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LRIT1 Gene

protein-coding   GIFtS: 49
GCID: GC10M085982

Leucine-Rich Repeat, Immunoglobulin-Like And Transmembrane...

(Previous name: leucine rich repeat containing 21)
(Previous symbol: LRRC21)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leucine-Rich Repeat, Immunoglobulin-Like And Transmembrane Domains
11 2
     PAL2 3
LRRC211 2 3     Fibronectin Type III1
Leucine Rich Repeat Containing 211 2     Immunoglobulin And Leucine Rich Repeat Domains 91
Leucine-Rich Repeat-Containing Protein 212 3     FIGLER92
Photoreceptor-Associated LRR Superfamily Protein2 3     Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 92
Retina-Specific Protein PAL2 3     Leucine-Rich Repeat, Immunoglobulin-Like Domain And Transmembrane
Domain-Containing Protein 12

External Ids:    HGNC: 234041   Entrez Gene: 261032   Ensembl: ENSG000001486027   UniProtKB: Q9P2V43   

Export aliases for LRIT1 gene to outside databases

Previous GC identifer: GC10M079836


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for LRIT1 Gene:
LRIT1 (leucine-rich repeat, immunoglobulin-like and transmembrane domains 1) is a protein-coding gene. An important paralog of this gene is LRIT3.

UniProtKB/Swiss-Prot: LRIT1_HUMAN, Q9P2V4
Function: Possible role in phototransduction




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the LRIT1 gene promoter:
         GR   GR-beta   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLRIT1 promoter sequence
   Search Chromatin IP Primers for LRIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LRIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q23.1   HGNC cytogenetic band: 10q23

LRIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LRIT1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M085982:  view genomic region     (about GC identifiers)

Start:
85,991,276 bp from pter      End:
86,001,217 bp from pter
Size:
9,942 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LRIT1_HUMAN, Q9P2V4 (See protein sequence)
Recommended Name: Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
precursor  
Size: 623 amino acids; 68041 Da
Subunit: Homodimer (By similarity)
Secondary accessions: Q0QD41 Q9Y4N7

Explore the universe of human proteins at neXtProt for LRIT1: NX_Q9P2V4

Explore proteomics data for LRIT1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn156, Asn296, Asn455
  • Modification sites at PhosphoSitePlus

  • See LRIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056428.1  
    ENSEMBL proteins: 
     ENSP00000361177  

    LRIT1 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for LRIT1
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for LRIT1

     
    Search eBioscience for Proteins for LRIT1 

     
    antibodies-online proteins for LRIT1 (3 products) 

     
    antibodies-online peptides for LRIT1

    LRIT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for LRIT1
    Cloud-Clone Corp. Antibodies for LRIT1
    Search ThermoFisher Antibodies for LRIT1
    LSBio Antibodies in human, mouse, rat for LRIT1
    antibodies-online antibodies for LRIT1 (9 products) 

    LRIT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for LRIT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for LRIT1
    Cloud-Clone Corp. CLIAs for LRIT1
    Search eBioscience for ELISAs for LRIT1 
    antibodies-online kits for LRIT1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 9):
     IPR003598 Ig_sub2
     IPR007110 Ig-like_dom
     IPR000483 Cys-rich_flank_reg_C
     IPR000372 LRR-contain_N
     IPR001611 Leu-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q9P2V4

    ProtoNet protein and cluster: Q9P2V4

    3 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB000483 Cysteine-rich flanking region
    IPB003598 Immunoglobulin C-2 type


    UniProtKB/Swiss-Prot: LRIT1_HUMAN, Q9P2V4
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 6 LRR (leucine-rich) repeats
    Similarity: Contains 1 LRRCT domain
    Similarity: Contains 1 LRRNT domain


    Find genes that share domains with LRIT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LRIT1_HUMAN, Q9P2V4
    Function: Possible role in phototransduction

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LRIT1           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LRIT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for LRIT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LRIT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LRIT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target LRIT1:
    hsa-mir-1229-3p (MIRT036337)

    Block miRNA regulation of human, mouse, rat LRIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRIT1 (see all 15):
    hsa-miR-3934 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-3136-5p hsa-miR-302a hsa-miR-302e hsa-miR-373
    SwitchGear 3'UTR luciferase reporter plasmidLRIT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for LRIT1
    Predesigned siRNA for gene silencing in human, mouse, rat LRIT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for LRIT1

    Clone
    Products:
         
    OriGene clones in human, mouse for LRIT1 (see all 5)
    OriGene ORF clones in mouse, rat for LRIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRIT1 (NM_015613)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for LRIT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for LRIT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LRIT1_HUMAN, Q9P2V4: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane3
    extracellular2
    golgi apparatus1
    lysosome1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030176integral component of endoplasmic reticulum membrane ISS--

    Find genes that share ontologies with LRIT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LRIT1
    Interactions:

        Search GeneGlobe Interaction Network for LRIT1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for LRIT1 (ENSP000003611774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAB39ENSP000002584184STRING: ENSP00000258418
    CAB39LENSP000002616694STRING: ENSP00000261669
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with LRIT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LRIT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LRIT1 gene: 
    NM_015613.2  

    Unigene Cluster for LRIT1:

    Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
    Hs.226000  [show with all ESTs]
    Unigene Representative Sequence: NM_015613
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000372105(uc001kcz.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat LRIT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate LRIT1 (see all 15):
    hsa-miR-3934 hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-3136-5p hsa-miR-302a hsa-miR-302e hsa-miR-373
    SwitchGear 3'UTR luciferase reporter plasmidLRIT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for LRIT1
    Predesigned siRNA for gene silencing in human, mouse, rat LRIT1
    Clone
    Products:
         
    OriGene clones in human, mouse for LRIT1 (see all 5)
    OriGene ORF clones in mouse, rat for LRIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: LRIT1 (NM_015613)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LRIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LRIT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for LRIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRIT1
      QuantiTect SYBR Green Assays in human, mouse, rat LRIT1
      QuantiFast Probe-based Assays in human, mouse, rat LRIT1

    Additional mRNA sequence: 

    AB031547.1 AL080175.1 DQ426881.1 DQ426882.1 

    1 DOTS entry:

    DT.91972920 

    5 AceView cDNA sequences:

    AL080175 BM716666 NM_015613 AB031547 BX510255 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LRIT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCGGGTGA
    LRIT1 Expression
    About this image


    LRIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
    LRIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LRIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.226000
        Custom PCR Arrays for LRIT1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for LRIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat LRIT1
    QuantiTect SYBR Green Assays in human, mouse, rat LRIT1
    QuantiFast Probe-based Assays in human, mouse, rat LRIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LRIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for LRIT1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lrit11 , 5 leucine-rich repeat, immunoglobulin-like and transmembrane more1, 5 79.35(n)1
    78.97(a)1
      14 (21.29 cM)5
    2390371  NM_146245.21  NP_666357.21 
     370548305 
    chicken
    (Gallus gallus)
    Aves LRIT11 leucine-rich repeat, immunoglobulin-like and transmembrane more 63.64(n)
    58.18(a)
      428935  XM_003641454.2  XP_003641502.1 
    lizard
    (Anolis carolinensis)
    Reptilia LRIT16
    leucine-rich repeat, immunoglobulin-like and trans...
    54(a)
    1 ↔ 1
    GL343199.1(3295391-3335577)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia lrit11 leucine-rich repeat, immunoglobulin-like and transmembrane more 57.27(n)
    53.36(a)
      100497318  XM_002933904.2  XP_002933950.2 
    zebrafish
    (Danio rerio)
    Actinopterygii lrit1b1 leucine-rich repeat, immunoglobulin-like and transmembrane more 58.7(n)
    52.06(a)
      553432  NM_001042753.1  NP_001036218.1 


    ENSEMBL Gene Tree for LRIT1 (if available)
    TreeFam Gene Tree for LRIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LRIT1 gene
    LRIT32  LRIT22  
    1 SIMAP similar gene for LRIT1 using alignment to 1 protein entry:     LRIT1_HUMAN:
    LRIT3

    Find genes that share paralogs with LRIT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LRIT1 (see all 368)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894948071,2
    --85990937(+) TAACCA/GTGGAT 1 -- ds50010--------
    rs797770021,2
    C,F--85990982(+) AATTTG/TCCTAG 1 -- ds50011Minor allele frequency- T:0.06NA 120
    rs171032641,2
    C,F,H--85990991(+) AGCTGT/CGTAAT 1 -- ds500114Minor allele frequency- C:0.17NA NS EA WA 926
    rs1817670011,2
    --85990992(+) GCTGTA/GTAATC 1 -- ds50010--------
    rs1162147621,2
    C,F--85991022(+) TCACTG/TTTCAG 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1151679111,2
    F--85991029(+) TCAGCA/GCATAT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1871617071,2
    --85991041(+) CCTTGC/GTCTAC 1 -- ds50010--------
    rs79099011,2
    C,F,A,H--85991083(+) GCCCCG/ATCAAA 1 -- ds500116Minor allele frequency- A:0.48NS EA NA WA CSA 794
    rs1140181651,2
    F--85991104(+) GCCATG/AAGACT 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1129354251,2
    C,F--85991176(+) ACAGGC/TATTGC 1 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for LRIT1 (85991276 - 86001217 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LRIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv895828CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LRIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for LRIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with LRIT1           About GenesLikeMe

    Genetic Association Database (GAD): LRIT1
    Human Genome Epidemiology (HuGE) Navigator: LRIT1 (3 documents)

    Export disorders for LRIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LRIT1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with LRIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a novel membrane glycoprotein, Pal, specifically expressed in photoreceptor cells of the retina and containing leucine- rich repeat. (PubMed id 10777785)1, 2, 3 Gomi F.... Tohyama M. (J. Neurosci. 2000)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    4. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    5. Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)2 Roni V.... Wissinger B. (BMC Genomics 2007)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26103 HGNC: 23404 AceView: LRRC21 Ensembl:ENSG00000148602 euGenes: HUgn26103
    ECgene: LRIT1 H-InvDB: LRIT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LRIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LRIT1 gene:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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