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Aliases for LRP1 Gene

Aliases for LRP1 Gene

  • Low Density Lipoprotein Receptor-Related Protein 1 2 3
  • Alpha-2-Macroglobulin Receptor 2 3 4
  • A2MR 3 4 6
  • Apolipoprotein E Receptor 3 4
  • APOER 3 4
  • LRP-1 3 4
  • APR 3 4
  • Prolow-Density Lipoprotein Receptor-Related Protein 1 3
  • TbetaR-V/LRP-1/IGFBP-3 Receptor 3
  • Type V Tgf-Beta Receptor 3
  • CD91 Antigen 4
  • EC 3.4.21.9 64
  • EC 1.1.1.94 64
  • IGFBP3R 3
  • TGFBR5 3
  • LRP1A 3
  • CD91 3
  • LRP 3

External Ids for LRP1 Gene

Previous Symbols for LRP1 Gene

  • APR
  • A2MR

Summaries for LRP1 Gene

Entrez Gene Summary for LRP1 Gene

  • The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq, Jan 2010]

GeneCards Summary for LRP1 Gene

LRP1 (Low Density Lipoprotein Receptor-Related Protein 1) is a Protein Coding gene. Diseases associated with LRP1 include compartment syndrome and alzheimer disease. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include calcium ion binding and protein complex binding. An important paralog of this gene is LRP1B.

UniProtKB/Swiss-Prot for LRP1 Gene

  • Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission

  • Functions as a receptor for Pseudomonas aeruginosa exotoxin A

Gene Wiki entry for LRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRP1 Gene

Genomics for LRP1 Gene

Genomic Location for LRP1 Gene

Start:
57,128,493 bp from pter
End:
57,213,359 bp from pter
Size:
84,867 bases
Orientation:
Plus strand

Genomic View for LRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRP1 Gene

Proteins for LRP1 Gene

  • Protein details for LRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q07954-LRP1_HUMAN
    Recommended name:
    Prolow-density lipoprotein receptor-related protein 1
    Protein Accession:
    Q07954
    Secondary Accessions:
    • Q2PP12
    • Q86SW0
    • Q8IVG8

    Protein attributes for LRP1 Gene

    Size:
    4544 amino acids
    Molecular mass:
    504606 Da
    Quaternary structure:
    • Heterodimer of an 85-kDa membrane-bound carboxyl subunit and a non-covalently attached 515-kDa N-terminal subunit. Intracellular domain interacts with MAFB (By similarity). Found in a complex with PID1/PCLI1, LRP1 and CUBNI. Interacts with SNX17, PID1/PCLI1, PDGF and CUBN. The intracellular domain interacts with SHC1, GULP1 and DAB1. Interacts with LRPAP1. Can weakly interact (via NPXY motif) with DAB2 (via PID domain); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif. Interacts with bacterial exotoxins.

    Three dimensional structures from OCA and Proteopedia for LRP1 Gene

    Alternative splice isoforms for LRP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRP1 Gene

Proteomics data for LRP1 Gene at MOPED

Selected DME Specific Peptides for LRP1 Gene

Post-translational modifications for LRP1 Gene

  • Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane.
  • Phosphorylated on serine and threonine residues
  • Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1
  • The N-terminus is blocked
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn114, Asn136, Asn185, Asn239, Asn274, Asn357, Asn446, Asn729, Thr894, Ser897, Asn928, Asn1050, Thr1101, Asn1154, Asn1155, Asn1195, Asn1218, Asn1511, Asn1558, Asn1575, Asn1616, Asn1645, Asn1723, Asn1733, Asn1763, Asn1825, Asn1933, Asn1995, Asn2048, Asn2117, Asn2127, Asn2472, Asn2502, Asn2521, Asn2539, Asn2601, Asn2620, Asn2638, Thr2773, Asn2815, Thr2857, Asn2905, Asn3048, Asn3089, Asn3264, Asn3333, Asn3488, Thr3535, Asn3662, Thr3735, Asn3788, Asn3839, Asn3953, Asn4075, Asn4125, Asn4179, Asn4278, Asn4279, and Asn4364

Other Protein References for LRP1 Gene

Domains for LRP1 Gene

Gene Families for LRP1 Gene

HGNC:
  • CD :CD molecules
  • LDLR :Low density lipoprotein receptors

UniProtKB/Swiss-Prot:

LRP1_HUMAN
Domain:
  • Contains 22 EGF-like domains.:
    • Q07954
  • Contains 31 LDL-receptor class A domains.:
    • Q07954
Family:
  • Belongs to the LDLR family.:
    • Q07954
Similarity:
  • Contains 34 LDL-receptor class B repeats.:
    • Q07954
genes like me logo Genes that share domains with LRP1: view

Function for LRP1 Gene

Molecular function for LRP1 Gene

GENATLAS Biochemistry: low-density lipoprotein receptor related protein 1,600kDa,LDLR superfamily,putative susceptibility factor for Alzheimer disease
UniProtKB/Swiss-Prot Function: Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission
UniProtKB/Swiss-Prot Function: Functions as a receptor for Pseudomonas aeruginosa exotoxin A

Enzyme Numbers (IUBMB) for LRP1 Gene

Gene Ontology (GO) - Molecular Function for LRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IEA --
GO:0004872 receptor activity TAS 10880251
GO:0005509 calcium ion binding ISS --
GO:0005515 protein binding IPI 17326667
GO:0032403 protein complex binding IDA 8626514
genes like me logo Genes that share ontologies with LRP1: view
genes like me logo Genes that share phenotypes with LRP1: view

Animal Models for LRP1 Gene

MGI Knock Outs for LRP1:

No data available for Transcription Factor Targeting and HOMER Transcription for LRP1 Gene

Localization for LRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRP1 Gene

Low-density lipoprotein receptor-related protein 1 85 kDa subunit: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.
Low-density lipoprotein receptor-related protein 1 515 kDa subunit: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.
Low-density lipoprotein receptor-related protein 1 intracellular domain: Cytoplasm. Nucleus. Note=After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus.

Gene Ontology (GO) - Cellular Components for LRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with LRP1: view

Pathways for LRP1 Gene

genes like me logo Genes that share pathways with LRP1: view

Pathways by source for LRP1 Gene

Gene Ontology (GO) - Biological Process for LRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007568 aging IEA --
GO:0007603 phototransduction, visible light TAS --
genes like me logo Genes that share ontologies with LRP1: view

Compounds for LRP1 Gene

(1) HMDB Compounds for LRP1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(3) Drugbank Compounds for LRP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Antihemophilic Factor
  • AHF
target modulator
Coagulation Factor IX
  • Christmas factor
9001-28-9 target
Tenecteplase
  • t- PA
191588-94-0 target

(53) Novoseek inferred chemical compound relationships for LRP1 Gene

Compound -log(P) Hits PubMed IDs
alpha 2 macroglobulin 72.4 2
exotoxin-a 58 9
methylamine 47.9 2
saporin 47.4 3
cholesterol 46.4 34
genes like me logo Genes that share compounds with LRP1: view

Transcripts for LRP1 Gene

Unigene Clusters for LRP1 Gene

Low density lipoprotein receptor-related protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - -
SP2: -
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SP14: -
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SP26:
SP27:
SP28:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^
SP1:
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SP27:
SP28:

ExUns: 39 ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44 ^ 45 ^ 46a · 46b ^ 47a · 47b ^ 48 ^ 49 ^ 50a · 50b · 50c ^ 51a · 51b ^ 52a · 52b ^ 53a · 53b · 53c · 53d ^ 54a ·
SP1:
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SP4:
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SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -
SP12:
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SP14:
SP15:
SP16:
SP17:
SP18: - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:

ExUns: 54b ^ 55 ^ 56 ^ 57a · 57b · 57c ^ 58 ^ 59 ^ 60a · 60b ^ 61a · 61b ^ 62a · 62b · 62c ^ 63 ^ 64a · 64b ^ 65 ^ 66 ^ 67 ^ 68 ^ 69 ^
SP1:
SP2:
SP3:
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SP25:
SP26:
SP27:
SP28:

Relevant External Links for LRP1 Gene

GeneLoc Exon Structure for
LRP1
ECgene alternative splicing isoforms for
LRP1

Expression for LRP1 Gene

mRNA expression in normal human tissues for LRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRP1 Gene

SOURCE GeneReport for Unigene cluster for LRP1 Gene Hs.162757

mRNA Expression by UniProt/SwissProt for LRP1 Gene

Q07954-LRP1_HUMAN
Tissue specificity: Most abundant in liver, brain and lung
genes like me logo Genes that share expressions with LRP1: view

Orthologs for LRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for LRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRP1 36
  • 93.65 (n)
  • 92.05 (a)
LRP1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRP1 36
  • 91.79 (n)
  • 98.2 (a)
LRP1 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRP1 36
  • 92.42 (n)
  • 98.48 (a)
LRP1 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrp1 36
  • 89.59 (n)
  • 98.03 (a)
Lrp1 16
Lrp1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRP1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRP1 37
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrp1 36
  • 89.6 (n)
  • 97.97 (a)
chicken
(Gallus gallus)
Aves LRP1 36
  • 81.14 (n)
  • 87.09 (a)
LRP1 37
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRP1 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18251 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485788 36
  • 73.68 (n)
  • 82.49 (a)
Str.10942 36
zebrafish
(Danio rerio)
Actinopterygii LOC565797 36
  • 72.43 (n)
  • 76.84 (a)
lrp1b 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012372 36
  • 51.09 (n)
  • 40.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta LRP1 36
  • 49.79 (n)
  • 40.19 (a)
yl 38
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea F14B4.1 37
  • 28 (a)
OneToMany
B0244.8 38
  • 31 (a)
R01H2.3 38
  • 32 (a)
F47B3.8 38
  • 29 (a)
T21E3.3 38
  • 31 (a)
lrp-1 38
  • 32 (a)
rme-2 38
  • 27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
ManyToMany
Species with no ortholog for LRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LRP1 Gene

ENSEMBL:
Gene Tree for LRP1 (if available)
TreeFam:
Gene Tree for LRP1 (if available)

Paralogs for LRP1 Gene

Paralogs for LRP1 Gene

Selected SIMAP similar genes for LRP1 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for LRP1 Gene

genes like me logo Genes that share paralogs with LRP1: view

Variants for LRP1 Gene

Sequence variations from dbSNP and Humsavar for LRP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs377819 -- 57,138,947(-) AAGAT(C/G/T)TGAGG intron-variant
rs377834 -- 57,138,938(-) GGATC(C/G)GACAA intron-variant
rs380732 -- 57,134,073(-) GGCAG(C/G)AGGTG intron-variant
rs432134 -- 57,138,960(-) CAAAG(C/G)ACAGA intron-variant
rs448011 -- 57,138,953(-) CAGAG(A/G)AAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRP1 Gene

Variant ID Type Subtype PubMed ID
nsv832428 CNV Gain 17160897
dgv96n21 CNV Loss 19592680
dgv1428n71 CNV Loss 21882294
nsv819001 CNV Loss 19587683
nsv899114 CNV Loss 21882294
nsv519293 CNV Loss 19592680
esv2571611 CNV Insertion 19546169
nsv899115 CNV Gain+Loss 21882294
nsv899116 CNV Loss 21882294

Relevant External Links for LRP1 Gene

HapMap Linkage Disequilibrium report
LRP1
Human Gene Mutation Database (HGMD)
LRP1

Disorders for LRP1 Gene

(53) Novoseek inferred disease relationships for LRP1 Gene

Disease -log(P) Hits PubMed IDs
alzheimers disease 74 78
senile plaques 57.4 10
cerebral amyloid angiopathy 39.6 2
glioblastoma 34.6 19
atherosclerosis 34.2 10

Relevant External Links for LRP1

Genetic Association Database (GAD)
LRP1
Human Genome Epidemiology (HuGE) Navigator
LRP1
genes like me logo Genes that share disorders with LRP1: view

No data available for UniProtKB/Swiss-Prot for LRP1 Gene

Publications for LRP1 Gene

  1. Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. (PMID: 1698775) Strickland D.K. … Argraves W.S. (J. Biol. Chem. 1990) 3 4 23
  2. Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment. (PMID: 2112085) Herz J. … Brown M.S. (EMBO J. 1990) 3 4 23
  3. NMR solution structure of complement-like repeat CR3 from the low density lipoprotein receptor-related protein. Evidence for specific binding to the receptor binding domain of human alpha(2)- macroglobulin. (PMID: 10652313) Dolmer K. … Gettins P.G.W. (J. Biol. Chem. 2000) 3 4 23
  4. Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. (PMID: 11076057) Hatanaka Y. … Ogihara T. (Clin. Genet. 2000) 3 23 49
  5. Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease. (PMID: 11436125) Prince J.A. … Brookes A.J. (Eur. J. Hum. Genet. 2001) 3 23 49

Products for LRP1 Gene

Sources for LRP1 Gene

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