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Aliases for LRMP Gene

Aliases for LRMP Gene

  • Lymphoid Restricted Membrane Protein 2 3 5
  • Lymphoid-Restricted Membrane Protein 2 3
  • Protein Jaw1 3 4
  • JAW1 3 4

External Ids for LRMP Gene

Previous GeneCards Identifiers for LRMP Gene

  • GC12P025565
  • GC12P025217
  • GC12P025105
  • GC12P025096
  • GC12P025205
  • GC12P024975
  • GC12P025173

Summaries for LRMP Gene

Entrez Gene Summary for LRMP Gene

  • The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]

GeneCards Summary for LRMP Gene

LRMP (Lymphoid Restricted Membrane Protein) is a Protein Coding gene. Diseases associated with LRMP include B-Cell Lymphomas and Respiratory System Benign Neoplasm. Among its related pathways are Innate Immune System. An important paralog of this gene is MRVI1.

UniProtKB/Swiss-Prot for LRMP Gene

  • Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRMP Gene

Genomics for LRMP Gene

Regulatory Elements for LRMP Gene

Enhancers for LRMP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G025050 1.5 FANTOM5 ENCODE dbSUPER 34.4 +49.6 49577 6.6 HDGF PKNOX1 ATF1 WRNIP1 SIN3A YY1 ZNF766 FOS JUNB TBX21 LRMP CASC1 ETFRF1 C12orf77 KRAS CENPUP2
GH12G025057 1.3 FANTOM5 ENCODE dbSUPER 20.3 +54.5 54455 1.6 TBP CTCF RAD21 YY1 POLR2A EED SMC3 IKZF2 CREM MTA2 LRMP C12orf77 CASC1 CENPUP2
GH12G024943 2 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -57.0 -56951 7.7 CREB3L1 ZFP64 DMAP1 YY1 SP3 NFYC TBX21 MEF2D ZNF610 GLIS1 LRMP BCAT1 CASC1 ENSG00000255921 DAD1P1
GH12G024951 1.6 FANTOM5 ENCODE dbSUPER 10.7 -52.1 -52124 1.8 PKNOX1 ATF1 ARNT ZNF143 ZNF207 JUNB NCOA1 TBX21 ZNF592 SREBF1 LRMP BCAT1 C12orf77 KRAS BRI3P2
GH12G024995 1.5 FANTOM5 Ensembl ENCODE 11.1 -6.8 -6756 3.7 TBP PKNOX1 TBL1XR1 SIN3A BMI1 GLI4 ZBTB40 CBX5 ELK1 ZNF143 C12orf77 LRMP LOC645177
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LRMP on UCSC Golden Path with GeneCards custom track

Genomic Location for LRMP Gene

Chromosome:
12
Start:
25,004,342 bp from pter
End:
25,108,335 bp from pter
Size:
103,994 bases
Orientation:
Plus strand

Genomic View for LRMP Gene

Genes around LRMP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LRMP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LRMP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRMP Gene

Proteins for LRMP Gene

  • Protein details for LRMP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12912-LRMP_HUMAN
    Recommended name:
    Lymphoid-restricted membrane protein
    Protein Accession:
    Q12912
    Secondary Accessions:
    • A0AVM2
    • B4E077
    • Q8N301

    Protein attributes for LRMP Gene

    Size:
    555 amino acids
    Molecular mass:
    62122 Da
    Quaternary structure:
    • Interacts (via coiled-coil domain) with ITPR3.
    SequenceCaution:
    • Sequence=AAH29391.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=AAI26418.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for LRMP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRMP Gene

Post-translational modifications for LRMP Gene

  • The removal of the C-terminal lumenal domain occurs by proteolytic processing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for LRMP Gene

Domains & Families for LRMP Gene

Protein Domains for LRMP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRMP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12912

UniProtKB/Swiss-Prot:

LRMP_HUMAN :
  • Belongs to the LRMP family.
Family:
  • Belongs to the LRMP family.
genes like me logo Genes that share domains with LRMP: view

No data available for Gene Families for LRMP Gene

Function for LRMP Gene

Molecular function for LRMP Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion.
genes like me logo Genes that share phenotypes with LRMP: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LRMP Gene

Localization for LRMP Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRMP Gene

Processed lymphoid-restricted membrane protein: Cytoplasm.
Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Membrane; Single-pass type IV membrane protein. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Chromosome. Note=Colocalized with ITPR3 on the endoplasmic reticulum membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LRMP gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 4
lysosome 4
cytoskeleton 3
extracellular 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for LRMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with LRMP: view

Pathways & Interactions for LRMP Gene

genes like me logo Genes that share pathways with LRMP: view

Pathways by source for LRMP Gene

3 Reactome pathways for LRMP Gene

Interacting Proteins for LRMP Gene

Gene Ontology (GO) - Biological Process for LRMP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006903 vesicle targeting TAS 8021504
GO:0006906 vesicle fusion TAS 8021504
GO:0007338 single fertilization IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with LRMP: view

No data available for SIGNOR curated interactions for LRMP Gene

Drugs & Compounds for LRMP Gene

No Compound Related Data Available

Transcripts for LRMP Gene

Unigene Clusters for LRMP Gene

Lymphoid-restricted membrane protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRMP Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - -
SP6:
SP7: - -
SP8: - - - - -
SP9: -
SP10: - - - -
SP11: - -
SP12: - - - - -
SP13:

ExUns: 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for LRMP Gene

GeneLoc Exon Structure for
LRMP
ECgene alternative splicing isoforms for
LRMP

Expression for LRMP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LRMP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRMP Gene

This gene is overexpressed in Whole Blood (x10.4).

Protein differential expression in normal tissues from HIPED for LRMP Gene

This gene is overexpressed in Ovary (31.7), Peripheral blood mononuclear cells (17.6), and Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for LRMP Gene



Protein tissue co-expression partners for LRMP Gene

NURSA nuclear receptor signaling pathways regulating expression of LRMP Gene:

LRMP

SOURCE GeneReport for Unigene cluster for LRMP Gene:

Hs.124922

mRNA Expression by UniProt/SwissProt for LRMP Gene:

Q12912-LRMP_HUMAN
Tissue specificity: Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles.

Evidence on tissue expression from TISSUES for LRMP Gene

  • Nervous system(4.2)
  • Liver(4.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with LRMP: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LRMP Gene

Orthologs for LRMP Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRMP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRMP 35 34
  • 98.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia LRMP 34 35
  • 89.29 (n)
cow
(Bos Taurus)
Mammalia LRMP 35 34
  • 87.9 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Lrmp 16 35 34
  • 74.87 (n)
rat
(Rattus norvegicus)
Mammalia Lrmp 34
  • 72.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
-- 35
  • 4 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LRMP 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves LRMP 35 34
  • 64.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 57 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia lrmp 34
  • 61.88 (n)
zebrafish
(Danio rerio)
Actinopterygii lrmp 34 35
  • 51.76 (n)
Species where no ortholog for LRMP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRMP Gene

ENSEMBL:
Gene Tree for LRMP (if available)
TreeFam:
Gene Tree for LRMP (if available)

Paralogs for LRMP Gene

Paralogs for LRMP Gene

(1) SIMAP similar genes for LRMP Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with LRMP: view

Variants for LRMP Gene

Sequence variations from dbSNP and Humsavar for LRMP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000067516 -- 25,096,527(+) TGTTT(A/G)GTTAC intron-variant
rs1000115510 -- 25,054,676(+) CTTGA(A/G)TTATG intron-variant
rs1000126534 -- 25,083,644(+) GCAAA(C/G)TAGTT intron-variant
rs1000165330 -- 25,066,046(+) AGTTG(C/T)TTAGT intron-variant
rs1000195336 -- 25,066,362(+) TACTG(C/T)AGATG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for LRMP Gene

Variant ID Type Subtype PubMed ID
dgv2412n54 CNV gain 21841781
esv1073866 CNV insertion 17803354
esv1691407 CNV insertion 17803354
esv2422312 CNV duplication 17116639
esv2521669 CNV insertion 19546169
esv2759884 CNV loss 17122850
esv3892163 CNV loss 25118596
nsv469169 CNV gain 19166990
nsv469173 CNV gain 19166990
nsv52528 CNV deletion 16902084
nsv557775 CNV gain 21841781
nsv951340 CNV duplication 24416366

Variation tolerance for LRMP Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.73; 96.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LRMP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LRMP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRMP Gene

Disorders for LRMP Gene

MalaCards: The human disease database

(2) MalaCards diseases for LRMP Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
b-cell lymphomas
  • b-cell lymphoma
respiratory system benign neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search LRMP in MalaCards View complete list of genes associated with diseases

Relevant External Links for LRMP

Genetic Association Database (GAD)
LRMP
Human Genome Epidemiology (HuGE) Navigator
LRMP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LRMP
genes like me logo Genes that share disorders with LRMP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LRMP Gene

Publications for LRMP Gene

  1. Jaw1, a lymphoid-restricted membrane protein localized to the endoplasmic reticulum. (PMID: 8021504) Behrens T.W. … Staudt L.M. (J. Immunol. 1994) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  4. A gene-based risk score for lung cancer susceptibility in smokers and ex-smokers. (PMID: 19789190) Young R.P. … Gamble G.D. (Postgrad Med J 2009) 3 46 64
  5. Association of KRAS polymorphisms with risk for lung adenocarcinoma accompanied by atypical adenomatous hyperplasias. (PMID: 18299280) Kohno T. … Yokota J. (Carcinogenesis 2008) 3 46 64

Products for LRMP Gene

Sources for LRMP Gene

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