
for LRP1

Transcripts
for LRP1

Expression
for LRP1

Orthologs
for LRP1

Paralogs
for LRP1

SNPs/Variants
for LRP1

Disorders & Mutations
for LRP1

Medical News
for LRP1

Publications
for LRP1

Licensable Technologies
for LRP1

Services
for LRP1