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Aliases for LRIT1 Gene

Aliases for LRIT1 Gene

  • Leucine-Rich Repeat, Immunoglobulin-Like And Transmembrane Domains 1 2 3
  • Photoreceptor-Associated LRR Superfamily Protein 3 4
  • Leucine-Rich Repeat-Containing Protein 21 3 4
  • Leucine Rich Repeat Containing 21 2 3
  • Retina-Specific Protein PAL 3 4
  • LRRC21 3 4
  • PAL 3 4
  • Leucine-Rich Repeat, Immunoglobulin-Like Domain And Transmembrane Domain-Containing Protein 1 3
  • Fibronectin Type III, Immunoglobulin And Leucine Rich Repeat Domains 9 3
  • Immunoglobulin And Leucine Rich Repeat Domains 9 2
  • Fibronectin Type III 2
  • FIGLER9 3

External Ids for LRIT1 Gene

Previous HGNC Symbols for LRIT1 Gene

  • LRRC21

Previous GeneCards Identifiers for LRIT1 Gene

  • GC10M085982
  • GC10M079836

Summaries for LRIT1 Gene

GeneCards Summary for LRIT1 Gene

LRIT1 (Leucine-Rich Repeat, Immunoglobulin-Like And Transmembrane Domains 1) is a Protein Coding gene. An important paralog of this gene is LRIT3.

UniProtKB/Swiss-Prot for LRIT1 Gene

  • Possible role in phototransduction.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIT1 Gene

Genomics for LRIT1 Gene

Regulatory Elements for LRIT1 Gene

Genomic Location for LRIT1 Gene

84,231,520 bp from pter
84,241,461 bp from pter
9,942 bases
Minus strand

Genomic View for LRIT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIT1 Gene

Proteins for LRIT1 Gene

  • Protein details for LRIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q0QD41
    • Q9Y4N7

    Protein attributes for LRIT1 Gene

    623 amino acids
    Molecular mass:
    68041 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for LRIT1 Gene

Proteomics data for LRIT1 Gene at MOPED

Post-translational modifications for LRIT1 Gene

  • Glycosylation at Asn156, Asn296, and Asn455
  • Modification sites at PhosphoSitePlus

Other Protein References for LRIT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LRIT1 Gene

Domains for LRIT1 Gene

Gene Families for LRIT1 Gene

  • FN3 :Fibronectin type III domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing

Suggested Antigen Peptide Sequences for LRIT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9P2V4
  • Contains 1 fibronectin type-III domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
  • Contains 6 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with LRIT1: view

Function for LRIT1 Gene

Molecular function for LRIT1 Gene

UniProtKB/Swiss-Prot Function:
Possible role in phototransduction.

Gene Ontology (GO) - Molecular Function for LRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LRIT1: view

Animal Model Products

miRNA for LRIT1 Gene

miRTarBase miRNAs that target LRIT1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRIT1 Gene

Localization for LRIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIT1 Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for LRIT1 Gene COMPARTMENTS Subcellular localization image for LRIT1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for LRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030176 integral component of endoplasmic reticulum membrane ISS --
genes like me logo Genes that share ontologies with LRIT1: view

Pathways for LRIT1 Gene

SuperPathways for LRIT1 Gene

No Data Available

Interacting Proteins for LRIT1 Gene

Gene Ontology (GO) - Biological Process for LRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LRIT1: view

No data available for Pathways by source for LRIT1 Gene

Transcripts for LRIT1 Gene

mRNA/cDNA for LRIT1 Gene

(5) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LRIT1 Gene

Leucine-rich repeat, immunoglobulin-like and transmembrane domains 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LRIT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LRIT1 Gene

No ASD Table

Relevant External Links for LRIT1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LRIT1 Gene

mRNA expression in normal human tissues for LRIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LRIT1 Gene

This gene is overexpressed in Testis (49.3).

Protein differential expression in normal tissues for LRIT1 Gene

This gene is overexpressed in Vitreous humor (50.3) and Retina (16.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for LRIT1 Gene

SOURCE GeneReport for Unigene cluster for LRIT1 Gene Hs.226000

genes like me logo Genes that share expressions with LRIT1: view

Expression partners for LRIT1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for LRIT1 Gene

Orthologs for LRIT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRIT1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LRIT1 35
  • 82.85 (n)
  • 80.39 (a)
LRIT1 36
  • 80 (a)
(Mus musculus)
Mammalia Lrit1 35
  • 79.35 (n)
  • 78.97 (a)
Lrit1 16
Lrit1 36
  • 79 (a)
(Pan troglodytes)
Mammalia LRIT1 35
  • 98.61 (n)
  • 98.23 (a)
LRIT1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Lrit1 35
  • 79.24 (n)
  • 78.81 (a)
(Canis familiaris)
Mammalia LRIT1 36
  • 75 (a)
(Monodelphis domestica)
Mammalia LRIT1 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia LRIT1 36
  • 48 (a)
(Gallus gallus)
Aves LRIT1 35
  • 63.64 (n)
  • 58.18 (a)
LRIT1 36
  • 55 (a)
(Anolis carolinensis)
Reptilia LRIT1 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia lrit1 35
  • 57.27 (n)
  • 53.36 (a)
(Danio rerio)
Actinopterygii lrit1b 35
  • 58.7 (n)
  • 52.06 (a)
lrit1a 36
  • 47 (a)
lrit1b 36
  • 46 (a)
Species with no ortholog for LRIT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRIT1 Gene

Gene Tree for LRIT1 (if available)
Gene Tree for LRIT1 (if available)

Paralogs for LRIT1 Gene

Paralogs for LRIT1 Gene

Selected SIMAP similar genes for LRIT1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with LRIT1: view

Variants for LRIT1 Gene

Sequence variations from dbSNP and Humsavar for LRIT1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs754620 -- 84,237,746(+) CCCAC(C/T)GCTAC intron-variant
rs754621 -- 84,237,932(+) GGTCC(G/T)GCAAG intron-variant
rs3814206 -- 84,234,154(-) CAGCA(C/T)TGCTA reference, synonymous-codon
rs3814207 -- 84,233,961(-) CTGGG(C/T)TTCCA intron-variant
rs3814208 -- 84,233,934(-) TTGAC(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LRIT1 Gene

Variant ID Type Subtype PubMed ID
nsv895828 CNV Loss 21882294

Relevant External Links for LRIT1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LRIT1 Gene

Disorders for LRIT1 Gene

Relevant External Links for LRIT1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for LRIT1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for LRIT1 Gene

Publications for LRIT1 Gene

  1. Molecular cloning of a novel membrane glycoprotein, Pal, specifically expressed in photoreceptor cells of the retina and containing leucine- rich repeat. (PMID: 10777785) Gomi F. … Tohyama M. (J. Neurosci. 2000) 2 3 4
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 4
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for LRIT1 Gene

Sources for LRIT1 Gene

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